int-snw-1982

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.981	2.40e-17	8.71e-04	1.86e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-1982 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
EIF4A1	1973	3	0.866	0.981	71	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
EIF2S2	8894	27	1.075	1.138	81	Yes	-
[ EIF4G2 ]	1982	1	0.012	0.981	29	-	-
RBX1	9978	97	1.185	1.151	139	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-

Interactions (6)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
EIF4A1	1973	EIF4G2	1982	pp	--	int.Intact: MI:0407(direct interaction); int.I2D: IntAct, BioGrid, MINT; int.Mint: MI:0915(physical association); int.HPRD: in vitro, in vivo
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
EIF4G2	1982	EIF2S2	8894	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association); int.HPRD: in vitro, in vivo
EIF4G2	1982	RPA2	6118	pp	--	int.Intact: MI:0915(physical association)

Related GO terms (145)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0008135	translation factor activity, nucleic acid binding	1.41e-07	2.03e-03	8.009	3	7	24
GO:0006413	translational initiation	2.23e-07	3.21e-03	5.975	4	17	131
GO:0003743	translation initiation factor activity	1.28e-06	1.84e-02	6.979	3	8	49
GO:0016281	eukaryotic translation initiation factor 4F complex	7.26e-06	1.05e-01	8.839	2	2	9
GO:0044267	cellular protein metabolic process	3.73e-05	5.37e-01	4.120	4	29	474
GO:0006412	translation	1.34e-04	1.00e+00	4.748	3	20	230
GO:0005829	cytosol	1.59e-04	1.00e+00	2.308	6	132	2496
GO:0044822	poly(A) RNA binding	8.36e-04	1.00e+00	2.964	4	49	1056
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9.70e-04	1.00e+00	10.009	1	1	2
GO:0002176	male germ cell proliferation	9.70e-04	1.00e+00	10.009	1	1	2
GO:0005055	laminin receptor activity	9.70e-04	1.00e+00	10.009	1	1	2
GO:0006407	rRNA export from nucleus	9.70e-04	1.00e+00	10.009	1	1	2
GO:0005850	eukaryotic translation initiation factor 2 complex	1.46e-03	1.00e+00	9.424	1	1	3
GO:0016032	viral process	1.58e-03	1.00e+00	3.533	3	55	534
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.94e-03	1.00e+00	9.009	1	1	4
GO:0030686	90S preribosome	1.94e-03	1.00e+00	9.009	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	1.94e-03	1.00e+00	9.009	1	1	4
GO:0019788	NEDD8 ligase activity	1.94e-03	1.00e+00	9.009	1	1	4
GO:0005515	protein binding	2.21e-03	1.00e+00	1.260	7	184	6024
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	2.42e-03	1.00e+00	8.687	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	2.42e-03	1.00e+00	8.687	1	1	5
GO:0030891	VCB complex	2.42e-03	1.00e+00	8.687	1	2	5
GO:0000730	DNA recombinase assembly	2.42e-03	1.00e+00	8.687	1	1	5
GO:2000001	regulation of DNA damage checkpoint	2.42e-03	1.00e+00	8.687	1	1	5
GO:0030957	Tat protein binding	2.91e-03	1.00e+00	8.424	1	3	6
GO:0031466	Cul5-RING ubiquitin ligase complex	2.91e-03	1.00e+00	8.424	1	1	6
GO:0010467	gene expression	3.02e-03	1.00e+00	3.208	3	59	669
GO:0031625	ubiquitin protein ligase binding	3.05e-03	1.00e+00	4.533	2	14	178
GO:0000028	ribosomal small subunit assembly	3.39e-03	1.00e+00	8.201	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	3.39e-03	1.00e+00	8.201	1	2	7
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	3.88e-03	1.00e+00	8.009	1	2	8
GO:0000339	RNA cap binding	3.88e-03	1.00e+00	8.009	1	1	8
GO:0070688	MLL5-L complex	3.88e-03	1.00e+00	8.009	1	1	8
GO:0045116	protein neddylation	3.88e-03	1.00e+00	8.009	1	2	8
GO:0019221	cytokine-mediated signaling pathway	4.67e-03	1.00e+00	4.221	2	9	221
GO:0016071	mRNA metabolic process	4.75e-03	1.00e+00	4.208	2	31	223
GO:0016020	membrane	4.81e-03	1.00e+00	2.294	4	90	1681
GO:0010569	regulation of double-strand break repair via homologous recombination	4.84e-03	1.00e+00	7.687	1	1	10
GO:0031571	mitotic G1 DNA damage checkpoint	5.33e-03	1.00e+00	7.549	1	4	11
GO:0016070	RNA metabolic process	5.80e-03	1.00e+00	4.060	2	32	247
GO:0005662	DNA replication factor A complex	6.29e-03	1.00e+00	7.308	1	1	13
GO:0006281	DNA repair	6.45e-03	1.00e+00	3.981	2	18	261
GO:0035267	NuA4 histone acetyltransferase complex	6.78e-03	1.00e+00	7.201	1	4	14
GO:0050998	nitric-oxide synthase binding	7.74e-03	1.00e+00	7.009	1	1	16
GO:0035861	site of double-strand break	8.71e-03	1.00e+00	6.839	1	1	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	9.19e-03	1.00e+00	6.761	1	1	19
GO:0006298	mismatch repair	9.67e-03	1.00e+00	6.687	1	3	20
GO:0032201	telomere maintenance via semi-conservative replication	1.01e-02	1.00e+00	6.616	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.01e-02	1.00e+00	6.616	1	4	21
GO:0006297	nucleotide-excision repair, DNA gap filling	1.06e-02	1.00e+00	6.549	1	3	22
GO:0030863	cortical cytoskeleton	1.06e-02	1.00e+00	6.549	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.06e-02	1.00e+00	6.549	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.11e-02	1.00e+00	6.485	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.11e-02	1.00e+00	6.485	1	3	23
GO:0043236	laminin binding	1.11e-02	1.00e+00	6.485	1	1	23
GO:0006513	protein monoubiquitination	1.11e-02	1.00e+00	6.485	1	1	23
GO:0005654	nucleoplasm	1.17e-02	1.00e+00	2.514	3	76	1082
GO:0000722	telomere maintenance via recombination	1.21e-02	1.00e+00	6.365	1	5	25
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	1.21e-02	1.00e+00	6.365	1	1	25
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.26e-02	1.00e+00	6.308	1	3	26
GO:0043022	ribosome binding	1.30e-02	1.00e+00	6.254	1	3	27
GO:0031492	nucleosomal DNA binding	1.30e-02	1.00e+00	6.254	1	4	27
GO:0008219	cell death	1.35e-02	1.00e+00	6.201	1	1	28
GO:0019894	kinesin binding	1.35e-02	1.00e+00	6.201	1	1	28
GO:0019005	SCF ubiquitin ligase complex	1.40e-02	1.00e+00	6.151	1	1	29
GO:0006271	DNA strand elongation involved in DNA replication	1.45e-02	1.00e+00	6.102	1	7	30
GO:0001895	retina homeostasis	1.64e-02	1.00e+00	5.921	1	1	34
GO:0034332	adherens junction organization	1.73e-02	1.00e+00	5.839	1	1	36
GO:0006446	regulation of translational initiation	1.73e-02	1.00e+00	5.839	1	4	36
GO:0051084	'de novo' posttranslational protein folding	1.78e-02	1.00e+00	5.799	1	4	37
GO:0006284	base-excision repair	1.78e-02	1.00e+00	5.799	1	3	37
GO:0070527	platelet aggregation	1.83e-02	1.00e+00	5.761	1	2	38
GO:0022627	cytosolic small ribosomal subunit	1.88e-02	1.00e+00	5.723	1	4	39
GO:0000781	chromosome, telomeric region	1.88e-02	1.00e+00	5.723	1	3	39
GO:0008026	ATP-dependent helicase activity	1.88e-02	1.00e+00	5.723	1	3	39
GO:0021762	substantia nigra development	2.12e-02	1.00e+00	5.549	1	2	44
GO:0006283	transcription-coupled nucleotide-excision repair	2.21e-02	1.00e+00	5.485	1	7	46
GO:0003684	damaged DNA binding	2.35e-02	1.00e+00	5.394	1	7	49
GO:0031100	organ regeneration	2.40e-02	1.00e+00	5.365	1	4	50
GO:0003725	double-stranded RNA binding	2.50e-02	1.00e+00	5.308	1	5	52
GO:0004386	helicase activity	2.50e-02	1.00e+00	5.308	1	2	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.54e-02	1.00e+00	5.281	1	5	53
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	2.54e-02	1.00e+00	5.281	1	1	53
GO:0045216	cell-cell junction organization	2.59e-02	1.00e+00	5.254	1	2	54
GO:0000724	double-strand break repair via homologous recombination	2.64e-02	1.00e+00	5.227	1	3	55
GO:0000723	telomere maintenance	2.69e-02	1.00e+00	5.201	1	6	56
GO:0019903	protein phosphatase binding	2.97e-02	1.00e+00	5.055	1	4	62
GO:0006302	double-strand break repair	2.97e-02	1.00e+00	5.055	1	4	62
GO:0006289	nucleotide-excision repair	3.25e-02	1.00e+00	4.921	1	11	68
GO:0034329	cell junction assembly	3.25e-02	1.00e+00	4.921	1	1	68
GO:0003697	single-stranded DNA binding	3.25e-02	1.00e+00	4.921	1	5	68
GO:0003729	mRNA binding	3.44e-02	1.00e+00	4.839	1	3	72
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	3.54e-02	1.00e+00	4.799	1	6	74
GO:0008584	male gonad development	3.58e-02	1.00e+00	4.780	1	3	75
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	3.58e-02	1.00e+00	4.780	1	2	75
GO:0019083	viral transcription	3.87e-02	1.00e+00	4.669	1	10	81
GO:0047485	protein N-terminus binding	4.10e-02	1.00e+00	4.582	1	5	86
GO:0006415	translational termination	4.15e-02	1.00e+00	4.566	1	10	87
GO:0016605	PML body	4.19e-02	1.00e+00	4.549	1	3	88
GO:0006928	cellular component movement	4.33e-02	1.00e+00	4.501	1	7	91
GO:0005200	structural constituent of cytoskeleton	4.33e-02	1.00e+00	4.501	1	8	91
GO:0071456	cellular response to hypoxia	4.38e-02	1.00e+00	4.485	1	6	92
GO:0006414	translational elongation	4.43e-02	1.00e+00	4.470	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	4.94e-02	1.00e+00	4.308	1	10	104
GO:0014069	postsynaptic density	4.99e-02	1.00e+00	4.294	1	3	105
GO:0072562	blood microparticle	5.27e-02	1.00e+00	4.214	1	3	111
GO:0030529	ribonucleoprotein complex	5.31e-02	1.00e+00	4.201	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	5.40e-02	1.00e+00	4.176	1	11	114
GO:0019058	viral life cycle	5.45e-02	1.00e+00	4.163	1	13	115
GO:0006325	chromatin organization	5.59e-02	1.00e+00	4.126	1	5	118
GO:0007219	Notch signaling pathway	5.68e-02	1.00e+00	4.102	1	5	120
GO:0006260	DNA replication	5.73e-02	1.00e+00	4.090	1	9	121
GO:0007050	cell cycle arrest	5.87e-02	1.00e+00	4.055	1	9	124
GO:0000790	nuclear chromatin	6.10e-02	1.00e+00	3.998	1	9	129
GO:0003735	structural constituent of ribosome	6.46e-02	1.00e+00	3.911	1	10	137
GO:0006457	protein folding	6.74e-02	1.00e+00	3.849	1	7	143
GO:0061024	membrane organization	6.83e-02	1.00e+00	3.829	1	7	145
GO:0000082	G1/S transition of mitotic cell cycle	7.01e-02	1.00e+00	3.790	1	32	149
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	7.74e-02	1.00e+00	3.642	1	7	165
GO:0030424	axon	7.79e-02	1.00e+00	3.634	1	4	166
GO:0032403	protein complex binding	8.55e-02	1.00e+00	3.493	1	10	183
GO:0001701	in utero embryonic development	9.36e-02	1.00e+00	3.358	1	8	201
GO:0070062	extracellular vesicular exosome	9.54e-02	1.00e+00	1.365	3	104	2400
GO:0004842	ubiquitin-protein transferase activity	1.17e-01	1.00e+00	3.014	1	6	255
GO:0005524	ATP binding	1.25e-01	1.00e+00	1.667	2	60	1298
GO:0019899	enzyme binding	1.27e-01	1.00e+00	2.895	1	12	277
GO:0005856	cytoskeleton	1.33e-01	1.00e+00	2.824	1	12	291
GO:0006200	ATP catabolic process	1.33e-01	1.00e+00	2.819	1	15	292
GO:0043234	protein complex	1.35e-01	1.00e+00	2.804	1	18	295
GO:0016567	protein ubiquitination	1.35e-01	1.00e+00	2.804	1	5	295
GO:0019901	protein kinase binding	1.44e-01	1.00e+00	2.700	1	21	317
GO:0007411	axon guidance	1.45e-01	1.00e+00	2.691	1	13	319
GO:0003723	RNA binding	1.55e-01	1.00e+00	2.591	1	20	342
GO:0005925	focal adhesion	1.65e-01	1.00e+00	2.493	1	19	366
GO:0007155	cell adhesion	1.66e-01	1.00e+00	2.481	1	6	369
GO:0000278	mitotic cell cycle	1.75e-01	1.00e+00	2.398	1	48	391
GO:0007596	blood coagulation	2.01e-01	1.00e+00	2.179	1	18	455
GO:0045087	innate immune response	2.56e-01	1.00e+00	1.790	1	24	596
GO:0005615	extracellular space	3.82e-01	1.00e+00	1.106	1	17	957
GO:0008270	zinc ion binding	3.94e-01	1.00e+00	1.047	1	12	997
GO:0046872	metal ion binding	4.86e-01	1.00e+00	0.657	1	25	1307
GO:0005730	nucleolus	5.71e-01	1.00e+00	0.328	1	69	1641
GO:0005737	cytoplasm	5.83e-01	1.00e+00	0.130	2	110	3767
GO:0005634	nucleus	7.04e-01	1.00e+00	-0.146	2	136	4559
GO:0005886	plasma membrane	7.49e-01	1.00e+00	-0.326	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-1982

Statistics

Genes (7)

Interactions (6)

Related GO terms (145)