int-snw-163

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.924 4.06e-15 3.08e-03 4.69e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-163 subnetwork

Genes (14)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
CAD 790 170.8071.007333--
RSL24D1 51187 361.3001.02059Yes-
EIF6 3692 140.7001.013267Yes-
EIF2S2 8894 271.0751.13881Yes-
CLTC 1213 350.8841.138247Yes-
RPL8 6132 90.7780.967218Yes-
RPL14 9045 421.2501.113143Yes-
[ AP2B1 ] 163 10.0410.924120--
ACTB 60 1671.1531.151587Yes-
PSMD11 5717 1211.0951.106183Yes-
POLR1B 84172 40.6130.988184Yes-
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-
RPL11 6135 90.7181.017200Yes-

Interactions (27)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PGD 5226 POLR1B 84172 pp -- int.I2D: YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
AP2B1 163 POLR1B 84172 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastLow
CLTC 1213 EIF2S2 8894 pp -- int.I2D: YeastLow
RPL11 6135 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
AP2B1 163 CLTC 1213 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
AP2B1 163 EIF6 3692 pp -- int.I2D: YeastLow
RPL8 6132 RPL11 6135 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium, IntAct_Yeast
AP2B1 163 RPL8 6132 pp -- int.I2D: IntAct_Yeast
AP2B1 163 CAD 790 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
CAD 790 RPSA 3921 pp -- int.I2D: IntAct_Yeast
RPL8 6132 POLR1B 84172 pp -- int.I2D: YeastMedium
RPL8 6132 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
EIF6 3692 PGD 5226 pp -- int.I2D: YeastLow
CAD 790 POLR1B 84172 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 CLTC 1213 pp -- int.I2D: IntAct_Yeast
AP2B1 163 RPL11 6135 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
EIF6 3692 POLR1B 84172 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastLow
ACTB 60 POLR1B 84172 pp -- int.I2D: BIND, BIND_Mouse
EIF6 3692 RPL8 6132 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 RPL11 6135 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
EIF6 3692 RSL24D1 51187 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 CAD 790 pp -- int.I2D: IntAct_Yeast
PSMD11 5717 POLR1B 84172 pp -- int.I2D: YeastLow

Related GO terms (200)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0006413translational initiation1.42e-092.04e-055.560617131
GO:0042273ribosomal large subunit biogenesis2.07e-072.99e-037.8933413
GO:0019083viral transcription8.85e-071.28e-025.66941081
GO:0005829cytosol8.90e-071.28e-022.183111322496
GO:0010467gene expression1.16e-061.67e-023.430759669
GO:0006415translational termination1.18e-061.70e-025.56641087
GO:0016071mRNA metabolic process1.51e-062.18e-024.530531223
GO:0006414translational elongation1.54e-062.23e-025.47041393
GO:0006412translation1.76e-062.54e-024.485520230
GO:0006614SRP-dependent cotranslational protein targeting to membrane2.42e-063.48e-025.308410104
GO:0016070RNA metabolic process2.50e-063.60e-024.382532247
GO:0044267cellular protein metabolic process2.93e-064.22e-023.705629474
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay3.49e-065.03e-025.176411114
GO:0019058viral life cycle3.61e-065.21e-025.163413115
GO:0016020membrane4.50e-066.49e-022.4649901681
GO:0016032viral process5.84e-068.42e-023.533655534
GO:0003735structural constituent of ribosome7.24e-061.04e-014.911410137
GO:0022625cytosolic large ribosomal subunit1.31e-051.88e-015.9793649
GO:0070062extracellular vesicular exosome8.64e-051.00e+001.95091042400
GO:0003723RNA binding2.58e-041.00e+003.591420342
GO:0044822poly(A) RNA binding2.73e-041.00e+002.5496491056
GO:0019843rRNA binding3.03e-041.00e+006.2542327
GO:0043022ribosome binding3.03e-041.00e+006.2542327
GO:0030669clathrin-coated endocytic vesicle membrane3.26e-041.00e+006.2012428
GO:0004151dihydroorotase activity9.71e-041.00e+0010.009111
GO:0019521D-gluconate metabolic process9.71e-041.00e+0010.009111
GO:0000054ribosomal subunit export from nucleus9.71e-041.00e+0010.009111
GO:0004070aspartate carbamoyltransferase activity9.71e-041.00e+0010.009111
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity9.71e-041.00e+0010.009111
GO:0070335aspartate binding9.71e-041.00e+0010.009111
GO:0003743translation initiation factor activity1.00e-031.00e+005.3942849
GO:0005048signal sequence binding1.94e-031.00e+009.009112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.94e-031.00e+009.009112
GO:0002176male germ cell proliferation1.94e-031.00e+009.009112
GO:0019322pentose biosynthetic process1.94e-031.00e+009.009122
GO:0005055laminin receptor activity1.94e-031.00e+009.009112
GO:0006407rRNA export from nucleus1.94e-031.00e+009.009112
GO:0070409carbamoyl phosphate biosynthetic process1.94e-031.00e+009.009112
GO:0043234protein complex2.61e-031.00e+003.389318295
GO:0005850eukaryotic translation initiation factor 2 complex2.91e-031.00e+008.424113
GO:1900126negative regulation of hyaluronan biosynthetic process2.91e-031.00e+008.424123
GO:0009051pentose-phosphate shunt, oxidative branch2.91e-031.00e+008.424123
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.91e-031.00e+008.424113
GO:0044205'de novo' UMP biosynthetic process2.91e-031.00e+008.424113
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process2.91e-031.00e+008.424113
GO:0071439clathrin complex2.91e-031.00e+008.424123
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II3.34e-031.00e+004.5172790
GO:0006364rRNA processing3.63e-031.00e+004.4542694
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.88e-031.00e+008.009114
GO:003068690S preribosome3.88e-031.00e+008.009114
GO:0032051clathrin light chain binding3.88e-031.00e+008.009114
GO:0006543glutamine catabolic process3.88e-031.00e+008.009114
GO:1903077negative regulation of protein localization to plasma membrane3.88e-031.00e+008.009114
GO:0032549ribonucleoside binding3.88e-031.00e+008.009124
GO:0005925focal adhesion4.79e-031.00e+003.078319366
GO:0051414response to cortisol4.84e-031.00e+007.687115
GO:0042256mature ribosome assembly4.84e-031.00e+007.687115
GO:0043248proteasome assembly4.84e-031.00e+007.687115
GO:0005638lamin filament4.84e-031.00e+007.687115
GO:0043023ribosomal large subunit binding4.84e-031.00e+007.687115
GO:0030130clathrin coat of trans-Golgi network vesicle5.81e-031.00e+007.424136
GO:0030957Tat protein binding5.81e-031.00e+007.424136
GO:0046134pyrimidine nucleoside biosynthetic process5.81e-031.00e+007.424116
GO:0030118clathrin coat5.81e-031.00e+007.424126
GO:0030132clathrin coat of coated pit6.78e-031.00e+007.201127
GO:0000028ribosomal small subunit assembly6.78e-031.00e+007.201117
GO:0035615clathrin adaptor activity7.74e-031.00e+007.009128
GO:0070688MLL5-L complex7.74e-031.00e+007.009118
GO:0061024membrane organization8.44e-031.00e+003.82927145
GO:0006228UTP biosynthetic process8.70e-031.00e+006.839119
GO:0014075response to amine8.70e-031.00e+006.839119
GO:0031000response to caffeine8.70e-031.00e+006.839129
GO:0006098pentose-phosphate shunt9.67e-031.00e+006.6871410
GO:0030122AP-2 adaptor complex9.67e-031.00e+006.6871210
GO:0005838proteasome regulatory particle1.16e-021.00e+006.4241712
GO:0072583clathrin-mediated endocytosis1.16e-021.00e+006.4241212
GO:0006886intracellular protein transport1.16e-021.00e+003.59125171
GO:0035267NuA4 histone acetyltransferase complex1.35e-021.00e+006.2011414
GO:0050998nitric-oxide synthase binding1.54e-021.00e+006.0091116
GO:0006541glutamine metabolic process1.64e-021.00e+005.9211117
GO:0022624proteasome accessory complex1.64e-021.00e+005.9211817
GO:0017144drug metabolic process1.73e-021.00e+005.8391118
GO:0048863stem cell differentiation1.83e-021.00e+005.7611119
GO:0030276clathrin binding1.92e-021.00e+005.6871220
GO:0071364cellular response to epidermal growth factor stimulus2.02e-021.00e+005.6161121
GO:0006206pyrimidine nucleobase metabolic process2.12e-021.00e+005.5491222
GO:0033574response to testosterone2.12e-021.00e+005.5491222
GO:0030863cortical cytoskeleton2.12e-021.00e+005.5491122
GO:0036464cytoplasmic ribonucleoprotein granule2.12e-021.00e+005.5491422
GO:0043044ATP-dependent chromatin remodeling2.21e-021.00e+005.4851423
GO:0006362transcription elongation from RNA polymerase I promoter2.21e-021.00e+005.4851323
GO:0043236laminin binding2.21e-021.00e+005.4851123
GO:0008135translation factor activity, nucleic acid binding2.31e-021.00e+005.4241724
GO:0006363termination of RNA polymerase I transcription2.31e-021.00e+005.4241324
GO:0003899DNA-directed RNA polymerase activity2.40e-021.00e+005.3651325
GO:0005515protein binding2.44e-021.00e+000.774101846024
GO:0006361transcription initiation from RNA polymerase I promoter2.50e-021.00e+005.3081326
GO:0050690regulation of defense response to virus by virus2.59e-021.00e+005.2541427
GO:0050661NADP binding2.59e-021.00e+005.2541227
GO:0031492nucleosomal DNA binding2.59e-021.00e+005.2541427
GO:0019894kinesin binding2.69e-021.00e+005.2011128
GO:0034504protein localization to nucleus2.69e-021.00e+005.2011228
GO:0006360transcription from RNA polymerase I promoter2.87e-021.00e+005.1021530
GO:0042254ribosome biogenesis2.87e-021.00e+005.1021130
GO:0033572transferrin transport2.87e-021.00e+005.1021530
GO:0031623receptor internalization2.97e-021.00e+005.0551231
GO:0032588trans-Golgi network membrane3.25e-021.00e+004.9211234
GO:0001895retina homeostasis3.25e-021.00e+004.9211134
GO:0006605protein targeting3.35e-021.00e+004.8791235
GO:0034332adherens junction organization3.44e-021.00e+004.8391136
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway3.44e-021.00e+004.8391436
GO:0018107peptidyl-threonine phosphorylation3.53e-021.00e+004.7991437
GO:0051084'de novo' posttranslational protein folding3.53e-021.00e+004.7991437
GO:0070527platelet aggregation3.63e-021.00e+004.7611238
GO:0019901protein kinase binding3.68e-021.00e+002.700221317
GO:0022627cytosolic small ribosomal subunit3.72e-021.00e+004.7231439
GO:0007595lactation3.72e-021.00e+004.7231239
GO:0007411axon guidance3.72e-021.00e+002.691213319
GO:0043195terminal bouton3.91e-021.00e+004.6511141
GO:0030136clathrin-coated vesicle4.00e-021.00e+004.6161442
GO:0006892post-Golgi vesicle-mediated transport4.10e-021.00e+004.5821343
GO:0021762substantia nigra development4.19e-021.00e+004.5491244
GO:0035690cellular response to drug4.65e-021.00e+004.3941249
GO:0006521regulation of cellular amino acid metabolic process4.75e-021.00e+004.36511750
GO:0031100organ regeneration4.75e-021.00e+004.3651450
GO:0003725double-stranded RNA binding4.93e-021.00e+004.3081552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding5.03e-021.00e+004.2811553
GO:0030666endocytic vesicle membrane5.03e-021.00e+004.2811453
GO:0045216cell-cell junction organization5.12e-021.00e+004.2541254
GO:0008565protein transporter activity5.30e-021.00e+004.2011556
GO:0000502proteasome complex5.49e-021.00e+004.15111758
GO:0042995cell projection5.67e-021.00e+004.1021660
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest6.04e-021.00e+004.00911964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.13e-021.00e+003.98612265
GO:0034329cell junction assembly6.40e-021.00e+003.9211168
GO:0005730nucleolus6.58e-021.00e+001.3284691641
GO:0055086nucleobase-containing small molecule metabolic process6.59e-021.00e+003.8791270
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.59e-021.00e+003.87912270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent6.77e-021.00e+003.83912072
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis6.95e-021.00e+003.7991674
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.95e-021.00e+003.79912274
GO:0008584male gonad development7.04e-021.00e+003.7801375
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I7.04e-021.00e+003.78012075
GO:0001889liver development7.22e-021.00e+003.7421477
GO:0007565female pregnancy7.31e-021.00e+003.7231178
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process7.40e-021.00e+003.70512379
GO:0006898receptor-mediated endocytosis7.86e-021.00e+003.6161384
GO:0005654nucleoplasm8.23e-021.00e+001.5143761082
GO:0042470melanosome8.48e-021.00e+003.5011991
GO:0016363nuclear matrix8.48e-021.00e+003.50111291
GO:0006928cellular component movement8.48e-021.00e+003.5011791
GO:0005200structural constituent of cytoskeleton8.48e-021.00e+003.5011891
GO:0001649osteoblast differentiation8.57e-021.00e+003.4851692
GO:0002474antigen processing and presentation of peptide antigen via MHC class I8.57e-021.00e+003.48512192
GO:0014069postsynaptic density9.73e-021.00e+003.29413105
GO:0030529ribonucleoprotein complex1.03e-011.00e+003.20118112
GO:0072562blood microparticle1.03e-011.00e+003.21413111
GO:0005819spindle1.03e-011.00e+003.20117112
GO:0044281small molecule metabolic process1.07e-011.00e+001.3523581211
GO:0000209protein polyubiquitination1.07e-011.00e+003.151120116
GO:0006325chromatin organization1.09e-011.00e+003.12615118
GO:0006511ubiquitin-dependent protein catabolic process1.16e-011.00e+003.03115126
GO:0000790nuclear chromatin1.18e-011.00e+002.99819129
GO:0031982vesicle1.20e-011.00e+002.97519131
GO:0007507heart development1.27e-011.00e+002.89017139
GO:0006457protein folding1.30e-011.00e+002.84917143
GO:0000082G1/S transition of mitotic cell cycle1.35e-011.00e+002.790132149
GO:0005198structural molecule activity1.36e-011.00e+002.78015150
GO:0042981regulation of apoptotic process1.36e-011.00e+002.780124150
GO:0046777protein autophosphorylation1.43e-011.00e+002.70517158
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.49e-011.00e+002.64217165
GO:0030424axon1.50e-011.00e+002.63414166
GO:0034641cellular nitrogen compound metabolic process1.54e-011.00e+002.591120171
GO:0004672protein kinase activity1.59e-011.00e+002.54116177
GO:0007173epidermal growth factor receptor signaling pathway1.69e-011.00e+002.446112189
GO:0001701in utero embryonic development1.78e-011.00e+002.35818201
GO:0007067mitotic nuclear division1.99e-011.00e+002.182114227
GO:0043025neuronal cell body2.13e-011.00e+002.07219245
GO:0005975carbohydrate metabolic process2.20e-011.00e+002.02619253
GO:0048011neurotrophin TRK receptor signaling pathway2.32e-011.00e+001.937115269
GO:0019899enzyme binding2.38e-011.00e+001.895112277
GO:0005856cytoskeleton2.48e-011.00e+001.824112291
GO:0043231intracellular membrane-bounded organelle2.68e-011.00e+001.69619318
GO:0007268synaptic transmission2.78e-011.00e+001.63416332
GO:0005737cytoplasm2.92e-011.00e+000.45151103767
GO:0007155cell adhesion3.04e-011.00e+001.48116369
GO:0000278mitotic cell cycle3.20e-011.00e+001.398148391
GO:0055114oxidation-reduction process3.39e-011.00e+001.294112420
GO:0043066negative regulation of apoptotic process3.42e-011.00e+001.281131424
GO:0007596blood coagulation3.62e-011.00e+001.179118455
GO:0005524ATP binding3.63e-011.00e+000.6672601298
GO:0046872metal ion binding3.67e-011.00e+000.6572251307
GO:0042802identical protein binding3.80e-011.00e+001.090120484
GO:0006915apoptotic process4.23e-011.00e+000.892133555
GO:0045087innate immune response4.46e-011.00e+000.790124596
GO:0005634nucleus4.69e-011.00e+000.17651364559
GO:0005886plasma membrane4.71e-011.00e+000.2593452582
GO:0005615extracellular space6.18e-011.00e+000.106117957
GO:0008270zinc ion binding6.33e-011.00e+000.047112997
GO:0003677DNA binding7.09e-011.00e+00-0.2421281218