meta-int-snw-7347

Interacting subnets

Subnetwork	Dataset	Score	p-value 1	p-value 2	p-value 3	Size	Highlighted genes
reg-snw-56655	wolf-screen-ratio-mammosphere-adherent	0.828	9.29e-07	2.91e-03	5.53e-03	8	7
int-snw-7347	wolf-screen-ratio-mammosphere-adherent	0.922	5.20e-15	3.27e-03	4.89e-02	9	8

wolf-screen-ratio-mammosphere-adherent-meta-int-snw-7347 subnetwork

Genes (14)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
NEDD8	4738	2	0.572	0.936	119	Yes	-
UBA1	7317	6	0.555	0.971	207	Yes	-
PSMA2	5683	112	1.093	1.106	108	Yes	-
RBX1	9978	115	1.185	0.934	148	Yes	-
PSMB7	5695	118	0.982	0.934	90	Yes	-
PSMB2	5690	116	0.877	0.956	169	Yes	-
PSMD11	5717	124	1.095	1.106	218	Yes	-
VARS	7407	86	0.549	1.002	204	Yes	-
ACTB	60	134	1.153	1.151	610	Yes	-
UCHL3	7347	2	0.113	0.922	25	-	-
POLE4	56655	63	0.177	0.828	56	-	-
RPSA	3921	120	1.327	1.151	152	Yes	-
PSMB3	5691	64	0.668	0.901	19	Yes	-
PGD	5226	89	1.201	1.106	152	Yes	-

Interactions (32)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMA2	5683	PSMB7	5695	pp	--	int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PSMB2	5690	POLE4	56655	pd	<	reg.ITFP.txt: no annot
NEDD8	4738	RBX1	9978	pp	--	int.I2D: BioGrid
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
PSMD11	5717	UCHL3	7347	pp	--	int.I2D: Krogan_NonCore
ACTB	60	PSMB2	5690	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	VARS	7407	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
PGD	5226	UBA1	7317	pp	--	int.I2D: YeastLow
PSMB7	5695	RBX1	9978	pd	<	reg.ITFP.txt: no annot
UBA1	7317	UCHL3	7347	pp	--	int.I2D: BioGrid_Yeast
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
VARS	7407	POLE4	56655	pd	<>	reg.ITFP.txt: no annot
PSMA2	5683	PSMB3	5691	pp	--	int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, INTEROLOG, Krogan_Core, MINT_Yeast, YeastHigh, Yu_GoldStd
PSMB7	5695	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
NEDD8	4738	UCHL3	7347	pp	--	int.I2D: BCI, BioGrid, HPRD; int.HPRD: in vitro, yeast 2-hybrid
PSMA2	5683	POLE4	56655	pd	<	reg.ITFP.txt: no annot
PGD	5226	UCHL3	7347	pp	--	int.I2D: Krogan_NonCore
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PSMB7	5695	POLE4	56655	pd	<	reg.ITFP.txt: no annot
PSMB2	5690	PSMB7	5695	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct
PSMB3	5691	PSMB7	5695	pp	--	int.Intact: MI:0915(physical association); int.I2D: BCI, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Yeast, YeastHigh, HPRD, Krogan_Core, MINT_Yeast, MIPS; int.HPRD: yeast 2-hybrid
ACTB	60	PSMB7	5695	pp	--	int.I2D: BioGrid_Yeast
PSMB2	5690	PSMB3	5691	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, INTEROLOG, MINT, Yu_GoldStd, BCI, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
UBA1	7317	VARS	7407	pp	--	int.I2D: Krogan_NonCore, YeastLow
PSMB3	5691	POLE4	56655	pd	<	reg.ITFP.txt: no annot
PSMB2	5690	PSMD11	5717	pd	<	reg.ITFP.txt: no annot
PSMB2	5690	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMB2	5690	VARS	7407	pd	<	reg.ITFP.txt: no annot
PSMB3	5691	PSMD11	5717	pp	--	int.I2D: YeastLow
PSMA2	5683	PSMB2	5690	pp	--	int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core

Related GO terms (168)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006521	regulation of cellular amino acid metabolic process	4.31e-10	7.03e-06	6.865	5	21	50
GO:0000502	proteasome complex	9.28e-10	1.51e-05	6.651	5	22	58
GO:0005839	proteasome core complex	1.03e-09	1.68e-05	8.017	4	11	18
GO:0004298	threonine-type endopeptidase activity	1.63e-09	2.66e-05	7.865	4	11	20
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.67e-09	2.72e-05	6.487	5	24	65
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	1.67e-09	2.72e-05	6.487	5	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.44e-09	3.98e-05	6.380	5	24	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	3.02e-09	4.93e-05	6.319	5	23	73
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.24e-09	5.29e-05	6.300	5	24	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	3.97e-09	6.48e-05	6.242	5	23	77
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	4.52e-09	7.38e-05	6.205	5	25	79
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	1.09e-08	1.78e-04	5.954	5	23	94
GO:0005829	cytosol	1.46e-08	2.38e-04	2.449	12	125	2562
GO:0016071	mRNA metabolic process	1.67e-08	2.72e-04	4.971	6	34	223
GO:0016070	RNA metabolic process	3.07e-08	5.01e-04	4.824	6	34	247
GO:0000209	protein polyubiquitination	3.16e-08	5.16e-04	5.651	5	21	116
GO:0000082	G1/S transition of mitotic cell cycle	1.15e-07	1.87e-03	5.280	5	33	150
GO:0016032	viral process	1.17e-07	1.91e-03	3.918	7	55	540
GO:0042981	regulation of apoptotic process	1.19e-07	1.94e-03	5.271	5	26	151
GO:0034641	cellular nitrogen compound metabolic process	2.62e-07	4.28e-03	5.041	5	25	177
GO:0070062	extracellular vesicular exosome	2.65e-07	4.32e-03	2.350	11	98	2516
GO:0010467	gene expression	5.03e-07	8.21e-03	3.609	7	58	669
GO:0005654	nucleoplasm	1.36e-05	2.21e-01	2.898	7	83	1095
GO:0000278	mitotic cell cycle	1.40e-05	2.29e-01	3.872	5	52	398
GO:0045116	protein neddylation	1.91e-05	3.11e-01	8.187	2	2	8
GO:0043066	negative regulation of apoptotic process	2.11e-05	3.44e-01	3.751	5	30	433
GO:0006915	apoptotic process	7.93e-05	1.00e+00	3.352	5	34	571
GO:0006511	ubiquitin-dependent protein catabolic process	1.57e-04	1.00e+00	4.783	3	5	127
GO:0005634	nucleus	2.13e-04	1.00e+00	1.409	11	131	4828
GO:0005515	protein binding	3.03e-04	1.00e+00	1.191	12	172	6127
GO:0044281	small molecule metabolic process	4.24e-04	1.00e+00	2.433	6	57	1295
GO:0014070	response to organic cyclic compound	6.05e-04	1.00e+00	5.761	2	3	43
GO:0019521	D-gluconate metabolic process	8.58e-04	1.00e+00	10.187	1	1	1
GO:0004832	valine-tRNA ligase activity	1.71e-03	1.00e+00	9.187	1	1	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.71e-03	1.00e+00	9.187	1	1	2
GO:0019322	pentose biosynthetic process	1.71e-03	1.00e+00	9.187	1	1	2
GO:0005055	laminin receptor activity	1.71e-03	1.00e+00	9.187	1	1	2
GO:0006407	rRNA export from nucleus	1.71e-03	1.00e+00	9.187	1	1	2
GO:0006438	valyl-tRNA aminoacylation	1.71e-03	1.00e+00	9.187	1	1	2
GO:0009051	pentose-phosphate shunt, oxidative branch	2.57e-03	1.00e+00	8.602	1	1	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.57e-03	1.00e+00	8.602	1	1	3
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3.43e-03	1.00e+00	8.187	1	1	4
GO:0030686	90S preribosome	3.43e-03	1.00e+00	8.187	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	3.43e-03	1.00e+00	8.187	1	1	4
GO:0004839	ubiquitin activating enzyme activity	3.43e-03	1.00e+00	8.187	1	1	4
GO:0019788	NEDD8 ligase activity	3.43e-03	1.00e+00	8.187	1	1	4
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	4.28e-03	1.00e+00	7.865	1	2	5
GO:0031461	cullin-RING ubiquitin ligase complex	4.28e-03	1.00e+00	7.865	1	1	5
GO:0043248	proteasome assembly	4.28e-03	1.00e+00	7.865	1	1	5
GO:0030891	VCB complex	4.28e-03	1.00e+00	7.865	1	2	5
GO:0008622	epsilon DNA polymerase complex	4.28e-03	1.00e+00	7.865	1	1	5
GO:0019941	modification-dependent protein catabolic process	4.28e-03	1.00e+00	7.865	1	1	5
GO:0030957	Tat protein binding	5.14e-03	1.00e+00	7.602	1	4	6
GO:0031466	Cul5-RING ubiquitin ligase complex	5.14e-03	1.00e+00	7.602	1	1	6
GO:0030867	rough endoplasmic reticulum membrane	5.99e-03	1.00e+00	7.380	1	1	7
GO:0000028	ribosomal small subunit assembly	5.99e-03	1.00e+00	7.380	1	1	7
GO:0002161	aminoacyl-tRNA editing activity	5.99e-03	1.00e+00	7.380	1	2	7
GO:0031462	Cul2-RING ubiquitin ligase complex	5.99e-03	1.00e+00	7.380	1	2	7
GO:0019773	proteasome core complex, alpha-subunit complex	6.84e-03	1.00e+00	7.187	1	5	8
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	6.84e-03	1.00e+00	7.187	1	2	8
GO:0070688	MLL5-L complex	6.84e-03	1.00e+00	7.187	1	1	8
GO:0006450	regulation of translational fidelity	8.55e-03	1.00e+00	6.865	1	2	10
GO:0006098	pentose-phosphate shunt	9.40e-03	1.00e+00	6.728	1	3	11
GO:0031625	ubiquitin protein ligase binding	1.01e-02	1.00e+00	3.695	2	13	180
GO:0005838	proteasome regulatory particle	1.02e-02	1.00e+00	6.602	1	7	12
GO:0035267	NuA4 histone acetyltransferase complex	1.19e-02	1.00e+00	6.380	1	4	14
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	1.28e-02	1.00e+00	6.280	1	1	15
GO:0050998	nitric-oxide synthase binding	1.36e-02	1.00e+00	6.187	1	1	16
GO:0010243	response to organonitrogen compound	1.45e-02	1.00e+00	6.100	1	2	17
GO:0022624	proteasome accessory complex	1.45e-02	1.00e+00	6.100	1	9	17
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.62e-02	1.00e+00	5.939	1	1	19
GO:0048863	stem cell differentiation	1.62e-02	1.00e+00	5.939	1	1	19
GO:0030163	protein catabolic process	1.87e-02	1.00e+00	5.728	1	1	22
GO:0000792	heterochromatin	1.87e-02	1.00e+00	5.728	1	2	22
GO:0030863	cortical cytoskeleton	1.87e-02	1.00e+00	5.728	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.87e-02	1.00e+00	5.728	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.96e-02	1.00e+00	5.664	1	4	23
GO:0030057	desmosome	1.96e-02	1.00e+00	5.664	1	1	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.96e-02	1.00e+00	5.664	1	2	23
GO:0043236	laminin binding	1.96e-02	1.00e+00	5.664	1	1	23
GO:0006513	protein monoubiquitination	1.96e-02	1.00e+00	5.664	1	1	23
GO:0004842	ubiquitin-protein transferase activity	1.97e-02	1.00e+00	3.187	2	4	256
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	2.21e-02	1.00e+00	5.487	1	2	26
GO:0043022	ribosome binding	2.38e-02	1.00e+00	5.380	1	3	28
GO:0031492	nucleosomal DNA binding	2.38e-02	1.00e+00	5.380	1	4	28
GO:0019894	kinesin binding	2.38e-02	1.00e+00	5.380	1	1	28
GO:0019005	SCF ubiquitin ligase complex	2.46e-02	1.00e+00	5.329	1	1	29
GO:0003887	DNA-directed DNA polymerase activity	2.46e-02	1.00e+00	5.329	1	3	29
GO:0071897	DNA biosynthetic process	2.46e-02	1.00e+00	5.329	1	2	29
GO:0016567	protein ubiquitination	2.63e-02	1.00e+00	2.963	2	5	299
GO:0050661	NADP binding	2.71e-02	1.00e+00	5.187	1	1	32
GO:0034332	adherens junction organization	3.05e-02	1.00e+00	5.017	1	1	36
GO:0001895	retina homeostasis	3.05e-02	1.00e+00	5.017	1	1	36
GO:0004221	ubiquitin thiolesterase activity	3.05e-02	1.00e+00	5.017	1	2	36
GO:0051084	'de novo' posttranslational protein folding	3.13e-02	1.00e+00	4.978	1	4	37
GO:0070527	platelet aggregation	3.21e-02	1.00e+00	4.939	1	2	38
GO:0022627	cytosolic small ribosomal subunit	3.30e-02	1.00e+00	4.902	1	3	39
GO:0006418	tRNA aminoacylation for protein translation	3.54e-02	1.00e+00	4.795	1	5	42
GO:0043966	histone H3 acetylation	3.79e-02	1.00e+00	4.695	1	2	45
GO:0021762	substantia nigra development	3.88e-02	1.00e+00	4.664	1	1	46
GO:0043130	ubiquitin binding	3.88e-02	1.00e+00	4.664	1	1	46
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	4.54e-02	1.00e+00	4.432	1	5	54
GO:0008233	peptidase activity	4.62e-02	1.00e+00	4.406	1	3	55
GO:0008104	protein localization	4.70e-02	1.00e+00	4.380	1	3	56
GO:0000932	cytoplasmic mRNA processing body	4.70e-02	1.00e+00	4.380	1	3	56
GO:0045216	cell-cell junction organization	4.95e-02	1.00e+00	4.304	1	2	59
GO:0016020	membrane	5.44e-02	1.00e+00	1.417	4	80	1746
GO:0004843	ubiquitin-specific protease activity	5.52e-02	1.00e+00	4.143	1	1	66
GO:0005739	mitochondrion	5.62e-02	1.00e+00	1.741	3	24	1046
GO:0034329	cell junction assembly	5.92e-02	1.00e+00	4.037	1	1	71
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6.33e-02	1.00e+00	3.939	1	3	76
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	6.41e-02	1.00e+00	3.920	1	5	77
GO:0044267	cellular protein metabolic process	6.57e-02	1.00e+00	2.236	2	24	495
GO:0019083	viral transcription	6.73e-02	1.00e+00	3.847	1	8	81
GO:0009653	anatomical structure morphogenesis	7.21e-02	1.00e+00	3.744	1	2	87
GO:0006415	translational termination	7.21e-02	1.00e+00	3.744	1	8	87
GO:0006464	cellular protein modification process	7.37e-02	1.00e+00	3.711	1	2	89
GO:0006928	cellular component movement	7.61e-02	1.00e+00	3.664	1	7	92
GO:0006414	translational elongation	7.69e-02	1.00e+00	3.648	1	11	93
GO:0005200	structural constituent of cytoskeleton	7.69e-02	1.00e+00	3.648	1	7	93
GO:0071456	cellular response to hypoxia	8.09e-02	1.00e+00	3.572	1	4	98
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	8.56e-02	1.00e+00	3.487	1	8	104
GO:0014069	postsynaptic density	8.72e-02	1.00e+00	3.459	1	1	106
GO:0015630	microtubule cytoskeleton	9.19e-02	1.00e+00	3.380	1	5	112
GO:0030529	ribonucleoprotein complex	9.35e-02	1.00e+00	3.354	1	8	114
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	9.35e-02	1.00e+00	3.354	1	10	114
GO:0019058	viral life cycle	9.43e-02	1.00e+00	3.342	1	10	115
GO:0072562	blood microparticle	9.51e-02	1.00e+00	3.329	1	4	116
GO:0006325	chromatin organization	1.01e-01	1.00e+00	3.245	1	4	123
GO:0007219	Notch signaling pathway	1.02e-01	1.00e+00	3.221	1	4	125
GO:0005524	ATP binding	1.04e-01	1.00e+00	1.369	3	46	1354
GO:0007179	transforming growth factor beta receptor signaling pathway	1.06e-01	1.00e+00	3.165	1	3	130
GO:0006413	translational initiation	1.07e-01	1.00e+00	3.154	1	12	131
GO:0000790	nuclear chromatin	1.08e-01	1.00e+00	3.132	1	7	133
GO:0009615	response to virus	1.08e-01	1.00e+00	3.143	1	6	132
GO:0003735	structural constituent of ribosome	1.14e-01	1.00e+00	3.048	1	8	141
GO:0061024	membrane organization	1.18e-01	1.00e+00	2.997	1	5	146
GO:0006457	protein folding	1.21e-01	1.00e+00	2.968	1	8	149
GO:0010008	endosome membrane	1.27e-01	1.00e+00	2.892	1	6	157
GO:0006974	cellular response to DNA damage stimulus	1.27e-01	1.00e+00	2.883	1	8	158
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.35e-01	1.00e+00	2.795	1	5	168
GO:0030424	axon	1.38e-01	1.00e+00	2.761	1	3	172
GO:0015629	actin cytoskeleton	1.46e-01	1.00e+00	2.671	1	5	183
GO:0032403	protein complex binding	1.48e-01	1.00e+00	2.656	1	7	185
GO:0005765	lysosomal membrane	1.72e-01	1.00e+00	2.419	1	5	218
GO:0006412	translation	1.84e-01	1.00e+00	2.311	1	15	235
GO:0006281	DNA repair	2.04e-01	1.00e+00	2.143	1	22	264
GO:0005975	carbohydrate metabolic process	2.11e-01	1.00e+00	2.089	1	5	274
GO:0006357	regulation of transcription from RNA polymerase II promoter	2.12e-01	1.00e+00	2.084	1	6	275
GO:0043234	protein complex	2.29e-01	1.00e+00	1.958	1	17	300
GO:0044822	poly(A) RNA binding	2.35e-01	1.00e+00	1.113	2	50	1078
GO:0005856	cytoskeleton	2.36e-01	1.00e+00	1.906	1	8	311
GO:0005737	cytoplasm	2.40e-01	1.00e+00	0.552	5	98	3976
GO:0019901	protein kinase binding	2.42e-01	1.00e+00	1.865	1	21	320
GO:0007411	axon guidance	2.47e-01	1.00e+00	1.834	1	9	327
GO:0043565	sequence-specific DNA binding	2.72e-01	1.00e+00	1.675	1	4	365
GO:0005925	focal adhesion	2.75e-01	1.00e+00	1.656	1	18	370
GO:0007155	cell adhesion	2.84e-01	1.00e+00	1.602	1	8	384
GO:0046982	protein heterodimerization activity	2.93e-01	1.00e+00	1.547	1	11	399
GO:0006508	proteolysis	3.00e-01	1.00e+00	1.508	1	9	410
GO:0007596	blood coagulation	3.32e-01	1.00e+00	1.329	1	14	464
GO:0055114	oxidation-reduction process	3.42e-01	1.00e+00	1.277	1	11	481
GO:0045087	innate immune response	4.17e-01	1.00e+00	0.920	1	20	616
GO:0005730	nucleolus	4.32e-01	1.00e+00	0.469	2	70	1684
GO:0005794	Golgi apparatus	4.34e-01	1.00e+00	0.843	1	14	650
GO:0005615	extracellular space	5.91e-01	1.00e+00	0.207	1	17	1010
GO:0008270	zinc ion binding	6.12e-01	1.00e+00	0.128	1	12	1067
GO:0005886	plasma membrane	9.31e-01	1.00e+00	-1.282	1	38	2834

Wolf-ratios-Mammosphere-Adherent

meta-int-snw-7347

Interacting subnets

Genes (14)

Interactions (32)

Related GO terms (168)