meta-int-snw-2771

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
reg-snw-56655 wolf-screen-ratio-mammosphere-adherent 0.828 9.29e-07 2.91e-03 5.53e-03 8 7
int-snw-2771 wolf-screen-ratio-mammosphere-adherent 1.057 1.36e-20 1.28e-04 4.17e-03 8 8
wolf-screen-ratio-mammosphere-adherent-meta-int-snw-2771 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 961.2501.15176Yes-
PSMD1 5707 860.8360.830118Yes-
PSMA2 5683 1121.0931.106108Yes-
RBX1 9978 1151.1850.934148Yes-
PSMB7 5695 1180.9820.93490Yes-
PSMB2 5690 1160.8770.956169Yes-
PSMD11 5717 1241.0951.106218Yes-
VARS 7407 860.5491.002204Yes-
ACTB 60 1341.1531.151610Yes-
GNAI2 2771 10-0.5161.05798-Yes
POLE4 56655 630.1770.82856--
PSMB3 5691 640.6680.90119Yes-
RPSA 3921 1201.3271.151152Yes-

Interactions (31)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PSMB2 5690 POLE4 56655 pd < reg.ITFP.txt: no annot
PSMA2 5683 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 VARS 7407 pp -- int.I2D: IntAct_Yeast
PSMD1 5707 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMB7 5695 RBX1 9978 pd < reg.ITFP.txt: no annot
VARS 7407 POLE4 56655 pd <> reg.ITFP.txt: no annot
PSMA2 5683 PSMB3 5691 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, INTEROLOG, Krogan_Core, MINT_Yeast, YeastHigh, Yu_GoldStd
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 POLE4 56655 pd < reg.ITFP.txt: no annot
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 POLE4 56655 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct
ACTB 60 GNAI2 2771 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMB3 5691 PSMB7 5695 pp -- int.Intact: MI:0915(physical association);
int.I2D: BCI, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Yeast, YeastHigh, HPRD, Krogan_Core, MINT_Yeast, MIPS;
int.HPRD: yeast 2-hybrid
PSMB7 5695 PSMD1 5707 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
PSMB2 5690 PSMB3 5691 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, INTEROLOG, MINT, Yu_GoldStd, BCI, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMB3 5691 POLE4 56655 pd < reg.ITFP.txt: no annot
GNAI2 2771 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
PSMB2 5690 PSMD11 5717 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMB2 5690 VARS 7407 pd < reg.ITFP.txt: no annot
PSMB3 5691 PSMD11 5717 pp -- int.I2D: YeastLow
PSMB2 5690 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMB2 5690 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core

Related GO terms (199)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0006521regulation of cellular amino acid metabolic process1.02e-121.67e-087.23562150
GO:0000502proteasome complex2.60e-124.24e-087.02162258
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.29e-128.63e-086.85762465
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest5.29e-128.63e-086.85762265
GO:0000082G1/S transition of mitotic cell cycle7.88e-121.29e-075.873733150
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle8.38e-121.37e-076.75062470
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent1.09e-111.77e-076.68962373
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.18e-111.93e-076.67062474
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I1.51e-112.47e-076.61262377
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.77e-112.89e-076.57562579
GO:0002474antigen processing and presentation of peptide antigen via MHC class I5.16e-118.42e-076.32462394
GO:0016071mRNA metabolic process1.30e-102.11e-065.300734223
GO:0000209protein polyubiquitination1.86e-103.04e-066.021621116
GO:0016070RNA metabolic process2.65e-104.33e-065.153734247
GO:0005839proteasome core complex7.36e-101.20e-058.12441118
GO:0042981regulation of apoptotic process9.23e-101.51e-055.641626151
GO:0004298threonine-type endopeptidase activity1.16e-091.90e-057.97241120
GO:0016032viral process1.52e-092.48e-054.217855540
GO:0034641cellular nitrogen compound metabolic process2.41e-093.93e-055.411625177
GO:0000278mitotic cell cycle7.36e-091.20e-044.465752398
GO:0010467gene expression8.20e-091.34e-043.908858669
GO:0005654nucleoplasm1.49e-082.43e-043.3679831095
GO:0005829cytosol8.02e-081.31e-032.430111252562
GO:0043066negative regulation of apoptotic process4.94e-078.06e-034.121630433
GO:0006915apoptotic process2.49e-064.06e-023.722634571
GO:0070062extracellular vesicular exosome1.92e-053.13e-012.1679982516
GO:0005838proteasome regulatory particle3.85e-056.28e-017.7092712
GO:0022624proteasome accessory complex7.91e-051.00e+007.2072917
GO:0044281small molecule metabolic process2.60e-041.00e+002.5406571295
GO:0005515protein binding6.98e-041.00e+001.172111726127
GO:0016020membrane1.31e-031.00e+002.1096801746
GO:0004832valine-tRNA ligase activity1.59e-031.00e+009.294112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.59e-031.00e+009.294112
GO:0005055laminin receptor activity1.59e-031.00e+009.294112
GO:0006407rRNA export from nucleus1.59e-031.00e+009.294112
GO:0006438valyl-tRNA aminoacylation1.59e-031.00e+009.294112
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.18e-031.00e+008.294114
GO:003068690S preribosome3.18e-031.00e+008.294114
GO:0031467Cul7-RING ubiquitin ligase complex3.18e-031.00e+008.294114
GO:0019788NEDD8 ligase activity3.18e-031.00e+008.294114
GO:0050805negative regulation of synaptic transmission3.18e-031.00e+008.294114
GO:0005634nucleus3.61e-031.00e+001.22791314828
GO:0031465Cul4B-RING E3 ubiquitin ligase complex3.98e-031.00e+007.972125
GO:0031461cullin-RING ubiquitin ligase complex3.98e-031.00e+007.972115
GO:0043248proteasome assembly3.98e-031.00e+007.972115
GO:0030891VCB complex3.98e-031.00e+007.972125
GO:0000730DNA recombinase assembly3.98e-031.00e+007.972135
GO:2000001regulation of DNA damage checkpoint3.98e-031.00e+007.972115
GO:0008622epsilon DNA polymerase complex3.98e-031.00e+007.972115
GO:0030957Tat protein binding4.77e-031.00e+007.709146
GO:0031466Cul5-RING ubiquitin ligase complex4.77e-031.00e+007.709116
GO:0000028ribosomal small subunit assembly5.56e-031.00e+007.487117
GO:0002161aminoacyl-tRNA editing activity5.56e-031.00e+007.487127
GO:0031462Cul2-RING ubiquitin ligase complex5.56e-031.00e+007.487127
GO:0019773proteasome core complex, alpha-subunit complex6.36e-031.00e+007.294158
GO:0031464Cul4A-RING E3 ubiquitin ligase complex6.36e-031.00e+007.294128
GO:0070688MLL5-L complex6.36e-031.00e+007.294118
GO:0045116protein neddylation6.36e-031.00e+007.294128
GO:0001973adenosine receptor signaling pathway7.15e-031.00e+007.124119
GO:0006450regulation of translational fidelity7.94e-031.00e+006.9721210
GO:0031625ubiquitin protein ligase binding8.71e-031.00e+003.802213180
GO:0010569regulation of double-strand break repair via homologous recombination8.73e-031.00e+006.8351111
GO:0007213G-protein coupled acetylcholine receptor signaling pathway8.73e-031.00e+006.8351111
GO:0031571mitotic G1 DNA damage checkpoint8.73e-031.00e+006.8351311
GO:0005662DNA replication factor A complex1.03e-021.00e+006.5941313
GO:0030234enzyme regulator activity1.03e-021.00e+006.5941313
GO:0035267NuA4 histone acetyltransferase complex1.11e-021.00e+006.4871414
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex1.19e-021.00e+006.3871115
GO:0050998nitric-oxide synthase binding1.27e-021.00e+006.2941116
GO:0042176regulation of protein catabolic process1.27e-021.00e+006.2941316
GO:0010243response to organonitrogen compound1.35e-021.00e+006.2071217
GO:0035861site of double-strand break1.42e-021.00e+006.1241118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.50e-021.00e+006.0461119
GO:0048863stem cell differentiation1.50e-021.00e+006.0461119
GO:0006298mismatch repair1.58e-021.00e+005.9721620
GO:0007214gamma-aminobutyric acid signaling pathway1.58e-021.00e+005.9721120
GO:0007194negative regulation of adenylate cyclase activity1.66e-021.00e+005.9021121
GO:0031683G-protein beta/gamma-subunit complex binding1.66e-021.00e+005.9021121
GO:0000718nucleotide-excision repair, DNA damage removal1.66e-021.00e+005.9021521
GO:0006297nucleotide-excision repair, DNA gap filling1.74e-021.00e+005.8351522
GO:0051924regulation of calcium ion transport1.74e-021.00e+005.8351122
GO:0032201telomere maintenance via semi-conservative replication1.74e-021.00e+005.8351722
GO:0030863cortical cytoskeleton1.74e-021.00e+005.8351122
GO:0036464cytoplasmic ribonucleoprotein granule1.74e-021.00e+005.8351422
GO:0006281DNA repair1.81e-021.00e+003.250222264
GO:0043044ATP-dependent chromatin remodeling1.82e-021.00e+005.7701423
GO:0031463Cul3-RING ubiquitin ligase complex1.82e-021.00e+005.7701223
GO:0043236laminin binding1.82e-021.00e+005.7701123
GO:0006513protein monoubiquitination1.82e-021.00e+005.7701123
GO:0000722telomere maintenance via recombination2.05e-021.00e+005.5941726
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.05e-021.00e+005.5941226
GO:0043022ribosome binding2.21e-021.00e+005.4871328
GO:0031492nucleosomal DNA binding2.21e-021.00e+005.4871428
GO:0019894kinesin binding2.21e-021.00e+005.4871128
GO:0019005SCF ubiquitin ligase complex2.29e-021.00e+005.4361129
GO:0003887DNA-directed DNA polymerase activity2.29e-021.00e+005.4361329
GO:0071897DNA biosynthetic process2.29e-021.00e+005.4361229
GO:0006271DNA strand elongation involved in DNA replication2.44e-021.00e+005.3401931
GO:0005834heterotrimeric G-protein complex2.68e-021.00e+005.2071134
GO:0034332adherens junction organization2.83e-021.00e+005.1241136
GO:0001895retina homeostasis2.83e-021.00e+005.1241136
GO:0051084'de novo' posttranslational protein folding2.91e-021.00e+005.0851437
GO:0070527platelet aggregation2.99e-021.00e+005.0461238
GO:0001664G-protein coupled receptor binding2.99e-021.00e+005.0461138
GO:0022627cytosolic small ribosomal subunit3.06e-021.00e+005.0091339
GO:0006284base-excision repair3.06e-021.00e+005.0091739
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway3.14e-021.00e+004.9721140
GO:0000781chromosome, telomeric region3.14e-021.00e+004.9721240
GO:0006418tRNA aminoacylation for protein translation3.30e-021.00e+004.9021542
GO:0014070response to organic cyclic compound3.37e-021.00e+004.8681343
GO:0043966histone H3 acetylation3.53e-021.00e+004.8021245
GO:0021762substantia nigra development3.60e-021.00e+004.7701146
GO:0006283transcription-coupled nucleotide-excision repair3.60e-021.00e+004.7701846
GO:0005730nucleolus3.77e-021.00e+001.5764701684
GO:0003684damaged DNA binding3.99e-021.00e+004.62211151
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.22e-021.00e+004.5391554
GO:0000186activation of MAPKK activity4.22e-021.00e+004.5391154
GO:0000932cytoplasmic mRNA processing body4.37e-021.00e+004.4871356
GO:0000724double-strand break repair via homologous recombination4.45e-021.00e+004.4611657
GO:0000723telomere maintenance4.60e-021.00e+004.4111859
GO:0045216cell-cell junction organization4.60e-021.00e+004.4111259
GO:0006302double-strand break repair4.83e-021.00e+004.3401862
GO:0019903protein phosphatase binding4.91e-021.00e+004.3171463
GO:0007596blood coagulation5.11e-021.00e+002.436214464
GO:0006289nucleotide-excision repair5.36e-021.00e+004.18511269
GO:0003697single-stranded DNA binding5.36e-021.00e+004.1851969
GO:0034329cell junction assembly5.51e-021.00e+004.1441171
GO:0007584response to nutrient5.59e-021.00e+004.1241372
GO:0044267cellular protein metabolic process5.74e-021.00e+002.343224495
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process5.89e-021.00e+004.0461376
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis5.96e-021.00e+004.0271577
GO:0051301cell division6.27e-021.00e+003.9541681
GO:0019083viral transcription6.27e-021.00e+003.9541881
GO:0047485protein N-terminus binding6.64e-021.00e+003.8681486
GO:0006415translational termination6.71e-021.00e+003.8511887
GO:0016605PML body7.09e-021.00e+003.7701592
GO:0006928cellular component movement7.09e-021.00e+003.7701792
GO:0006414translational elongation7.16e-021.00e+003.75511193
GO:0005200structural constituent of cytoskeleton7.16e-021.00e+003.7551793
GO:0071456cellular response to hypoxia7.53e-021.00e+003.6791498
GO:0006614SRP-dependent cotranslational protein targeting to membrane7.98e-021.00e+003.59418104
GO:0014069postsynaptic density8.12e-021.00e+003.56611106
GO:0030496midbody8.35e-021.00e+003.52614109
GO:0015630microtubule cytoskeleton8.57e-021.00e+003.48715112
GO:0030529ribonucleoprotein complex8.71e-021.00e+003.46118114
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay8.71e-021.00e+003.461110114
GO:0019058viral life cycle8.79e-021.00e+003.449110115
GO:0072562blood microparticle8.86e-021.00e+003.43614116
GO:0006325chromatin organization9.37e-021.00e+003.35114123
GO:0007219Notch signaling pathway9.51e-021.00e+003.32814125
GO:0006260DNA replication9.51e-021.00e+003.328112125
GO:0006511ubiquitin-dependent protein catabolic process9.66e-021.00e+003.30515127
GO:0006413translational initiation9.95e-021.00e+003.261112131
GO:0009615response to virus1.00e-011.00e+003.25016132
GO:0000790nuclear chromatin1.01e-011.00e+003.23917133
GO:0031982vesicle1.02e-011.00e+003.228110134
GO:0003735structural constituent of ribosome1.07e-011.00e+003.15418141
GO:0061024membrane organization1.10e-011.00e+003.10415146
GO:0006457protein folding1.12e-011.00e+003.07518149
GO:0045121membrane raft1.21e-011.00e+002.96318161
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.26e-011.00e+002.90215168
GO:0030424axon1.29e-011.00e+002.86813172
GO:0007049cell cycle1.32e-011.00e+002.82613177
GO:0015629actin cytoskeleton1.36e-011.00e+002.77815183
GO:0032403protein complex binding1.38e-011.00e+002.76317185
GO:0003924GTPase activity1.50e-011.00e+002.62919203
GO:0030168platelet activation1.52e-011.00e+002.61519205
GO:0004871signal transducer activity1.59e-011.00e+002.53914216
GO:0006184GTP catabolic process1.62e-011.00e+002.51319220
GO:0006412translation1.72e-011.00e+002.417115235
GO:0004842ubiquitin-protein transferase activity1.86e-011.00e+002.29414256
GO:0005739mitochondrion2.01e-011.00e+001.2632241046
GO:0019899enzyme binding2.07e-011.00e+002.124111288
GO:0043234protein complex2.14e-011.00e+002.065117300
GO:0016567protein ubiquitination2.14e-011.00e+002.07015299
GO:0005856cytoskeleton2.21e-011.00e+002.01318311
GO:0035556intracellular signal transduction2.25e-011.00e+001.98616317
GO:0019901protein kinase binding2.27e-011.00e+001.972121320
GO:0007411axon guidance2.31e-011.00e+001.94119327
GO:0005525GTP binding2.32e-011.00e+001.936111328
GO:0008283cell proliferation2.34e-011.00e+001.923112331
GO:0005813centrosome2.39e-011.00e+001.889112339
GO:0007268synaptic transmission2.48e-011.00e+001.83012353
GO:0043565sequence-specific DNA binding2.55e-011.00e+001.78214365
GO:0007186G-protein coupled receptor signaling pathway2.56e-011.00e+001.77415367
GO:0005925focal adhesion2.58e-011.00e+001.763118370
GO:0007155cell adhesion2.66e-011.00e+001.70918384
GO:0008284positive regulation of cell proliferation2.71e-011.00e+001.67918392
GO:0046982protein heterodimerization activity2.75e-011.00e+001.654111399
GO:0005524ATP binding2.94e-011.00e+000.8912461354
GO:0005737cytoplasm3.94e-011.00e+000.3374983976
GO:0045087innate immune response3.94e-011.00e+001.027120616
GO:0005794Golgi apparatus4.11e-011.00e+000.950114650
GO:0007165signal transduction5.42e-011.00e+000.402117950
GO:0005615extracellular space5.64e-011.00e+000.3141171010
GO:0008270zinc ion binding5.85e-011.00e+000.2351121067
GO:0044822poly(A) RNA binding5.89e-011.00e+000.2201501078
GO:0005886plasma membrane6.87e-011.00e+00-0.1752382834
GO:0046872metal ion binding7.06e-011.00e+00-0.2231241465