meta-int-snw-10980

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
reg-snw-3145 chia-screen-data-Fav 2.226 2.10e-07 3.98e-02 3.04e-02 23 17
int-snw-10980 chia-screen-data-Fav 2.797 4.21e-15 7.56e-04 4.65e-03 12 8
chia-screen-data-Fav-meta-int-snw-10980 subnetwork

Genes (31)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
NDUFA4L2 56901 10-2.4772.45921Yes-
EP300 2033 2-2.2743.120415YesYes
ANAPC5 51433 6-1.2642.263239--
CENPA 1058 5-2.1852.393205Yes-
COPS2 9318 2-2.5313.04346Yes-
CNOT1 23019 7-2.3472.263124Yes-
PHB2 11331 6-2.2362.994151Yes-
PHB 5245 12-2.7432.689163YesYes
REXO4 57109 3-1.7432.28795--
MED13L 23389 8-2.5502.30750Yes-
YAP1 10413 12-4.2563.53853Yes-
HMOX2 3163 2-2.1162.79736Yes-
POU5F1 5460 12-5.1483.538179YesYes
KLHL8 57563 2-1.9932.79735--
FBXL6 26233 5-2.2532.68922Yes-
SUV39H2 79723 7-2.3072.41021YesYes
COPS4 51138 2-3.1983.04362YesYes
SNAP23 8773 3-2.0732.43015Yes-
COPS3 8533 5-1.8732.435118--
POLR2E 5434 5-2.0372.644316Yes-
NOD2 64127 2-1.9212.79726--
HMBS 3145 3-1.1172.22622--
CLPP 8192 3-2.2002.29110Yes-
CCT7 10574 10-2.3352.459173Yes-
HNRNPU 3192 12-2.8692.644172Yes-
EIF2B3 8891 5-2.5462.43513YesYes
COPS6 10980 3-1.7652.393157--
GPS1 2873 10-3.6212.68962YesYes
ZNRD1 30834 3-1.3752.226106--
FUBP1 8880 6-2.4142.38941YesYes
TMEM14B 81853 3-2.8792.2266YesYes

Interactions (48)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CENPA 1058 ZNRD1 30834 pd <> reg.ITFP.txt: no annot
CCT7 10574 REXO4 57109 pd < reg.ITFP.txt: no annot
CCT7 10574 ZNRD1 30834 pd < reg.ITFP.txt: no annot
EP300 2033 COPS6 10980 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, HPRD, IntAct, StelzlMedium;
int.HPRD: yeast 2-hybrid
GPS1 2873 PHB 5245 pd > reg.ITFP.txt: no annot
POLR2E 5434 ANAPC5 51433 pd <> reg.ITFP.txt: no annot
COPS6 10980 KLHL8 57563 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, IntAct
HNRNPU 3192 ANAPC5 51433 pd < reg.ITFP.txt: no annot
COPS3 8533 COPS6 10980 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, BIND, HPRD, IntAct, BCI, INNATEDB, MGI;
int.HPRD: in vitro;
int.DIP: MI:0915(physical association)
COPS6 10980 COPS4 51138 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, BioGrid_Fly, BIND_Fly, FlyLow, HPRD, IntAct, IntAct_Fly, BIND, MGI, MINT_Fly;
int.HPRD: in vitro
CNOT1 23019 ANAPC5 51433 pd < reg.ITFP.txt: no annot
COPS3 8533 COPS2 9318 pp -- int.I2D: BioGrid, BCI, HPRD, INNATEDB, MGI;
int.HPRD: in vitro;
int.DIP: MI:0915(physical association)
HMOX2 3163 COPS6 10980 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, HPRD, MINT, StelzlMedium, IntAct;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
GPS1 2873 COPS6 10980 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid, HPRD, MGI;
int.HPRD: in vitro
HMBS 3145 COPS3 8533 pd < reg.ITFP.txt: no annot
GPS1 2873 COPS4 51138 pp -- int.Intact: MI:0915(physical association);
int.I2D: BIND, IntAct, MGI
CENPA 1058 SUV39H2 79723 pd > reg.ITFP.txt: no annot
POLR2E 5434 SNAP23 8773 pd > reg.ITFP.txt: no annot
PHB 5245 PHB2 11331 pp -- int.I2D: BioGrid, BioGrid_Yeast, IntAct_Yeast
CENPA 1058 FBXL6 26233 pd > reg.ITFP.txt: no annot
HMBS 3145 REXO4 57109 pd < reg.ITFP.txt: no annot
HMBS 3145 ZNRD1 30834 pd < reg.ITFP.txt: no annot
CENPA 1058 HMBS 3145 pd > reg.ITFP.txt: no annot
HMBS 3145 ANAPC5 51433 pd < reg.ITFP.txt: no annot
PHB2 11331 ZNRD1 30834 pd < reg.ITFP.txt: no annot
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
GPS1 2873 COPS2 9318 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Worm, MGI, MINT_Worm, BioGrid_Worm, BIND, BIND_Worm, CORE_1, HPRD, IntAct, INNATEDB;
int.HPRD: in vitro, yeast 2-hybrid
GPS1 2873 CLPP 8192 pd > reg.ITFP.txt: no annot
COPS2 9318 COPS4 51138 pp -- int.I2D: BIND, HPRD, MGI;
int.HPRD: in vitro, in vivo
COPS6 10980 NOD2 64127 pp -- int.I2D: INNATEDB
GPS1 2873 COPS3 8533 pp -- int.Intact: MI:0915(physical association);
int.I2D: HPRD, IntAct, INNATEDB, BioGrid, MGI;
int.HPRD: in vitro, yeast 2-hybrid
ZNRD1 30834 TMEM14B 81853 pd > reg.ITFP.txt: no annot
PHB 5245 ZNRD1 30834 pd < reg.ITFP.txt: no annot
COPS3 8533 EIF2B3 8891 pd > reg.ITFP.txt: no annot
HMBS 3145 COPS6 10980 pd < reg.ITFP.txt: no annot
EP300 2033 YAP1 10413 pp -- int.I2D: BioGrid
MED13L 23389 ANAPC5 51433 pd < reg.ITFP.txt: no annot
CENPA 1058 NDUFA4L2 56901 pd > reg.ITFP.txt: no annot
EP300 2033 HNRNPU 3192 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vitro, in vivo
GPS1 2873 PHB2 11331 pd > reg.ITFP.txt: no annot
SNAP23 8773 ANAPC5 51433 pd < reg.ITFP.txt: no annot
EP300 2033 ANAPC5 51433 pp -- int.I2D: BioGrid
HNRNPU 3192 POLR2E 5434 pd < reg.ITFP.txt: no annot
COPS2 9318 COPS6 10980 pp -- int.Intact: MI:0915(physical association);
int.I2D: BCI, BIND, BioGrid, HPRD, IntAct, MGI;
int.HPRD: in vitro
FUBP1 8880 ANAPC5 51433 pd <> reg.ITFP.txt: no annot
CLPP 8192 COPS6 10980 pd < reg.ITFP.txt: no annot
COPS3 8533 COPS4 51138 pp -- int.I2D: BIND, HPRD, BioGrid, INNATEDB, MGI;
int.HPRD: in vitro, in vivo;
int.DIP: MI:0915(physical association)

Related GO terms (421)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0010388cullin deneddylation2.21e-123.60e-088.192559
GO:0008180COP9 signalosome3.64e-115.94e-076.5386634
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway1.56e-041.00e+006.7182210
GO:0005515protein binding1.62e-041.00e+000.91922776127
GO:0001054RNA polymerase I activity1.90e-041.00e+006.5812211
GO:0005736DNA-directed RNA polymerase I complex2.28e-041.00e+006.4552212
GO:0006778porphyrin-containing compound metabolic process5.24e-041.00e+005.8702218
GO:0005654nucleoplasm7.86e-041.00e+001.9448311095
GO:0006366transcription from RNA polymerase II promoter1.14e-031.00e+002.631514425
GO:0030331estrogen receptor binding1.19e-031.00e+005.2852227
GO:0002367cytokine production involved in immune response1.90e-031.00e+009.040111
GO:1901985positive regulation of protein acetylation1.90e-031.00e+009.040111
GO:0032498detection of muramyl dipeptide1.90e-031.00e+009.040111
GO:0043969histone H2B acetylation1.90e-031.00e+009.040111
GO:0090308regulation of methylation-dependent chromatin silencing1.90e-031.00e+009.040111
GO:0032500muramyl dipeptide binding1.90e-031.00e+009.040111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway1.90e-031.00e+009.040111
GO:0002710negative regulation of T cell mediated immunity1.90e-031.00e+009.040111
GO:0060795cell fate commitment involved in formation of primary germ layer1.90e-031.00e+009.040111
GO:0060177regulation of angiotensin metabolic process1.90e-031.00e+009.040111
GO:0071608macrophage inflammatory protein-1 alpha production1.90e-031.00e+009.040111
GO:0018160peptidyl-pyrromethane cofactor linkage1.90e-031.00e+009.040111
GO:0002732positive regulation of dendritic cell cytokine production1.90e-031.00e+009.040111
GO:2000629negative regulation of miRNA metabolic process1.90e-031.00e+009.040111
GO:0004418hydroxymethylbilane synthase activity1.90e-031.00e+009.040111
GO:2000363positive regulation of prostaglandin-E synthase activity1.90e-031.00e+009.040111
GO:0032701negative regulation of interleukin-18 production1.90e-031.00e+009.040111
GO:0046645positive regulation of gamma-delta T cell activation1.90e-031.00e+009.040111
GO:0005634nucleus2.86e-031.00e+000.89017554828
GO:0060242contact inhibition3.80e-031.00e+008.040112
GO:0009368endopeptidase Clp complex3.80e-031.00e+008.040112
GO:0035419activation of MAPK activity involved in innate immune response3.80e-031.00e+008.040112
GO:0000939condensed chromosome inner kinetochore3.80e-031.00e+008.040112
GO:0009786regulation of asymmetric cell division3.80e-031.00e+008.040112
GO:0090043regulation of tubulin deacetylation3.80e-031.00e+008.040112
GO:0071389cellular response to mineralocorticoid stimulus3.80e-031.00e+008.040112
GO:0060965negative regulation of gene silencing by miRNA3.80e-031.00e+008.040112
GO:0006788heme oxidation3.80e-031.00e+008.040112
GO:0014737positive regulation of muscle atrophy3.80e-031.00e+008.040112
GO:0006965positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria3.80e-031.00e+008.040112
GO:0035984cellular response to trichostatin A3.80e-031.00e+008.040112
GO:0004392heme oxygenase (decyclizing) activity3.80e-031.00e+008.040112
GO:0044212transcription regulatory region DNA binding4.09e-031.00e+003.20735171
GO:0007254JNK cascade4.20e-031.00e+004.3682251
GO:0000775chromosome, centromeric region4.36e-031.00e+004.3402352
GO:0000122negative regulation of transcription from RNA polymerase II promoter4.70e-031.00e+002.160510589
GO:0036123histone H3-K9 dimethylation5.69e-031.00e+007.455113
GO:0090022regulation of neutrophil chemotaxis5.69e-031.00e+007.455113
GO:0000338protein deneddylation5.69e-031.00e+007.455113
GO:0018076N-terminal peptidyl-lysine acetylation5.69e-031.00e+007.455113
GO:0071225cellular response to muramyl dipeptide5.69e-031.00e+007.455113
GO:0071459protein localization to chromosome, centromeric region5.69e-031.00e+007.455113
GO:0010560positive regulation of glycoprotein biosynthetic process5.69e-031.00e+007.455113
GO:0009595detection of biotic stimulus5.69e-031.00e+007.455113
GO:0034136negative regulation of toll-like receptor 2 signaling pathway5.69e-031.00e+007.455113
GO:0003130BMP signaling pathway involved in heart induction5.69e-031.00e+007.455113
GO:0060585positive regulation of prostaglandin-endoperoxide synthase activity5.69e-031.00e+007.455113
GO:0032481positive regulation of type I interferon production5.96e-031.00e+004.1102261
GO:0051716cellular response to stimulus7.58e-031.00e+007.040124
GO:0000778condensed nuclear chromosome kinetochore7.58e-031.00e+007.040114
GO:0097157pre-mRNA intronic binding7.58e-031.00e+007.040114
GO:0060913cardiac cell fate determination7.58e-031.00e+007.040114
GO:0018393internal peptidyl-lysine acetylation7.58e-031.00e+007.040114
GO:2000110negative regulation of macrophage apoptotic process7.58e-031.00e+007.040114
GO:0071224cellular response to peptidoglycan7.58e-031.00e+007.040114
GO:0050871positive regulation of B cell activation7.58e-031.00e+007.040114
GO:0010467gene expression7.99e-031.00e+001.976527669
GO:0000785chromatin8.44e-031.00e+003.8502273
GO:0001714endodermal cell fate specification9.46e-031.00e+006.718115
GO:0004468lysine N-acetyltransferase activity, acting on acetyl phosphate as donor9.46e-031.00e+006.718115
GO:0070934CRD-mediated mRNA stabilization9.46e-031.00e+006.718125
GO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulin9.46e-031.00e+006.718115
GO:0010606positive regulation of cytoplasmic mRNA processing body assembly9.46e-031.00e+006.718115
GO:0065004protein-DNA complex assembly9.46e-031.00e+006.718115
GO:0070431nucleotide-binding oligomerization domain containing 2 signaling pathway9.46e-031.00e+006.718115
GO:0033600negative regulation of mammary gland epithelial cell proliferation9.46e-031.00e+006.718115
GO:0032057negative regulation of translational initiation in response to stress9.46e-031.00e+006.718115
GO:0036124histone H3-K9 trimethylation9.46e-031.00e+006.718115
GO:0002830positive regulation of type 2 immune response9.46e-031.00e+006.718115
GO:0060298positive regulation of sarcomere organization9.46e-031.00e+006.718115
GO:0032025response to cobalt ion9.46e-031.00e+006.718115
GO:0050847progesterone receptor signaling pathway1.13e-021.00e+006.455116
GO:0002381immunoglobulin production involved in immunoglobulin mediated immune response1.13e-021.00e+006.455116
GO:0046974histone methyltransferase activity (H3-K9 specific)1.13e-021.00e+006.455116
GO:0060744mammary gland branching involved in thelarche1.13e-021.00e+006.455116
GO:2000323negative regulation of glucocorticoid receptor signaling pathway1.13e-021.00e+006.455116
GO:0070937CRD-mediated mRNA stability complex1.13e-021.00e+006.455126
GO:0005851eukaryotic translation initiation factor 2B complex1.13e-021.00e+006.455136
GO:0042167heme catabolic process1.13e-021.00e+006.455116
GO:0002862negative regulation of inflammatory response to antigenic stimulus1.13e-021.00e+006.455116
GO:0006333chromatin assembly or disassembly1.13e-021.00e+006.455116
GO:0060762regulation of branching involved in mammary gland duct morphogenesis1.13e-021.00e+006.455116
GO:0005730nucleolus1.14e-021.00e+001.3238281684
GO:0051353positive regulation of oxidoreductase activity1.32e-021.00e+006.233117
GO:0002606positive regulation of dendritic cell antigen processing and presentation1.32e-021.00e+006.233117
GO:0032731positive regulation of interleukin-1 beta production1.32e-021.00e+006.233117
GO:0006475internal protein amino acid acetylation1.32e-021.00e+006.233117
GO:0001649osteoblast differentiation1.40e-021.00e+003.4702395
GO:0071456cellular response to hypoxia1.48e-021.00e+003.4262298
GO:0042582azurophil granule1.51e-021.00e+006.040118
GO:0001055RNA polymerase II activity1.51e-021.00e+006.040118
GO:0042754negative regulation of circadian rhythm1.51e-021.00e+006.040118
GO:0006903vesicle targeting1.51e-021.00e+006.040118
GO:0000780condensed nuclear chromosome, centromeric region1.51e-021.00e+006.040118
GO:0050700CARD domain binding1.51e-021.00e+006.040118
GO:0016779nucleotidyltransferase activity1.51e-021.00e+006.040118
GO:0005829cytosol1.67e-021.00e+001.03910382562
GO:0071354cellular response to interleukin-61.70e-021.00e+005.870119
GO:0035259glucocorticoid receptor binding1.70e-021.00e+005.870119
GO:0045793positive regulation of cell size1.70e-021.00e+005.870119
GO:0006782protoporphyrinogen IX biosynthetic process1.70e-021.00e+005.870119
GO:0060765regulation of androgen receptor signaling pathway1.70e-021.00e+005.870119
GO:0005832chaperonin-containing T-complex1.70e-021.00e+005.870119
GO:0042834peptidoglycan binding1.70e-021.00e+005.870119
GO:0032495response to muramyl dipeptide1.70e-021.00e+005.870129
GO:0016032viral process1.84e-021.00e+001.963416540
GO:0002199zona pellucida receptor complex1.88e-021.00e+005.7181110
GO:0032703negative regulation of interleukin-2 production1.88e-021.00e+005.7181110
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay1.88e-021.00e+005.7181110
GO:0051382kinetochore assembly1.88e-021.00e+005.7181110
GO:0016407acetyltransferase activity1.88e-021.00e+005.7181110
GO:0010944negative regulation of transcription by competitive promoter binding1.88e-021.00e+005.7181110
GO:0048387negative regulation of retinoic acid receptor signaling pathway2.07e-021.00e+005.5811111
GO:0030277maintenance of gastrointestinal epithelium2.07e-021.00e+005.5811111
GO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening2.07e-021.00e+005.5811111
GO:0043923positive regulation by host of viral transcription2.07e-021.00e+005.5811111
GO:0035413positive regulation of catenin import into nucleus2.07e-021.00e+005.5811111
GO:0032740positive regulation of interleukin-17 production2.07e-021.00e+005.5811111
GO:0004535poly(A)-specific ribonuclease activity2.07e-021.00e+005.5811111
GO:0033160positive regulation of protein import into nucleus, translocation2.07e-021.00e+005.5811111
GO:2000036regulation of stem cell maintenance2.07e-021.00e+005.5811111
GO:0042975peroxisome proliferator activated receptor binding2.07e-021.00e+005.5811111
GO:0060391positive regulation of SMAD protein import into nucleus2.07e-021.00e+005.5811111
GO:0032874positive regulation of stress-activated MAPK cascade2.26e-021.00e+005.4551112
GO:0032695negative regulation of interleukin-12 production2.26e-021.00e+005.4551112
GO:0042581specific granule2.26e-021.00e+005.4551112
GO:0007140male meiosis2.44e-021.00e+005.3401113
GO:0042974retinoic acid receptor binding2.44e-021.00e+005.3401113
GO:0009416response to light stimulus2.44e-021.00e+005.3401113
GO:0042789mRNA transcription from RNA polymerase II promoter2.44e-021.00e+005.3401213
GO:0060766negative regulation of androgen receptor signaling pathway2.44e-021.00e+005.3401113
GO:0051019mitogen-activated protein kinase binding2.44e-021.00e+005.3401213
GO:0035198miRNA binding2.44e-021.00e+005.3401113
GO:0003682chromatin binding2.50e-021.00e+002.24237334
GO:0071480cellular response to gamma radiation2.63e-021.00e+005.2331114
GO:0004527exonuclease activity2.63e-021.00e+005.2331114
GO:0016045detection of bacterium2.63e-021.00e+005.2331114
GO:0005095GTPase inhibitor activity2.63e-021.00e+005.2331114
GO:0070542response to fatty acid2.63e-021.00e+005.2331114
GO:0051770positive regulation of nitric-oxide synthase biosynthetic process2.63e-021.00e+005.2331114
GO:0032993protein-DNA complex2.63e-021.00e+005.2331114
GO:0001824blastocyst development2.81e-021.00e+005.1331115
GO:0030014CCR4-NOT complex2.81e-021.00e+005.1331115
GO:0060749mammary gland alveolus development2.81e-021.00e+005.1331115
GO:1990090cellular response to nerve growth factor stimulus2.81e-021.00e+005.1331115
GO:0005665DNA-directed RNA polymerase II, core complex3.00e-021.00e+005.0401116
GO:0016746transferase activity, transferring acyl groups3.00e-021.00e+005.0401216
GO:0051603proteolysis involved in cellular protein catabolic process3.00e-021.00e+005.0401116
GO:0000132establishment of mitotic spindle orientation3.00e-021.00e+005.0401116
GO:0001056RNA polymerase III activity3.00e-021.00e+005.0401116
GO:0001829trophectodermal cell differentiation3.18e-021.00e+004.9531217
GO:0005666DNA-directed RNA polymerase III complex3.18e-021.00e+004.9531117
GO:0044130negative regulation of growth of symbiont in host3.18e-021.00e+004.9531117
GO:0001666response to hypoxia3.28e-021.00e+002.81123150
GO:0006386termination of RNA polymerase III transcription3.37e-021.00e+004.8701118
GO:0050718positive regulation of interleukin-1 beta secretion3.37e-021.00e+004.8701118
GO:0006385transcription elongation from RNA polymerase III promoter3.37e-021.00e+004.8701118
GO:0045773positive regulation of axon extension3.37e-021.00e+004.8701118
GO:0033613activating transcription factor binding3.37e-021.00e+004.8701118
GO:0032733positive regulation of interleukin-10 production3.55e-021.00e+004.7921219
GO:0035257nuclear hormone receptor binding3.55e-021.00e+004.7921119
GO:0071549cellular response to dexamethasone stimulus3.73e-021.00e+004.7181120
GO:0010942positive regulation of cell death3.73e-021.00e+004.7181120
GO:0002227innate immune response in mucosa3.73e-021.00e+004.7181120
GO:0005680anaphase-promoting complex3.73e-021.00e+004.7181120
GO:0014003oligodendrocyte development3.73e-021.00e+004.7181320
GO:0006783heme biosynthetic process3.73e-021.00e+004.7181120
GO:0000398mRNA splicing, via spliceosome3.90e-021.00e+002.67429165
GO:0000278mitotic cell cycle3.91e-021.00e+001.989312398
GO:0032967positive regulation of collagen biosynthetic process3.92e-021.00e+004.6481121
GO:0045862positive regulation of proteolysis3.92e-021.00e+004.6481221
GO:0000123histone acetyltransferase complex3.92e-021.00e+004.6481221
GO:0016575histone deacetylation3.92e-021.00e+004.6481121
GO:0005720nuclear heterochromatin4.10e-021.00e+004.5811122
GO:0036464cytoplasmic ribonucleoprotein granule4.10e-021.00e+004.5811122
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription4.10e-021.00e+004.5811222
GO:0031463Cul3-RING ubiquitin ligase complex4.28e-021.00e+004.5171123
GO:0045747positive regulation of Notch signaling pathway4.28e-021.00e+004.5171123
GO:0008135translation factor activity, nucleic acid binding4.46e-021.00e+004.4551224
GO:0050766positive regulation of phagocytosis4.46e-021.00e+004.4551124
GO:0032689negative regulation of interferon-gamma production4.46e-021.00e+004.4551124
GO:0043388positive regulation of DNA binding4.46e-021.00e+004.4551124
GO:0006363termination of RNA polymerase I transcription4.46e-021.00e+004.4551124
GO:0043425bHLH transcription factor binding4.46e-021.00e+004.4551124
GO:0005667transcription factor complex4.47e-021.00e+002.56523178
GO:0003714transcription corepressor activity4.52e-021.00e+002.55625179
GO:0045892negative regulation of transcription, DNA-templated4.57e-021.00e+001.89737424
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening4.65e-021.00e+004.3961125
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway4.65e-021.00e+004.3961125
GO:0003899DNA-directed RNA polymerase activity4.65e-021.00e+004.3961125
GO:0051059NF-kappaB binding4.65e-021.00e+004.3961225
GO:0032735positive regulation of interleukin-12 production4.65e-021.00e+004.3961225
GO:0006367transcription initiation from RNA polymerase II promoter4.75e-021.00e+002.51725184
GO:0035329hippo signaling4.83e-021.00e+004.3401126
GO:0031047gene silencing by RNA4.83e-021.00e+004.3401226
GO:0070979protein K11-linked ubiquitination4.83e-021.00e+004.3401126
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia4.83e-021.00e+004.3401126
GO:0061025membrane fusion4.83e-021.00e+004.3401126
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic4.83e-021.00e+004.3401126
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity4.83e-021.00e+004.3401126
GO:0032720negative regulation of tumor necrosis factor production5.01e-021.00e+004.2851227
GO:0000188inactivation of MAPK activity5.01e-021.00e+004.2851127
GO:0034080CENP-A containing nucleosome assembly5.01e-021.00e+004.2851227
GO:0048565digestive tract development5.01e-021.00e+004.2851127
GO:0007339binding of sperm to zona pellucida5.01e-021.00e+004.2851127
GO:0044822poly(A) RNA binding5.06e-021.00e+001.2885271078
GO:0003700sequence-specific DNA binding transcription factor activity5.16e-021.00e+001.493410748
GO:0003823antigen binding5.19e-021.00e+004.2331128
GO:0034612response to tumor necrosis factor5.19e-021.00e+004.2331128
GO:0000976transcription regulatory region sequence-specific DNA binding5.19e-021.00e+004.2331128
GO:0043967histone H4 acetylation5.19e-021.00e+004.2331128
GO:0050714positive regulation of protein secretion5.37e-021.00e+004.1821129
GO:0071897DNA biosynthetic process5.37e-021.00e+004.1821129
GO:0005737cytoplasm5.40e-021.00e+000.66812433976
GO:0006355regulation of transcription, DNA-templated5.50e-021.00e+001.2545131104
GO:00063707-methylguanosine mRNA capping5.55e-021.00e+004.1331230
GO:0006360transcription from RNA polymerase I promoter5.55e-021.00e+004.1331130
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator5.55e-021.00e+004.1331130
GO:0043330response to exogenous dsRNA5.55e-021.00e+004.1331130
GO:0007094mitotic spindle assembly checkpoint5.73e-021.00e+004.0861331
GO:0006139nucleobase-containing compound metabolic process5.91e-021.00e+004.0401132
GO:0043491protein kinase B signaling5.91e-021.00e+004.0401132
GO:1903507negative regulation of nucleic acid-templated transcription5.91e-021.00e+004.0401132
GO:0001104RNA polymerase II transcription cofactor activity6.09e-021.00e+003.9961333
GO:0016592mediator complex6.44e-021.00e+003.9111535
GO:0071333cellular response to glucose stimulus6.44e-021.00e+003.9111135
GO:0045944positive regulation of transcription from RNA polymerase II promoter6.57e-021.00e+001.377413811
GO:0032755positive regulation of interleukin-6 production6.62e-021.00e+003.8701236
GO:0001102RNA polymerase II activating transcription factor binding6.80e-021.00e+003.8311137
GO:0051084'de novo' posttranslational protein folding6.80e-021.00e+003.8311137
GO:0032760positive regulation of tumor necrosis factor production6.80e-021.00e+003.8311137
GO:0001756somitogenesis6.98e-021.00e+003.7921138
GO:0050681androgen receptor binding6.98e-021.00e+003.7921138
GO:0006383transcription from RNA polymerase III promoter7.15e-021.00e+003.7551339
GO:0031490chromatin DNA binding7.15e-021.00e+003.7551139
GO:0008380RNA splicing7.15e-021.00e+002.182214232
GO:0071407cellular response to organic cyclic compound7.15e-021.00e+003.7551339
GO:0032092positive regulation of protein binding7.15e-021.00e+003.7551139
GO:0046332SMAD binding7.33e-021.00e+003.7181140
GO:0009408response to heat7.33e-021.00e+003.7181240
GO:0035019somatic stem cell maintenance7.33e-021.00e+003.7181240
GO:0070301cellular response to hydrogen peroxide7.51e-021.00e+003.6831141
GO:0051259protein oligomerization7.51e-021.00e+003.6831141
GO:0007519skeletal muscle tissue development7.51e-021.00e+003.6831241
GO:0003713transcription coactivator activity7.52e-021.00e+002.13927239
GO:0035914skeletal muscle cell differentiation7.68e-021.00e+003.6481142
GO:0071320cellular response to cAMP7.68e-021.00e+003.6481142
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway7.86e-021.00e+003.6141143
GO:0004402histone acetyltransferase activity7.86e-021.00e+003.6141143
GO:0008134transcription factor binding7.91e-021.00e+002.09826246
GO:0006892post-Golgi vesicle-mediated transport8.04e-021.00e+003.5811144
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding8.04e-021.00e+003.5811144
GO:0050434positive regulation of viral transcription8.04e-021.00e+003.5811244
GO:0043966histone H3 acetylation8.21e-021.00e+003.5481145
GO:0001047core promoter binding8.39e-021.00e+003.5171246
GO:0044297cell body8.39e-021.00e+003.5171146
GO:0006283transcription-coupled nucleotide-excision repair8.39e-021.00e+003.5171146
GO:0045727positive regulation of translation8.39e-021.00e+003.5171246
GO:0043434response to peptide hormone8.39e-021.00e+003.5171246
GO:0050727regulation of inflammatory response8.56e-021.00e+003.4861147
GO:0048511rhythmic process8.56e-021.00e+003.4861247
GO:0003743translation initiation factor activity8.91e-021.00e+003.4261549
GO:0050830defense response to Gram-positive bacterium8.91e-021.00e+003.4261149
GO:0005778peroxisomal membrane9.08e-021.00e+003.3961250
GO:0035690cellular response to drug9.08e-021.00e+003.3961250
GO:0031398positive regulation of protein ubiquitination9.43e-021.00e+003.3401152
GO:0009611response to wounding9.60e-021.00e+003.3121153
GO:0006952defense response9.60e-021.00e+003.3121153
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay9.60e-021.00e+003.3121253
GO:0090305nucleic acid phosphodiester bond hydrolysis9.77e-021.00e+003.2851154
GO:0007623circadian rhythm9.77e-021.00e+003.2851254
GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process9.77e-021.00e+003.2851154
GO:0051403stress-activated MAPK cascade9.77e-021.00e+003.2851254
GO:0050679positive regulation of epithelial cell proliferation9.77e-021.00e+003.2851154
GO:0008233peptidase activity9.94e-021.00e+003.2591155
GO:0051592response to calcium ion9.94e-021.00e+003.2591155
GO:0002039p53 binding9.94e-021.00e+003.2591355
GO:0046330positive regulation of JNK cascade9.94e-021.00e+003.2591155
GO:0000932cytoplasmic mRNA processing body1.01e-011.00e+003.2331256
GO:0071300cellular response to retinoic acid1.01e-011.00e+003.2331156
GO:0043627response to estrogen1.03e-011.00e+003.2071157
GO:0019899enzyme binding1.03e-011.00e+001.87023288
GO:0006879cellular iron ion homeostasis1.03e-011.00e+003.2071157
GO:0006396RNA processing1.08e-011.00e+003.1331460
GO:0008013beta-catenin binding1.08e-011.00e+003.1331460
GO:0003677DNA binding1.09e-011.00e+000.9625161351
GO:0016567protein ubiquitination1.10e-011.00e+001.81625299
GO:0045087innate immune response1.10e-011.00e+001.35834616
GO:0005743mitochondrial inner membrane1.11e-011.00e+001.81123300
GO:0043234protein complex1.11e-011.00e+001.81124300
GO:0019903protein phosphatase binding1.13e-011.00e+003.0631163
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process1.13e-011.00e+003.0631163
GO:0006417regulation of translation1.13e-011.00e+003.0631163
GO:0032088negative regulation of NF-kappaB transcription factor activity1.15e-011.00e+003.0401264
GO:0009749response to glucose1.15e-011.00e+003.0401264
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.16e-011.00e+003.0181365
GO:0034166toll-like receptor 10 signaling pathway1.16e-011.00e+003.0181265
GO:0034146toll-like receptor 5 signaling pathway1.16e-011.00e+003.0181265
GO:0006368transcription elongation from RNA polymerase II promoter1.20e-011.00e+002.9741367
GO:0006338chromatin remodeling1.22e-011.00e+002.9531168
GO:0006289nucleotide-excision repair1.23e-011.00e+002.9321169
GO:0003697single-stranded DNA binding1.23e-011.00e+002.9321269
GO:0006887exocytosis1.23e-011.00e+002.9321169
GO:0000786nucleosome1.25e-011.00e+002.9111170
GO:0042742defense response to bacterium1.25e-011.00e+002.9111170
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.25e-011.00e+002.9111470
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway1.27e-011.00e+002.8901271
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway1.27e-011.00e+002.8901271
GO:0007584response to nutrient1.28e-011.00e+002.8701172
GO:0034162toll-like receptor 9 signaling pathway1.28e-011.00e+002.8701272
GO:0010468regulation of gene expression1.28e-011.00e+002.8701172
GO:0008021synaptic vesicle1.30e-011.00e+002.8501273
GO:0008283cell proliferation1.30e-011.00e+001.67023331
GO:0034134toll-like receptor 2 signaling pathway1.30e-011.00e+002.8501273
GO:0005085guanyl-nucleotide exchange factor activity1.32e-011.00e+002.8311274
GO:0042826histone deacetylase binding1.32e-011.00e+002.8311274
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.32e-011.00e+002.8311474
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation1.33e-011.00e+002.8111175
GO:0005739mitochondrion1.34e-011.00e+001.0104161046
GO:0030324lung development1.35e-011.00e+002.7921176
GO:0035666TRIF-dependent toll-like receptor signaling pathway1.35e-011.00e+002.7921276
GO:0030182neuron differentiation1.36e-011.00e+002.7731177
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity1.36e-011.00e+002.7731277
GO:0002756MyD88-independent toll-like receptor signaling pathway1.38e-011.00e+002.7551278
GO:0006334nucleosome assembly1.40e-011.00e+002.7361379
GO:0071013catalytic step 2 spliceosome1.40e-011.00e+002.7361379
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.40e-011.00e+002.7361479
GO:0002755MyD88-dependent toll-like receptor signaling pathway1.41e-011.00e+002.7181380
GO:0034138toll-like receptor 3 signaling pathway1.41e-011.00e+002.7181280
GO:0001889liver development1.45e-011.00e+002.6831282
GO:0009653anatomical structure morphogenesis1.53e-011.00e+002.5971187
GO:0045471response to ethanol1.54e-011.00e+002.5811188
GO:0009887organ morphogenesis1.56e-011.00e+002.5651189
GO:0000187activation of MAPK activity1.58e-011.00e+002.5481290
GO:0016363nuclear matrix1.61e-011.00e+002.5171592
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity1.62e-011.00e+002.5011293
GO:0051082unfolded protein binding1.66e-011.00e+002.4701395
GO:0034142toll-like receptor 4 signaling pathway1.67e-011.00e+002.4551296
GO:0051726regulation of cell cycle1.77e-011.00e+002.36814102
GO:0001934positive regulation of protein phosphorylation1.86e-011.00e+002.28511108
GO:0002224toll-like receptor signaling pathway1.88e-011.00e+002.27212109
GO:0070374positive regulation of ERK1 and ERK2 cascade1.89e-011.00e+002.25911110
GO:0009986cell surface1.91e-011.00e+001.31924422
GO:0030308negative regulation of cell growth1.94e-011.00e+002.22012113
GO:0030529ribonucleoprotein complex1.95e-011.00e+002.20716114
GO:0004252serine-type endopeptidase activity2.03e-011.00e+002.14511119
GO:0032496response to lipopolysaccharide2.08e-011.00e+002.11011122
GO:0003676nucleic acid binding2.08e-011.00e+002.11012122
GO:0006325chromatin organization2.09e-011.00e+002.09813123
GO:0051092positive regulation of NF-kappaB transcription factor activity2.12e-011.00e+002.07411125
GO:0007219Notch signaling pathway2.12e-011.00e+002.07412125
GO:0006413translational initiation2.21e-011.00e+002.00714131
GO:0031982vesicle2.26e-011.00e+001.97412134
GO:0000086G2/M transition of mitotic cell cycle2.30e-011.00e+001.94213137
GO:0045202synapse2.35e-011.00e+001.91111140
GO:0007507heart development2.36e-011.00e+001.90112141
GO:0042802identical protein binding2.39e-011.00e+001.10126491
GO:0044267cellular protein metabolic process2.42e-011.00e+001.08927495
GO:0061024membrane organization2.43e-011.00e+001.85011146
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling2.46e-011.00e+001.83111148
GO:0010628positive regulation of gene expression2.48e-011.00e+001.82112149
GO:0006457protein folding2.48e-011.00e+001.82111149
GO:0051260protein homooligomerization2.49e-011.00e+001.81111150
GO:0042981regulation of apoptotic process2.51e-011.00e+001.80213151
GO:0006974cellular response to DNA damage stimulus2.61e-011.00e+001.73614158
GO:0043005neuron projection2.65e-011.00e+001.70914161
GO:0007165signal transduction2.69e-011.00e+000.73338950
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2.75e-011.00e+001.64813168
GO:0007049cell cycle2.87e-011.00e+001.57314177
GO:0031625ubiquitin protein ligase binding2.91e-011.00e+001.54812180
GO:0032403protein complex binding2.98e-011.00e+001.50912185
GO:0043547positive regulation of GTPase activity3.05e-011.00e+001.47012190
GO:0008270zinc ion binding3.31e-011.00e+000.5663111067
GO:0001701in utero embryonic development3.31e-011.00e+001.32612210
GO:0004871signal transducer activity3.39e-011.00e+001.28511216
GO:0070062extracellular vesicular exosome3.41e-011.00e+000.3286152516
GO:0016071mRNA metabolic process3.47e-011.00e+001.23918223
GO:0006351transcription, DNA-templated3.55e-011.00e+000.4104171585
GO:0007067mitotic nuclear division3.57e-011.00e+001.18814231
GO:0005759mitochondrial matrix3.60e-011.00e+001.17614233
GO:0006412translation3.62e-011.00e+001.16415235
GO:0007399nervous system development3.75e-011.00e+001.10413245
GO:0016070RNA metabolic process3.77e-011.00e+001.09218247
GO:0004842ubiquitin-protein transferase activity3.88e-011.00e+001.04015256
GO:0005874microtubule3.90e-011.00e+001.02913258
GO:0006281DNA repair3.97e-011.00e+000.99614264
GO:0006357regulation of transcription from RNA polymerase II promoter4.10e-011.00e+000.93714275
GO:0016020membrane4.27e-011.00e+000.2704271746
GO:0005856cytoskeleton4.50e-011.00e+000.75912311
GO:0035556intracellular signal transduction4.56e-011.00e+000.73212317
GO:0019901protein kinase binding4.59e-011.00e+000.71814320
GO:0030154cell differentiation4.64e-011.00e+000.69612325
GO:0005524ATP binding4.81e-011.00e+000.2223131354
GO:0003723RNA binding4.95e-011.00e+000.569115355
GO:0030054cell junction4.96e-011.00e+000.56513356
GO:0015031protein transport4.97e-011.00e+000.56012357
GO:0043565sequence-specific DNA binding5.04e-011.00e+000.52813365
GO:0008285negative regulation of cell proliferation5.06e-011.00e+000.52114367
GO:0005925focal adhesion5.09e-011.00e+000.50912370
GO:0046982protein heterodimerization activity5.36e-011.00e+000.40013399
GO:0006508proteolysis5.46e-011.00e+000.36112410
GO:0045893positive regulation of transcription, DNA-templated6.09e-011.00e+000.11216487
GO:0055085transmembrane transport6.30e-011.00e+000.03515514
GO:0006915apoptotic process6.69e-011.00e+00-0.11718571
GO:0005789endoplasmic reticulum membrane7.09e-011.00e+00-0.27312636
GO:0044281small molecule metabolic process7.17e-011.00e+00-0.2982121295
GO:0005887integral component of plasma membrane8.48e-011.00e+00-0.86811961
GO:0005615extracellular space8.62e-011.00e+00-0.940141010
GO:0005886plasma membrane9.24e-011.00e+00-0.8433142834
GO:0046872metal ion binding9.46e-011.00e+00-1.476161465
GO:0016021integral component of membrane9.94e-011.00e+00-2.238172483