meta-int-snw-9133

Interacting subnets

Subnetwork	Dataset	Score	p-value 1	p-value 2	p-value 3	Size	Highlighted genes
reg-snw-317781	wolf-screen-ratio-mammosphere-adherent	0.823	1.13e-06	3.23e-03	6.07e-03	9	9
int-snw-9133	wolf-screen-ratio-mammosphere-adherent	0.990	1.04e-17	7.06e-04	1.58e-02	9	9

wolf-screen-ratio-mammosphere-adherent-meta-int-snw-9133 subnetwork

Genes (15)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
EIF6	3692	67	0.700	0.876	316	Yes	-
RBX1	9978	115	1.185	0.934	148	Yes	-
PSMD3	5709	100	0.986	1.106	201	Yes	-
RPS11	6205	62	0.993	1.113	175	Yes	-
PSMB7	5695	118	0.982	0.934	90	Yes	-
RPL14	9045	49	1.250	1.113	166	Yes	-
TUBG1	7283	98	0.974	0.973	91	Yes	-
PSMB2	5690	116	0.877	0.956	169	Yes	-
PSMD11	5717	124	1.095	1.106	218	Yes	-
VARS	7407	86	0.549	1.002	204	Yes	-
ACTB	60	134	1.153	1.151	610	Yes	-
DDX51	317781	53	0.059	0.823	210	Yes	-
CCNB2	9133	2	-0.027	0.990	82	Yes	-
RPSA	3921	120	1.327	1.151	152	Yes	-
PGD	5226	89	1.201	1.106	152	Yes	-

Interactions (34)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMB7	5695	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast
PSMD3	5709	CCNB2	9133	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
ACTB	60	PSMB2	5690	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	VARS	7407	pp	--	int.I2D: IntAct_Yeast
PSMD3	5709	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
EIF6	3692	PGD	5226	pp	--	int.I2D: YeastLow
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
TUBG1	7283	VARS	7407	pd	<	reg.ITFP.txt: no annot
PSMD11	5717	CCNB2	9133	pp	--	int.I2D: BioGrid_Yeast
PSMB7	5695	RBX1	9978	pd	<	reg.ITFP.txt: no annot
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
PSMD3	5709	TUBG1	7283	pd	>	reg.ITFP.txt: no annot
PSMB7	5695	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PGD	5226	PSMD3	5709	pp	--	int.I2D: YeastLow
PSMB7	5695	DDX51	317781	pd	<	reg.ITFP.txt: no annot
PSMB2	5690	CCNB2	9133	pp	--	int.I2D: BioGrid_Yeast
PSMB2	5690	PSMB7	5695	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct
RPS11	6205	DDX51	317781	pp	--	int.I2D: IntAct_Yeast
PSMB2	5690	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastMedium
RPS11	6205	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
VARS	7407	DDX51	317781	pd	<>	reg.ITFP.txt: no annot
PSMD3	5709	VARS	7407	pd	<>	reg.ITFP.txt: no annot
PSMD11	5717	TUBG1	7283	pd	>	reg.ITFP.txt: no annot
ACTB	60	PSMB7	5695	pp	--	int.I2D: BioGrid_Yeast
PSMB2	5690	DDX51	317781	pd	<	reg.ITFP.txt: no annot
RPS11	6205	CCNB2	9133	pp	--	int.I2D: BIND_Yeast, MINT_Yeast, MIPS, IntAct_Yeast, YeastLow
PSMB2	5690	PSMD11	5717	pd	<	reg.ITFP.txt: no annot
PSMB2	5690	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMB2	5690	VARS	7407	pd	<	reg.ITFP.txt: no annot
RPSA	3921	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
EIF6	3692	DDX51	317781	pd	<	reg.ITFP.txt: no annot

Related GO terms (173)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0016071	mRNA metabolic process	4.75e-10	7.74e-06	5.094	7	34	223
GO:0016070	RNA metabolic process	9.69e-10	1.58e-05	4.947	7	34	247
GO:0005829	cytosol	2.63e-09	4.29e-05	2.465	13	125	2562
GO:0016032	viral process	7.15e-09	1.17e-04	4.011	8	55	540
GO:0010467	gene expression	3.81e-08	6.22e-04	3.702	8	58	669
GO:0006521	regulation of cellular amino acid metabolic process	1.04e-07	1.69e-03	6.444	4	21	50
GO:0000502	proteasome complex	1.90e-07	3.11e-03	6.230	4	22	58
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.03e-07	4.94e-03	6.065	4	24	65
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	3.03e-07	4.94e-03	6.065	4	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.09e-07	6.67e-03	5.958	4	24	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	4.84e-07	7.90e-03	5.898	4	23	73
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.12e-07	8.35e-03	5.878	4	24	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	6.01e-07	9.81e-03	5.821	4	23	77
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	6.66e-07	1.09e-02	5.784	4	25	79
GO:0000278	mitotic cell cycle	8.41e-07	1.37e-02	4.036	6	52	398
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	1.34e-06	2.19e-02	5.533	4	23	94
GO:0000209	protein polyubiquitination	3.11e-06	5.08e-02	5.230	4	21	116
GO:0016020	membrane	4.93e-06	8.05e-02	2.488	9	80	1746
GO:0006413	translational initiation	5.05e-06	8.25e-02	5.054	4	12	131
GO:0000082	G1/S transition of mitotic cell cycle	8.65e-06	1.41e-01	4.859	4	33	150
GO:0042981	regulation of apoptotic process	8.88e-06	1.45e-01	4.849	4	26	151
GO:0070062	extracellular vesicular exosome	1.06e-05	1.73e-01	2.113	10	98	2516
GO:0034641	cellular nitrogen compound metabolic process	1.66e-05	2.71e-01	4.620	4	25	177
GO:0005654	nucleoplasm	2.39e-05	3.91e-01	2.798	7	83	1095
GO:0019083	viral transcription	5.13e-05	8.38e-01	5.333	3	8	81
GO:0005838	proteasome regulatory particle	5.18e-05	8.45e-01	7.503	2	7	12
GO:0042273	ribosomal large subunit biogenesis	6.11e-05	9.98e-01	7.387	2	4	13
GO:0006415	translational termination	6.36e-05	1.00e+00	5.230	3	8	87
GO:0006414	translational elongation	7.76e-05	1.00e+00	5.133	3	11	93
GO:0022624	proteasome accessory complex	1.06e-04	1.00e+00	7.000	2	9	17
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	1.08e-04	1.00e+00	4.972	3	8	104
GO:0005839	proteasome core complex	1.20e-04	1.00e+00	6.918	2	11	18
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1.42e-04	1.00e+00	4.840	3	10	114
GO:0019058	viral life cycle	1.46e-04	1.00e+00	4.827	3	10	115
GO:0004298	threonine-type endopeptidase activity	1.48e-04	1.00e+00	6.766	2	11	20
GO:0003735	structural constituent of ribosome	2.66e-04	1.00e+00	4.533	3	8	141
GO:0043022	ribosome binding	2.94e-04	1.00e+00	6.280	2	3	28
GO:0043066	negative regulation of apoptotic process	5.29e-04	1.00e+00	3.329	4	30	433
GO:0022627	cytosolic small ribosomal subunit	5.73e-04	1.00e+00	5.802	2	3	39
GO:0044267	cellular protein metabolic process	8.74e-04	1.00e+00	3.136	4	24	495
GO:0000054	ribosomal subunit export from nucleus	9.19e-04	1.00e+00	10.088	1	1	1
GO:0019521	D-gluconate metabolic process	9.19e-04	1.00e+00	10.088	1	1	1
GO:0006412	translation	1.18e-03	1.00e+00	3.796	3	15	235
GO:0006915	apoptotic process	1.49e-03	1.00e+00	2.930	4	34	571
GO:0004832	valine-tRNA ligase activity	1.84e-03	1.00e+00	9.088	1	1	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.84e-03	1.00e+00	9.088	1	1	2
GO:0019322	pentose biosynthetic process	1.84e-03	1.00e+00	9.088	1	1	2
GO:0005055	laminin receptor activity	1.84e-03	1.00e+00	9.088	1	1	2
GO:0006407	rRNA export from nucleus	1.84e-03	1.00e+00	9.088	1	1	2
GO:0006438	valyl-tRNA aminoacylation	1.84e-03	1.00e+00	9.088	1	1	2
GO:0009051	pentose-phosphate shunt, oxidative branch	2.75e-03	1.00e+00	8.503	1	1	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.75e-03	1.00e+00	8.503	1	1	3
GO:0005200	structural constituent of cytoskeleton	3.21e-03	1.00e+00	4.548	2	7	93
GO:0006364	rRNA processing	3.42e-03	1.00e+00	4.503	2	5	96
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3.67e-03	1.00e+00	8.088	1	1	4
GO:0000212	meiotic spindle organization	3.67e-03	1.00e+00	8.088	1	1	4
GO:0030686	90S preribosome	3.67e-03	1.00e+00	8.088	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	3.67e-03	1.00e+00	8.088	1	1	4
GO:0019788	NEDD8 ligase activity	3.67e-03	1.00e+00	8.088	1	1	4
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	4.59e-03	1.00e+00	7.766	1	2	5
GO:0031461	cullin-RING ubiquitin ligase complex	4.59e-03	1.00e+00	7.766	1	1	5
GO:0042256	mature ribosome assembly	4.59e-03	1.00e+00	7.766	1	1	5
GO:0043248	proteasome assembly	4.59e-03	1.00e+00	7.766	1	1	5
GO:0030891	VCB complex	4.59e-03	1.00e+00	7.766	1	2	5
GO:0005827	polar microtubule	4.59e-03	1.00e+00	7.766	1	1	5
GO:0005638	lamin filament	4.59e-03	1.00e+00	7.766	1	1	5
GO:0015630	microtubule cytoskeleton	4.62e-03	1.00e+00	4.280	2	5	112
GO:0044281	small molecule metabolic process	4.77e-03	1.00e+00	2.071	5	57	1295
GO:0005515	protein binding	5.32e-03	1.00e+00	0.966	11	172	6127
GO:0030957	Tat protein binding	5.50e-03	1.00e+00	7.503	1	4	6
GO:0043023	ribosomal large subunit binding	5.50e-03	1.00e+00	7.503	1	2	6
GO:0031466	Cul5-RING ubiquitin ligase complex	5.50e-03	1.00e+00	7.503	1	1	6
GO:0000028	ribosomal small subunit assembly	6.42e-03	1.00e+00	7.280	1	1	7
GO:0002161	aminoacyl-tRNA editing activity	6.42e-03	1.00e+00	7.280	1	2	7
GO:0000930	gamma-tubulin complex	6.42e-03	1.00e+00	7.280	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	6.42e-03	1.00e+00	7.280	1	2	7
GO:0000086	G2/M transition of mitotic cell cycle	6.84e-03	1.00e+00	3.990	2	7	137
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	7.33e-03	1.00e+00	7.088	1	2	8
GO:0070688	MLL5-L complex	7.33e-03	1.00e+00	7.088	1	1	8
GO:0045116	protein neddylation	7.33e-03	1.00e+00	7.088	1	2	8
GO:0006450	regulation of translational fidelity	9.16e-03	1.00e+00	6.766	1	2	10
GO:0006098	pentose-phosphate shunt	1.01e-02	1.00e+00	6.628	1	3	11
GO:0030234	enzyme regulator activity	1.19e-02	1.00e+00	6.387	1	3	13
GO:0035267	NuA4 histone acetyltransferase complex	1.28e-02	1.00e+00	6.280	1	4	14
GO:0007020	microtubule nucleation	1.28e-02	1.00e+00	6.280	1	1	14
GO:0005730	nucleolus	1.44e-02	1.00e+00	1.692	5	70	1684
GO:0044822	poly(A) RNA binding	1.44e-02	1.00e+00	2.013	4	50	1078
GO:0050998	nitric-oxide synthase binding	1.46e-02	1.00e+00	6.088	1	1	16
GO:0042176	regulation of protein catabolic process	1.46e-02	1.00e+00	6.088	1	3	16
GO:0010243	response to organonitrogen compound	1.55e-02	1.00e+00	6.000	1	2	17
GO:0031122	cytoplasmic microtubule organization	1.64e-02	1.00e+00	5.918	1	2	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.73e-02	1.00e+00	5.840	1	1	19
GO:0048863	stem cell differentiation	1.73e-02	1.00e+00	5.840	1	1	19
GO:0043029	T cell homeostasis	2.00e-02	1.00e+00	5.628	1	1	22
GO:0030863	cortical cytoskeleton	2.00e-02	1.00e+00	5.628	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	2.00e-02	1.00e+00	5.628	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	2.09e-02	1.00e+00	5.564	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	2.09e-02	1.00e+00	5.564	1	2	23
GO:0043236	laminin binding	2.09e-02	1.00e+00	5.564	1	1	23
GO:0006513	protein monoubiquitination	2.09e-02	1.00e+00	5.564	1	1	23
GO:0000794	condensed nuclear chromosome	2.18e-02	1.00e+00	5.503	1	2	24
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	2.36e-02	1.00e+00	5.387	1	2	26
GO:0019843	rRNA binding	2.45e-02	1.00e+00	5.333	1	3	27
GO:0040007	growth	2.54e-02	1.00e+00	5.280	1	1	28
GO:0031492	nucleosomal DNA binding	2.54e-02	1.00e+00	5.280	1	4	28
GO:0019894	kinesin binding	2.54e-02	1.00e+00	5.280	1	1	28
GO:0019005	SCF ubiquitin ligase complex	2.63e-02	1.00e+00	5.230	1	1	29
GO:0050661	NADP binding	2.90e-02	1.00e+00	5.088	1	1	32
GO:0034332	adherens junction organization	3.26e-02	1.00e+00	4.918	1	1	36
GO:0001895	retina homeostasis	3.26e-02	1.00e+00	4.918	1	1	36
GO:0048538	thymus development	3.26e-02	1.00e+00	4.918	1	2	36
GO:0007077	mitotic nuclear envelope disassembly	3.35e-02	1.00e+00	4.878	1	1	37
GO:0051084	'de novo' posttranslational protein folding	3.35e-02	1.00e+00	4.878	1	4	37
GO:0019901	protein kinase binding	3.40e-02	1.00e+00	2.766	2	21	320
GO:0070527	platelet aggregation	3.44e-02	1.00e+00	4.840	1	2	38
GO:0008026	ATP-dependent helicase activity	3.53e-02	1.00e+00	4.802	1	3	39
GO:0005813	centrosome	3.78e-02	1.00e+00	2.682	2	12	339
GO:0006418	tRNA aminoacylation for protein translation	3.79e-02	1.00e+00	4.695	1	5	42
GO:0014070	response to organic cyclic compound	3.88e-02	1.00e+00	4.661	1	3	43
GO:0021762	substantia nigra development	4.15e-02	1.00e+00	4.564	1	1	46
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	4.24e-02	1.00e+00	4.533	1	3	47
GO:0022625	cytosolic large ribosomal subunit	4.41e-02	1.00e+00	4.473	1	5	49
GO:0003743	translation initiation factor activity	4.41e-02	1.00e+00	4.473	1	4	49
GO:0005925	focal adhesion	4.43e-02	1.00e+00	2.556	2	18	370
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	4.85e-02	1.00e+00	4.333	1	5	54
GO:0000226	microtubule cytoskeleton organization	4.94e-02	1.00e+00	4.306	1	3	55
GO:0005840	ribosome	5.29e-02	1.00e+00	4.205	1	2	59
GO:0045216	cell-cell junction organization	5.29e-02	1.00e+00	4.205	1	2	59
GO:0034329	cell junction assembly	6.33e-02	1.00e+00	3.938	1	1	71
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6.76e-02	1.00e+00	3.840	1	3	76
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	6.85e-02	1.00e+00	3.821	1	5	77
GO:0006928	cellular component movement	8.13e-02	1.00e+00	3.564	1	7	92
GO:0001649	osteoblast differentiation	8.39e-02	1.00e+00	3.518	1	6	95
GO:0071456	cellular response to hypoxia	8.64e-02	1.00e+00	3.473	1	4	98
GO:0051726	regulation of cell cycle	8.98e-02	1.00e+00	3.415	1	3	102
GO:0014069	postsynaptic density	9.32e-02	1.00e+00	3.360	1	1	106
GO:0030529	ribonucleoprotein complex	9.98e-02	1.00e+00	3.255	1	8	114
GO:0072562	blood microparticle	1.02e-01	1.00e+00	3.230	1	4	116
GO:0006325	chromatin organization	1.07e-01	1.00e+00	3.145	1	4	123
GO:0007219	Notch signaling pathway	1.09e-01	1.00e+00	3.122	1	4	125
GO:0006511	ubiquitin-dependent protein catabolic process	1.11e-01	1.00e+00	3.099	1	5	127
GO:0000790	nuclear chromatin	1.16e-01	1.00e+00	3.032	1	7	133
GO:0005524	ATP binding	1.23e-01	1.00e+00	1.270	3	46	1354
GO:0005634	nucleus	1.23e-01	1.00e+00	0.658	7	131	4828
GO:0061024	membrane organization	1.26e-01	1.00e+00	2.898	1	5	146
GO:0006457	protein folding	1.29e-01	1.00e+00	2.868	1	8	149
GO:0005737	cytoplasm	1.35e-01	1.00e+00	0.715	6	98	3976
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.44e-01	1.00e+00	2.695	1	5	168
GO:0030424	axon	1.47e-01	1.00e+00	2.661	1	3	172
GO:0031625	ubiquitin protein ligase binding	1.53e-01	1.00e+00	2.596	1	13	180
GO:0032403	protein complex binding	1.57e-01	1.00e+00	2.556	1	7	185
GO:0003924	GTPase activity	1.71e-01	1.00e+00	2.422	1	9	203
GO:0001701	in utero embryonic development	1.77e-01	1.00e+00	2.373	1	6	210
GO:0006184	GTP catabolic process	1.84e-01	1.00e+00	2.306	1	9	220
GO:0007067	mitotic nuclear division	1.93e-01	1.00e+00	2.236	1	13	231
GO:0004842	ubiquitin-protein transferase activity	2.11e-01	1.00e+00	2.088	1	4	256
GO:0006281	DNA repair	2.17e-01	1.00e+00	2.043	1	22	264
GO:0005975	carbohydrate metabolic process	2.24e-01	1.00e+00	1.990	1	5	274
GO:0016567	protein ubiquitination	2.42e-01	1.00e+00	1.864	1	5	299
GO:0043234	protein complex	2.43e-01	1.00e+00	1.859	1	17	300
GO:0006200	ATP catabolic process	2.45e-01	1.00e+00	1.844	1	14	303
GO:0005856	cytoskeleton	2.51e-01	1.00e+00	1.807	1	8	311
GO:0007411	axon guidance	2.62e-01	1.00e+00	1.734	1	9	327
GO:0005525	GTP binding	2.63e-01	1.00e+00	1.730	1	11	328
GO:0003723	RNA binding	2.81e-01	1.00e+00	1.616	1	19	355
GO:0007155	cell adhesion	3.00e-01	1.00e+00	1.503	1	8	384
GO:0007596	blood coagulation	3.51e-01	1.00e+00	1.230	1	14	464
GO:0055114	oxidation-reduction process	3.62e-01	1.00e+00	1.178	1	11	481
GO:0045087	innate immune response	4.39e-01	1.00e+00	0.821	1	20	616
GO:0005615	extracellular space	6.17e-01	1.00e+00	0.107	1	17	1010
GO:0005739	mitochondrion	6.30e-01	1.00e+00	0.057	1	24	1046
GO:0008270	zinc ion binding	6.37e-01	1.00e+00	0.028	1	12	1067
GO:0005886	plasma membrane	9.43e-01	1.00e+00	-1.381	1	38	2834

Wolf-ratios-Mammosphere-Adherent

meta-int-snw-9133

Interacting subnets

Genes (15)

Interactions (34)

Related GO terms (173)