int-snw-10477

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.926 3.62e-15 3.00e-03 4.60e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-10477 subnetwork

Genes (9)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
RBX1 9978 971.1851.151139Yes-
RPS11 6205 360.9931.113175Yes-
RPL14 9045 421.2501.113143Yes-
ACTB 60 1671.1531.151587Yes-
RNF2 6045 20.4230.926106--
[ UBE2E3 ] 10477 10.2740.92668--
UBB 7314 20.4771.041147--
RPSA 3921 1561.3271.151152Yes-

Interactions (9)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 UBB 7314 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
RPSA 3921 RPS11 6205 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
UBB 7314 UBE2E3 10477 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
RNF2 6045 UBE2E3 10477 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, IntAct
RPS11 6205 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
RPL14 9045 UBE2E3 10477 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct

Related GO terms (222)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0019058viral life cycle4.69e-076.76e-035.801413115
GO:0016071mRNA metabolic process6.60e-069.51e-024.845431223
GO:0016032viral process7.60e-061.10e-013.907555534
GO:0016070RNA metabolic process9.89e-061.43e-014.698432247
GO:0019083viral transcription1.40e-052.02e-015.89131081
GO:0006415translational termination1.73e-052.50e-015.78831087
GO:0006414translational elongation2.12e-053.06e-015.69231393
GO:0006614SRP-dependent cotranslational protein targeting to membrane2.96e-054.28e-015.531310104
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay3.90e-055.63e-015.398311114
GO:0006413translational initiation5.91e-058.52e-015.198317131
GO:0003735structural constituent of ribosome6.75e-059.74e-015.133310137
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.12e-041.00e+006.9462326
GO:0044267cellular protein metabolic process1.27e-041.00e+003.757429474
GO:0005654nucleoplasm2.30e-041.00e+002.8895761082
GO:0022627cytosolic small ribosomal subunit2.53e-041.00e+006.3612439
GO:0006412translation3.13e-041.00e+004.386320230
GO:0004842ubiquitin-protein transferase activity4.24e-041.00e+004.23736255
GO:0006281DNA repair4.54e-041.00e+004.203318261
GO:0010467gene expression4.79e-041.00e+003.260459669
GO:0036353histone H2A-K119 monoubiquitination6.24e-041.00e+0010.646111
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.25e-031.00e+009.646112
GO:0005055laminin receptor activity1.25e-031.00e+009.646112
GO:0006407rRNA export from nucleus1.25e-031.00e+009.646112
GO:1902255positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator1.25e-031.00e+009.646112
GO:0005829cytosol1.39e-031.00e+001.94661322496
GO:0071456cellular response to hypoxia1.41e-031.00e+005.1232692
GO:0000278mitotic cell cycle1.47e-031.00e+003.620348391
GO:0071535RING-like zinc finger domain binding1.87e-031.00e+009.061113
GO:0007219Notch signaling pathway2.38e-031.00e+004.73925120
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.49e-031.00e+008.646114
GO:003068690S preribosome2.49e-031.00e+008.646114
GO:0031467Cul7-RING ubiquitin ligase complex2.49e-031.00e+008.646114
GO:0019788NEDD8 ligase activity2.49e-031.00e+008.646114
GO:0031465Cul4B-RING E3 ubiquitin ligase complex3.12e-031.00e+008.324135
GO:0031461cullin-RING ubiquitin ligase complex3.12e-031.00e+008.324115
GO:0030891VCB complex3.12e-031.00e+008.324125
GO:0000730DNA recombinase assembly3.12e-031.00e+008.324115
GO:2000001regulation of DNA damage checkpoint3.12e-031.00e+008.324115
GO:0061024membrane organization3.45e-031.00e+004.46627145
GO:0000082G1/S transition of mitotic cell cycle3.64e-031.00e+004.427232149
GO:0000791euchromatin3.74e-031.00e+008.061116
GO:0030957Tat protein binding3.74e-031.00e+008.061136
GO:0031466Cul5-RING ubiquitin ligase complex3.74e-031.00e+008.061116
GO:0000028ribosomal small subunit assembly4.36e-031.00e+007.839117
GO:0001739sex chromatin4.36e-031.00e+007.839117
GO:0031462Cul2-RING ubiquitin ligase complex4.36e-031.00e+007.839127
GO:0031464Cul4A-RING E3 ubiquitin ligase complex4.98e-031.00e+007.646128
GO:0070688MLL5-L complex4.98e-031.00e+007.646118
GO:0045116protein neddylation4.98e-031.00e+007.646128
GO:0031625ubiquitin protein ligase binding5.15e-031.00e+004.170214178
GO:0005515protein binding5.23e-031.00e+001.09081846024
GO:0047497mitochondrion transport along microtubule5.60e-031.00e+007.476139
GO:0010569regulation of double-strand break repair via homologous recombination6.22e-031.00e+007.3241110
GO:0031571mitotic G1 DNA damage checkpoint6.85e-031.00e+007.1871411
GO:0035518histone H2A monoubiquitination6.85e-031.00e+007.1871311
GO:0061136regulation of proteasomal protein catabolic process7.47e-031.00e+007.0611212
GO:0035102PRC1 complex7.47e-031.00e+007.0611112
GO:1901214regulation of neuron death7.47e-031.00e+007.0611112
GO:0019082viral protein processing7.47e-031.00e+007.0611112
GO:0042273ribosomal large subunit biogenesis8.09e-031.00e+006.9461413
GO:0005662DNA replication factor A complex8.09e-031.00e+006.9461113
GO:0032479regulation of type I interferon production8.09e-031.00e+006.9461113
GO:0035267NuA4 histone acetyltransferase complex8.70e-031.00e+006.8391414
GO:0009948anterior/posterior axis specification8.70e-031.00e+006.8391214
GO:0070062extracellular vesicular exosome8.87e-031.00e+001.73951042400
GO:0050998nitric-oxide synthase binding9.94e-031.00e+006.6461116
GO:0075733intracellular transport of virus1.06e-021.00e+006.5591317
GO:0019068virion assembly1.06e-021.00e+006.5591117
GO:0035861site of double-strand break1.12e-021.00e+006.4761118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.18e-021.00e+006.3981119
GO:0006298mismatch repair1.24e-021.00e+006.3241320
GO:0051881regulation of mitochondrial membrane potential1.24e-021.00e+006.3241220
GO:0032201telomere maintenance via semi-conservative replication1.30e-021.00e+006.2541521
GO:0001702gastrulation with mouth forming second1.30e-021.00e+006.2541221
GO:0000718nucleotide-excision repair, DNA damage removal1.30e-021.00e+006.2541421
GO:0007220Notch receptor processing1.36e-021.00e+006.1871122
GO:0006297nucleotide-excision repair, DNA gap filling1.36e-021.00e+006.1871322
GO:0030863cortical cytoskeleton1.36e-021.00e+006.1871122
GO:0036464cytoplasmic ribonucleoprotein granule1.36e-021.00e+006.1871422
GO:0043044ATP-dependent chromatin remodeling1.43e-021.00e+006.1231423
GO:0031463Cul3-RING ubiquitin ligase complex1.43e-021.00e+006.1231323
GO:0043236laminin binding1.43e-021.00e+006.1231123
GO:0016020membrane1.43e-021.00e+001.9314901681
GO:0006513protein monoubiquitination1.43e-021.00e+006.1231123
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway1.55e-021.00e+006.0021325
GO:0000722telomere maintenance via recombination1.55e-021.00e+006.0021525
GO:0031519PcG protein complex1.55e-021.00e+006.0021425
GO:0005978glycogen biosynthetic process1.61e-021.00e+005.9461126
GO:0070979protein K11-linked ubiquitination1.61e-021.00e+005.9461626
GO:0019843rRNA binding1.67e-021.00e+005.8911327
GO:0043022ribosome binding1.67e-021.00e+005.8911327
GO:0071339MLL1 complex1.67e-021.00e+005.8911327
GO:0031492nucleosomal DNA binding1.67e-021.00e+005.8911427
GO:0019894kinesin binding1.73e-021.00e+005.8391128
GO:0019005SCF ubiquitin ligase complex1.80e-021.00e+005.7881129
GO:0006271DNA strand elongation involved in DNA replication1.86e-021.00e+005.7391730
GO:0048812neuron projection morphogenesis1.92e-021.00e+005.6921131
GO:0070534protein K63-linked ubiquitination1.92e-021.00e+005.6921131
GO:0016604nuclear body1.92e-021.00e+005.6921231
GO:0032480negative regulation of type I interferon production1.98e-021.00e+005.6461132
GO:0005925focal adhesion2.05e-021.00e+003.130219366
GO:0001895retina homeostasis2.10e-021.00e+005.5591134
GO:0034332adherens junction organization2.22e-021.00e+005.4761136
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway2.22e-021.00e+005.4761436
GO:0051084'de novo' posttranslational protein folding2.29e-021.00e+005.4371437
GO:0016881acid-amino acid ligase activity2.29e-021.00e+005.4371237
GO:0006284base-excision repair2.29e-021.00e+005.4371337
GO:0044822poly(A) RNA binding2.35e-021.00e+002.1873491056
GO:0070527platelet aggregation2.35e-021.00e+005.3981238
GO:0000781chromosome, telomeric region2.41e-021.00e+005.3611339
GO:0007249I-kappaB kinase/NF-kappaB signaling2.53e-021.00e+005.2891241
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway2.65e-021.00e+005.2201443
GO:0021762substantia nigra development2.71e-021.00e+005.1871244
GO:0070936protein K48-linked ubiquitination2.71e-021.00e+005.1871244
GO:0006283transcription-coupled nucleotide-excision repair2.83e-021.00e+005.1231746
GO:0022625cytosolic large ribosomal subunit3.02e-021.00e+005.0311649
GO:0007254JNK cascade3.02e-021.00e+005.0311349
GO:0003684damaged DNA binding3.02e-021.00e+005.0311749
GO:0040008regulation of growth3.08e-021.00e+005.0021550
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.26e-021.00e+004.9181553
GO:0030666endocytic vesicle membrane3.26e-021.00e+004.9181453
GO:0045216cell-cell junction organization3.32e-021.00e+004.8911254
GO:0051403stress-activated MAPK cascade3.32e-021.00e+004.8911254
GO:0000724double-strand break repair via homologous recombination3.38e-021.00e+004.8651355
GO:0000723telomere maintenance3.44e-021.00e+004.8391656
GO:0016197endosomal transport3.50e-021.00e+004.8131157
GO:0005840ribosome3.56e-021.00e+004.7881158
GO:0032481positive regulation of type I interferon production3.74e-021.00e+004.7151661
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway3.74e-021.00e+004.7151261
GO:0019903protein phosphatase binding3.80e-021.00e+004.6921462
GO:0006302double-strand break repair3.80e-021.00e+004.6921462
GO:0000151ubiquitin ligase complex3.86e-021.00e+004.6691163
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest3.92e-021.00e+004.64611964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.98e-021.00e+004.62412265
GO:0034146toll-like receptor 5 signaling pathway3.98e-021.00e+004.6241265
GO:0034166toll-like receptor 10 signaling pathway3.98e-021.00e+004.6241265
GO:0006289nucleotide-excision repair4.17e-021.00e+004.55911168
GO:0034329cell junction assembly4.17e-021.00e+004.5591168
GO:0003697single-stranded DNA binding4.17e-021.00e+004.5591568
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.29e-021.00e+004.51712270
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway4.35e-021.00e+004.4961271
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway4.35e-021.00e+004.4961271
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent4.41e-021.00e+004.47612072
GO:0034162toll-like receptor 9 signaling pathway4.41e-021.00e+004.4761272
GO:0034134toll-like receptor 2 signaling pathway4.47e-021.00e+004.4561273
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.53e-021.00e+004.4371674
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.53e-021.00e+004.43712274
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process4.59e-021.00e+004.4171275
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I4.59e-021.00e+004.41712075
GO:0035666TRIF-dependent toll-like receptor signaling pathway4.64e-021.00e+004.3981376
GO:0000122negative regulation of transcription from RNA polymerase II promoter4.67e-021.00e+002.491216570
GO:0002756MyD88-independent toll-like receptor signaling pathway4.76e-021.00e+004.3611378
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process4.82e-021.00e+004.34212379
GO:0034138toll-like receptor 3 signaling pathway4.82e-021.00e+004.3421379
GO:0002755MyD88-dependent toll-like receptor signaling pathway4.88e-021.00e+004.3241380
GO:0045087innate immune response5.06e-021.00e+002.427224596
GO:0050852T cell receptor signaling pathway5.18e-021.00e+004.2371485
GO:0047485protein N-terminus binding5.24e-021.00e+004.2201586
GO:0016605PML body5.36e-021.00e+004.1871388
GO:0000187activation of MAPK activity5.48e-021.00e+004.1541590
GO:0006928cellular component movement5.54e-021.00e+004.1381791
GO:0005200structural constituent of cytoskeleton5.54e-021.00e+004.1381891
GO:0001649osteoblast differentiation5.60e-021.00e+004.1231692
GO:0002474antigen processing and presentation of peptide antigen via MHC class I5.60e-021.00e+004.12312192
GO:0006364rRNA processing5.72e-021.00e+004.0921694
GO:0034142toll-like receptor 4 signaling pathway5.83e-021.00e+004.0611396
GO:0014069postsynaptic density6.37e-021.00e+003.93213105
GO:0002224toll-like receptor signaling pathway6.60e-021.00e+003.87813109
GO:0072562blood microparticle6.72e-021.00e+003.85213111
GO:0030529ribonucleoprotein complex6.78e-021.00e+003.83918112
GO:0097190apoptotic signaling pathway6.84e-021.00e+003.82616113
GO:0000209protein polyubiquitination7.01e-021.00e+003.788120116
GO:0006006glucose metabolic process7.13e-021.00e+003.76417118
GO:0006325chromatin organization7.13e-021.00e+003.76415118
GO:0006260DNA replication7.30e-021.00e+003.72719121
GO:0051092positive regulation of NF-kappaB transcription factor activity7.48e-021.00e+003.69214124
GO:0007179transforming growth factor beta receptor signaling pathway7.71e-021.00e+003.64614128
GO:0000790nuclear chromatin7.77e-021.00e+003.63519129
GO:0000086G2/M transition of mitotic cell cycle8.18e-021.00e+003.55919136
GO:0006457protein folding8.58e-021.00e+003.48617143
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling8.69e-021.00e+003.46614145
GO:0034220ion transmembrane transport8.92e-021.00e+003.42714149
GO:0042981regulation of apoptotic process8.98e-021.00e+003.417124150
GO:0010008endosome membrane9.04e-021.00e+003.40817151
GO:0008543fibroblast growth factor receptor signaling pathway9.33e-021.00e+003.36119156
GO:0043005neuron projection9.38e-021.00e+003.35216157
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9.84e-021.00e+003.28017165
GO:0030424axon9.90e-021.00e+003.27114166
GO:0038095Fc-epsilon receptor signaling pathway1.00e-011.00e+003.254112168
GO:0032403protein complex binding1.09e-011.00e+003.130110183
GO:0006367transcription initiation from RNA polymerase II promoter1.09e-011.00e+003.12318184
GO:0007173epidermal growth factor receptor signaling pathway1.12e-011.00e+003.084112189
GO:0008270zinc ion binding1.24e-011.00e+001.685212997
GO:0016874ligase activity1.26e-011.00e+002.90511214
GO:0019221cytokine-mediated signaling pathway1.30e-011.00e+002.85819221
GO:0043025neuronal cell body1.43e-011.00e+002.71019245
GO:0005975carbohydrate metabolic process1.47e-011.00e+002.66319253
GO:0043065positive regulation of apoptotic process1.55e-011.00e+002.580110268
GO:0048011neurotrophin TRK receptor signaling pathway1.56e-011.00e+002.575115269
GO:0019899enzyme binding1.60e-011.00e+002.532112277
GO:0005856cytoskeleton1.68e-011.00e+002.461112291
GO:0043234protein complex1.70e-011.00e+002.442118295
GO:0016567protein ubiquitination1.70e-011.00e+002.44215295
GO:0019901protein kinase binding1.81e-011.00e+002.338121317
GO:0007411axon guidance1.82e-011.00e+002.329113319
GO:0005737cytoplasm1.87e-011.00e+000.76741103767
GO:0003682chromatin binding1.87e-011.00e+002.293111327
GO:0005524ATP binding1.91e-011.00e+001.3042601298
GO:0003723RNA binding1.94e-011.00e+002.228120342
GO:0007155cell adhesion2.08e-011.00e+002.11916369
GO:0006351transcription, DNA-templated2.26e-011.00e+001.1482311446
GO:0043066negative regulation of apoptotic process2.36e-011.00e+001.918131424
GO:0055085transmembrane transport2.41e-011.00e+001.881110435
GO:0007596blood coagulation2.51e-011.00e+001.816118455
GO:0005730nucleolus2.73e-011.00e+000.9662691641
GO:0006915apoptotic process2.98e-011.00e+001.530133555
GO:0005634nucleus3.08e-011.00e+000.49241364559
GO:0045944positive regulation of transcription from RNA polymerase II promoter3.97e-011.00e+001.022119789
GO:0005615extracellular space4.61e-011.00e+000.744117957
GO:0005739mitochondrion4.76e-011.00e+000.683128998
GO:0005886plasma membrane4.98e-011.00e+000.3122452582
GO:0044281small molecule metabolic process5.46e-011.00e+000.4041581211