meta-int-snw-8453

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
reg-snw-317781 wolf-screen-ratio-mammosphere-adherent 0.823 1.13e-06 3.23e-03 6.07e-03 9 9
int-snw-8453 wolf-screen-ratio-mammosphere-adherent 0.955 2.74e-16 1.60e-03 2.91e-02 9 8
wolf-screen-ratio-mammosphere-adherent-meta-int-snw-8453 subnetwork

Genes (15)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 961.2501.15176Yes-
EIF6 3692 670.7000.876316Yes-
KEAP1 9817 20.5800.98163Yes-
RBX1 9978 1151.1850.934148Yes-
PSMD3 5709 1000.9861.106201Yes-
CUL2 8453 20.0200.95564--
PSMB7 5695 1180.9820.93490Yes-
TUBG1 7283 980.9740.97391Yes-
PSMB2 5690 1160.8770.956169Yes-
PSMA1 5682 1000.9960.878152Yes-
PSMD11 5717 1241.0951.106218Yes-
ACTB 60 1341.1531.151610Yes-
VARS 7407 860.5491.002204Yes-
DDX51 317781 530.0590.823210Yes-
RPSA 3921 1201.3271.151152Yes-

Interactions (33)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMA1 5682 PSMB2 5690 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
CUL2 8453 RBX1 9978 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct, IntAct_Worm, MINT;
int.Mint: MI:0915(physical association), MI:0914(association)
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 VARS 7407 pp -- int.I2D: IntAct_Yeast
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
TUBG1 7283 VARS 7407 pd < reg.ITFP.txt: no annot
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 RBX1 9978 pd < reg.ITFP.txt: no annot
PSMD3 5709 TUBG1 7283 pd > reg.ITFP.txt: no annot
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 DDX51 317781 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct
CUL2 8453 KEAP1 9817 pp -- int.I2D: BioGrid
PSMB2 5690 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
VARS 7407 DDX51 317781 pd <> reg.ITFP.txt: no annot
PSMD3 5709 VARS 7407 pd <> reg.ITFP.txt: no annot
PSMD11 5717 TUBG1 7283 pd > reg.ITFP.txt: no annot
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMB2 5690 DDX51 317781 pd < reg.ITFP.txt: no annot
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMB2 5690 PSMD11 5717 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
KEAP1 9817 RBX1 9978 pp -- int.I2D: BioGrid, BioGrid_Mouse
PSMB2 5690 VARS 7407 pd < reg.ITFP.txt: no annot
EIF6 3692 DDX51 317781 pd < reg.ITFP.txt: no annot
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium

Related GO terms (195)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0000082G1/S transition of mitotic cell cycle2.91e-114.75e-075.666733150
GO:0006521regulation of cellular amino acid metabolic process6.45e-101.05e-056.76652150
GO:0000502proteasome complex1.39e-092.27e-056.55152258
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.49e-094.07e-056.38752465
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest2.49e-094.07e-056.38752265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.65e-095.95e-056.28052470
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent4.52e-097.37e-056.22052373
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.84e-097.90e-056.20052474
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I5.93e-099.68e-056.14352377
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process6.76e-091.10e-046.10652579
GO:0016032viral process7.15e-091.17e-044.011855540
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.63e-082.67e-045.85552394
GO:0000278mitotic cell cycle2.65e-084.32e-044.258752398
GO:0016071mRNA metabolic process2.75e-084.48e-044.872634223
GO:0000209protein polyubiquitination4.72e-087.70e-045.551521116
GO:0016070RNA metabolic process5.05e-088.24e-044.724634247
GO:0005829cytosol6.25e-081.02e-032.349121252562
GO:0005654nucleoplasm9.23e-081.51e-033.1619831095
GO:0042981regulation of apoptotic process1.77e-072.89e-035.171526151
GO:0034641cellular nitrogen compound metabolic process3.90e-076.36e-034.942525177
GO:0005839proteasome core complex5.08e-078.30e-037.50331118
GO:0004298threonine-type endopeptidase activity7.09e-071.16e-027.35131120
GO:0010467gene expression9.10e-071.48e-023.509758669
GO:0005730nucleolus3.64e-065.94e-022.5409701684
GO:0030891VCB complex7.87e-061.28e-018.766225
GO:0031462Cul2-RING ubiquitin ligase complex1.65e-052.70e-018.280227
GO:0043066negative regulation of apoptotic process3.10e-055.05e-013.651530433
GO:0005838proteasome regulatory particle5.18e-058.45e-017.5032712
GO:0022624proteasome accessory complex1.06e-041.00e+007.0002917
GO:0006915apoptotic process1.16e-041.00e+003.252534571
GO:0031463Cul3-RING ubiquitin ligase complex1.97e-041.00e+006.5642223
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.53e-041.00e+006.3872226
GO:0043022ribosome binding2.94e-041.00e+006.2802328
GO:0031625ubiquitin protein ligase binding5.44e-041.00e+004.181313180
GO:0070062extracellular vesicular exosome7.32e-041.00e+001.7918982516
GO:0000054ribosomal subunit export from nucleus9.19e-041.00e+0010.088111
GO:0005515protein binding9.95e-041.00e+001.092121726127
GO:0004832valine-tRNA ligase activity1.84e-031.00e+009.088112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.84e-031.00e+009.088112
GO:0005055laminin receptor activity1.84e-031.00e+009.088112
GO:0006407rRNA export from nucleus1.84e-031.00e+009.088112
GO:0006438valyl-tRNA aminoacylation1.84e-031.00e+009.088112
GO:0016567protein ubiquitination2.35e-031.00e+003.44935299
GO:0045604regulation of epidermal cell differentiation2.75e-031.00e+008.503113
GO:0016020membrane3.17e-031.00e+001.9036801746
GO:0005200structural constituent of cytoskeleton3.21e-031.00e+004.5482793
GO:0005634nucleus3.24e-031.00e+001.172101314828
GO:0071456cellular response to hypoxia3.56e-031.00e+004.4732498
GO:0010499proteasomal ubiquitin-independent protein catabolic process3.67e-031.00e+008.088114
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.67e-031.00e+008.088114
GO:0000212meiotic spindle organization3.67e-031.00e+008.088114
GO:003068690S preribosome3.67e-031.00e+008.088114
GO:0031467Cul7-RING ubiquitin ligase complex3.67e-031.00e+008.088114
GO:0019788NEDD8 ligase activity3.67e-031.00e+008.088114
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.59e-031.00e+007.766125
GO:0031461cullin-RING ubiquitin ligase complex4.59e-031.00e+007.766115
GO:0042256mature ribosome assembly4.59e-031.00e+007.766115
GO:0043248proteasome assembly4.59e-031.00e+007.766115
GO:0005827polar microtubule4.59e-031.00e+007.766115
GO:0000730DNA recombinase assembly4.59e-031.00e+007.766135
GO:2000001regulation of DNA damage checkpoint4.59e-031.00e+007.766115
GO:0005638lamin filament4.59e-031.00e+007.766115
GO:0044281small molecule metabolic process4.77e-031.00e+002.0715571295
GO:0030957Tat protein binding5.50e-031.00e+007.503146
GO:0043023ribosomal large subunit binding5.50e-031.00e+007.503126
GO:0031466Cul5-RING ubiquitin ligase complex5.50e-031.00e+007.503116
GO:0006511ubiquitin-dependent protein catabolic process5.90e-031.00e+004.09925127
GO:0006413translational initiation6.27e-031.00e+004.054212131
GO:0000028ribosomal small subunit assembly6.42e-031.00e+007.280117
GO:0002161aminoacyl-tRNA editing activity6.42e-031.00e+007.280127
GO:0000930gamma-tubulin complex6.42e-031.00e+007.280117
GO:0019773proteasome core complex, alpha-subunit complex7.33e-031.00e+007.088158
GO:0031464Cul4A-RING E3 ubiquitin ligase complex7.33e-031.00e+007.088128
GO:0070688MLL5-L complex7.33e-031.00e+007.088118
GO:0045116protein neddylation7.33e-031.00e+007.088128
GO:0006450regulation of translational fidelity9.16e-031.00e+006.7661210
GO:0010569regulation of double-strand break repair via homologous recombination1.01e-021.00e+006.6281111
GO:0031571mitotic G1 DNA damage checkpoint1.01e-021.00e+006.6281311
GO:0042273ribosomal large subunit biogenesis1.19e-021.00e+006.3871413
GO:0005662DNA replication factor A complex1.19e-021.00e+006.3871313
GO:0030234enzyme regulator activity1.19e-021.00e+006.3871313
GO:0032403protein complex binding1.22e-021.00e+003.55627185
GO:0035267NuA4 histone acetyltransferase complex1.28e-021.00e+006.2801414
GO:0007020microtubule nucleation1.28e-021.00e+006.2801114
GO:0050998nitric-oxide synthase binding1.46e-021.00e+006.0881116
GO:0042176regulation of protein catabolic process1.46e-021.00e+006.0881316
GO:0010243response to organonitrogen compound1.55e-021.00e+006.0001217
GO:0031122cytoplasmic microtubule organization1.64e-021.00e+005.9181218
GO:0035861site of double-strand break1.64e-021.00e+005.9181118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.73e-021.00e+005.8401119
GO:0048863stem cell differentiation1.73e-021.00e+005.8401119
GO:0071353cellular response to interleukin-41.82e-021.00e+005.7661120
GO:0006298mismatch repair1.82e-021.00e+005.7661620
GO:0000718nucleotide-excision repair, DNA damage removal1.91e-021.00e+005.6951521
GO:0006297nucleotide-excision repair, DNA gap filling2.00e-021.00e+005.6281522
GO:0032201telomere maintenance via semi-conservative replication2.00e-021.00e+005.6281722
GO:0030863cortical cytoskeleton2.00e-021.00e+005.6281122
GO:0036464cytoplasmic ribonucleoprotein granule2.00e-021.00e+005.6281422
GO:0043044ATP-dependent chromatin remodeling2.09e-021.00e+005.5641423
GO:0043236laminin binding2.09e-021.00e+005.5641123
GO:0006513protein monoubiquitination2.09e-021.00e+005.5641123
GO:0000794condensed nuclear chromosome2.18e-021.00e+005.5031224
GO:0005844polysome2.27e-021.00e+005.4441425
GO:0000722telomere maintenance via recombination2.36e-021.00e+005.3871726
GO:0006281DNA repair2.38e-021.00e+003.043222264
GO:0031492nucleosomal DNA binding2.54e-021.00e+005.2801428
GO:0019894kinesin binding2.54e-021.00e+005.2801128
GO:0019005SCF ubiquitin ligase complex2.63e-021.00e+005.2301129
GO:0006271DNA strand elongation involved in DNA replication2.81e-021.00e+005.1331931
GO:0034332adherens junction organization3.26e-021.00e+004.9181136
GO:0001895retina homeostasis3.26e-021.00e+004.9181136
GO:0051084'de novo' posttranslational protein folding3.35e-021.00e+004.8781437
GO:0070527platelet aggregation3.44e-021.00e+004.8401238
GO:0022627cytosolic small ribosomal subunit3.53e-021.00e+004.8021339
GO:0008026ATP-dependent helicase activity3.53e-021.00e+004.8021339
GO:0006284base-excision repair3.53e-021.00e+004.8021739
GO:0000781chromosome, telomeric region3.62e-021.00e+004.7661240
GO:0005813centrosome3.78e-021.00e+002.682212339
GO:0006418tRNA aminoacylation for protein translation3.79e-021.00e+004.6951542
GO:0014070response to organic cyclic compound3.88e-021.00e+004.6611343
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process3.97e-021.00e+004.6281344
GO:0021762substantia nigra development4.15e-021.00e+004.5641146
GO:0006283transcription-coupled nucleotide-excision repair4.15e-021.00e+004.5641846
GO:0003743translation initiation factor activity4.41e-021.00e+004.4731449
GO:0003684damaged DNA binding4.59e-021.00e+004.41511151
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.85e-021.00e+004.3331554
GO:0000226microtubule cytoskeleton organization4.94e-021.00e+004.3061355
GO:0097193intrinsic apoptotic signaling pathway4.94e-021.00e+004.3061455
GO:0000724double-strand break repair via homologous recombination5.11e-021.00e+004.2551657
GO:0000723telomere maintenance5.29e-021.00e+004.2051859
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity5.29e-021.00e+004.2051459
GO:0045216cell-cell junction organization5.29e-021.00e+004.2051259
GO:0006302double-strand break repair5.55e-021.00e+004.1331862
GO:0019903protein phosphatase binding5.64e-021.00e+004.1101463
GO:0006289nucleotide-excision repair6.16e-021.00e+003.97911269
GO:0003697single-stranded DNA binding6.16e-021.00e+003.9791969
GO:0034329cell junction assembly6.33e-021.00e+003.9381171
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.76e-021.00e+003.8401376
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis6.85e-021.00e+003.8211577
GO:0019083viral transcription7.19e-021.00e+003.7481881
GO:0044267cellular protein metabolic process7.43e-021.00e+002.136224495
GO:0047485protein N-terminus binding7.62e-021.00e+003.6611486
GO:0006415translational termination7.71e-021.00e+003.6451887
GO:0016605PML body8.13e-021.00e+003.5641592
GO:0006928cellular component movement8.13e-021.00e+003.5641792
GO:0006414translational elongation8.22e-021.00e+003.54811193
GO:0006364rRNA processing8.47e-021.00e+003.5031596
GO:0006614SRP-dependent cotranslational protein targeting to membrane9.15e-021.00e+003.38718104
GO:0014069postsynaptic density9.32e-021.00e+003.36011106
GO:0030496midbody9.57e-021.00e+003.31914109
GO:0005815microtubule organizing center9.65e-021.00e+003.30614110
GO:0015630microtubule cytoskeleton9.82e-021.00e+003.28015112
GO:0030529ribonucleoprotein complex9.98e-021.00e+003.25518114
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay9.98e-021.00e+003.255110114
GO:0019058viral life cycle1.01e-011.00e+003.242110115
GO:0072562blood microparticle1.02e-011.00e+003.23014116
GO:0006325chromatin organization1.07e-011.00e+003.14514123
GO:0007219Notch signaling pathway1.09e-011.00e+003.12214125
GO:0006260DNA replication1.09e-011.00e+003.122112125
GO:0007050cell cycle arrest1.10e-011.00e+003.11017126
GO:0000790nuclear chromatin1.16e-011.00e+003.03217133
GO:0000086G2/M transition of mitotic cell cycle1.19e-011.00e+002.99017137
GO:0003735structural constituent of ribosome1.22e-011.00e+002.94818141
GO:0005524ATP binding1.23e-011.00e+001.2703461354
GO:0061024membrane organization1.26e-011.00e+002.89815146
GO:0006457protein folding1.29e-011.00e+002.86818149
GO:0005737cytoplasm1.35e-011.00e+000.7156983976
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.44e-011.00e+002.69515168
GO:0030424axon1.47e-011.00e+002.66113172
GO:0003924GTPase activity1.71e-011.00e+002.42219203
GO:0001701in utero embryonic development1.77e-011.00e+002.37316210
GO:0006184GTP catabolic process1.84e-011.00e+002.30619220
GO:0006412translation1.96e-011.00e+002.211115235
GO:0008134transcription factor binding2.04e-011.00e+002.14518246
GO:0004842ubiquitin-protein transferase activity2.11e-011.00e+002.08814256
GO:0019899enzyme binding2.34e-011.00e+001.918111288
GO:0043234protein complex2.43e-011.00e+001.859117300
GO:0006200ATP catabolic process2.45e-011.00e+001.844114303
GO:0005856cytoskeleton2.51e-011.00e+001.80718311
GO:0019901protein kinase binding2.57e-011.00e+001.766121320
GO:0044822poly(A) RNA binding2.61e-011.00e+001.0132501078
GO:0007411axon guidance2.62e-011.00e+001.73419327
GO:0005525GTP binding2.63e-011.00e+001.730111328
GO:0003723RNA binding2.81e-011.00e+001.616119355
GO:0008285negative regulation of cell proliferation2.89e-011.00e+001.568111367
GO:0005925focal adhesion2.91e-011.00e+001.556118370
GO:0007155cell adhesion3.00e-011.00e+001.50318384
GO:0007596blood coagulation3.51e-011.00e+001.230114464
GO:0005783endoplasmic reticulum4.35e-011.00e+000.83519610
GO:0045087innate immune response4.39e-011.00e+000.821120616
GO:0005615extracellular space6.17e-011.00e+000.1071171010
GO:0005739mitochondrion6.30e-011.00e+000.0571241046
GO:0008270zinc ion binding6.37e-011.00e+000.0281121067
GO:0006351transcription, DNA-templated7.84e-011.00e+00-0.5431251585
GO:0005886plasma membrane9.43e-011.00e+00-1.3811382834