int-snw-1211

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.956	2.43e-16	1.55e-03	2.85e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-1211 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
EIF2S2	8894	27	1.075	1.138	81	Yes	-
CLTC	1213	35	0.884	1.138	247	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
[ CLTA ]	1211	1	0.273	0.956	24	-	-
ATP6V1B2	526	44	0.881	1.076	278	-	-
RPSA	3921	156	1.327	1.151	152	Yes	-
TACC3	10460	2	0.806	0.956	10	Yes	-

Interactions (9)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ATP6V1B2	526	CLTC	1213	pp	--	int.I2D: IntAct_Yeast
CLTC	1213	EIF2S2	8894	pp	--	int.I2D: YeastLow
ACTB	60	CLTC	1213	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
ATP6V1B2	526	RPSA	3921	pp	--	int.I2D: IntAct_Yeast
ACTB	60	ATP6V1B2	526	pp	--	int.I2D: BioGrid_Yeast
CLTA	1211	TACC3	10460	pp	--	int.I2D: MINT; int.Mint: MI:0914(association), MI:0915(physical association)
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
CLTA	1211	CLTC	1213	pp	--	int.I2D: BCI, HPRD; int.HPRD: in vitro, yeast 2-hybrid

Related GO terms (169)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0071439	clathrin complex	8.07e-07	1.16e-02	10.231	2	2	3
GO:0030130	clathrin coat of trans-Golgi network vesicle	4.03e-06	5.82e-02	9.231	2	3	6
GO:0030118	clathrin coat	4.03e-06	5.82e-02	9.231	2	2	6
GO:0030132	clathrin coat of coated pit	5.65e-06	8.14e-02	9.009	2	2	7
GO:0061024	membrane organization	5.37e-05	7.75e-01	5.221	3	7	145
GO:0030669	clathrin-coated endocytic vesicle membrane	1.01e-04	1.00e+00	7.009	2	4	28
GO:0033572	transferrin transport	1.16e-04	1.00e+00	6.909	2	5	30
GO:0032588	trans-Golgi network membrane	1.50e-04	1.00e+00	6.729	2	2	34
GO:0006892	post-Golgi vesicle-mediated transport	2.40e-04	1.00e+00	6.390	2	3	43
GO:0005829	cytosol	5.44e-04	1.00e+00	2.116	6	132	2496
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	1.05e-03	1.00e+00	5.324	2	7	90
GO:0042470	melanosome	1.08e-03	1.00e+00	5.308	2	9	91
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.11e-03	1.00e+00	9.816	1	1	2
GO:0002176	male germ cell proliferation	1.11e-03	1.00e+00	9.816	1	1	2
GO:0005055	laminin receptor activity	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006407	rRNA export from nucleus	1.11e-03	1.00e+00	9.816	1	1	2
GO:0005850	eukaryotic translation initiation factor 2 complex	1.66e-03	1.00e+00	9.231	1	1	3
GO:1900126	negative regulation of hyaluronan biosynthetic process	1.66e-03	1.00e+00	9.231	1	2	3
GO:0030953	astral microtubule organization	1.66e-03	1.00e+00	9.231	1	1	3
GO:0044267	cellular protein metabolic process	1.75e-03	1.00e+00	3.512	3	29	474
GO:0006413	translational initiation	2.21e-03	1.00e+00	4.783	2	17	131
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.22e-03	1.00e+00	8.816	1	1	4
GO:0030686	90S preribosome	2.22e-03	1.00e+00	8.816	1	1	4
GO:0032050	clathrin heavy chain binding	2.22e-03	1.00e+00	8.816	1	1	4
GO:0032051	clathrin light chain binding	2.22e-03	1.00e+00	8.816	1	1	4
GO:1903077	negative regulation of protein localization to plasma membrane	2.22e-03	1.00e+00	8.816	1	1	4
GO:0000730	DNA recombinase assembly	2.77e-03	1.00e+00	8.494	1	1	5
GO:2000001	regulation of DNA damage checkpoint	2.77e-03	1.00e+00	8.494	1	1	5
GO:0005198	structural molecule activity	2.89e-03	1.00e+00	4.587	2	5	150
GO:0030957	Tat protein binding	3.32e-03	1.00e+00	8.231	1	3	6
GO:0006886	intracellular protein transport	3.73e-03	1.00e+00	4.398	2	5	171
GO:0033180	proton-transporting V-type ATPase, V1 domain	3.88e-03	1.00e+00	8.009	1	2	7
GO:0000028	ribosomal small subunit assembly	3.88e-03	1.00e+00	8.009	1	1	7
GO:0070688	MLL5-L complex	4.43e-03	1.00e+00	7.816	1	1	8
GO:0022027	interkinetic nuclear migration	4.98e-03	1.00e+00	7.646	1	1	9
GO:0010569	regulation of double-strand break repair via homologous recombination	5.53e-03	1.00e+00	7.494	1	1	10
GO:0031571	mitotic G1 DNA damage checkpoint	6.09e-03	1.00e+00	7.357	1	4	11
GO:0032886	regulation of microtubule-based process	6.64e-03	1.00e+00	7.231	1	3	12
GO:0006412	translation	6.65e-03	1.00e+00	3.971	2	20	230
GO:0005662	DNA replication factor A complex	7.19e-03	1.00e+00	7.116	1	1	13
GO:0042994	cytoplasmic sequestering of transcription factor	7.19e-03	1.00e+00	7.116	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	7.74e-03	1.00e+00	7.009	1	4	14
GO:0046961	proton-transporting ATPase activity, rotational mechanism	8.29e-03	1.00e+00	6.909	1	3	15
GO:0046034	ATP metabolic process	8.29e-03	1.00e+00	6.909	1	1	15
GO:0016020	membrane	8.74e-03	1.00e+00	2.101	4	90	1681
GO:0050998	nitric-oxide synthase binding	8.84e-03	1.00e+00	6.816	1	1	16
GO:0035861	site of double-strand break	9.94e-03	1.00e+00	6.646	1	1	18
GO:0015078	hydrogen ion transmembrane transporter activity	1.05e-02	1.00e+00	6.568	1	3	19
GO:0043234	protein complex	1.08e-02	1.00e+00	3.612	2	18	295
GO:0006298	mismatch repair	1.10e-02	1.00e+00	6.494	1	3	20
GO:0005515	protein binding	1.12e-02	1.00e+00	1.067	7	184	6024
GO:0032201	telomere maintenance via semi-conservative replication	1.16e-02	1.00e+00	6.424	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.16e-02	1.00e+00	6.424	1	4	21
GO:0006297	nucleotide-excision repair, DNA gap filling	1.21e-02	1.00e+00	6.357	1	3	22
GO:0030863	cortical cytoskeleton	1.21e-02	1.00e+00	6.357	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.21e-02	1.00e+00	6.357	1	4	22
GO:0019901	protein kinase binding	1.24e-02	1.00e+00	3.508	2	21	317
GO:0043231	intracellular membrane-bounded organelle	1.24e-02	1.00e+00	3.503	2	9	318
GO:0007411	axon guidance	1.25e-02	1.00e+00	3.499	2	13	319
GO:0043044	ATP-dependent chromatin remodeling	1.27e-02	1.00e+00	6.293	1	4	23
GO:0043236	laminin binding	1.27e-02	1.00e+00	6.293	1	1	23
GO:0008135	translation factor activity, nucleic acid binding	1.32e-02	1.00e+00	6.231	1	7	24
GO:0022008	neurogenesis	1.32e-02	1.00e+00	6.231	1	1	24
GO:0000722	telomere maintenance via recombination	1.38e-02	1.00e+00	6.172	1	5	25
GO:0015991	ATP hydrolysis coupled proton transport	1.43e-02	1.00e+00	6.116	1	4	26
GO:0043022	ribosome binding	1.49e-02	1.00e+00	6.061	1	3	27
GO:0031492	nucleosomal DNA binding	1.49e-02	1.00e+00	6.061	1	4	27
GO:0019894	kinesin binding	1.54e-02	1.00e+00	6.009	1	1	28
GO:0015992	proton transport	1.60e-02	1.00e+00	5.958	1	3	29
GO:0005925	focal adhesion	1.63e-02	1.00e+00	3.300	2	19	366
GO:0006271	DNA strand elongation involved in DNA replication	1.65e-02	1.00e+00	5.909	1	7	30
GO:0044822	poly(A) RNA binding	1.66e-02	1.00e+00	2.357	3	49	1056
GO:0031623	receptor internalization	1.71e-02	1.00e+00	5.862	1	2	31
GO:0051701	interaction with host	1.76e-02	1.00e+00	5.816	1	4	32
GO:0001895	retina homeostasis	1.87e-02	1.00e+00	5.729	1	1	34
GO:0042277	peptide binding	1.93e-02	1.00e+00	5.687	1	3	35
GO:0034332	adherens junction organization	1.98e-02	1.00e+00	5.646	1	1	36
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	1.98e-02	1.00e+00	5.646	1	4	36
GO:0090382	phagosome maturation	1.98e-02	1.00e+00	5.646	1	5	36
GO:0051084	'de novo' posttranslational protein folding	2.03e-02	1.00e+00	5.607	1	4	37
GO:0006284	base-excision repair	2.03e-02	1.00e+00	5.607	1	3	37
GO:0005902	microvillus	2.09e-02	1.00e+00	5.568	1	2	38
GO:0070527	platelet aggregation	2.09e-02	1.00e+00	5.568	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.14e-02	1.00e+00	5.531	1	4	39
GO:0000781	chromosome, telomeric region	2.14e-02	1.00e+00	5.531	1	3	39
GO:0021987	cerebral cortex development	2.31e-02	1.00e+00	5.424	1	3	42
GO:0030136	clathrin-coated vesicle	2.31e-02	1.00e+00	5.424	1	4	42
GO:0021762	substantia nigra development	2.42e-02	1.00e+00	5.357	1	2	44
GO:0006283	transcription-coupled nucleotide-excision repair	2.52e-02	1.00e+00	5.293	1	7	46
GO:0003743	translation initiation factor activity	2.69e-02	1.00e+00	5.201	1	8	49
GO:0003684	damaged DNA binding	2.69e-02	1.00e+00	5.201	1	7	49
GO:0006879	cellular iron ion homeostasis	2.79e-02	1.00e+00	5.144	1	4	51
GO:0003725	double-stranded RNA binding	2.85e-02	1.00e+00	5.116	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.90e-02	1.00e+00	5.088	1	5	53
GO:0045216	cell-cell junction organization	2.96e-02	1.00e+00	5.061	1	2	54
GO:0000724	double-strand break repair via homologous recombination	3.01e-02	1.00e+00	5.035	1	3	55
GO:0070062	extracellular vesicular exosome	3.05e-02	1.00e+00	1.587	4	104	2400
GO:0000723	telomere maintenance	3.06e-02	1.00e+00	5.009	1	6	56
GO:0012505	endomembrane system	3.06e-02	1.00e+00	5.009	1	2	56
GO:0030097	hemopoiesis	3.06e-02	1.00e+00	5.009	1	1	56
GO:0019903	protein phosphatase binding	3.39e-02	1.00e+00	4.862	1	4	62
GO:0006302	double-strand break repair	3.39e-02	1.00e+00	4.862	1	4	62
GO:0006289	nucleotide-excision repair	3.71e-02	1.00e+00	4.729	1	11	68
GO:0034329	cell junction assembly	3.71e-02	1.00e+00	4.729	1	1	68
GO:0003697	single-stranded DNA binding	3.71e-02	1.00e+00	4.729	1	5	68
GO:0005886	plasma membrane	3.90e-02	1.00e+00	1.482	4	45	2582
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.03e-02	1.00e+00	4.607	1	6	74
GO:0008584	male gonad development	4.09e-02	1.00e+00	4.587	1	3	75
GO:0001726	ruffle	4.35e-02	1.00e+00	4.494	1	4	80
GO:0019083	viral transcription	4.41e-02	1.00e+00	4.476	1	10	81
GO:0006898	receptor-mediated endocytosis	4.57e-02	1.00e+00	4.424	1	3	84
GO:0047485	protein N-terminus binding	4.67e-02	1.00e+00	4.390	1	5	86
GO:0006415	translational termination	4.73e-02	1.00e+00	4.373	1	10	87
GO:0016605	PML body	4.78e-02	1.00e+00	4.357	1	3	88
GO:0006928	cellular component movement	4.94e-02	1.00e+00	4.308	1	7	91
GO:0005200	structural constituent of cytoskeleton	4.94e-02	1.00e+00	4.308	1	8	91
GO:0001649	osteoblast differentiation	4.99e-02	1.00e+00	4.293	1	6	92
GO:0010467	gene expression	4.99e-02	1.00e+00	2.430	2	59	669
GO:0006414	translational elongation	5.04e-02	1.00e+00	4.277	1	13	93
GO:0051726	regulation of cell cycle	5.26e-02	1.00e+00	4.216	1	5	97
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	5.63e-02	1.00e+00	4.116	1	10	104
GO:0014069	postsynaptic density	5.68e-02	1.00e+00	4.102	1	3	105
GO:0016023	cytoplasmic membrane-bounded vesicle	5.68e-02	1.00e+00	4.102	1	5	105
GO:0006897	endocytosis	5.73e-02	1.00e+00	4.088	1	8	106
GO:0072562	blood microparticle	5.99e-02	1.00e+00	4.022	1	3	111
GO:0030529	ribonucleoprotein complex	6.05e-02	1.00e+00	4.009	1	8	112
GO:0005819	spindle	6.05e-02	1.00e+00	4.009	1	7	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.15e-02	1.00e+00	3.983	1	11	114
GO:0019058	viral life cycle	6.20e-02	1.00e+00	3.971	1	13	115
GO:0006325	chromatin organization	6.36e-02	1.00e+00	3.933	1	5	118
GO:0006260	DNA replication	6.52e-02	1.00e+00	3.897	1	9	121
GO:0000790	nuclear chromatin	6.94e-02	1.00e+00	3.805	1	9	129
GO:0031982	vesicle	7.04e-02	1.00e+00	3.783	1	9	131
GO:0003735	structural constituent of ribosome	7.35e-02	1.00e+00	3.718	1	10	137
GO:0008286	insulin receptor signaling pathway	7.61e-02	1.00e+00	3.666	1	7	142
GO:0006457	protein folding	7.66e-02	1.00e+00	3.656	1	7	143
GO:0001666	response to hypoxia	7.97e-02	1.00e+00	3.597	1	5	149
GO:0000082	G1/S transition of mitotic cell cycle	7.97e-02	1.00e+00	3.597	1	32	149
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	8.80e-02	1.00e+00	3.450	1	7	165
GO:0030424	axon	8.85e-02	1.00e+00	3.441	1	4	166
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	14	178
GO:0019904	protein domain specific binding	9.51e-02	1.00e+00	3.332	1	6	179
GO:0007173	epidermal growth factor receptor signaling pathway	1.00e-01	1.00e+00	3.254	1	12	189
GO:0001701	in utero embryonic development	1.06e-01	1.00e+00	3.165	1	8	201
GO:0005765	lysosomal membrane	1.07e-01	1.00e+00	3.151	1	5	203
GO:0005654	nucleoplasm	1.16e-01	1.00e+00	1.737	2	76	1082
GO:0016071	mRNA metabolic process	1.17e-01	1.00e+00	3.015	1	31	223
GO:0007067	mitotic nuclear division	1.19e-01	1.00e+00	2.990	1	14	227
GO:0016070	RNA metabolic process	1.29e-01	1.00e+00	2.868	1	32	247
GO:0006281	DNA repair	1.36e-01	1.00e+00	2.788	1	18	261
GO:0048011	neurotrophin TRK receptor signaling pathway	1.40e-01	1.00e+00	2.745	1	15	269
GO:0019899	enzyme binding	1.44e-01	1.00e+00	2.702	1	12	277
GO:0005856	cytoskeleton	1.50e-01	1.00e+00	2.631	1	12	291
GO:0005524	ATP binding	1.58e-01	1.00e+00	1.474	2	60	1298
GO:0005813	centrosome	1.67e-01	1.00e+00	2.467	1	14	326
GO:0003723	RNA binding	1.75e-01	1.00e+00	2.398	1	20	342
GO:0007155	cell adhesion	1.87e-01	1.00e+00	2.289	1	6	369
GO:0000278	mitotic cell cycle	1.97e-01	1.00e+00	2.205	1	48	391
GO:0055085	transmembrane transport	2.17e-01	1.00e+00	2.051	1	10	435
GO:0003674	molecular_function	2.21e-01	1.00e+00	2.022	1	4	444
GO:0007596	blood coagulation	2.26e-01	1.00e+00	1.986	1	18	455
GO:0016032	viral process	2.61e-01	1.00e+00	1.755	1	55	534
GO:0045087	innate immune response	2.87e-01	1.00e+00	1.597	1	24	596
GO:0005737	cytoplasm	3.49e-01	1.00e+00	0.522	3	110	3767
GO:0005615	extracellular space	4.23e-01	1.00e+00	0.914	1	17	957
GO:0046872	metal ion binding	5.32e-01	1.00e+00	0.464	1	25	1307
GO:0005730	nucleolus	6.20e-01	1.00e+00	0.136	1	69	1641
GO:0016021	integral component of membrane	6.94e-01	1.00e+00	-0.137	1	27	1982
GO:0005634	nucleus	7.75e-01	1.00e+00	-0.338	2	136	4559

Wolf-ratios-Mammosphere-Adherent

int-snw-1211

Statistics

Genes (8)

Interactions (9)

Related GO terms (169)