int-snw-1857

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.946 6.29e-16 1.96e-03 3.38e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-1857 subnetwork

Genes (14)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
ACO2 50 501.0001.076191Yes-
PSMA2 5683 601.0931.10689Yes-
PPP2R1A 5518 90.6440.985249Yes-
RPS11 6205 360.9931.113175Yes-
RPL14 9045 421.2501.113143Yes-
PSMB7 5695 480.9821.05257Yes-
PSMA1 5682 610.9961.052123Yes-
EIF4A1 1973 30.8660.98171Yes-
PSMD11 5717 1211.0951.106183Yes-
[ DVL3 ] 1857 1-0.0260.946146--
ACTB 60 1671.1531.151587Yes-
KPNB1 3837 60.6131.017296Yes-
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-

Interactions (31)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PGD 5226 PPP2R1A 5518 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
DVL3 1857 PPP2R1A 5518 pp -- int.I2D: Jorgensen_EphR
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
EIF4A1 1973 PPP2R1A 5518 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
KPNB1 3837 PSMA2 5683 pp -- int.I2D: Krogan_NonCore, YeastLow
ACO2 50 KPNB1 3837 pp -- int.I2D: IntAct_Yeast
ACTB 60 KPNB1 3837 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMA2 5683 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
ACO2 50 PGD 5226 pp -- int.I2D: YeastLow
DVL3 1857 KPNB1 3837 pp -- int.I2D: Jorgensen_EphR
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
PPP2R1A 5518 PSMA1 5682 pp -- int.I2D: IntAct_Mouse
KPNB1 3837 PSMD11 5717 pp -- int.I2D: Krogan_NonCore
KPNB1 3837 PSMA1 5682 pp -- int.I2D: YeastLow
ACTB 60 PPP2R1A 5518 pp -- int.I2D: BioGrid_Yeast
PPP2R1A 5518 PSMA2 5683 pp -- int.I2D: IntAct_Mouse
RPSA 3921 RPS11 6205 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PPP2R1A 5518 PSMB7 5695 pp -- int.I2D: IntAct_Mouse
DVL3 1857 EIF4A1 1973 pp -- int.I2D: Jorgensen_EphR
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
DVL3 1857 RPS11 6205 pp -- int.I2D: Jorgensen_EphR
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
ACO2 50 PSMD11 5717 pp -- int.I2D: YeastLow

Related GO terms (205)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0016071mRNA metabolic process8.05e-141.16e-095.378931223
GO:0016070RNA metabolic process2.04e-132.94e-095.230932247
GO:0016032viral process2.08e-102.99e-064.118955534
GO:0010467gene expression1.53e-092.21e-053.793959669
GO:0070062extracellular vesicular exosome2.88e-084.15e-042.365121042400
GO:0005829cytosol4.54e-086.55e-042.308121322496
GO:0006521regulation of cellular amino acid metabolic process1.25e-071.80e-036.36541750
GO:0000502proteasome complex2.29e-073.30e-036.15141758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest3.41e-074.92e-036.00941964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.63e-075.24e-035.98642265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.91e-077.08e-035.87942270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent5.50e-077.94e-035.83942072
GO:0005839proteasome core complex5.89e-078.50e-037.4243818
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.15e-078.87e-035.79942274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I6.49e-079.36e-035.78042075
GO:0004298threonine-type endopeptidase activity6.99e-071.01e-027.3463819
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process8.00e-071.15e-025.70542379
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.48e-062.13e-025.48542192
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay3.49e-065.03e-025.176411114
GO:0019058viral life cycle3.61e-065.21e-025.163413115
GO:0000209protein polyubiquitination3.74e-065.39e-025.151420116
GO:0006413translational initiation6.06e-068.75e-024.975417131
GO:0006915apoptotic process7.29e-061.05e-013.477633555
GO:0000082G1/S transition of mitotic cell cycle1.01e-051.46e-014.790432149
GO:0042981regulation of apoptotic process1.04e-051.50e-014.780424150
GO:0034641cellular nitrogen compound metabolic process1.74e-052.51e-014.591420171
GO:0000278mitotic cell cycle2.33e-053.37e-013.720548391
GO:0019773proteasome core complex, alpha-subunit complex2.44e-053.52e-018.009248
GO:0016020membrane5.26e-057.58e-012.2948901681
GO:0006412translation5.56e-058.02e-014.163420230
GO:0044281small molecule metabolic process5.85e-058.44e-012.5747581211
GO:0044267cellular protein metabolic process5.88e-058.48e-013.442529474
GO:0019083viral transcription5.94e-058.57e-015.25431081
GO:0006415translational termination7.35e-051.00e+005.15131087
GO:0006414translational elongation8.97e-051.00e+005.05531393
GO:0006614SRP-dependent cotranslational protein targeting to membrane1.25e-041.00e+004.893310104
GO:0003735structural constituent of ribosome2.83e-041.00e+004.496310137
GO:0005654nucleoplasm3.12e-041.00e+002.5146761082
GO:0043066negative regulation of apoptotic process5.83e-041.00e+003.281431424
GO:0022627cytosolic small ribosomal subunit6.35e-041.00e+005.7232439
GO:0005515protein binding9.66e-041.00e+001.037121846024
GO:0070262peptidyl-serine dephosphorylation9.71e-041.00e+0010.009111
GO:0019521D-gluconate metabolic process9.71e-041.00e+0010.009111
GO:00515383 iron, 4 sulfur cluster binding1.94e-031.00e+009.009112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.94e-031.00e+009.009112
GO:0019322pentose biosynthetic process1.94e-031.00e+009.009122
GO:0003994aconitate hydratase activity1.94e-031.00e+009.009112
GO:0005055laminin receptor activity1.94e-031.00e+009.009112
GO:0006407rRNA export from nucleus1.94e-031.00e+009.009112
GO:0044822poly(A) RNA binding2.39e-031.00e+002.2865491056
GO:0009051pentose-phosphate shunt, oxidative branch2.91e-031.00e+008.424123
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.91e-031.00e+008.424113
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.88e-031.00e+008.009114
GO:003068690S preribosome3.88e-031.00e+008.009114
GO:0006610ribosomal protein import into nucleus3.88e-031.00e+008.009114
GO:0071782endoplasmic reticulum tubular network3.88e-031.00e+008.009114
GO:0019932second-messenger-mediated signaling4.84e-031.00e+007.687115
GO:0043248proteasome assembly4.84e-031.00e+007.687115
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 protein4.84e-031.00e+007.687115
GO:0006102isocitrate metabolic process4.84e-031.00e+007.687115
GO:0038031non-canonical Wnt signaling pathway via JNK cascade4.84e-031.00e+007.687115
GO:0035567non-canonical Wnt signaling pathway4.84e-031.00e+007.687115
GO:0060026convergent extension4.84e-031.00e+007.687115
GO:0015630microtubule cytoskeleton4.94e-031.00e+004.22724110
GO:0030957Tat protein binding5.81e-031.00e+007.424136
GO:0006101citrate metabolic process5.81e-031.00e+007.424116
GO:0000028ribosomal small subunit assembly6.78e-031.00e+007.201117
GO:0000339RNA cap binding7.74e-031.00e+007.009118
GO:0070688MLL5-L complex7.74e-031.00e+007.009118
GO:0008139nuclear localization sequence binding8.70e-031.00e+006.839139
GO:0016281eukaryotic translation initiation factor 4F complex8.70e-031.00e+006.839129
GO:0006098pentose-phosphate shunt9.67e-031.00e+006.6871410
GO:0060071Wnt signaling pathway, planar cell polarity pathway9.67e-031.00e+006.6871210
GO:0007084mitotic nuclear envelope reassembly9.67e-031.00e+006.6871110
GO:0006275regulation of DNA replication1.16e-021.00e+006.4241212
GO:0030111regulation of Wnt signaling pathway1.16e-021.00e+006.4241112
GO:0005838proteasome regulatory particle1.16e-021.00e+006.4241712
GO:0005634nucleus1.20e-021.00e+001.02491364559
GO:0006672ceramide metabolic process1.26e-021.00e+006.3081113
GO:0042273ribosomal large subunit biogenesis1.26e-021.00e+006.3081413
GO:0090179planar cell polarity pathway involved in neural tube closure1.26e-021.00e+006.3081113
GO:0035267NuA4 histone acetyltransferase complex1.35e-021.00e+006.2011414
GO:0003148outflow tract septum morphogenesis1.35e-021.00e+006.2011114
GO:0006607NLS-bearing protein import into nucleus1.35e-021.00e+006.2011314
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand1.45e-021.00e+006.1021215
GO:0050998nitric-oxide synthase binding1.54e-021.00e+006.0091116
GO:0075733intracellular transport of virus1.64e-021.00e+005.9211317
GO:0006309apoptotic DNA fragmentation1.64e-021.00e+005.9211117
GO:0022624proteasome accessory complex1.64e-021.00e+005.9211817
GO:0048863stem cell differentiation1.83e-021.00e+005.7611119
GO:0019221cytokine-mediated signaling pathway1.88e-021.00e+003.22129221
GO:0008601protein phosphatase type 2A regulator activity1.92e-021.00e+005.6871220
GO:0090103cochlea morphogenesis1.92e-021.00e+005.6871220
GO:0000159protein phosphatase type 2A complex1.92e-021.00e+005.6871220
GO:0045595regulation of cell differentiation2.02e-021.00e+005.6161121
GO:0003823antigen binding2.12e-021.00e+005.5491122
GO:0030863cortical cytoskeleton2.12e-021.00e+005.5491122
GO:0036464cytoplasmic ribonucleoprotein granule2.12e-021.00e+005.5491422
GO:0043044ATP-dependent chromatin remodeling2.21e-021.00e+005.4851423
GO:0005844polysome2.21e-021.00e+005.4851423
GO:0043236laminin binding2.21e-021.00e+005.4851123
GO:0008135translation factor activity, nucleic acid binding2.31e-021.00e+005.4241724
GO:0000060protein import into nucleus, translocation2.31e-021.00e+005.4241524
GO:0008536Ran GTPase binding2.40e-021.00e+005.3651125
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening2.40e-021.00e+005.3651125
GO:0010033response to organic substance2.59e-021.00e+005.2541227
GO:0019843rRNA binding2.59e-021.00e+005.2541327
GO:0043022ribosome binding2.59e-021.00e+005.2541327
GO:0050661NADP binding2.59e-021.00e+005.2541227
GO:0000188inactivation of MAPK activity2.59e-021.00e+005.2541127
GO:0031492nucleosomal DNA binding2.59e-021.00e+005.2541427
GO:0006099tricarboxylic acid cycle2.69e-021.00e+005.2011428
GO:0043507positive regulation of JUN kinase activity2.69e-021.00e+005.2011228
GO:0019894kinesin binding2.69e-021.00e+005.2011128
GO:0006606protein import into nucleus2.87e-021.00e+005.1021230
GO:0005109frizzled binding2.97e-021.00e+005.0551131
GO:0001895retina homeostasis3.25e-021.00e+004.9211134
GO:00515394 iron, 4 sulfur cluster binding3.35e-021.00e+004.8791335
GO:0034332adherens junction organization3.44e-021.00e+004.8391136
GO:0051084'de novo' posttranslational protein folding3.53e-021.00e+004.7991437
GO:0070527platelet aggregation3.63e-021.00e+004.7611238
GO:0008026ATP-dependent helicase activity3.72e-021.00e+004.7231339
GO:0004722protein serine/threonine phosphatase activity4.00e-021.00e+004.6161142
GO:0030155regulation of cell adhesion4.00e-021.00e+004.6161242
GO:0021762substantia nigra development4.19e-021.00e+004.5491244
GO:0003723RNA binding4.23e-021.00e+002.591220342
GO:0006921cellular component disassembly involved in execution phase of apoptosis4.47e-021.00e+004.4541547
GO:0022625cytosolic large ribosomal subunit4.65e-021.00e+004.3941649
GO:0003743translation initiation factor activity4.65e-021.00e+004.3941849
GO:0006091generation of precursor metabolites and energy4.75e-021.00e+004.3651350
GO:0000775chromosome, centromeric region4.75e-021.00e+004.3651250
GO:0031100organ regeneration4.75e-021.00e+004.3651450
GO:0040008regulation of growth4.75e-021.00e+004.3651550
GO:0005925focal adhesion4.78e-021.00e+002.493219366
GO:0003725double-stranded RNA binding4.93e-021.00e+004.3081552
GO:0004386helicase activity4.93e-021.00e+004.3081252
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding5.03e-021.00e+004.2811553
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay5.03e-021.00e+004.2811153
GO:0046982protein heterodimerization activity5.11e-021.00e+002.439213380
GO:0045216cell-cell junction organization5.12e-021.00e+004.2541254
GO:0000932cytoplasmic mRNA processing body5.12e-021.00e+004.2541354
GO:0008565protein transporter activity5.30e-021.00e+004.2011556
GO:0005643nuclear pore5.40e-021.00e+004.1761457
GO:0005840ribosome5.49e-021.00e+004.1511158
GO:0008013beta-catenin binding5.67e-021.00e+004.1021360
GO:0007059chromosome segregation5.86e-021.00e+004.0551462
GO:0034329cell junction assembly6.40e-021.00e+003.9211168
GO:0003729mRNA binding6.77e-021.00e+003.8391372
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis6.95e-021.00e+003.7991674
GO:0002020protease binding6.95e-021.00e+003.7991474
GO:0060070canonical Wnt signaling pathway7.04e-021.00e+003.7801375
GO:0006928cellular component movement8.48e-021.00e+003.5011791
GO:0005200structural constituent of cytoskeleton8.48e-021.00e+003.5011891
GO:0001649osteoblast differentiation8.57e-021.00e+003.4851692
GO:0006364rRNA processing8.75e-021.00e+003.4541694
GO:0006470protein dephosphorylation9.11e-021.00e+003.3941198
GO:0005938cell cortex9.64e-021.00e+003.30813104
GO:0001934positive regulation of protein phosphorylation9.64e-021.00e+003.30816104
GO:0014069postsynaptic density9.73e-021.00e+003.29413105
GO:0005506iron ion binding9.73e-021.00e+003.29414105
GO:0030308negative regulation of cell growth1.02e-011.00e+003.22716110
GO:0030529ribonucleoprotein complex1.03e-011.00e+003.20118112
GO:0006461protein complex assembly1.03e-011.00e+003.21416111
GO:0072562blood microparticle1.03e-011.00e+003.21413111
GO:0005635nuclear envelope1.04e-011.00e+003.18916113
GO:0044237cellular metabolic process1.08e-011.00e+003.13815117
GO:0006325chromatin organization1.09e-011.00e+003.12615118
GO:0006511ubiquitin-dependent protein catabolic process1.16e-011.00e+003.03115126
GO:0009615response to virus1.16e-011.00e+003.03115126
GO:0000790nuclear chromatin1.18e-011.00e+002.99819129
GO:0000086G2/M transition of mitotic cell cycle1.24e-011.00e+002.92119136
GO:0016055Wnt signaling pathway1.26e-011.00e+002.90017138
GO:0006457protein folding1.30e-011.00e+002.84917143
GO:0061024membrane organization1.32e-011.00e+002.82917145
GO:0008543fibroblast growth factor receptor signaling pathway1.41e-011.00e+002.72319156
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.49e-011.00e+002.64217165
GO:0030424axon1.50e-011.00e+002.63414166
GO:0031965nuclear membrane1.51e-011.00e+002.61613168
GO:0019904protein domain specific binding1.60e-011.00e+002.52516179
GO:0008380RNA splicing2.00e-011.00e+002.176111228
GO:0005759mitochondrial matrix2.00e-011.00e+002.176114228
GO:0005730nucleolus2.08e-011.00e+000.9133691641
GO:0005975carbohydrate metabolic process2.20e-011.00e+002.02619253
GO:0005102receptor binding2.25e-011.00e+001.98616260
GO:0019899enzyme binding2.38e-011.00e+001.895112277
GO:0042493response to drug2.43e-011.00e+001.859113284
GO:0005856cytoskeleton2.48e-011.00e+001.824112291
GO:0006200ATP catabolic process2.49e-011.00e+001.819115292
GO:0043234protein complex2.51e-011.00e+001.804118295
GO:0005739mitochondrion2.52e-011.00e+001.046228998
GO:0035556intracellular signal transduction2.57e-011.00e+001.76619303
GO:0019901protein kinase binding2.67e-011.00e+001.700121317
GO:0007411axon guidance2.69e-011.00e+001.691113319
GO:0005813centrosome2.74e-011.00e+001.660114326
GO:0007155cell adhesion3.04e-011.00e+001.48116369
GO:0055114oxidation-reduction process3.39e-011.00e+001.294112420
GO:0007596blood coagulation3.62e-011.00e+001.179118455
GO:0005524ATP binding3.63e-011.00e+000.6672601298
GO:0045893positive regulation of transcription, DNA-templated3.76e-011.00e+001.108113478
GO:0045087innate immune response4.46e-011.00e+000.790124596
GO:0005737cytoplasm5.18e-011.00e+000.13041103767
GO:0005615extracellular space6.18e-011.00e+000.106117957
GO:0006355regulation of transcription, DNA-templated6.33e-011.00e+000.047118997
GO:0008270zinc ion binding6.33e-011.00e+000.047112997
GO:0005886plasma membrane9.37e-011.00e+00-1.3261452582