meta-int-snw-7407

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
reg-snw-56655 wolf-screen-ratio-mammosphere-adherent 0.828 9.29e-07 2.91e-03 5.53e-03 8 7
int-snw-7407 wolf-screen-ratio-mammosphere-adherent 1.002 3.42e-18 5.32e-04 1.28e-02 11 11
wolf-screen-ratio-mammosphere-adherent-meta-int-snw-7407 subnetwork

Genes (16)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
ACACB 32 120.6561.002184Yes-
PSMA2 5683 1121.0931.106108Yes-
RBX1 9978 1151.1850.934148Yes-
PSMC3 5702 510.7191.002276Yes-
PSMB7 5695 1180.9820.93490Yes-
VARS 7407 860.5491.002204Yes-
POLE4 56655 630.1770.82856--
RPSA 3921 1201.3271.151152Yes-
PSMB3 5691 640.6680.90119Yes-
PGD 5226 891.2011.106152Yes-
RSL24D1 51187 381.3001.02059Yes-
RPL14 9045 491.2501.113166Yes-
PSMB2 5690 1160.8770.956169Yes-
ACTB 60 1341.1531.151610Yes-
PSMD11 5717 1241.0951.106218Yes-
CFL1 1072 180.6741.020203Yes-

Interactions (42)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMB2 5690 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMC3 5702 VARS 7407 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PSMB2 5690 POLE4 56655 pd < reg.ITFP.txt: no annot
ACACB 32 PGD 5226 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 VARS 7407 pp -- int.I2D: IntAct_Yeast
PSMC3 5702 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
RPSA 3921 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CFL1 1072 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, MINT_Yeast, MIPS, BioGrid, BIND_Yeast, HPRD, IntAct, IntAct_Yeast, MINT, VidalHuman_core, YeastLow, Yu_GoldStd;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
PSMB7 5695 RBX1 9978 pd < reg.ITFP.txt: no annot
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
PSMA2 5683 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast, YeastLow
VARS 7407 POLE4 56655 pd <> reg.ITFP.txt: no annot
PSMA2 5683 PSMB3 5691 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, INTEROLOG, Krogan_Core, MINT_Yeast, YeastHigh, Yu_GoldStd
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 POLE4 56655 pd < reg.ITFP.txt: no annot
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 POLE4 56655 pd < reg.ITFP.txt: no annot
CFL1 1072 PGD 5226 pp -- int.I2D: YeastLow
PSMB2 5690 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct
ACACB 32 RPSA 3921 pp -- int.I2D: IntAct_Yeast, YeastMedium
PSMB3 5691 PSMB7 5695 pp -- int.Intact: MI:0915(physical association);
int.I2D: BCI, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Yeast, YeastHigh, HPRD, Krogan_Core, MINT_Yeast, MIPS;
int.HPRD: yeast 2-hybrid
ACTB 60 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
PSMC3 5702 PSMD11 5717 pd < reg.ITFP.txt: no annot
PSMC3 5702 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
ACACB 32 VARS 7407 pp -- int.I2D: IntAct_Yeast
PSMB2 5690 PSMB3 5691 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, INTEROLOG, MINT, Yu_GoldStd, BCI, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
PSMB3 5691 POLE4 56655 pd < reg.ITFP.txt: no annot
CFL1 1072 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
ACACB 32 PSMB3 5691 pp -- int.I2D: YeastLow
CFL1 1072 RSL24D1 51187 pp -- int.I2D: YeastLow
PSMB2 5690 PSMD11 5717 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMB2 5690 VARS 7407 pd < reg.ITFP.txt: no annot
CFL1 1072 VARS 7407 pp -- int.I2D: YeastLow
PSMB3 5691 PSMD11 5717 pp -- int.I2D: YeastLow
ACACB 32 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMA2 5683 PSMB2 5690 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core

Related GO terms (200)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0006521regulation of cellular amino acid metabolic process4.74e-127.74e-086.93662150
GO:0000502proteasome complex1.20e-111.96e-076.72162258
GO:0016071mRNA metabolic process1.26e-112.05e-075.194834223
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.44e-113.99e-076.55762465
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest2.44e-113.99e-076.55762265
GO:0016070RNA metabolic process2.85e-114.65e-075.046834247
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.87e-116.32e-076.45062470
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent5.02e-118.19e-076.39062373
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.46e-118.91e-076.37062474
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I6.97e-111.14e-066.31362377
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process8.17e-111.33e-066.27662579
GO:0002474antigen processing and presentation of peptide antigen via MHC class I2.37e-103.87e-066.02562394
GO:0016032viral process4.14e-106.75e-064.088955540
GO:0000209protein polyubiquitination8.55e-101.40e-055.721621116
GO:0005839proteasome core complex1.87e-093.05e-057.82541118
GO:0010467gene expression2.74e-094.47e-053.779958669
GO:0004298threonine-type endopeptidase activity2.96e-094.82e-057.67341120
GO:0000082G1/S transition of mitotic cell cycle4.05e-096.60e-055.351633150
GO:0042981regulation of apoptotic process4.21e-096.87e-055.341626151
GO:0034641cellular nitrogen compound metabolic process1.09e-081.79e-045.112625177
GO:0005829cytosol1.20e-081.96e-042.372131252562
GO:0043066negative regulation of apoptotic process8.20e-081.34e-034.044730433
GO:0000278mitotic cell cycle1.32e-062.15e-023.943652398
GO:0005654nucleoplasm3.17e-065.17e-022.8988831095
GO:0006915apoptotic process1.06e-051.73e-013.422634571
GO:0044281small molecule metabolic process1.11e-051.81e-012.6568571295
GO:0070062extracellular vesicular exosome2.43e-053.97e-012.01910982516
GO:0022624proteasome accessory complex1.21e-041.00e+006.9072917
GO:0005515protein binding4.55e-041.00e+001.114131726127
GO:0016020membrane7.56e-041.00e+002.0327801746
GO:0014070response to organic cyclic compound7.95e-041.00e+005.5682343
GO:0019521D-gluconate metabolic process9.80e-041.00e+009.994111
GO:0000932cytoplasmic mRNA processing body1.35e-031.00e+005.1872356
GO:0005634nucleus1.37e-031.00e+001.217111314828
GO:0004832valine-tRNA ligase activity1.96e-031.00e+008.994112
GO:2001295malonyl-CoA biosynthetic process1.96e-031.00e+008.994112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.96e-031.00e+008.994112
GO:0003989acetyl-CoA carboxylase activity1.96e-031.00e+008.994112
GO:0019322pentose biosynthetic process1.96e-031.00e+008.994112
GO:0005055laminin receptor activity1.96e-031.00e+008.994112
GO:0006407rRNA export from nucleus1.96e-031.00e+008.994112
GO:0006438valyl-tRNA aminoacylation1.96e-031.00e+008.994112
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis2.53e-031.00e+004.7282577
GO:0019083viral transcription2.79e-031.00e+004.6552881
GO:0006084acetyl-CoA metabolic process2.94e-031.00e+008.409113
GO:0009051pentose-phosphate shunt, oxidative branch2.94e-031.00e+008.409113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.94e-031.00e+008.409113
GO:0006415translational termination3.21e-031.00e+004.5512887
GO:0006414translational elongation3.66e-031.00e+004.45521193
GO:0001842neural fold formation3.92e-031.00e+007.994114
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.92e-031.00e+007.994114
GO:003068690S preribosome3.92e-031.00e+007.994114
GO:0031467Cul7-RING ubiquitin ligase complex3.92e-031.00e+007.994114
GO:0019788NEDD8 ligase activity3.92e-031.00e+007.994114
GO:0006614SRP-dependent cotranslational protein targeting to membrane4.55e-031.00e+004.29428104
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.89e-031.00e+007.673125
GO:0031461cullin-RING ubiquitin ligase complex4.89e-031.00e+007.673115
GO:0043248proteasome assembly4.89e-031.00e+007.673115
GO:0030891VCB complex4.89e-031.00e+007.673125
GO:0008622epsilon DNA polymerase complex4.89e-031.00e+007.673115
GO:0009374biotin binding4.89e-031.00e+007.673115
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay5.44e-031.00e+004.162210114
GO:0019058viral life cycle5.54e-031.00e+004.149210115
GO:0030957Tat protein binding5.87e-031.00e+007.409146
GO:0004075biotin carboxylase activity5.87e-031.00e+007.409116
GO:0031466Cul5-RING ubiquitin ligase complex5.87e-031.00e+007.409116
GO:0000028ribosomal small subunit assembly6.84e-031.00e+007.187117
GO:0030836positive regulation of actin filament depolymerization6.84e-031.00e+007.187127
GO:0002161aminoacyl-tRNA editing activity6.84e-031.00e+007.187127
GO:0031462Cul2-RING ubiquitin ligase complex6.84e-031.00e+007.187127
GO:0006413translational initiation7.13e-031.00e+003.961212131
GO:0009615response to virus7.23e-031.00e+003.95026132
GO:0019773proteasome core complex, alpha-subunit complex7.82e-031.00e+006.994158
GO:0031464Cul4A-RING E3 ubiquitin ligase complex7.82e-031.00e+006.994128
GO:0031325positive regulation of cellular metabolic process7.82e-031.00e+006.994118
GO:0070688MLL5-L complex7.82e-031.00e+006.994118
GO:0030042actin filament depolymerization7.82e-031.00e+006.994128
GO:0045116protein neddylation7.82e-031.00e+006.994128
GO:0003735structural constituent of ribosome8.21e-031.00e+003.85528141
GO:0006853carnitine shuttle8.79e-031.00e+006.825119
GO:0006450regulation of translational fidelity9.76e-031.00e+006.6731210
GO:0006768biotin metabolic process9.76e-031.00e+006.6731110
GO:0006098pentose-phosphate shunt1.07e-021.00e+006.5351311
GO:0061001regulation of dendritic spine morphogenesis1.07e-021.00e+006.5351211
GO:0044267cellular protein metabolic process1.16e-021.00e+002.628324495
GO:0005838proteasome regulatory particle1.17e-021.00e+006.4091712
GO:0042273ribosomal large subunit biogenesis1.27e-021.00e+006.2941413
GO:0035267NuA4 histone acetyltransferase complex1.36e-021.00e+006.1871414
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex1.46e-021.00e+006.0881115
GO:0050998nitric-oxide synthase binding1.56e-021.00e+005.9941116
GO:0010243response to organonitrogen compound1.65e-021.00e+005.9071217
GO:0031258lamellipodium membrane1.65e-021.00e+005.9071217
GO:0022604regulation of cell morphogenesis1.65e-021.00e+005.9071117
GO:1903506regulation of nucleic acid-templated transcription1.85e-021.00e+005.7471119
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.85e-021.00e+005.7471119
GO:0048863stem cell differentiation1.85e-021.00e+005.7471119
GO:0030010establishment of cell polarity2.04e-021.00e+005.6021221
GO:0000281mitotic cytokinesis2.04e-021.00e+005.6021221
GO:0030863cortical cytoskeleton2.14e-021.00e+005.5351122
GO:0036464cytoplasmic ribonucleoprotein granule2.14e-021.00e+005.5351422
GO:0006412translation2.17e-021.00e+003.118215235
GO:0043044ATP-dependent chromatin remodeling2.23e-021.00e+005.4711423
GO:0031463Cul3-RING ubiquitin ligase complex2.23e-021.00e+005.4711223
GO:0043236laminin binding2.23e-021.00e+005.4711123
GO:0043200response to amino acid2.23e-021.00e+005.4711123
GO:0006513protein monoubiquitination2.23e-021.00e+005.4711123
GO:0030864cortical actin cytoskeleton2.42e-021.00e+005.3511125
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.52e-021.00e+005.2941226
GO:0043022ribosome binding2.71e-021.00e+005.1871328
GO:0031492nucleosomal DNA binding2.71e-021.00e+005.1871428
GO:0019894kinesin binding2.71e-021.00e+005.1871128
GO:0019005SCF ubiquitin ligase complex2.81e-021.00e+005.1361129
GO:0003887DNA-directed DNA polymerase activity2.81e-021.00e+005.1361329
GO:0071897DNA biosynthetic process2.81e-021.00e+005.1361229
GO:0001755neural crest cell migration2.90e-021.00e+005.0881230
GO:0042254ribosome biogenesis2.90e-021.00e+005.0881130
GO:0050661NADP binding3.09e-021.00e+004.9941132
GO:1903507negative regulation of nucleic acid-templated transcription3.09e-021.00e+004.9941232
GO:0034332adherens junction organization3.47e-021.00e+004.8251136
GO:0001895retina homeostasis3.47e-021.00e+004.8251136
GO:0051084'de novo' posttranslational protein folding3.57e-021.00e+004.7851437
GO:0006633fatty acid biosynthetic process3.57e-021.00e+004.7851237
GO:0070527platelet aggregation3.66e-021.00e+004.7471238
GO:0022627cytosolic small ribosomal subunit3.76e-021.00e+004.7091339
GO:0005524ATP binding3.83e-021.00e+001.5914461354
GO:0007411axon guidance3.99e-021.00e+002.64129327
GO:0006418tRNA aminoacylation for protein translation4.04e-021.00e+004.6021542
GO:0043966histone H3 acetylation4.32e-021.00e+004.5031245
GO:0021762substantia nigra development4.42e-021.00e+004.4711146
GO:0007266Rho protein signal transduction4.61e-021.00e+004.4091248
GO:0022625cytosolic large ribosomal subunit4.70e-021.00e+004.3801549
GO:0005925focal adhesion4.99e-021.00e+002.463218370
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding5.17e-021.00e+004.2401554
GO:0051289protein homotetramerization5.17e-021.00e+004.2401154
GO:0012505endomembrane system5.45e-021.00e+004.1621257
GO:0045216cell-cell junction organization5.63e-021.00e+004.1121259
GO:0034329cell junction assembly6.74e-021.00e+003.8451171
GO:0032587ruffle membrane6.83e-021.00e+003.8251472
GO:0006767water-soluble vitamin metabolic process7.11e-021.00e+003.7661375
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process7.20e-021.00e+003.7471376
GO:0006766vitamin metabolic process7.38e-021.00e+003.7091378
GO:0007596blood coagulation7.44e-021.00e+002.136214464
GO:0002576platelet degranulation7.75e-021.00e+003.6371482
GO:0005739mitochondrion7.87e-021.00e+001.5493241046
GO:0016363nuclear matrix8.65e-021.00e+003.47111192
GO:0006928cellular component movement8.65e-021.00e+003.4711792
GO:0005200structural constituent of cytoskeleton8.74e-021.00e+003.4551793
GO:0006364rRNA processing9.01e-021.00e+003.4091596
GO:0007010cytoskeleton organization9.01e-021.00e+003.4091296
GO:0071456cellular response to hypoxia9.19e-021.00e+003.3801498
GO:0006112energy reserve metabolic process9.28e-021.00e+003.3651199
GO:0014069postsynaptic density9.90e-021.00e+003.26711106
GO:0005741mitochondrial outer membrane1.01e-011.00e+003.24014108
GO:0015630microtubule cytoskeleton1.04e-011.00e+003.18715112
GO:0030529ribonucleoprotein complex1.06e-011.00e+003.16218114
GO:0072562blood microparticle1.08e-011.00e+003.13614116
GO:0006325chromatin organization1.14e-011.00e+003.05214123
GO:0007219Notch signaling pathway1.16e-011.00e+003.02914125
GO:0006511ubiquitin-dependent protein catabolic process1.18e-011.00e+003.00615127
GO:0030036actin cytoskeleton organization1.19e-011.00e+002.98315129
GO:0045087innate immune response1.21e-011.00e+001.728220616
GO:0000790nuclear chromatin1.23e-011.00e+002.93917133
GO:0031982vesicle1.24e-011.00e+002.928110134
GO:0044255cellular lipid metabolic process1.29e-011.00e+002.86514140
GO:0005911cell-cell junction1.31e-011.00e+002.84513142
GO:0016887ATPase activity1.32e-011.00e+002.82517144
GO:0061024membrane organization1.34e-011.00e+002.80515146
GO:0006457protein folding1.37e-011.00e+002.77518149
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.53e-011.00e+002.60215168
GO:0030424axon1.56e-011.00e+002.56813172
GO:0003714transcription corepressor activity1.62e-011.00e+002.51117179
GO:0031625ubiquitin protein ligase binding1.63e-011.00e+002.503113180
GO:0015629actin cytoskeleton1.65e-011.00e+002.47915183
GO:0032403protein complex binding1.67e-011.00e+002.46317185
GO:0030168platelet activation1.83e-011.00e+002.31519205
GO:0003713transcription coactivator activity2.10e-011.00e+002.094110239
GO:0005730nucleolus2.24e-011.00e+000.8623701684
GO:0004842ubiquitin-protein transferase activity2.24e-011.00e+001.99414256
GO:0006281DNA repair2.30e-011.00e+001.950122264
GO:0005975carbohydrate metabolic process2.37e-011.00e+001.89615274
GO:0003779actin binding2.38e-011.00e+001.89117275
GO:0042493response to drug2.48e-011.00e+001.825111288
GO:0016567protein ubiquitination2.56e-011.00e+001.77015299
GO:0043234protein complex2.57e-011.00e+001.766117300
GO:0006200ATP catabolic process2.59e-011.00e+001.751114303
GO:0005615extracellular space2.60e-011.00e+001.0142171010
GO:0005856cytoskeleton2.65e-011.00e+001.71418311
GO:0019901protein kinase binding2.72e-011.00e+001.673121320
GO:0044822poly(A) RNA binding2.86e-011.00e+000.9202501078
GO:0003723RNA binding2.97e-011.00e+001.523119355
GO:0043565sequence-specific DNA binding3.04e-011.00e+001.48314365
GO:0007155cell adhesion3.17e-011.00e+001.40918384
GO:0046982protein heterodimerization activity3.27e-011.00e+001.354111399
GO:0005737cytoplasm3.47e-011.00e+000.3595983976
GO:0006468protein phosphorylation3.72e-011.00e+001.127110467
GO:0055114oxidation-reduction process3.81e-011.00e+001.085111481
GO:0005794Golgi apparatus4.78e-011.00e+000.650114650
GO:0008270zinc ion binding6.61e-011.00e+00-0.0651121067
GO:0046872metal ion binding7.78e-011.00e+00-0.5221241465
GO:0005886plasma membrane9.53e-011.00e+00-1.4741382834