meta-reg-snw-8450

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
int-snw-51741 tai-screen-luciferase 6.174 2.67e-126 1.32e-06 4.54e-03 24 19
reg-snw-8450 tai-screen-luciferase 5.269 2.26e-31 3.26e-05 6.40e-05 5 2
tai-screen-luciferase-meta-reg-snw-8450 subnetwork

Genes (27)

Gene Symbol Entrez Gene ID Frequency tai-screen-luciferase gene score Best subnetwork score Degree List-Gonzales GI Tai-Hits
MAPK8 5599 28-4.4036.468153--
PRIM2 5558 6-3.5075.26967--
COPA 1314 48-9.3955.672340YesYes
RNF20 56254 28-4.5646.17418--
CUL4B 8450 21-2.8095.269142--
HSF1 3297 46-4.1795.027209-Yes
RPS24 6229 46-7.0348.389217Yes-
TCERG1 10915 28-3.8086.17458Yes-
SRC 6714 28-2.8066.174419Yes-
RPS9 6203 45-7.1277.555140Yes-
COPB2 9276 48-13.1689.06341YesYes
CKAP5 9793 46-7.2145.672130YesYes
RPS4X 6191 44-6.7477.555263Yes-
COPZ1 22818 48-8.3019.06313YesYes
RPS15A 6210 36-5.4137.555177Yes-
CDC42 998 44-6.9604.707276YesYes
WWOX 51741 28-2.4486.17438--
RPS27A 6233 45-5.6318.389344Yes-
RPS11 6205 44-6.5887.555175Yes-
RPS6 6194 44-5.6038.046217Yes-
NFKBIB 4793 28-3.9786.17478--
UBB 7314 30-4.2896.428147--
RPS26 6231 43-7.4788.04660Yes-
ARCN1 372 48-8.2329.063118YesYes
COPB1 1315 39-6.2219.063118YesYes
RPS13 6207 43-6.5897.555174Yes-
CDC5L 988 34-3.4195.672155--

Interactions (49)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CDC42 998 RPS27A 6233 pp -- int.I2D: SOURAV_MAPK_HIGH
ARCN1 372 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
RPS11 6205 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
TCERG1 10915 WWOX 51741 pp -- int.I2D: BioGrid, MINT, Pawson1;
int.Mint: MI:0915(physical association)
RPS6 6194 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
CDC5L 988 CUL4B 8450 pd <> reg.ITFP.txt: no annot
RPS11 6205 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
SRC 6714 CKAP5 9793 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
RPS6 6194 RPS26 6231 pp -- int.I2D: YeastLow
CDC42 998 UBB 7314 pp -- int.I2D: SOURAV_MAPK_HIGH
NFKBIB 4793 UBB 7314 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
RPS9 6203 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS4X 6191 RPS11 6205 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
RPS9 6203 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS9 6203 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS4X 6191 RPS9 6203 pp -- int.I2D: BioGrid_Yeast
UBB 7314 WWOX 51741 pp -- int.I2D: BCI, HPRD;
int.HPRD: in vivo
UBB 7314 RNF20 56254 pp -- int.Intact: MI:0220(ubiquitination reaction);
int.I2D: IntAct
RPS11 6205 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
SRC 6714 WWOX 51741 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
RPS27A 6233 UBB 7314 pp -- int.I2D: BIND
RPS4X 6191 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS4X 6191 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast, YeastMedium, INTEROLOG
RPS6 6194 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
RPS13 6207 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS27A 6233 pp -- int.I2D: YeastLow
COPA 1314 COPB1 1315 pp -- int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh
CDC5L 988 CKAP5 9793 pd <> reg.ITFP.txt: no annot
HSF1 3297 MAPK8 5599 pp -- int.I2D: HPRD, INNATEDB;
int.HPRD: in vitro, in vivo
COPA 1314 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
COPA 1314 COPB2 9276 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vivo
COPB1 1315 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium;
int.DIP: MI:0915(physical association)
RPS4X 6191 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS15A 6210 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS13 6207 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
CDC5L 988 COPA 1314 pd <> reg.ITFP.txt: no annot
COPA 1314 CUL4B 8450 pd <> reg.ITFP.txt: no annot
COPB1 1315 COPB2 9276 pp -- int.I2D: BioGrid
ARCN1 372 COPB1 1315 pp -- int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS;
int.HPRD: in vivo
RPS9 6203 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
ARCN1 372 COPA 1314 pp -- int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core;
int.HPRD: in vivo
RPS4X 6191 RPS6 6194 pp -- int.I2D: BioGrid_Yeast
COPA 1314 RPS27A 6233 pp -- int.I2D: YeastLow
MAPK8 5599 WWOX 51741 pp -- int.I2D: MINT, HPRD;
int.Mint: MI:0915(physical association);
int.HPRD: in vivo, yeast 2-hybrid
RPS15A 6210 RPS27A 6233 pp -- int.I2D: YeastLow
ARCN1 372 COPB2 9276 pp -- int.I2D: HPRD, BCI;
int.HPRD: in vivo
PRIM2 5558 CUL4B 8450 pd < reg.ITFP.txt: no annot
RPS24 6229 RPS27A 6233 pp -- int.I2D: YeastMedium

Related GO terms (440)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0022627cytosolic small ribosomal subunit4.27e-186.96e-147.12492139
GO:0019058viral life cycle1.54e-152.52e-115.7161025115
GO:0019083viral transcription5.04e-158.22e-116.07092281
GO:0006415translational termination9.84e-151.61e-105.96792287
GO:0006414translational elongation1.84e-143.00e-105.87092293
GO:0006614SRP-dependent cotranslational protein targeting to membrane5.18e-148.46e-105.709922104
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.21e-131.98e-095.577922114
GO:0006413translational initiation4.34e-137.09e-095.376927131
GO:0003735structural constituent of ribosome8.51e-131.39e-085.270924141
GO:0016071mRNA metabolic process1.28e-122.08e-084.7611029223
GO:0005829cytosol1.36e-122.22e-082.30921742562
GO:0016070RNA metabolic process3.54e-125.77e-084.6131029247
GO:0048205COPI coating of Golgi vesicle1.07e-111.74e-077.8615613
GO:0030126COPI vesicle coat1.07e-111.74e-077.8615613
GO:0016032viral process1.69e-112.75e-073.7481237540
GO:0015935small ribosomal subunit5.11e-118.34e-077.4745917
GO:0061024membrane organization6.50e-111.06e-065.050811146
GO:0006412translation8.54e-111.39e-064.533929235
GO:0006890retrograde vesicle-mediated transport, Golgi to ER4.35e-107.10e-066.9185625
GO:0016020membrane1.29e-082.11e-042.37715481746
GO:0044822poly(A) RNA binding4.46e-087.28e-042.75012421078
GO:0010467gene expression5.61e-089.16e-043.1761036669
GO:0044267cellular protein metabolic process5.82e-089.49e-043.458929495
GO:0005840ribosome2.54e-064.15e-025.35741059
GO:0006891intra-Golgi vesicle-mediated transport2.70e-064.41e-026.7373317
GO:0034166toll-like receptor 10 signaling pathway3.75e-066.13e-025.2174565
GO:0034146toll-like receptor 5 signaling pathway3.75e-066.13e-025.2174565
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway5.35e-068.73e-025.0904571
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway5.35e-068.73e-025.0904571
GO:0034162toll-like receptor 9 signaling pathway5.66e-069.23e-025.0704572
GO:0034134toll-like receptor 2 signaling pathway5.98e-069.76e-025.0504573
GO:0036464cytoplasmic ribonucleoprotein granule6.09e-069.94e-026.3653522
GO:0035666TRIF-dependent toll-like receptor signaling pathway7.02e-061.15e-014.9924576
GO:0002756MyD88-independent toll-like receptor signaling pathway7.79e-061.27e-014.9544578
GO:0006886intracellular protein transport8.44e-061.38e-014.12756173
GO:0002755MyD88-dependent toll-like receptor signaling pathway8.62e-061.41e-014.9184580
GO:0034138toll-like receptor 3 signaling pathway8.62e-061.41e-014.9184580
GO:0019843rRNA binding1.15e-051.88e-016.0703427
GO:0034142toll-like receptor 4 signaling pathway1.78e-052.90e-014.6554596
GO:0033119negative regulation of RNA splicing2.63e-054.29e-017.918225
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway2.78e-054.54e-015.6553336
GO:0002224toll-like receptor signaling pathway2.93e-054.79e-014.47145109
GO:0043065positive regulation of apoptotic process7.67e-051.00e+003.46356274
GO:0007254JNK cascade7.97e-051.00e+005.1523351
GO:0051403stress-activated MAPK cascade9.47e-051.00e+005.0703454
GO:0000082G1/S transition of mitotic cell cycle1.02e-041.00e+004.011411150
GO:0032481positive regulation of type I interferon production1.36e-041.00e+004.8943361
GO:0042274ribosomal small subunit biogenesis1.72e-041.00e+006.6552612
GO:0019082viral protein processing1.72e-041.00e+006.6552212
GO:0032479regulation of type I interferon production2.03e-041.00e+006.5392213
GO:0007173epidermal growth factor receptor signaling pathway2.58e-041.00e+003.66245191
GO:0005925focal adhesion3.12e-041.00e+003.030523370
GO:0070062extracellular vesicular exosome3.15e-041.00e+001.52812512516
GO:0075733intracellular transport of virus3.53e-041.00e+006.1522317
GO:0019068virion assembly3.53e-041.00e+006.1522217
GO:0045087innate immune response4.24e-041.00e+002.558611616
GO:0071456cellular response to hypoxia5.53e-041.00e+004.2103398
GO:0007220Notch receptor processing5.97e-041.00e+005.7802222
GO:0043066negative regulation of apoptotic process6.40e-041.00e+002.803514433
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway7.72e-041.00e+005.5962225
GO:0005844polysome7.72e-041.00e+005.5962225
GO:0005978glycogen biosynthetic process8.36e-041.00e+005.5392226
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia8.36e-041.00e+005.5392226
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity8.36e-041.00e+005.5392226
GO:0030529ribonucleoprotein complex8.59e-041.00e+003.99238114
GO:0097190apoptotic signaling pathway9.04e-041.00e+003.96733116
GO:0000209protein polyubiquitination9.04e-041.00e+003.96737116
GO:0048011neurotrophin TRK receptor signaling pathway9.92e-041.00e+003.14745273
GO:0005730nucleolus1.08e-031.00e+001.6929361684
GO:0051092positive regulation of NF-kappaB transcription factor activity1.12e-031.00e+003.85933125
GO:0007179transforming growth factor beta receptor signaling pathway1.26e-031.00e+003.80234130
GO:0032480negative regulation of type I interferon production1.27e-031.00e+005.2402232
GO:0000086G2/M transition of mitotic cell cycle1.46e-031.00e+003.72636137
GO:0034332adherens junction organization1.60e-031.00e+005.0702436
GO:2001286regulation of caveolin-mediated endocytosis1.65e-031.00e+009.240111
GO:0022605oogenesis stage1.65e-031.00e+009.240111
GO:0071393cellular response to progesterone stimulus1.65e-031.00e+009.240111
GO:0021691cerebellar Purkinje cell layer maturation1.65e-031.00e+009.240111
GO:0005737cytoplasm1.87e-031.00e+001.09014653976
GO:0005515protein binding2.02e-031.00e+000.82918876127
GO:0007249I-kappaB kinase/NF-kappaB signaling2.08e-031.00e+004.8822441
GO:0005198structural molecule activity2.24e-031.00e+003.51235159
GO:0008543fibroblast growth factor receptor signaling pathway2.24e-031.00e+003.51233159
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway2.28e-031.00e+004.8132243
GO:0043005neuron projection2.32e-031.00e+003.49436161
GO:0038095Fc-epsilon receptor signaling pathway2.75e-031.00e+003.40733171
GO:0071338positive regulation of hair follicle cell proliferation3.31e-031.00e+008.240112
GO:0071987WD40-repeat domain binding3.31e-031.00e+008.240112
GO:0060661submandibular salivary gland formation3.31e-031.00e+008.240112
GO:0072422signal transduction involved in DNA damage checkpoint3.31e-031.00e+008.240112
GO:1902255positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator3.31e-031.00e+008.240112
GO:1990077primosome complex3.31e-031.00e+008.240122
GO:0010632regulation of epithelial cell migration3.31e-031.00e+008.240112
GO:0090135actin filament branching3.31e-031.00e+008.240112
GO:0030666endocytic vesicle membrane3.58e-031.00e+004.4852254
GO:0000278mitotic cell cycle3.92e-031.00e+002.603416398
GO:0016197endosomal transport4.11e-031.00e+004.3822358
GO:0051683establishment of Golgi localization4.96e-031.00e+007.655123
GO:0010641positive regulation of platelet-derived growth factor receptor signaling pathway4.96e-031.00e+007.655113
GO:0001162RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding4.96e-031.00e+007.655113
GO:0003161cardiac conduction system development4.96e-031.00e+007.655113
GO:0030951establishment or maintenance of microtubule cytoskeleton polarity4.96e-031.00e+007.655113
GO:0033146regulation of intracellular estrogen receptor signaling pathway4.96e-031.00e+007.655113
GO:0090045positive regulation of deacetylase activity4.96e-031.00e+007.655113
GO:0035033histone deacetylase regulator activity4.96e-031.00e+007.655113
GO:2000017positive regulation of determination of dorsal identity4.96e-031.00e+007.655113
GO:0004705JUN kinase activity4.96e-031.00e+007.655113
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway4.99e-031.00e+004.2402264
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.14e-031.00e+004.2172665
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest5.14e-031.00e+004.2172665
GO:0031295T cell costimulation5.45e-031.00e+004.1732367
GO:0018105peptidyl-serine phosphorylation5.77e-031.00e+004.1312569
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.94e-031.00e+004.1102870
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent6.44e-031.00e+004.0502673
GO:0003729mRNA binding6.44e-031.00e+004.0502373
GO:0007258JUN phosphorylation6.60e-031.00e+007.240114
GO:0034191apolipoprotein A-I receptor binding6.60e-031.00e+007.240114
GO:0048664neuron fate determination6.60e-031.00e+007.240114
GO:0033503HULC complex6.60e-031.00e+007.240114
GO:0032463negative regulation of protein homooligomerization6.60e-031.00e+007.240114
GO:0051902negative regulation of mitochondrial depolarization6.60e-031.00e+007.240114
GO:0031062positive regulation of histone methylation6.60e-031.00e+007.240114
GO:0031063regulation of histone deacetylation6.60e-031.00e+007.240114
GO:0060684epithelial-mesenchymal cell signaling6.60e-031.00e+007.240114
GO:0070851growth factor receptor binding6.60e-031.00e+007.240114
GO:0051835positive regulation of synapse structural plasticity6.60e-031.00e+007.240114
GO:0033625positive regulation of integrin activation6.60e-031.00e+007.240114
GO:0090231regulation of spindle checkpoint6.60e-031.00e+007.240114
GO:0072384organelle transport along microtubule6.60e-031.00e+007.240124
GO:0003896DNA primase activity6.60e-031.00e+007.240124
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.62e-031.00e+004.0302874
GO:0003713transcription coactivator activity7.00e-031.00e+002.92436239
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis7.14e-031.00e+003.9732477
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I7.14e-031.00e+003.9732677
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process7.51e-031.00e+003.9362879
GO:0071222cellular response to lipopolysaccharide7.88e-031.00e+003.9002481
GO:0031465Cul4B-RING E3 ubiquitin ligase complex8.25e-031.00e+006.918115
GO:2000641regulation of early endosome to late endosome transport8.25e-031.00e+006.918115
GO:0036336dendritic cell migration8.25e-031.00e+006.918115
GO:0035088establishment or maintenance of apical/basal cell polarity8.25e-031.00e+006.918115
GO:0051385response to mineralocorticoid8.25e-031.00e+006.918115
GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)8.25e-031.00e+006.918135
GO:0006269DNA replication, synthesis of RNA primer8.25e-031.00e+006.918125
GO:0097300programmed necrotic cell death8.25e-031.00e+006.918115
GO:0031256leading edge membrane8.25e-031.00e+006.918115
GO:0071803positive regulation of podosome assembly8.25e-031.00e+006.918115
GO:0050852T cell receptor signaling pathway9.24e-031.00e+003.7802288
GO:0000187activation of MAPK activity9.65e-031.00e+003.7482390
GO:0050847progesterone receptor signaling pathway9.89e-031.00e+006.655116
GO:0007143female meiotic division9.89e-031.00e+006.655116
GO:0002309T cell proliferation involved in immune response9.89e-031.00e+006.655116
GO:0045182translation regulator activity9.89e-031.00e+006.655126
GO:0045056transcytosis9.89e-031.00e+006.655116
GO:0000974Prp19 complex9.89e-031.00e+006.655116
GO:0060789hair follicle placode formation9.89e-031.00e+006.655116
GO:0048554positive regulation of metalloenzyme activity9.89e-031.00e+006.655116
GO:0006924activation-induced cell death of T cells9.89e-031.00e+006.655126
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.05e-021.00e+003.6852794
GO:0001649osteoblast differentiation1.07e-021.00e+003.6702395
GO:0006364rRNA processing1.09e-021.00e+003.6552896
GO:0050658RNA transport1.15e-021.00e+006.432117
GO:0007097nuclear migration1.15e-021.00e+006.432127
GO:0003334keratinocyte development1.15e-021.00e+006.432117
GO:0051988regulation of attachment of spindle microtubules to kinetochore1.15e-021.00e+006.432117
GO:0070914UV-damage excision repair1.15e-021.00e+006.432117
GO:0000028ribosomal small subunit assembly1.15e-021.00e+006.432137
GO:0010447response to acidic pH1.15e-021.00e+006.432117
GO:0034101erythrocyte homeostasis1.15e-021.00e+006.432117
GO:0010907positive regulation of glucose metabolic process1.15e-021.00e+006.432117
GO:0030157pancreatic juice secretion1.15e-021.00e+006.432117
GO:0060136embryonic process involved in female pregnancy1.15e-021.00e+006.432117
GO:0000930gamma-tubulin complex1.15e-021.00e+006.432117
GO:0043497regulation of protein heterodimerization activity1.15e-021.00e+006.432117
GO:0043114regulation of vascular permeability1.32e-021.00e+006.240118
GO:0045124regulation of bone resorption1.32e-021.00e+006.240118
GO:0051489regulation of filopodium assembly1.32e-021.00e+006.240118
GO:0033523histone H2B ubiquitination1.32e-021.00e+006.240118
GO:0007172signal complex assembly1.32e-021.00e+006.240118
GO:0090136epithelial cell-cell adhesion1.48e-021.00e+006.070129
GO:0047497mitochondrion transport along microtubule1.48e-021.00e+006.070119
GO:0071732cellular response to nitric oxide1.48e-021.00e+006.070119
GO:0046628positive regulation of insulin receptor signaling pathway1.48e-021.00e+006.070119
GO:0000122negative regulation of transcription from RNA polymerase II promoter1.52e-021.00e+002.03749589
GO:0006006glucose metabolic process1.64e-021.00e+003.34524119
GO:0031274positive regulation of pseudopodium assembly1.64e-021.00e+005.9181210
GO:0022407regulation of cell-cell adhesion1.64e-021.00e+005.9181110
GO:0005798Golgi-associated vesicle1.64e-021.00e+005.9181110
GO:0060047heart contraction1.64e-021.00e+005.9181110
GO:0003682chromatin binding1.73e-021.00e+002.44134334
GO:0007219Notch signaling pathway1.80e-021.00e+003.27424125
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity1.81e-021.00e+005.7801111
GO:0060065uterus development1.81e-021.00e+005.7801111
GO:0051895negative regulation of focal adhesion assembly1.81e-021.00e+005.7801111
GO:0045120pronucleus1.81e-021.00e+005.7801111
GO:0010390histone monoubiquitination1.81e-021.00e+005.7801111
GO:0035518histone H2A monoubiquitination1.81e-021.00e+005.7801211
GO:2000573positive regulation of DNA biosynthetic process1.81e-021.00e+005.7801211
GO:0006511ubiquitin-dependent protein catabolic process1.86e-021.00e+003.25123127
GO:0061136regulation of proteasomal protein catabolic process1.97e-021.00e+005.6551112
GO:0007051spindle organization1.97e-021.00e+005.6551112
GO:0043149stress fiber assembly1.97e-021.00e+005.6551212
GO:1901214regulation of neuron death1.97e-021.00e+005.6551112
GO:0009615response to virus2.00e-021.00e+003.19524132
GO:0031929TOR signaling2.13e-021.00e+005.5391113
GO:0005662DNA replication factor A complex2.13e-021.00e+005.5391113
GO:0071398cellular response to fatty acid2.13e-021.00e+005.5391213
GO:1900087positive regulation of G1/S transition of mitotic cell cycle2.13e-021.00e+005.5391113
GO:0060444branching involved in mammary gland duct morphogenesis2.13e-021.00e+005.5391113
GO:0035371microtubule plus-end2.29e-021.00e+005.4321114
GO:0031333negative regulation of protein complex assembly2.29e-021.00e+005.4321114
GO:0031996thioesterase binding2.29e-021.00e+005.4321114
GO:0050662coenzyme binding2.29e-021.00e+005.4321114
GO:0048821erythrocyte development2.45e-021.00e+005.3331215
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand2.45e-021.00e+005.3331115
GO:0048477oogenesis2.45e-021.00e+005.3331115
GO:0030131clathrin adaptor complex2.45e-021.00e+005.3331115
GO:0030225macrophage differentiation2.45e-021.00e+005.3331115
GO:0031369translation initiation factor binding2.45e-021.00e+005.3331215
GO:0051233spindle midzone2.45e-021.00e+005.3331215
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling2.47e-021.00e+003.03023148
GO:0010628positive regulation of gene expression2.50e-021.00e+003.02024149
GO:0042981regulation of apoptotic process2.57e-021.00e+003.00127151
GO:0042176regulation of protein catabolic process2.62e-021.00e+005.2401416
GO:0014911positive regulation of smooth muscle cell migration2.62e-021.00e+005.2401116
GO:0008284positive regulation of cell proliferation2.62e-021.00e+002.21037392
GO:2000811negative regulation of anoikis2.62e-021.00e+005.2401116
GO:0048037cofactor binding2.62e-021.00e+005.2401116
GO:0010008endosome membrane2.76e-021.00e+002.94522157
GO:0030742GTP-dependent protein binding2.78e-021.00e+005.1521117
GO:0070064proline-rich region binding2.94e-021.00e+005.0701118
GO:0031954positive regulation of protein autophosphorylation2.94e-021.00e+005.0701118
GO:0090316positive regulation of intracellular protein transport2.94e-021.00e+005.0701118
GO:0034220ion transmembrane transport3.09e-021.00e+002.85622167
GO:0007088regulation of mitosis3.10e-021.00e+004.9921119
GO:0045453bone resorption3.10e-021.00e+004.9921119
GO:0031667response to nutrient levels3.10e-021.00e+004.9921119
GO:0005634nucleus3.21e-021.00e+000.70313664828
GO:0032148activation of protein kinase B activity3.26e-021.00e+004.9181120
GO:0051090regulation of sequence-specific DNA binding transcription factor activity3.26e-021.00e+004.9181220
GO:0043473pigmentation3.26e-021.00e+004.9181220
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator3.26e-021.00e+004.9181120
GO:0043393regulation of protein binding3.26e-021.00e+004.9181220
GO:0046847filopodium assembly3.42e-021.00e+004.8471121
GO:0007369gastrulation3.42e-021.00e+004.8471121
GO:0051881regulation of mitochondrial membrane potential3.42e-021.00e+004.8471121
GO:0007049cell cycle3.44e-021.00e+002.77224177
GO:0031625ubiquitin protein ligase binding3.54e-021.00e+002.74824180
GO:0001106RNA polymerase II transcription corepressor activity3.58e-021.00e+004.7801122
GO:0031435mitogen-activated protein kinase kinase kinase binding3.58e-021.00e+004.7801122
GO:2001243negative regulation of intrinsic apoptotic signaling pathway3.58e-021.00e+004.7801122
GO:0046686response to cadmium ion3.58e-021.00e+004.7801122
GO:0032201telomere maintenance via semi-conservative replication3.58e-021.00e+004.7801222
GO:0006270DNA replication initiation3.58e-021.00e+004.7801222
GO:0006367transcription initiation from RNA polymerase II promoter3.69e-021.00e+002.71625184
GO:0001892embryonic placenta development3.74e-021.00e+004.7161123
GO:1900026positive regulation of substrate adhesion-dependent cell spreading3.74e-021.00e+004.7161123
GO:0051297centrosome organization3.74e-021.00e+004.7161223
GO:0045787positive regulation of cell cycle3.74e-021.00e+004.7161223
GO:0002040sprouting angiogenesis3.74e-021.00e+004.7161123
GO:0051017actin filament bundle assembly3.74e-021.00e+004.7161123
GO:0007163establishment or maintenance of cell polarity3.90e-021.00e+004.6551224
GO:0051602response to electrical stimulus3.90e-021.00e+004.6551124
GO:0050715positive regulation of cytokine secretion4.06e-021.00e+004.5961125
GO:0048705skeletal system morphogenesis4.06e-021.00e+004.5961125
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway4.22e-021.00e+004.5391126
GO:0000722telomere maintenance via recombination4.22e-021.00e+004.5391226
GO:0045859regulation of protein kinase activity4.22e-021.00e+004.5391126
GO:0045944positive regulation of transcription from RNA polymerase II promoter4.28e-021.00e+001.576411811
GO:0031424keratinization4.38e-021.00e+004.4851127
GO:0051149positive regulation of muscle cell differentiation4.38e-021.00e+004.4851227
GO:0032720negative regulation of tumor necrosis factor production4.38e-021.00e+004.4851127
GO:0001103RNA polymerase II repressing transcription factor binding4.38e-021.00e+004.4851127
GO:0030331estrogen receptor binding4.38e-021.00e+004.4851127
GO:2001238positive regulation of extrinsic apoptotic signaling pathway4.38e-021.00e+004.4851127
GO:0031069hair follicle morphogenesis4.38e-021.00e+004.4851127
GO:0032467positive regulation of cytokinesis4.53e-021.00e+004.4321128
GO:0034605cellular response to heat4.69e-021.00e+004.3821129
GO:0072686mitotic spindle4.69e-021.00e+004.3821129
GO:0042169SH2 domain binding4.85e-021.00e+004.3331130
GO:0031647regulation of protein stability4.85e-021.00e+004.3331130
GO:0040018positive regulation of multicellular organism growth4.85e-021.00e+004.3331130
GO:0046875ephrin receptor binding4.85e-021.00e+004.3331230
GO:0070555response to interleukin-15.01e-021.00e+004.2851131
GO:0006271DNA strand elongation involved in DNA replication5.01e-021.00e+004.2851231
GO:0007093mitotic cell cycle checkpoint5.01e-021.00e+004.2851231
GO:0051219phosphoprotein binding5.17e-021.00e+004.2401432
GO:0032091negative regulation of protein binding5.32e-021.00e+004.1951133
GO:0033077T cell differentiation in thymus5.32e-021.00e+004.1951133
GO:0005158insulin receptor binding5.32e-021.00e+004.1951233
GO:0048812neuron projection morphogenesis5.32e-021.00e+004.1951133
GO:0042692muscle cell differentiation5.48e-021.00e+004.1521234
GO:0001890placenta development5.48e-021.00e+004.1521134
GO:0019221cytokine-mediated signaling pathway5.51e-021.00e+002.39425230
GO:0007067mitotic nuclear division5.55e-021.00e+002.38827231
GO:2001237negative regulation of extrinsic apoptotic signaling pathway5.64e-021.00e+004.1101135
GO:0071560cellular response to transforming growth factor beta stimulus5.79e-021.00e+004.0701136
GO:0030178negative regulation of Wnt signaling pathway5.79e-021.00e+004.0701136
GO:0016301kinase activity5.95e-021.00e+004.0301237
GO:0018107peptidyl-threonine phosphorylation5.95e-021.00e+004.0301137
GO:0032880regulation of protein localization5.95e-021.00e+004.0301137
GO:00515394 iron, 4 sulfur cluster binding5.95e-021.00e+004.0301137
GO:0097191extrinsic apoptotic signaling pathway6.10e-021.00e+003.9921338
GO:0045740positive regulation of DNA replication6.10e-021.00e+003.9921138
GO:0042542response to hydrogen peroxide6.42e-021.00e+003.9181140
GO:0043025neuronal cell body6.56e-021.00e+002.25125254
GO:0045785positive regulation of cell adhesion6.57e-021.00e+003.8821141
GO:0070301cellular response to hydrogen peroxide6.57e-021.00e+003.8821141
GO:0006915apoptotic process6.69e-021.00e+001.66739571
GO:0005902microvillus6.73e-021.00e+003.8471142
GO:0004715non-membrane spanning protein tyrosine kinase activity6.73e-021.00e+003.8471142
GO:0006281DNA repair7.02e-021.00e+002.19525264
GO:0034613cellular protein localization7.03e-021.00e+003.7801244
GO:0005080protein kinase C binding7.03e-021.00e+003.7801144
GO:0009411response to UV7.19e-021.00e+003.7481245
GO:0021762substantia nigra development7.34e-021.00e+003.7161246
GO:0044297cell body7.34e-021.00e+003.7161146
GO:0043525positive regulation of neuron apoptotic process7.34e-021.00e+003.7161246
GO:0045727positive regulation of translation7.34e-021.00e+003.7161146
GO:0005975carbohydrate metabolic process7.49e-021.00e+002.14223274
GO:0043406positive regulation of MAP kinase activity7.50e-021.00e+003.6851147
GO:0008344adult locomotory behavior7.50e-021.00e+003.6851247
GO:0006950response to stress7.65e-021.00e+003.6551148
GO:0005070SH3/SH2 adaptor activity7.80e-021.00e+003.6251149
GO:0007030Golgi organization7.96e-021.00e+003.5961350
GO:0090263positive regulation of canonical Wnt signaling pathway8.11e-021.00e+003.5671151
GO:0030900forebrain development8.11e-021.00e+003.5671151
GO:0003684damaged DNA binding8.11e-021.00e+003.5671251
GO:0045732positive regulation of protein catabolic process8.11e-021.00e+003.5671151
GO:0019899enzyme binding8.16e-021.00e+002.07025288
GO:0008202steroid metabolic process8.26e-021.00e+003.5391152
GO:0006952defense response8.41e-021.00e+003.5121153
GO:0030175filopodium8.41e-021.00e+003.5121253
GO:0009612response to mechanical stimulus8.57e-021.00e+003.4851154
GO:0097193intrinsic apoptotic signaling pathway8.72e-021.00e+003.4581255
GO:0002039p53 binding8.72e-021.00e+003.4581155
GO:0046330positive regulation of JNK cascade8.72e-021.00e+003.4581155
GO:0043234protein complex8.75e-021.00e+002.01129300
GO:0005793endoplasmic reticulum-Golgi intermediate compartment9.02e-021.00e+003.4071157
GO:0005794Golgi apparatus9.07e-021.00e+001.48038650
GO:0005739mitochondrion9.11e-021.00e+001.2094101046
GO:0000723telomere maintenance9.32e-021.00e+003.3571259
GO:0033138positive regulation of peptidyl-serine phosphorylation9.62e-021.00e+003.3091161
GO:0019901protein kinase binding9.76e-021.00e+001.91829320
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription9.77e-021.00e+003.2851162
GO:0000151ubiquitin ligase complex9.92e-021.00e+003.2621163
GO:0005901caveola9.92e-021.00e+003.2621163
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process9.92e-021.00e+003.2621263
GO:0006417regulation of translation9.92e-021.00e+003.2621463
GO:0032869cellular response to insulin stimulus1.01e-011.00e+003.2401264
GO:0007411axon guidance1.01e-011.00e+001.88623327
GO:0016491oxidoreductase activity1.02e-011.00e+003.2171165
GO:0071260cellular response to mechanical stimulus1.04e-011.00e+003.1951366
GO:0005654nucleoplasm1.04e-011.00e+001.1434261095
GO:0043231intracellular membrane-bounded organelle1.04e-011.00e+001.86523332
GO:0030141secretory granule1.05e-011.00e+003.1731267
GO:0035264multicellular organism growth1.10e-011.00e+003.1101170
GO:0042393histone binding1.11e-011.00e+003.0901171
GO:0001503ossification1.11e-011.00e+003.0901271
GO:0006351transcription, DNA-templated1.15e-011.00e+000.9315171585
GO:0042826histone deacetylase binding1.16e-011.00e+003.0301174
GO:0060070canonical Wnt signaling pathway1.17e-011.00e+003.0111275
GO:0007265Ras protein signal transduction1.17e-011.00e+003.0111375
GO:0051897positive regulation of protein kinase B signaling1.17e-011.00e+003.0111175
GO:0044325ion channel binding1.20e-011.00e+002.9731377
GO:0007229integrin-mediated signaling pathway1.21e-011.00e+002.9541278
GO:0071013catalytic step 2 spliceosome1.23e-011.00e+002.9361179
GO:0010629negative regulation of gene expression1.24e-011.00e+002.9181280
GO:0045177apical part of cell1.27e-011.00e+002.8821182
GO:0004713protein tyrosine kinase activity1.27e-011.00e+002.8821182
GO:0030336negative regulation of cell migration1.29e-011.00e+002.8651283
GO:0005179hormone activity1.30e-011.00e+002.8471184
GO:0042593glucose homeostasis1.37e-011.00e+002.7641189
GO:0000922spindle pole1.40e-011.00e+002.7321591
GO:0016337single organismal cell-cell adhesion1.42e-011.00e+002.7161292
GO:0005770late endosome1.45e-011.00e+002.6851194
GO:0000139Golgi membrane1.46e-011.00e+001.56727408
GO:0005178integrin binding1.49e-011.00e+002.6401197
GO:0014069postsynaptic density1.61e-011.00e+002.51213106
GO:0030496midbody1.66e-011.00e+002.47114109
GO:0005815microtubule organizing center1.67e-011.00e+002.45814110
GO:0070374positive regulation of ERK1 and ERK2 cascade1.67e-011.00e+002.45811110
GO:0020037heme binding1.68e-011.00e+002.44511111
GO:0050900leukocyte migration1.68e-011.00e+002.44511111
GO:0015630microtubule cytoskeleton1.70e-011.00e+002.43214112
GO:0005886plasma membrane1.76e-011.00e+000.5787242834
GO:0007596blood coagulation1.78e-011.00e+001.38225464
GO:0032496response to lipopolysaccharide1.84e-011.00e+002.30911122
GO:0051056regulation of small GTPase mediated signal transduction1.85e-011.00e+002.29713123
GO:0045893positive regulation of transcription, DNA-templated1.92e-011.00e+001.31228487
GO:0030036actin cytoskeleton organization1.93e-011.00e+002.22813129
GO:0046983protein dimerization activity1.96e-011.00e+002.20613131
GO:0018108peptidyl-tyrosine phosphorylation1.98e-011.00e+002.18411133
GO:0055085transmembrane transport2.08e-011.00e+001.23423514
GO:0016055Wnt signaling pathway2.09e-011.00e+002.10013141
GO:0005911cell-cell junction2.10e-011.00e+002.09012142
GO:0008286insulin receptor signaling pathway2.13e-011.00e+002.07014144
GO:0046777protein autophosphorylation2.31e-011.00e+001.93611158
GO:0008022protein C-terminus binding2.35e-011.00e+001.90914161
GO:0000398mRNA splicing, via spliceosome2.40e-011.00e+001.87312165
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2.44e-011.00e+001.84714168
GO:0016607nuclear speck2.53e-011.00e+001.78812175
GO:0004672protein kinase activity2.56e-011.00e+001.76414178
GO:0005764lysosome2.61e-011.00e+001.73212182
GO:0003924GTPase activity2.87e-011.00e+001.57416203
GO:0030168platelet activation2.89e-011.00e+001.56014205
GO:0004871signal transducer activity3.02e-011.00e+001.48511216
GO:0006184GTP catabolic process3.07e-011.00e+001.45816220
GO:0016874ligase activity3.12e-011.00e+001.43212224
GO:0030425dendrite3.30e-011.00e+001.33313240
GO:0004842ubiquitin-protein transferase activity3.48e-011.00e+001.24013256
GO:0005102receptor binding3.61e-011.00e+001.17312268
GO:0000166nucleotide binding3.65e-011.00e+001.15212272
GO:0007283spermatogenesis3.69e-011.00e+001.13112276
GO:0042493response to drug3.82e-011.00e+001.07012288
GO:0007264small GTPase mediated signal transduction3.84e-011.00e+001.06017290
GO:0005743mitochondrial inner membrane3.94e-011.00e+001.01111300
GO:0004674protein serine/threonine kinase activity4.06e-011.00e+000.95416312
GO:0035556intracellular signal transduction4.11e-011.00e+000.93115317
GO:0005525GTP binding4.22e-011.00e+000.88216328
GO:0008283cell proliferation4.25e-011.00e+000.86914331
GO:0005813centrosome4.33e-011.00e+000.83419339
GO:0007275multicellular organismal development4.38e-011.00e+000.81312344
GO:0003723RNA binding4.48e-011.00e+000.768110355
GO:0008285negative regulation of cell proliferation4.59e-011.00e+000.72013367
GO:0007165signal transduction4.72e-011.00e+000.34827950
GO:0045892negative regulation of transcription, DNA-templated5.09e-011.00e+000.51212424
GO:0006366transcription from RNA polymerase II promoter5.10e-011.00e+000.50813425
GO:0006468protein phosphorylation5.44e-011.00e+000.37216467
GO:0055114oxidation-reduction process5.54e-011.00e+000.33012481
GO:0006355regulation of transcription, DNA-templated5.54e-011.00e+000.1312101104
GO:0042802identical protein binding5.62e-011.00e+000.30014491
GO:0048471perinuclear region of cytoplasm5.85e-011.00e+000.20919523
GO:0005783endoplasmic reticulum6.43e-011.00e+00-0.01316610
GO:0044281small molecule metabolic process6.43e-011.00e+00-0.0992161295
GO:0003677DNA binding6.67e-011.00e+00-0.1602141351
GO:0005524ATP binding6.68e-011.00e+00-0.1632191354
GO:0046872metal ion binding7.11e-011.00e+00-0.2772141465
GO:0003700sequence-specific DNA binding transcription factor activity7.19e-011.00e+00-0.30719748
GO:0005615extracellular space8.22e-011.00e+00-0.741131010
GO:0008270zinc ion binding8.39e-011.00e+00-0.820171067