meta-int-snw-6613

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
reg-snw-6418 wolf-screen-ratio-mammosphere-adherent 0.858 2.92e-07 1.56e-03 3.18e-03 8 6
int-snw-6613 wolf-screen-ratio-mammosphere-adherent 0.983 2.05e-17 8.36e-04 1.80e-02 8 6
wolf-screen-ratio-mammosphere-adherent-meta-int-snw-6613 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
CAD 790 910.8070.973400--
CCNA2 890 540.5500.973246Yes-
RUVBL1 8607 950.7200.973469Yes-
PSMA2 5683 1121.0931.106108Yes-
SET 6418 60.3170.85830--
SUMO2 6613 11-0.4660.983199--
HNRNPC 3183 1081.8120.973181Yes-
RRM1 6240 150.5870.872117Yes-
TUBG1 7283 980.9740.97391Yes-
PSMD11 5717 1241.0951.106218Yes-
ACTB 60 1341.1531.151610Yes-
RPSA 3921 1201.3271.151152Yes-
PGD 5226 891.2011.106152Yes-

Interactions (21)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMD11 5717 RUVBL1 8607 pp -- int.I2D: YeastLow
ACTB 60 RUVBL1 8607 pp -- int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
CCNA2 890 RUVBL1 8607 pd <> reg.ITFP.txt: no annot
CAD 790 RUVBL1 8607 pd < reg.ITFP.txt: no annot
CAD 790 RUVBL1 8607 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
CCNA2 890 RRM1 6240 pd > reg.ITFP.txt: no annot
PSMD11 5717 SUMO2 6613 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 CAD 790 pp -- int.I2D: IntAct_Yeast
CCNA2 890 SET 6418 pd > reg.ITFP.txt: no annot
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
HNRNPC 3183 RUVBL1 8607 pd < reg.ITFP.txt: no annot
ACTB 60 SET 6418 pp -- int.I2D: IntAct_Worm, BioGrid_Mouse, BioGrid_Worm, BIND_Worm, MINT_Worm
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
SUMO2 6613 RUVBL1 8607 pp -- int.I2D: BioGrid
TUBG1 7283 RUVBL1 8607 pd < reg.ITFP.txt: no annot
PSMD11 5717 TUBG1 7283 pd > reg.ITFP.txt: no annot
CAD 790 SUMO2 6613 pp -- int.I2D: BioGrid
PSMD11 5717 RRM1 6240 pd > reg.ITFP.txt: no annot
CAD 790 RPSA 3921 pp -- int.I2D: IntAct_Yeast

Related GO terms (226)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005654nucleoplasm1.49e-082.43e-043.3679831095
GO:0000278mitotic cell cycle3.01e-074.91e-034.242652398
GO:0005829cytosol1.62e-062.64e-022.293101252562
GO:0070062extracellular vesicular exosome1.92e-053.13e-012.1679982516
GO:0016071mRNA metabolic process2.20e-053.59e-014.493434223
GO:0016070RNA metabolic process3.29e-055.37e-014.346434247
GO:0035267NuA4 histone acetyltransferase complex5.30e-058.65e-017.4872414
GO:0043234protein complex7.02e-051.00e+004.065417300
GO:0010467gene expression1.12e-041.00e+003.230558669
GO:0043044ATP-dependent chromatin remodeling1.47e-041.00e+006.7702423
GO:0006206pyrimidine nucleobase metabolic process1.60e-041.00e+006.7092224
GO:0031492nucleosomal DNA binding2.19e-041.00e+006.4872428
GO:0005634nucleus5.72e-041.00e+001.379101314828
GO:0005515protein binding6.98e-041.00e+001.172111726127
GO:0006521regulation of cellular amino acid metabolic process7.02e-041.00e+005.65022150
GO:0031100organ regeneration7.02e-041.00e+005.6502450
GO:0004151dihydroorotase activity7.97e-041.00e+0010.294111
GO:0019521D-gluconate metabolic process7.97e-041.00e+0010.294111
GO:0004070aspartate carbamoyltransferase activity7.97e-041.00e+0010.294111
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity7.97e-041.00e+0010.294111
GO:0070335aspartate binding7.97e-041.00e+0010.294111
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding8.19e-041.00e+005.5392554
GO:0000502proteasome complex9.44e-041.00e+005.43622258
GO:0042995cell projection1.11e-031.00e+005.3172663
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.18e-031.00e+005.27222465
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.18e-031.00e+005.27222265
GO:0016020membrane1.31e-031.00e+002.1096801746
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.37e-031.00e+005.16522470
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent1.49e-031.00e+005.10422373
GO:0055086nucleobase-containing small molecule metabolic process1.49e-031.00e+005.1042573
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.53e-031.00e+005.08522474
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.59e-031.00e+009.294112
GO:0019322pentose biosynthetic process1.59e-031.00e+009.294112
GO:0005055laminin receptor activity1.59e-031.00e+009.294112
GO:0006407rRNA export from nucleus1.59e-031.00e+009.294112
GO:0070409carbamoyl phosphate biosynthetic process1.59e-031.00e+009.294112
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I1.66e-031.00e+005.02722377
GO:0006334nucleosome assembly1.74e-031.00e+004.9902479
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.74e-031.00e+004.99022579
GO:0044281small molecule metabolic process2.34e-031.00e+002.2775571295
GO:0016363nuclear matrix2.35e-031.00e+004.77021192
GO:0009263deoxyribonucleotide biosynthetic process2.39e-031.00e+008.709113
GO:0009051pentose-phosphate shunt, oxidative branch2.39e-031.00e+008.709113
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor2.39e-031.00e+008.709113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.39e-031.00e+008.709113
GO:0044205'de novo' UMP biosynthetic process2.39e-031.00e+008.709113
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process2.39e-031.00e+008.709113
GO:0005200structural constituent of cytoskeleton2.41e-031.00e+004.7552793
GO:0002474antigen processing and presentation of peptide antigen via MHC class I2.46e-031.00e+004.73922394
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.18e-031.00e+008.294114
GO:0000212meiotic spindle organization3.18e-031.00e+008.294114
GO:003068690S preribosome3.18e-031.00e+008.294114
GO:0006543glutamine catabolic process3.18e-031.00e+008.294114
GO:0030529ribonucleoprotein complex3.59e-031.00e+004.46128114
GO:0000209protein polyubiquitination3.71e-031.00e+004.436221116
GO:0051414response to cortisol3.98e-031.00e+007.972115
GO:0043248proteasome assembly3.98e-031.00e+007.972115
GO:0001940male pronucleus3.98e-031.00e+007.972115
GO:0005827polar microtubule3.98e-031.00e+007.972115
GO:0006325chromatin organization4.16e-031.00e+004.35124123
GO:0006260DNA replication4.30e-031.00e+004.328212125
GO:0030957Tat protein binding4.77e-031.00e+007.709146
GO:0046134pyrimidine nucleoside biosynthetic process4.77e-031.00e+007.709116
GO:0000790nuclear chromatin4.85e-031.00e+004.23927133
GO:0000086G2/M transition of mitotic cell cycle5.14e-031.00e+004.19627137
GO:0000028ribosomal small subunit assembly5.56e-031.00e+007.487117
GO:0000930gamma-tubulin complex5.56e-031.00e+007.487117
GO:0001939female pronucleus5.56e-031.00e+007.487117
GO:0000082G1/S transition of mitotic cell cycle6.12e-031.00e+004.065233150
GO:0042981regulation of apoptotic process6.20e-031.00e+004.056226151
GO:0044267cellular protein metabolic process6.32e-031.00e+002.928324495
GO:0019773proteasome core complex, alpha-subunit complex6.36e-031.00e+007.294158
GO:0035067negative regulation of histone acetylation6.36e-031.00e+007.294118
GO:0070688MLL5-L complex6.36e-031.00e+007.294118
GO:0000812Swr1 complex6.36e-031.00e+007.294138
GO:0006228UTP biosynthetic process7.15e-031.00e+007.124119
GO:0010389regulation of G2/M transition of mitotic cell cycle7.15e-031.00e+007.124119
GO:0014075response to amine7.15e-031.00e+007.124119
GO:0031000response to caffeine7.15e-031.00e+007.124129
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding7.63e-031.00e+003.90225168
GO:0016032viral process8.04e-031.00e+002.802355540
GO:0034641cellular nitrogen compound metabolic process8.43e-031.00e+003.826225177
GO:0006098pentose-phosphate shunt8.73e-031.00e+006.8351311
GO:0019789SUMO ligase activity8.73e-031.00e+006.8351111
GO:0021846cell proliferation in forebrain8.73e-031.00e+006.8351111
GO:0033762response to glucagon8.73e-031.00e+006.8351111
GO:0051290protein heterotetramerization8.73e-031.00e+006.8351211
GO:0045120pronucleus8.73e-031.00e+006.8351111
GO:00709353'-UTR-mediated mRNA stabilization9.52e-031.00e+006.7091212
GO:0043968histone H2A acetylation9.52e-031.00e+006.7091312
GO:0005838proteasome regulatory particle9.52e-031.00e+006.7091712
GO:0008266poly(U) RNA binding1.03e-021.00e+006.5941113
GO:0007020microtubule nucleation1.11e-021.00e+006.4871114
GO:0007095mitotic G2 DNA damage checkpoint1.11e-021.00e+006.4871114
GO:0031011Ino80 complex1.11e-021.00e+006.4871314
GO:0050998nitric-oxide synthase binding1.27e-021.00e+006.2941116
GO:0006337nucleosome disassembly1.35e-021.00e+006.2071417
GO:0022624proteasome accessory complex1.35e-021.00e+006.2071917
GO:0007067mitotic nuclear division1.40e-021.00e+003.442213231
GO:0006541glutamine metabolic process1.42e-021.00e+006.1241118
GO:0031122cytoplasmic microtubule organization1.42e-021.00e+006.1241218
GO:0015949nucleobase-containing small molecule interconversion1.42e-021.00e+006.1241218
GO:0005839proteasome core complex1.42e-021.00e+006.12411118
GO:0003678DNA helicase activity1.50e-021.00e+006.0461319
GO:0048863stem cell differentiation1.50e-021.00e+006.0461119
GO:0008601protein phosphatase type 2A regulator activity1.58e-021.00e+005.9721320
GO:0004298threonine-type endopeptidase activity1.58e-021.00e+005.97211120
GO:0071364cellular response to epidermal growth factor stimulus1.66e-021.00e+005.9021121
GO:0043025neuronal cell body1.68e-021.00e+003.30524254
GO:0033574response to testosterone1.74e-021.00e+005.8351222
GO:0030863cortical cytoskeleton1.74e-021.00e+005.8351122
GO:0036464cytoplasmic ribonucleoprotein granule1.74e-021.00e+005.8351422
GO:0043236laminin binding1.82e-021.00e+005.7701123
GO:0005524ATP binding1.84e-021.00e+001.8914461354
GO:0000794condensed nuclear chromosome1.90e-021.00e+005.7091224
GO:0004864protein phosphatase inhibitor activity1.97e-021.00e+005.6501125
GO:0017144drug metabolic process1.97e-021.00e+005.6501125
GO:0005737cytoplasm2.11e-021.00e+001.1447983976
GO:0006913nucleocytoplasmic transport2.13e-021.00e+005.5391227
GO:0034080CENP-A containing nucleosome assembly2.13e-021.00e+005.5391227
GO:0016925protein sumoylation2.13e-021.00e+005.5391127
GO:0071339MLL1 complex2.13e-021.00e+005.5391327
GO:0043022ribosome binding2.21e-021.00e+005.4871328
GO:0043967histone H4 acetylation2.21e-021.00e+005.4871328
GO:0019894kinesin binding2.21e-021.00e+005.4871128
GO:0003730mRNA 3'-UTR binding2.29e-021.00e+005.4361229
GO:0050661NADP binding2.52e-021.00e+005.2941132
GO:0019901protein kinase binding2.59e-021.00e+002.972221320
GO:0034332adherens junction organization2.83e-021.00e+005.1241136
GO:0001895retina homeostasis2.83e-021.00e+005.1241136
GO:0018107peptidyl-threonine phosphorylation2.91e-021.00e+005.0851137
GO:0051084'de novo' posttranslational protein folding2.91e-021.00e+005.0851437
GO:0070527platelet aggregation2.99e-021.00e+005.0461238
GO:0022627cytosolic small ribosomal subunit3.06e-021.00e+005.0091339
GO:0007595lactation3.06e-021.00e+005.0091239
GO:0043195terminal bouton3.22e-021.00e+004.9361141
GO:0032508DNA duplex unwinding3.30e-021.00e+004.9021442
GO:0010212response to ionizing radiation3.37e-021.00e+004.8681143
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process3.45e-021.00e+004.8351344
GO:0048146positive regulation of fibroblast proliferation3.45e-021.00e+004.8351244
GO:0021762substantia nigra development3.60e-021.00e+004.7701146
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity3.68e-021.00e+004.7391347
GO:0035690cellular response to drug3.91e-021.00e+004.6501250
GO:0040008regulation of growth3.99e-021.00e+004.6221351
GO:0060041retina development in camera-type eye4.14e-021.00e+004.5661353
GO:0000226microtubule cytoskeleton organization4.29e-021.00e+004.5131355
GO:0000932cytoplasmic mRNA processing body4.37e-021.00e+004.4871356
GO:0043066negative regulation of apoptotic process4.52e-021.00e+002.536230433
GO:0045216cell-cell junction organization4.60e-021.00e+004.4111259
GO:0044822poly(A) RNA binding4.99e-021.00e+001.8053501078
GO:0006310DNA recombination5.21e-021.00e+004.2281467
GO:0050790regulation of catalytic activity5.36e-021.00e+004.1851369
GO:0055114oxidation-reduction process5.45e-021.00e+002.384211481
GO:0042393histone binding5.51e-021.00e+004.1441371
GO:0034329cell junction assembly5.51e-021.00e+004.1441171
GO:0042802identical protein binding5.66e-021.00e+002.354218491
GO:0032355response to estradiol5.66e-021.00e+004.1041573
GO:0043086negative regulation of catalytic activity5.74e-021.00e+004.0851274
GO:0007265Ras protein signal transduction5.81e-021.00e+004.0651375
GO:0008584male gonad development5.96e-021.00e+004.0271277
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis5.96e-021.00e+004.0271577
GO:0071013catalytic step 2 spliceosome6.12e-021.00e+003.9901779
GO:0007565female pregnancy6.19e-021.00e+003.9721280
GO:0019083viral transcription6.27e-021.00e+003.9541881
GO:0001889liver development6.34e-021.00e+003.9361382
GO:0005681spliceosomal complex6.42e-021.00e+003.9191383
GO:0006415translational termination6.71e-021.00e+003.8511887
GO:0016605PML body7.09e-021.00e+003.7701592
GO:0006928cellular component movement7.09e-021.00e+003.7701792
GO:0006414translational elongation7.16e-021.00e+003.75511193
GO:0001649osteoblast differentiation7.31e-021.00e+003.7241695
GO:0006915apoptotic process7.39e-021.00e+002.137234571
GO:0006614SRP-dependent cotranslational protein targeting to membrane7.98e-021.00e+003.59418104
GO:0014069postsynaptic density8.12e-021.00e+003.56611106
GO:0005815microtubule organizing center8.42e-021.00e+003.51314110
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay8.71e-021.00e+003.461110114
GO:0019058viral life cycle8.79e-021.00e+003.449110115
GO:0072562blood microparticle8.86e-021.00e+003.43614116
GO:0005635nuclear envelope8.86e-021.00e+003.43616116
GO:0043524negative regulation of neuron apoptotic process9.08e-021.00e+003.39912119
GO:0006511ubiquitin-dependent protein catabolic process9.66e-021.00e+003.30515127
GO:0006413translational initiation9.95e-021.00e+003.261112131
GO:0009615response to virus1.00e-011.00e+003.25016132
GO:0003735structural constituent of ribosome1.07e-011.00e+003.15418141
GO:0007507heart development1.07e-011.00e+003.15415141
GO:0016887ATPase activity1.09e-011.00e+003.12417144
GO:0061024membrane organization1.10e-011.00e+003.10415146
GO:0006457protein folding1.12e-011.00e+003.07518149
GO:0046777protein autophosphorylation1.19e-011.00e+002.99013158
GO:0000398mRNA splicing, via spliceosome1.24e-011.00e+002.928112165
GO:0030424axon1.29e-011.00e+002.86813172
GO:0004672protein kinase activity1.33e-011.00e+002.81812178
GO:0031625ubiquitin protein ligase binding1.34e-011.00e+002.802113180
GO:0043687post-translational protein modification1.35e-011.00e+002.79414181
GO:0003924GTPase activity1.50e-011.00e+002.62919203
GO:0006184GTP catabolic process1.62e-011.00e+002.51319220
GO:0008380RNA splicing1.70e-011.00e+002.436113232
GO:0006412translation1.72e-011.00e+002.417115235
GO:0006281DNA repair1.91e-011.00e+002.250122264
GO:0000166nucleotide binding1.96e-011.00e+002.20716272
GO:0005975carbohydrate metabolic process1.98e-011.00e+002.19615274
GO:0006357regulation of transcription from RNA polymerase II promoter1.98e-011.00e+002.19116275
GO:0007283spermatogenesis1.99e-011.00e+002.18516276
GO:0019899enzyme binding2.07e-011.00e+002.124111288
GO:0005856cytoskeleton2.21e-011.00e+002.01318311
GO:0007411axon guidance2.31e-011.00e+001.94119327
GO:0005525GTP binding2.32e-011.00e+001.936111328
GO:0043231intracellular membrane-bounded organelle2.35e-011.00e+001.91918332
GO:0005813centrosome2.39e-011.00e+001.889112339
GO:0003723RNA binding2.49e-011.00e+001.822119355
GO:0005925focal adhesion2.58e-011.00e+001.763118370
GO:0007155cell adhesion2.66e-011.00e+001.70918384
GO:0045892negative regulation of transcription, DNA-templated2.90e-011.00e+001.566114424
GO:0007596blood coagulation3.13e-011.00e+001.436114464
GO:0045893positive regulation of transcription, DNA-templated3.26e-011.00e+001.366117487
GO:0048471perinuclear region of cytoplasm3.45e-011.00e+001.263112523
GO:0005783endoplasmic reticulum3.91e-011.00e+001.04119610
GO:0005730nucleolus3.94e-011.00e+000.5762701684
GO:0045087innate immune response3.94e-011.00e+001.027120616
GO:0005794Golgi apparatus4.11e-011.00e+000.950114650
GO:0045944positive regulation of transcription from RNA polymerase II promoter4.85e-011.00e+000.630119811
GO:0005615extracellular space5.64e-011.00e+000.3141171010
GO:0008270zinc ion binding5.85e-011.00e+000.2351121067
GO:0003677DNA binding6.75e-011.00e+00-0.1061261351
GO:0006351transcription, DNA-templated7.35e-011.00e+00-0.3361251585
GO:0005886plasma membrane9.16e-011.00e+00-1.1751382834