int-snw-2146

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.934	1.80e-15	2.53e-03	4.07e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-2146 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
ATP1A1	476	2	0.842	1.002	82	Yes	-
SAP18	10284	8	1.115	1.069	57	Yes	-
PHB2	11331	9	0.829	1.076	140	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
[ EZH2 ]	2146	1	0.020	0.934	105	-	-

Interactions (7)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
RPSA	3921	PHB2	11331	pp	--	int.I2D: IntAct_Yeast
ACTB	60	PHB2	11331	pp	--	int.I2D: IntAct_Yeast
EZH2	2146	SAP18	10284	pp	--	int.I2D: IntAct_Fly, BIND_Fly
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ATP1A1	476	EZH2	2146	pp	--	int.Intact: MI:0915(physical association); int.I2D: HPRD, IntAct, BioGrid, StelzlMedium; int.HPRD: yeast 2-hybrid
EZH2	2146	PHB2	11331	pp	--	int.I2D: BioGrid
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct

Related GO terms (205)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0043234	protein complex	2.79e-04	1.00e+00	4.389	3	18	295
GO:0014013	regulation of gliogenesis	4.85e-04	1.00e+00	11.009	1	1	1
GO:0045605	negative regulation of epidermal cell differentiation	4.85e-04	1.00e+00	11.009	1	1	1
GO:0045989	positive regulation of striated muscle contraction	4.85e-04	1.00e+00	11.009	1	1	1
GO:0031947	negative regulation of glucocorticoid biosynthetic process	4.85e-04	1.00e+00	11.009	1	1	1
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9.70e-04	1.00e+00	10.009	1	1	2
GO:0005055	laminin receptor activity	9.70e-04	1.00e+00	10.009	1	1	2
GO:0006407	rRNA export from nucleus	9.70e-04	1.00e+00	10.009	1	1	2
GO:0006325	chromatin organization	1.36e-03	1.00e+00	5.126	2	5	118
GO:0051154	negative regulation of striated muscle cell differentiation	1.46e-03	1.00e+00	9.424	1	1	3
GO:0061574	ASAP complex	1.46e-03	1.00e+00	9.424	1	1	3
GO:1990239	steroid hormone binding	1.46e-03	1.00e+00	9.424	1	1	3
GO:0070314	G1 to G0 transition	1.46e-03	1.00e+00	9.424	1	1	3
GO:1903416	response to glycoside	1.46e-03	1.00e+00	9.424	1	1	3
GO:0031402	sodium ion binding	1.46e-03	1.00e+00	9.424	1	1	3
GO:0000790	nuclear chromatin	1.62e-03	1.00e+00	4.998	2	9	129
GO:0046976	histone methyltransferase activity (H3-K27 specific)	1.94e-03	1.00e+00	9.009	1	1	4
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.94e-03	1.00e+00	9.009	1	1	4
GO:0030686	90S preribosome	1.94e-03	1.00e+00	9.009	1	1	4
GO:0070734	histone H3-K27 methylation	1.94e-03	1.00e+00	9.009	1	1	4
GO:0005515	protein binding	2.21e-03	1.00e+00	1.260	7	184	6024
GO:0071168	protein localization to chromatin	2.42e-03	1.00e+00	8.687	1	1	5
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	2.42e-03	1.00e+00	8.687	1	1	5
GO:0000730	DNA recombinase assembly	2.42e-03	1.00e+00	8.687	1	1	5
GO:2000001	regulation of DNA damage checkpoint	2.42e-03	1.00e+00	8.687	1	1	5
GO:0045823	positive regulation of heart contraction	2.42e-03	1.00e+00	8.687	1	1	5
GO:0021695	cerebellar cortex development	2.91e-03	1.00e+00	8.424	1	2	6
GO:0045822	negative regulation of heart contraction	2.91e-03	1.00e+00	8.424	1	1	6
GO:0030957	Tat protein binding	2.91e-03	1.00e+00	8.424	1	3	6
GO:0060744	mammary gland branching involved in thelarche	2.91e-03	1.00e+00	8.424	1	1	6
GO:0036376	sodium ion export from cell	2.91e-03	1.00e+00	8.424	1	1	6
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	2.91e-03	1.00e+00	8.424	1	1	6
GO:0086013	membrane repolarization during cardiac muscle cell action potential	3.39e-03	1.00e+00	8.201	1	1	7
GO:0000028	ribosomal small subunit assembly	3.39e-03	1.00e+00	8.201	1	1	7
GO:0045814	negative regulation of gene expression, epigenetic	3.39e-03	1.00e+00	8.201	1	1	7
GO:0030955	potassium ion binding	3.39e-03	1.00e+00	8.201	1	1	7
GO:0005391	sodium:potassium-exchanging ATPase activity	3.88e-03	1.00e+00	8.009	1	1	8
GO:0042054	histone methyltransferase activity	3.88e-03	1.00e+00	8.009	1	1	8
GO:0048387	negative regulation of retinoic acid receptor signaling pathway	3.88e-03	1.00e+00	8.009	1	2	8
GO:0086009	membrane repolarization	3.88e-03	1.00e+00	8.009	1	1	8
GO:0070688	MLL5-L complex	3.88e-03	1.00e+00	8.009	1	1	8
GO:0030007	cellular potassium ion homeostasis	4.36e-03	1.00e+00	7.839	1	2	9
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter	4.84e-03	1.00e+00	7.687	1	1	10
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	4.84e-03	1.00e+00	7.687	1	1	10
GO:0010569	regulation of double-strand break repair via homologous recombination	4.84e-03	1.00e+00	7.687	1	1	10
GO:0071383	cellular response to steroid hormone stimulus	4.84e-03	1.00e+00	7.687	1	1	10
GO:0086004	regulation of cardiac muscle cell contraction	4.84e-03	1.00e+00	7.687	1	1	10
GO:0005890	sodium:potassium-exchanging ATPase complex	4.84e-03	1.00e+00	7.687	1	1	10
GO:0031571	mitotic G1 DNA damage checkpoint	5.33e-03	1.00e+00	7.549	1	4	11
GO:0045120	pronucleus	5.33e-03	1.00e+00	7.549	1	2	11
GO:0086064	cell communication by electrical coupling involved in cardiac conduction	5.81e-03	1.00e+00	7.424	1	2	12
GO:0055119	relaxation of cardiac muscle	5.81e-03	1.00e+00	7.424	1	1	12
GO:0006883	cellular sodium ion homeostasis	5.81e-03	1.00e+00	7.424	1	1	12
GO:0060081	membrane hyperpolarization	5.81e-03	1.00e+00	7.424	1	1	12
GO:0010107	potassium ion import	6.29e-03	1.00e+00	7.308	1	1	13
GO:0005662	DNA replication factor A complex	6.29e-03	1.00e+00	7.308	1	1	13
GO:0002028	regulation of sodium ion transport	6.29e-03	1.00e+00	7.308	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	6.78e-03	1.00e+00	7.201	1	4	14
GO:0035098	ESC/E(Z) complex	7.26e-03	1.00e+00	7.102	1	1	15
GO:0048025	negative regulation of mRNA splicing, via spliceosome	7.26e-03	1.00e+00	7.102	1	1	15
GO:0060749	mammary gland alveolus development	7.26e-03	1.00e+00	7.102	1	2	15
GO:0050998	nitric-oxide synthase binding	7.74e-03	1.00e+00	7.009	1	1	16
GO:0002026	regulation of the force of heart contraction	8.22e-03	1.00e+00	6.921	1	1	17
GO:0006754	ATP biosynthetic process	8.71e-03	1.00e+00	6.839	1	1	18
GO:0035861	site of double-strand break	8.71e-03	1.00e+00	6.839	1	1	18
GO:0016791	phosphatase activity	8.71e-03	1.00e+00	6.839	1	1	18
GO:0035145	exon-exon junction complex	9.19e-03	1.00e+00	6.761	1	1	19
GO:0019901	protein kinase binding	9.40e-03	1.00e+00	3.700	2	21	317
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	9.67e-03	1.00e+00	6.687	1	2	20
GO:0006298	mismatch repair	9.67e-03	1.00e+00	6.687	1	3	20
GO:0030506	ankyrin binding	9.67e-03	1.00e+00	6.687	1	1	20
GO:0043548	phosphatidylinositol 3-kinase binding	1.01e-02	1.00e+00	6.616	1	2	21
GO:0032201	telomere maintenance via semi-conservative replication	1.01e-02	1.00e+00	6.616	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.01e-02	1.00e+00	6.616	1	4	21
GO:0006306	DNA methylation	1.06e-02	1.00e+00	6.549	1	1	22
GO:0006297	nucleotide-excision repair, DNA gap filling	1.06e-02	1.00e+00	6.549	1	3	22
GO:0030863	cortical cytoskeleton	1.06e-02	1.00e+00	6.549	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.06e-02	1.00e+00	6.549	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.11e-02	1.00e+00	6.485	1	4	23
GO:0043236	laminin binding	1.11e-02	1.00e+00	6.485	1	1	23
GO:0005654	nucleoplasm	1.17e-02	1.00e+00	2.514	3	76	1082
GO:0010718	positive regulation of epithelial to mesenchymal transition	1.21e-02	1.00e+00	6.365	1	1	25
GO:0000722	telomere maintenance via recombination	1.21e-02	1.00e+00	6.365	1	5	25
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	1.26e-02	1.00e+00	6.308	1	1	26
GO:0071902	positive regulation of protein serine/threonine kinase activity	1.26e-02	1.00e+00	6.308	1	1	26
GO:0030331	estrogen receptor binding	1.30e-02	1.00e+00	6.254	1	2	27
GO:0043022	ribosome binding	1.30e-02	1.00e+00	6.254	1	3	27
GO:0031492	nucleosomal DNA binding	1.30e-02	1.00e+00	6.254	1	4	27
GO:0043531	ADP binding	1.35e-02	1.00e+00	6.201	1	1	28
GO:0000118	histone deacetylase complex	1.35e-02	1.00e+00	6.201	1	1	28
GO:0019894	kinesin binding	1.35e-02	1.00e+00	6.201	1	1	28
GO:0006271	DNA strand elongation involved in DNA replication	1.45e-02	1.00e+00	6.102	1	7	30
GO:0032320	positive regulation of Ras GTPase activity	1.54e-02	1.00e+00	6.009	1	2	32
GO:1903507	negative regulation of nucleic acid-templated transcription	1.54e-02	1.00e+00	6.009	1	2	32
GO:0045892	negative regulation of transcription, DNA-templated	1.56e-02	1.00e+00	3.319	2	15	413
GO:0001895	retina homeostasis	1.64e-02	1.00e+00	5.921	1	1	34
GO:0034332	adherens junction organization	1.73e-02	1.00e+00	5.839	1	1	36
GO:0070062	extracellular vesicular exosome	1.75e-02	1.00e+00	1.780	4	104	2400
GO:0030315	T-tubule	1.78e-02	1.00e+00	5.799	1	1	37
GO:0051084	'de novo' posttranslational protein folding	1.78e-02	1.00e+00	5.799	1	4	37
GO:0042752	regulation of circadian rhythm	1.78e-02	1.00e+00	5.799	1	2	37
GO:0006284	base-excision repair	1.78e-02	1.00e+00	5.799	1	3	37
GO:0070527	platelet aggregation	1.83e-02	1.00e+00	5.761	1	2	38
GO:0031490	chromatin DNA binding	1.83e-02	1.00e+00	5.761	1	3	38
GO:0022627	cytosolic small ribosomal subunit	1.88e-02	1.00e+00	5.723	1	4	39
GO:0000781	chromosome, telomeric region	1.88e-02	1.00e+00	5.723	1	3	39
GO:0060048	cardiac muscle contraction	1.88e-02	1.00e+00	5.723	1	1	39
GO:0070301	cellular response to hydrogen peroxide	1.97e-02	1.00e+00	5.651	1	1	41
GO:0044267	cellular protein metabolic process	2.03e-02	1.00e+00	3.120	2	29	474
GO:0021762	substantia nigra development	2.12e-02	1.00e+00	5.549	1	2	44
GO:0001047	core promoter binding	2.16e-02	1.00e+00	5.517	1	2	45
GO:0048511	rhythmic process	2.16e-02	1.00e+00	5.517	1	3	45
GO:0006283	transcription-coupled nucleotide-excision repair	2.21e-02	1.00e+00	5.485	1	7	46
GO:0043406	positive regulation of MAP kinase activity	2.21e-02	1.00e+00	5.485	1	4	46
GO:0003684	damaged DNA binding	2.35e-02	1.00e+00	5.394	1	7	49
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.54e-02	1.00e+00	5.281	1	5	53
GO:0006351	transcription, DNA-templated	2.58e-02	1.00e+00	2.096	3	31	1446
GO:0045216	cell-cell junction organization	2.59e-02	1.00e+00	5.254	1	2	54
GO:0000724	double-strand break repair via homologous recombination	2.64e-02	1.00e+00	5.227	1	3	55
GO:0000723	telomere maintenance	2.69e-02	1.00e+00	5.201	1	6	56
GO:0008217	regulation of blood pressure	2.73e-02	1.00e+00	5.176	1	4	57
GO:0051087	chaperone binding	2.83e-02	1.00e+00	5.126	1	6	59
GO:0019903	protein phosphatase binding	2.97e-02	1.00e+00	5.055	1	4	62
GO:0005901	caveola	2.97e-02	1.00e+00	5.055	1	5	62
GO:0006302	double-strand break repair	2.97e-02	1.00e+00	5.055	1	4	62
GO:0071260	cellular response to mechanical stimulus	3.11e-02	1.00e+00	4.986	1	5	65
GO:0006289	nucleotide-excision repair	3.25e-02	1.00e+00	4.921	1	11	68
GO:0034329	cell junction assembly	3.25e-02	1.00e+00	4.921	1	1	68
GO:0003697	single-stranded DNA binding	3.25e-02	1.00e+00	4.921	1	5	68
GO:0042383	sarcolemma	3.40e-02	1.00e+00	4.859	1	3	71
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	3.54e-02	1.00e+00	4.799	1	6	74
GO:0005634	nucleus	3.60e-02	1.00e+00	1.176	5	136	4559
GO:0005730	nucleolus	3.62e-02	1.00e+00	1.913	3	69	1641
GO:0016020	membrane	3.85e-02	1.00e+00	1.879	3	90	1681
GO:0019083	viral transcription	3.87e-02	1.00e+00	4.669	1	10	81
GO:0016311	dephosphorylation	4.05e-02	1.00e+00	4.599	1	3	85
GO:0047485	protein N-terminus binding	4.10e-02	1.00e+00	4.582	1	5	86
GO:0006415	translational termination	4.15e-02	1.00e+00	4.566	1	10	87
GO:0016605	PML body	4.19e-02	1.00e+00	4.549	1	3	88
GO:0042470	melanosome	4.33e-02	1.00e+00	4.501	1	9	91
GO:0016363	nuclear matrix	4.33e-02	1.00e+00	4.501	1	12	91
GO:0006928	cellular component movement	4.33e-02	1.00e+00	4.501	1	7	91
GO:0005200	structural constituent of cytoskeleton	4.33e-02	1.00e+00	4.501	1	8	91
GO:0006414	translational elongation	4.43e-02	1.00e+00	4.470	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	4.94e-02	1.00e+00	4.308	1	10	104
GO:0014069	postsynaptic density	4.99e-02	1.00e+00	4.294	1	3	105
GO:0042127	regulation of cell proliferation	5.17e-02	1.00e+00	4.241	1	3	109
GO:0072562	blood microparticle	5.27e-02	1.00e+00	4.214	1	3	111
GO:0030529	ribonucleoprotein complex	5.31e-02	1.00e+00	4.201	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	5.40e-02	1.00e+00	4.176	1	11	114
GO:0019058	viral life cycle	5.45e-02	1.00e+00	4.163	1	13	115
GO:0006260	DNA replication	5.73e-02	1.00e+00	4.090	1	9	121
GO:0006413	translational initiation	6.19e-02	1.00e+00	3.975	1	17	131
GO:0031982	vesicle	6.19e-02	1.00e+00	3.975	1	9	131
GO:0016323	basolateral plasma membrane	6.37e-02	1.00e+00	3.932	1	4	135
GO:0003735	structural constituent of ribosome	6.46e-02	1.00e+00	3.911	1	10	137
GO:0006457	protein folding	6.74e-02	1.00e+00	3.849	1	7	143
GO:0061024	membrane organization	6.83e-02	1.00e+00	3.829	1	7	145
GO:0034220	ion transmembrane transport	7.01e-02	1.00e+00	3.790	1	4	149
GO:0000082	G1/S transition of mitotic cell cycle	7.01e-02	1.00e+00	3.790	1	32	149
GO:0006397	mRNA processing	7.51e-02	1.00e+00	3.687	1	2	160
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	7.74e-02	1.00e+00	3.642	1	7	165
GO:0030424	axon	7.79e-02	1.00e+00	3.634	1	4	166
GO:0005768	endosome	7.92e-02	1.00e+00	3.608	1	6	169
GO:0016607	nuclear speck	8.06e-02	1.00e+00	3.582	1	3	172
GO:0005737	cytoplasm	8.13e-02	1.00e+00	1.130	4	110	3767
GO:0031625	ubiquitin protein ligase binding	8.33e-02	1.00e+00	3.533	1	14	178
GO:0003714	transcription corepressor activity	8.33e-02	1.00e+00	3.533	1	8	178
GO:0019904	protein domain specific binding	8.37e-02	1.00e+00	3.525	1	6	179
GO:0044822	poly(A) RNA binding	8.79e-02	1.00e+00	1.964	2	49	1056
GO:0016324	apical plasma membrane	9.27e-02	1.00e+00	3.372	1	5	199
GO:0016071	mRNA metabolic process	1.03e-01	1.00e+00	3.208	1	31	223
GO:0008380	RNA splicing	1.06e-01	1.00e+00	3.176	1	11	228
GO:0006412	translation	1.06e-01	1.00e+00	3.163	1	20	230
GO:0016070	RNA metabolic process	1.14e-01	1.00e+00	3.060	1	32	247
GO:0006281	DNA repair	1.20e-01	1.00e+00	2.981	1	18	261
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.21e-01	1.00e+00	2.964	1	8	264
GO:0043065	positive regulation of apoptotic process	1.23e-01	1.00e+00	2.943	1	10	268
GO:0005524	ATP binding	1.25e-01	1.00e+00	1.667	2	60	1298
GO:0005743	mitochondrial inner membrane	1.27e-01	1.00e+00	2.895	1	8	277
GO:0019899	enzyme binding	1.27e-01	1.00e+00	2.895	1	12	277
GO:0042493	response to drug	1.30e-01	1.00e+00	2.859	1	13	284
GO:0005856	cytoskeleton	1.33e-01	1.00e+00	2.824	1	12	291
GO:0007411	axon guidance	1.45e-01	1.00e+00	2.691	1	13	319
GO:0003682	chromatin binding	1.48e-01	1.00e+00	2.656	1	11	327
GO:0003723	RNA binding	1.55e-01	1.00e+00	2.591	1	20	342
GO:0043565	sequence-specific DNA binding	1.56e-01	1.00e+00	2.574	1	6	346
GO:0005925	focal adhesion	1.65e-01	1.00e+00	2.493	1	19	366
GO:0007155	cell adhesion	1.66e-01	1.00e+00	2.481	1	6	369
GO:0000278	mitotic cell cycle	1.75e-01	1.00e+00	2.398	1	48	391
GO:0055085	transmembrane transport	1.93e-01	1.00e+00	2.244	1	10	435
GO:0007596	blood coagulation	2.01e-01	1.00e+00	2.179	1	18	455
GO:0016032	viral process	2.32e-01	1.00e+00	1.948	1	55	534
GO:0005783	endoplasmic reticulum	2.41e-01	1.00e+00	1.890	1	10	556
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	2.46e-01	1.00e+00	1.854	1	16	570
GO:0045087	innate immune response	2.56e-01	1.00e+00	1.790	1	24	596
GO:0005794	Golgi apparatus	2.61e-01	1.00e+00	1.756	1	15	610
GO:0010467	gene expression	2.83e-01	1.00e+00	1.623	1	59	669
GO:0005829	cytosol	3.48e-01	1.00e+00	0.723	2	132	2496
GO:0005886	plasma membrane	3.65e-01	1.00e+00	0.674	2	45	2582
GO:0005615	extracellular space	3.82e-01	1.00e+00	1.106	1	17	957
GO:0006355	regulation of transcription, DNA-templated	3.94e-01	1.00e+00	1.047	1	18	997
GO:0005739	mitochondrion	3.95e-01	1.00e+00	1.046	1	28	998
GO:0003677	DNA binding	4.61e-01	1.00e+00	0.758	1	28	1218
GO:0016021	integral component of membrane	6.45e-01	1.00e+00	0.056	1	27	1982

Wolf-ratios-Mammosphere-Adherent

int-snw-2146

Statistics

Genes (7)

Interactions (7)

Related GO terms (205)