Subnetwork | Dataset | Score | p-value 1 | p-value 2 | p-value 3 | Size | Highlighted genes |
---|---|---|---|---|---|---|---|
reg-snw-56655 | wolf-screen-ratio-mammosphere-adherent | 0.828 | 9.29e-07 | 2.91e-03 | 5.53e-03 | 8 | 7 |
int-snw-1857 | wolf-screen-ratio-mammosphere-adherent | 0.946 | 6.29e-16 | 1.96e-03 | 3.38e-02 | 14 | 13 |
Gene Symbol | Entrez Gene ID | Frequency | wolf-screen-ratio-mammosphere-adherent gene score | Best subnetwork score | Degree | wolf adherent-list Hits GI | wolf mammosphere no adherent-list Hits GI |
---|---|---|---|---|---|---|---|
PSMA2 | 5683 | 112 | 1.093 | 1.106 | 108 | Yes | - |
RBX1 | 9978 | 115 | 1.185 | 0.934 | 148 | Yes | - |
PSMB7 | 5695 | 118 | 0.982 | 0.934 | 90 | Yes | - |
PSMA1 | 5682 | 100 | 0.996 | 0.878 | 152 | Yes | - |
EIF4A1 | 1973 | 6 | 0.866 | 0.981 | 71 | Yes | - |
VARS | 7407 | 86 | 0.549 | 1.002 | 204 | Yes | - |
DVL3 | 1857 | 2 | -0.026 | 0.946 | 146 | - | - |
POLE4 | 56655 | 63 | 0.177 | 0.828 | 56 | - | - |
RPSA | 3921 | 120 | 1.327 | 1.151 | 152 | Yes | - |
PSMB3 | 5691 | 64 | 0.668 | 0.901 | 19 | Yes | - |
PGD | 5226 | 89 | 1.201 | 1.106 | 152 | Yes | - |
ACO2 | 50 | 65 | 1.000 | 1.076 | 191 | Yes | - |
PPP2R1A | 5518 | 19 | 0.644 | 0.985 | 249 | Yes | - |
RPS11 | 6205 | 62 | 0.993 | 1.113 | 175 | Yes | - |
RPL14 | 9045 | 49 | 1.250 | 1.113 | 166 | Yes | - |
PSMB2 | 5690 | 116 | 0.877 | 0.956 | 169 | Yes | - |
ACTB | 60 | 134 | 1.153 | 1.151 | 610 | Yes | - |
PSMD11 | 5717 | 124 | 1.095 | 1.106 | 218 | Yes | - |
KPNB1 | 3837 | 17 | 0.613 | 1.017 | 296 | Yes | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
PSMA1 | 5682 | PSMB2 | 5690 | pp | -- | int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid |
PPP2R1A | 5518 | PSMB3 | 5691 | pp | -- | int.I2D: IntAct_Mouse |
ACTB | 60 | KPNB1 | 3837 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
PSMA2 | 5683 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast |
PSMB2 | 5690 | POLE4 | 56655 | pd | < | reg.ITFP.txt: no annot |
PPP2R1A | 5518 | PSMA1 | 5682 | pp | -- | int.I2D: IntAct_Mouse |
PSMA2 | 5683 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
RPSA | 3921 | PSMD11 | 5717 | pp | -- | int.I2D: IntAct_Yeast |
ACO2 | 50 | PSMD11 | 5717 | pp | -- | int.I2D: YeastLow |
ACTB | 60 | PSMB2 | 5690 | pp | -- | int.I2D: BioGrid_Yeast |
PSMA1 | 5682 | PSMB3 | 5691 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct, IntAct_Fly, IntAct_Mouse, IntAct_Yeast, YeastHigh, BioGrid_Yeast |
RPSA | 3921 | VARS | 7407 | pp | -- | int.I2D: IntAct_Yeast |
ACTB | 60 | RBX1 | 9978 | pp | -- | int.I2D: BioGrid_Yeast |
PSMA1 | 5682 | PSMA2 | 5683 | pp | -- | int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid |
ACTB | 60 | RPSA | 3921 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct |
DVL3 | 1857 | EIF4A1 | 1973 | pp | -- | int.I2D: Jorgensen_EphR |
PSMA1 | 5682 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast |
PPP2R1A | 5518 | PSMB2 | 5690 | pp | -- | int.I2D: IntAct_Mouse |
ACTB | 60 | PPP2R1A | 5518 | pp | -- | int.I2D: BioGrid_Yeast |
ACTB | 60 | PSMA1 | 5682 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB7 | 5695 | RBX1 | 9978 | pd | < | reg.ITFP.txt: no annot |
PGD | 5226 | PSMD11 | 5717 | pp | -- | int.I2D: YeastLow |
VARS | 7407 | POLE4 | 56655 | pd | <> | reg.ITFP.txt: no annot |
PSMA2 | 5683 | PSMB3 | 5691 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, INTEROLOG, Krogan_Core, MINT_Yeast, YeastHigh, Yu_GoldStd |
PPP2R1A | 5518 | PSMB7 | 5695 | pp | -- | int.I2D: IntAct_Mouse |
EIF4A1 | 1973 | PPP2R1A | 5518 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
PSMB7 | 5695 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
KPNB1 | 3837 | PSMA2 | 5683 | pp | -- | int.I2D: Krogan_NonCore, YeastLow |
PSMA2 | 5683 | POLE4 | 56655 | pd | < | reg.ITFP.txt: no annot |
ACTB | 60 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB7 | 5695 | POLE4 | 56655 | pd | < | reg.ITFP.txt: no annot |
PSMB2 | 5690 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct |
ACO2 | 50 | KPNB1 | 3837 | pp | -- | int.I2D: IntAct_Yeast |
DVL3 | 1857 | RPS11 | 6205 | pp | -- | int.I2D: Jorgensen_EphR |
PSMB3 | 5691 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: BCI, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Yeast, YeastHigh, HPRD, Krogan_Core, MINT_Yeast, MIPS; int.HPRD: yeast 2-hybrid |
RPS11 | 6205 | RPL14 | 9045 | pp | -- | int.I2D: BioGrid_Yeast |
PGD | 5226 | PPP2R1A | 5518 | pp | -- | int.I2D: YeastLow |
ACTB | 60 | PSMB7 | 5695 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB2 | 5690 | PSMB3 | 5691 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct, INTEROLOG, MINT, Yu_GoldStd, BCI, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid |
KPNB1 | 3837 | PSMA1 | 5682 | pp | -- | int.I2D: YeastLow |
ACO2 | 50 | PGD | 5226 | pp | -- | int.I2D: YeastLow |
PSMB3 | 5691 | POLE4 | 56655 | pd | < | reg.ITFP.txt: no annot |
DVL3 | 1857 | KPNB1 | 3837 | pp | -- | int.I2D: Jorgensen_EphR |
PPP2R1A | 5518 | PSMA2 | 5683 | pp | -- | int.I2D: IntAct_Mouse |
PSMA1 | 5682 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
DVL3 | 1857 | PPP2R1A | 5518 | pp | -- | int.I2D: Jorgensen_EphR |
PSMB2 | 5690 | PSMD11 | 5717 | pd | < | reg.ITFP.txt: no annot |
PSMB2 | 5690 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
PSMB2 | 5690 | VARS | 7407 | pd | < | reg.ITFP.txt: no annot |
PSMB3 | 5691 | PSMD11 | 5717 | pp | -- | int.I2D: YeastLow |
KPNB1 | 3837 | PSMD11 | 5717 | pp | -- | int.I2D: Krogan_NonCore |
RPSA | 3921 | RPS11 | 6205 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast |
PSMA2 | 5683 | PSMB2 | 5690 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0016071 | mRNA metabolic process | 1.66e-16 | 2.71e-12 | 5.405 | 11 | 34 | 223 |
GO:0016070 | RNA metabolic process | 5.19e-16 | 8.46e-12 | 5.258 | 11 | 34 | 247 |
GO:0016032 | viral process | 6.23e-14 | 1.02e-09 | 4.255 | 12 | 55 | 540 |
GO:0010467 | gene expression | 7.91e-13 | 1.29e-08 | 3.946 | 12 | 58 | 669 |
GO:0005839 | proteasome core complex | 1.02e-11 | 1.67e-07 | 7.899 | 5 | 11 | 18 |
GO:0006521 | regulation of cellular amino acid metabolic process | 1.60e-11 | 2.60e-07 | 6.688 | 6 | 21 | 50 |
GO:0004298 | threonine-type endopeptidase activity | 1.85e-11 | 3.02e-07 | 7.747 | 5 | 11 | 20 |
GO:0000502 | proteasome complex | 4.04e-11 | 6.60e-07 | 6.473 | 6 | 22 | 58 |
GO:0005829 | cytosol | 7.86e-11 | 1.28e-06 | 2.423 | 16 | 125 | 2562 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 8.21e-11 | 1.34e-06 | 6.309 | 6 | 24 | 65 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 8.21e-11 | 1.34e-06 | 6.309 | 6 | 22 | 65 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.30e-10 | 2.12e-06 | 6.202 | 6 | 24 | 70 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 1.68e-10 | 2.75e-06 | 6.142 | 6 | 23 | 73 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.83e-10 | 2.99e-06 | 6.122 | 6 | 24 | 74 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 2.34e-10 | 3.81e-06 | 6.065 | 6 | 23 | 77 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 2.74e-10 | 4.46e-06 | 6.028 | 6 | 25 | 79 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 7.93e-10 | 1.29e-05 | 5.777 | 6 | 23 | 94 |
GO:0000209 | protein polyubiquitination | 2.85e-09 | 4.65e-05 | 5.473 | 6 | 21 | 116 |
GO:0000082 | G1/S transition of mitotic cell cycle | 1.34e-08 | 2.19e-04 | 5.103 | 6 | 33 | 150 |
GO:0042981 | regulation of apoptotic process | 1.39e-08 | 2.28e-04 | 5.093 | 6 | 26 | 151 |
GO:0070062 | extracellular vesicular exosome | 2.23e-08 | 3.64e-04 | 2.257 | 14 | 98 | 2516 |
GO:0034641 | cellular nitrogen compound metabolic process | 3.61e-08 | 5.89e-04 | 4.864 | 6 | 25 | 177 |
GO:0006915 | apoptotic process | 1.15e-07 | 1.88e-03 | 3.589 | 8 | 34 | 571 |
GO:0000278 | mitotic cell cycle | 1.90e-07 | 3.11e-03 | 3.917 | 7 | 52 | 398 |
GO:0005654 | nucleoplasm | 1.33e-06 | 2.17e-02 | 2.820 | 9 | 83 | 1095 |
GO:0044281 | small molecule metabolic process | 5.39e-06 | 8.80e-02 | 2.578 | 9 | 57 | 1295 |
GO:0043066 | negative regulation of apoptotic process | 6.81e-06 | 1.11e-01 | 3.573 | 6 | 30 | 433 |
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 8.07e-06 | 1.32e-01 | 4.914 | 4 | 10 | 114 |
GO:0019058 | viral life cycle | 8.36e-06 | 1.36e-01 | 4.901 | 4 | 10 | 115 |
GO:0006413 | translational initiation | 1.40e-05 | 2.28e-01 | 4.713 | 4 | 12 | 131 |
GO:0019773 | proteasome core complex, alpha-subunit complex | 3.58e-05 | 5.84e-01 | 7.747 | 2 | 5 | 8 |
GO:0005515 | protein binding | 4.05e-05 | 6.61e-01 | 1.166 | 16 | 172 | 6127 |
GO:0016020 | membrane | 6.11e-05 | 9.97e-01 | 2.147 | 9 | 80 | 1746 |
GO:0019083 | viral transcription | 1.08e-04 | 1.00e+00 | 4.992 | 3 | 8 | 81 |
GO:0006415 | translational termination | 1.33e-04 | 1.00e+00 | 4.889 | 3 | 8 | 87 |
GO:0006412 | translation | 1.37e-04 | 1.00e+00 | 3.870 | 4 | 15 | 235 |
GO:0006414 | translational elongation | 1.62e-04 | 1.00e+00 | 4.792 | 3 | 11 | 93 |
GO:0044267 | cellular protein metabolic process | 2.06e-04 | 1.00e+00 | 3.117 | 5 | 24 | 495 |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 2.26e-04 | 1.00e+00 | 4.631 | 3 | 8 | 104 |
GO:0003735 | structural constituent of ribosome | 5.53e-04 | 1.00e+00 | 4.192 | 3 | 8 | 141 |
GO:0022627 | cytosolic small ribosomal subunit | 9.27e-04 | 1.00e+00 | 5.461 | 2 | 3 | 39 |
GO:0070262 | peptidyl-serine dephosphorylation | 1.16e-03 | 1.00e+00 | 9.747 | 1 | 1 | 1 |
GO:0019521 | D-gluconate metabolic process | 1.16e-03 | 1.00e+00 | 9.747 | 1 | 1 | 1 |
GO:0004832 | valine-tRNA ligase activity | 2.33e-03 | 1.00e+00 | 8.747 | 1 | 1 | 2 |
GO:0051538 | 3 iron, 4 sulfur cluster binding | 2.33e-03 | 1.00e+00 | 8.747 | 1 | 1 | 2 |
GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 2.33e-03 | 1.00e+00 | 8.747 | 1 | 1 | 2 |
GO:0019322 | pentose biosynthetic process | 2.33e-03 | 1.00e+00 | 8.747 | 1 | 1 | 2 |
GO:0003994 | aconitate hydratase activity | 2.33e-03 | 1.00e+00 | 8.747 | 1 | 1 | 2 |
GO:0005055 | laminin receptor activity | 2.33e-03 | 1.00e+00 | 8.747 | 1 | 1 | 2 |
GO:0006407 | rRNA export from nucleus | 2.33e-03 | 1.00e+00 | 8.747 | 1 | 1 | 2 |
GO:0006438 | valyl-tRNA aminoacylation | 2.33e-03 | 1.00e+00 | 8.747 | 1 | 1 | 2 |
GO:0005634 | nucleus | 2.46e-03 | 1.00e+00 | 1.094 | 12 | 131 | 4828 |
GO:0009051 | pentose-phosphate shunt, oxidative branch | 3.49e-03 | 1.00e+00 | 8.162 | 1 | 1 | 3 |
GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity | 3.49e-03 | 1.00e+00 | 8.162 | 1 | 1 | 3 |
GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 4.65e-03 | 1.00e+00 | 7.747 | 1 | 1 | 4 |
GO:0030686 | 90S preribosome | 4.65e-03 | 1.00e+00 | 7.747 | 1 | 1 | 4 |
GO:0031467 | Cul7-RING ubiquitin ligase complex | 4.65e-03 | 1.00e+00 | 7.747 | 1 | 1 | 4 |
GO:0019788 | NEDD8 ligase activity | 4.65e-03 | 1.00e+00 | 7.747 | 1 | 1 | 4 |
GO:0006610 | ribosomal protein import into nucleus | 4.65e-03 | 1.00e+00 | 7.747 | 1 | 1 | 4 |
GO:0071782 | endoplasmic reticulum tubular network | 4.65e-03 | 1.00e+00 | 7.747 | 1 | 1 | 4 |
GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex | 5.81e-03 | 1.00e+00 | 7.425 | 1 | 2 | 5 |
GO:0031461 | cullin-RING ubiquitin ligase complex | 5.81e-03 | 1.00e+00 | 7.425 | 1 | 1 | 5 |
GO:0019932 | second-messenger-mediated signaling | 5.81e-03 | 1.00e+00 | 7.425 | 1 | 1 | 5 |
GO:0043248 | proteasome assembly | 5.81e-03 | 1.00e+00 | 7.425 | 1 | 1 | 5 |
GO:0042518 | negative regulation of tyrosine phosphorylation of Stat3 protein | 5.81e-03 | 1.00e+00 | 7.425 | 1 | 1 | 5 |
GO:0006102 | isocitrate metabolic process | 5.81e-03 | 1.00e+00 | 7.425 | 1 | 1 | 5 |
GO:0030891 | VCB complex | 5.81e-03 | 1.00e+00 | 7.425 | 1 | 2 | 5 |
GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade | 5.81e-03 | 1.00e+00 | 7.425 | 1 | 1 | 5 |
GO:0035567 | non-canonical Wnt signaling pathway | 5.81e-03 | 1.00e+00 | 7.425 | 1 | 1 | 5 |
GO:0008622 | epsilon DNA polymerase complex | 5.81e-03 | 1.00e+00 | 7.425 | 1 | 1 | 5 |
GO:0060026 | convergent extension | 5.81e-03 | 1.00e+00 | 7.425 | 1 | 1 | 5 |
GO:0044822 | poly(A) RNA binding | 6.64e-03 | 1.00e+00 | 1.994 | 5 | 50 | 1078 |
GO:0030957 | Tat protein binding | 6.97e-03 | 1.00e+00 | 7.162 | 1 | 4 | 6 |
GO:0006101 | citrate metabolic process | 6.97e-03 | 1.00e+00 | 7.162 | 1 | 1 | 6 |
GO:0031466 | Cul5-RING ubiquitin ligase complex | 6.97e-03 | 1.00e+00 | 7.162 | 1 | 1 | 6 |
GO:0015630 | microtubule cytoskeleton | 7.40e-03 | 1.00e+00 | 3.939 | 2 | 5 | 112 |
GO:0000028 | ribosomal small subunit assembly | 8.12e-03 | 1.00e+00 | 6.939 | 1 | 1 | 7 |
GO:0002161 | aminoacyl-tRNA editing activity | 8.12e-03 | 1.00e+00 | 6.939 | 1 | 2 | 7 |
GO:0031462 | Cul2-RING ubiquitin ligase complex | 8.12e-03 | 1.00e+00 | 6.939 | 1 | 2 | 7 |
GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex | 9.28e-03 | 1.00e+00 | 6.747 | 1 | 2 | 8 |
GO:0000339 | RNA cap binding | 9.28e-03 | 1.00e+00 | 6.747 | 1 | 1 | 8 |
GO:0070688 | MLL5-L complex | 9.28e-03 | 1.00e+00 | 6.747 | 1 | 1 | 8 |
GO:0045116 | protein neddylation | 9.28e-03 | 1.00e+00 | 6.747 | 1 | 2 | 8 |
GO:0008139 | nuclear localization sequence binding | 1.04e-02 | 1.00e+00 | 6.577 | 1 | 2 | 9 |
GO:0016281 | eukaryotic translation initiation factor 4F complex | 1.04e-02 | 1.00e+00 | 6.577 | 1 | 1 | 9 |
GO:0046982 | protein heterodimerization activity | 1.05e-02 | 1.00e+00 | 2.691 | 3 | 11 | 399 |
GO:0006450 | regulation of translational fidelity | 1.16e-02 | 1.00e+00 | 6.425 | 1 | 2 | 10 |
GO:0007084 | mitotic nuclear envelope reassembly | 1.16e-02 | 1.00e+00 | 6.425 | 1 | 1 | 10 |
GO:0006098 | pentose-phosphate shunt | 1.27e-02 | 1.00e+00 | 6.287 | 1 | 3 | 11 |
GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 1.27e-02 | 1.00e+00 | 6.287 | 1 | 2 | 11 |
GO:0006275 | regulation of DNA replication | 1.39e-02 | 1.00e+00 | 6.162 | 1 | 2 | 12 |
GO:0030111 | regulation of Wnt signaling pathway | 1.39e-02 | 1.00e+00 | 6.162 | 1 | 1 | 12 |
GO:0005838 | proteasome regulatory particle | 1.39e-02 | 1.00e+00 | 6.162 | 1 | 7 | 12 |
GO:0042273 | ribosomal large subunit biogenesis | 1.50e-02 | 1.00e+00 | 6.046 | 1 | 4 | 13 |
GO:0090179 | planar cell polarity pathway involved in neural tube closure | 1.50e-02 | 1.00e+00 | 6.046 | 1 | 1 | 13 |
GO:0035267 | NuA4 histone acetyltransferase complex | 1.62e-02 | 1.00e+00 | 5.939 | 1 | 4 | 14 |
GO:0003148 | outflow tract septum morphogenesis | 1.62e-02 | 1.00e+00 | 5.939 | 1 | 1 | 14 |
GO:0006607 | NLS-bearing protein import into nucleus | 1.62e-02 | 1.00e+00 | 5.939 | 1 | 2 | 14 |
GO:0006672 | ceramide metabolic process | 1.73e-02 | 1.00e+00 | 5.840 | 1 | 1 | 15 |
GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | 1.73e-02 | 1.00e+00 | 5.840 | 1 | 1 | 15 |
GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | 1.73e-02 | 1.00e+00 | 5.840 | 1 | 2 | 15 |
GO:0050998 | nitric-oxide synthase binding | 1.85e-02 | 1.00e+00 | 5.747 | 1 | 1 | 16 |
GO:0075733 | intracellular transport of virus | 1.96e-02 | 1.00e+00 | 5.659 | 1 | 2 | 17 |
GO:0010243 | response to organonitrogen compound | 1.96e-02 | 1.00e+00 | 5.659 | 1 | 2 | 17 |
GO:0006309 | apoptotic DNA fragmentation | 1.96e-02 | 1.00e+00 | 5.659 | 1 | 1 | 17 |
GO:0022624 | proteasome accessory complex | 1.96e-02 | 1.00e+00 | 5.659 | 1 | 9 | 17 |
GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 2.19e-02 | 1.00e+00 | 5.499 | 1 | 1 | 19 |
GO:0048863 | stem cell differentiation | 2.19e-02 | 1.00e+00 | 5.499 | 1 | 1 | 19 |
GO:0008601 | protein phosphatase type 2A regulator activity | 2.30e-02 | 1.00e+00 | 5.425 | 1 | 3 | 20 |
GO:0000159 | protein phosphatase type 2A complex | 2.30e-02 | 1.00e+00 | 5.425 | 1 | 2 | 20 |
GO:0090103 | cochlea morphogenesis | 2.42e-02 | 1.00e+00 | 5.354 | 1 | 2 | 21 |
GO:0045595 | regulation of cell differentiation | 2.42e-02 | 1.00e+00 | 5.354 | 1 | 1 | 21 |
GO:0030863 | cortical cytoskeleton | 2.53e-02 | 1.00e+00 | 5.287 | 1 | 1 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 2.53e-02 | 1.00e+00 | 5.287 | 1 | 4 | 22 |
GO:0043044 | ATP-dependent chromatin remodeling | 2.65e-02 | 1.00e+00 | 5.223 | 1 | 4 | 23 |
GO:0031463 | Cul3-RING ubiquitin ligase complex | 2.65e-02 | 1.00e+00 | 5.223 | 1 | 2 | 23 |
GO:0043236 | laminin binding | 2.65e-02 | 1.00e+00 | 5.223 | 1 | 1 | 23 |
GO:0006513 | protein monoubiquitination | 2.65e-02 | 1.00e+00 | 5.223 | 1 | 1 | 23 |
GO:0008135 | translation factor activity, nucleic acid binding | 2.76e-02 | 1.00e+00 | 5.162 | 1 | 4 | 24 |
GO:0000060 | protein import into nucleus, translocation | 2.76e-02 | 1.00e+00 | 5.162 | 1 | 4 | 24 |
GO:0008536 | Ran GTPase binding | 2.87e-02 | 1.00e+00 | 5.103 | 1 | 2 | 25 |
GO:0005844 | polysome | 2.87e-02 | 1.00e+00 | 5.103 | 1 | 4 | 25 |
GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening | 2.87e-02 | 1.00e+00 | 5.103 | 1 | 1 | 25 |
GO:0019221 | cytokine-mediated signaling pathway | 2.89e-02 | 1.00e+00 | 2.901 | 2 | 3 | 230 |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 2.99e-02 | 1.00e+00 | 5.046 | 1 | 2 | 26 |
GO:0005739 | mitochondrion | 3.00e-02 | 1.00e+00 | 1.716 | 4 | 24 | 1046 |
GO:0019843 | rRNA binding | 3.10e-02 | 1.00e+00 | 4.992 | 1 | 3 | 27 |
GO:0000188 | inactivation of MAPK activity | 3.10e-02 | 1.00e+00 | 4.992 | 1 | 1 | 27 |
GO:0003823 | antigen binding | 3.21e-02 | 1.00e+00 | 4.939 | 1 | 1 | 28 |
GO:0010033 | response to organic substance | 3.21e-02 | 1.00e+00 | 4.939 | 1 | 2 | 28 |
GO:0043022 | ribosome binding | 3.21e-02 | 1.00e+00 | 4.939 | 1 | 3 | 28 |
GO:0043507 | positive regulation of JUN kinase activity | 3.21e-02 | 1.00e+00 | 4.939 | 1 | 2 | 28 |
GO:0031492 | nucleosomal DNA binding | 3.21e-02 | 1.00e+00 | 4.939 | 1 | 4 | 28 |
GO:0019894 | kinesin binding | 3.21e-02 | 1.00e+00 | 4.939 | 1 | 1 | 28 |
GO:0006099 | tricarboxylic acid cycle | 3.32e-02 | 1.00e+00 | 4.889 | 1 | 3 | 29 |
GO:0019005 | SCF ubiquitin ligase complex | 3.32e-02 | 1.00e+00 | 4.889 | 1 | 1 | 29 |
GO:0003887 | DNA-directed DNA polymerase activity | 3.32e-02 | 1.00e+00 | 4.889 | 1 | 3 | 29 |
GO:0071897 | DNA biosynthetic process | 3.32e-02 | 1.00e+00 | 4.889 | 1 | 2 | 29 |
GO:0006606 | protein import into nucleus | 3.44e-02 | 1.00e+00 | 4.840 | 1 | 1 | 30 |
GO:0005109 | frizzled binding | 3.66e-02 | 1.00e+00 | 4.747 | 1 | 1 | 32 |
GO:0050661 | NADP binding | 3.66e-02 | 1.00e+00 | 4.747 | 1 | 1 | 32 |
GO:0034332 | adherens junction organization | 4.11e-02 | 1.00e+00 | 4.577 | 1 | 1 | 36 |
GO:0001895 | retina homeostasis | 4.11e-02 | 1.00e+00 | 4.577 | 1 | 1 | 36 |
GO:0051084 | 'de novo' posttranslational protein folding | 4.22e-02 | 1.00e+00 | 4.537 | 1 | 4 | 37 |
GO:0051539 | 4 iron, 4 sulfur cluster binding | 4.22e-02 | 1.00e+00 | 4.537 | 1 | 3 | 37 |
GO:0070527 | platelet aggregation | 4.33e-02 | 1.00e+00 | 4.499 | 1 | 2 | 38 |
GO:0008026 | ATP-dependent helicase activity | 4.45e-02 | 1.00e+00 | 4.461 | 1 | 3 | 39 |
GO:0006418 | tRNA aminoacylation for protein translation | 4.78e-02 | 1.00e+00 | 4.354 | 1 | 5 | 42 |
GO:0004722 | protein serine/threonine phosphatase activity | 4.78e-02 | 1.00e+00 | 4.354 | 1 | 1 | 42 |
GO:0030155 | regulation of cell adhesion | 4.78e-02 | 1.00e+00 | 4.354 | 1 | 3 | 42 |
GO:0014070 | response to organic cyclic compound | 4.89e-02 | 1.00e+00 | 4.320 | 1 | 3 | 43 |
GO:0043966 | histone H3 acetylation | 5.11e-02 | 1.00e+00 | 4.255 | 1 | 2 | 45 |
GO:0021762 | substantia nigra development | 5.22e-02 | 1.00e+00 | 4.223 | 1 | 1 | 46 |
GO:0006921 | cellular component disassembly involved in execution phase of apoptosis | 5.33e-02 | 1.00e+00 | 4.192 | 1 | 5 | 47 |
GO:0022625 | cytosolic large ribosomal subunit | 5.56e-02 | 1.00e+00 | 4.132 | 1 | 5 | 49 |
GO:0003743 | translation initiation factor activity | 5.56e-02 | 1.00e+00 | 4.132 | 1 | 4 | 49 |
GO:0031100 | organ regeneration | 5.67e-02 | 1.00e+00 | 4.103 | 1 | 4 | 50 |
GO:0006091 | generation of precursor metabolites and energy | 5.78e-02 | 1.00e+00 | 4.074 | 1 | 3 | 51 |
GO:0040008 | regulation of growth | 5.78e-02 | 1.00e+00 | 4.074 | 1 | 3 | 51 |
GO:0000775 | chromosome, centromeric region | 5.89e-02 | 1.00e+00 | 4.046 | 1 | 2 | 52 |
GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 6.00e-02 | 1.00e+00 | 4.019 | 1 | 1 | 53 |
GO:0003725 | double-stranded RNA binding | 6.11e-02 | 1.00e+00 | 3.992 | 1 | 6 | 54 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 6.11e-02 | 1.00e+00 | 3.992 | 1 | 5 | 54 |
GO:0003723 | RNA binding | 6.33e-02 | 1.00e+00 | 2.275 | 2 | 19 | 355 |
GO:0004386 | helicase activity | 6.33e-02 | 1.00e+00 | 3.939 | 1 | 4 | 56 |
GO:0000932 | cytoplasmic mRNA processing body | 6.33e-02 | 1.00e+00 | 3.939 | 1 | 3 | 56 |
GO:0008565 | protein transporter activity | 6.43e-02 | 1.00e+00 | 3.914 | 1 | 2 | 57 |
GO:0005840 | ribosome | 6.65e-02 | 1.00e+00 | 3.864 | 1 | 2 | 59 |
GO:0045216 | cell-cell junction organization | 6.65e-02 | 1.00e+00 | 3.864 | 1 | 2 | 59 |
GO:0005643 | nuclear pore | 6.65e-02 | 1.00e+00 | 3.864 | 1 | 4 | 59 |
GO:0008013 | beta-catenin binding | 6.76e-02 | 1.00e+00 | 3.840 | 1 | 4 | 60 |
GO:0005925 | focal adhesion | 6.80e-02 | 1.00e+00 | 2.215 | 2 | 18 | 370 |
GO:0007059 | chromosome segregation | 7.20e-02 | 1.00e+00 | 3.747 | 1 | 3 | 64 |
GO:0034329 | cell junction assembly | 7.95e-02 | 1.00e+00 | 3.597 | 1 | 1 | 71 |
GO:0003729 | mRNA binding | 8.17e-02 | 1.00e+00 | 3.557 | 1 | 4 | 73 |
GO:0002020 | protease binding | 8.28e-02 | 1.00e+00 | 3.537 | 1 | 4 | 74 |
GO:0060070 | canonical Wnt signaling pathway | 8.38e-02 | 1.00e+00 | 3.518 | 1 | 3 | 75 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 8.49e-02 | 1.00e+00 | 3.499 | 1 | 3 | 76 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 8.60e-02 | 1.00e+00 | 3.480 | 1 | 5 | 77 |
GO:0006928 | cellular component movement | 1.02e-01 | 1.00e+00 | 3.223 | 1 | 7 | 92 |
GO:0005200 | structural constituent of cytoskeleton | 1.03e-01 | 1.00e+00 | 3.207 | 1 | 7 | 93 |
GO:0001649 | osteoblast differentiation | 1.05e-01 | 1.00e+00 | 3.177 | 1 | 6 | 95 |
GO:0006364 | rRNA processing | 1.06e-01 | 1.00e+00 | 3.162 | 1 | 5 | 96 |
GO:0071456 | cellular response to hypoxia | 1.08e-01 | 1.00e+00 | 3.132 | 1 | 4 | 98 |
GO:0006470 | protein dephosphorylation | 1.09e-01 | 1.00e+00 | 3.117 | 1 | 1 | 99 |
GO:0014069 | postsynaptic density | 1.17e-01 | 1.00e+00 | 3.019 | 1 | 1 | 106 |
GO:0001934 | positive regulation of protein phosphorylation | 1.19e-01 | 1.00e+00 | 2.992 | 1 | 5 | 108 |
GO:0005938 | cell cortex | 1.20e-01 | 1.00e+00 | 2.978 | 1 | 3 | 109 |
GO:0006461 | protein complex assembly | 1.22e-01 | 1.00e+00 | 2.952 | 1 | 6 | 111 |
GO:0030308 | negative regulation of cell growth | 1.24e-01 | 1.00e+00 | 2.926 | 1 | 6 | 113 |
GO:0005730 | nucleolus | 1.25e-01 | 1.00e+00 | 1.029 | 4 | 70 | 1684 |
GO:0030529 | ribonucleoprotein complex | 1.25e-01 | 1.00e+00 | 2.914 | 1 | 8 | 114 |
GO:0072562 | blood microparticle | 1.27e-01 | 1.00e+00 | 2.889 | 1 | 4 | 116 |
GO:0005635 | nuclear envelope | 1.27e-01 | 1.00e+00 | 2.889 | 1 | 6 | 116 |
GO:0044237 | cellular metabolic process | 1.29e-01 | 1.00e+00 | 2.864 | 1 | 3 | 118 |
GO:0006325 | chromatin organization | 1.34e-01 | 1.00e+00 | 2.804 | 1 | 4 | 123 |
GO:0007219 | Notch signaling pathway | 1.36e-01 | 1.00e+00 | 2.781 | 1 | 4 | 125 |
GO:0005506 | iron ion binding | 1.38e-01 | 1.00e+00 | 2.758 | 1 | 3 | 127 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 1.38e-01 | 1.00e+00 | 2.758 | 1 | 5 | 127 |
GO:0009615 | response to virus | 1.43e-01 | 1.00e+00 | 2.702 | 1 | 6 | 132 |
GO:0000790 | nuclear chromatin | 1.44e-01 | 1.00e+00 | 2.691 | 1 | 7 | 133 |
GO:0000086 | G2/M transition of mitotic cell cycle | 1.48e-01 | 1.00e+00 | 2.648 | 1 | 7 | 137 |
GO:0016055 | Wnt signaling pathway | 1.52e-01 | 1.00e+00 | 2.607 | 1 | 6 | 141 |
GO:0061024 | membrane organization | 1.57e-01 | 1.00e+00 | 2.557 | 1 | 5 | 146 |
GO:0006457 | protein folding | 1.60e-01 | 1.00e+00 | 2.527 | 1 | 8 | 149 |
GO:0008543 | fibroblast growth factor receptor signaling pathway | 1.70e-01 | 1.00e+00 | 2.434 | 1 | 4 | 159 |
GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 1.79e-01 | 1.00e+00 | 2.354 | 1 | 5 | 168 |
GO:0030424 | axon | 1.82e-01 | 1.00e+00 | 2.320 | 1 | 3 | 172 |
GO:0031965 | nuclear membrane | 1.86e-01 | 1.00e+00 | 2.287 | 1 | 4 | 176 |
GO:0031625 | ubiquitin protein ligase binding | 1.90e-01 | 1.00e+00 | 2.255 | 1 | 13 | 180 |
GO:0019904 | protein domain specific binding | 1.91e-01 | 1.00e+00 | 2.247 | 1 | 6 | 181 |
GO:0015629 | actin cytoskeleton | 1.93e-01 | 1.00e+00 | 2.231 | 1 | 5 | 183 |
GO:0032403 | protein complex binding | 1.95e-01 | 1.00e+00 | 2.215 | 1 | 7 | 185 |
GO:0005524 | ATP binding | 2.05e-01 | 1.00e+00 | 0.928 | 3 | 46 | 1354 |
GO:0008380 | RNA splicing | 2.38e-01 | 1.00e+00 | 1.889 | 1 | 13 | 232 |
GO:0005759 | mitochondrial matrix | 2.39e-01 | 1.00e+00 | 1.882 | 1 | 12 | 233 |
GO:0004842 | ubiquitin-protein transferase activity | 2.60e-01 | 1.00e+00 | 1.747 | 1 | 4 | 256 |
GO:0006281 | DNA repair | 2.67e-01 | 1.00e+00 | 1.702 | 1 | 22 | 264 |
GO:0005102 | receptor binding | 2.70e-01 | 1.00e+00 | 1.680 | 1 | 5 | 268 |
GO:0005975 | carbohydrate metabolic process | 2.75e-01 | 1.00e+00 | 1.648 | 1 | 5 | 274 |
GO:0042493 | response to drug | 2.87e-01 | 1.00e+00 | 1.577 | 1 | 11 | 288 |
GO:0019899 | enzyme binding | 2.87e-01 | 1.00e+00 | 1.577 | 1 | 11 | 288 |
GO:0016567 | protein ubiquitination | 2.96e-01 | 1.00e+00 | 1.523 | 1 | 5 | 299 |
GO:0043234 | protein complex | 2.97e-01 | 1.00e+00 | 1.518 | 1 | 17 | 300 |
GO:0006200 | ATP catabolic process | 3.00e-01 | 1.00e+00 | 1.503 | 1 | 14 | 303 |
GO:0005856 | cytoskeleton | 3.06e-01 | 1.00e+00 | 1.466 | 1 | 8 | 311 |
GO:0035556 | intracellular signal transduction | 3.11e-01 | 1.00e+00 | 1.438 | 1 | 6 | 317 |
GO:0019901 | protein kinase binding | 3.14e-01 | 1.00e+00 | 1.425 | 1 | 21 | 320 |
GO:0007411 | axon guidance | 3.19e-01 | 1.00e+00 | 1.393 | 1 | 9 | 327 |
GO:0005813 | centrosome | 3.29e-01 | 1.00e+00 | 1.341 | 1 | 12 | 339 |
GO:0043565 | sequence-specific DNA binding | 3.49e-01 | 1.00e+00 | 1.235 | 1 | 4 | 365 |
GO:0008270 | zinc ion binding | 3.55e-01 | 1.00e+00 | 0.687 | 2 | 12 | 1067 |
GO:0007155 | cell adhesion | 3.64e-01 | 1.00e+00 | 1.162 | 1 | 8 | 384 |
GO:0007596 | blood coagulation | 4.22e-01 | 1.00e+00 | 0.889 | 1 | 14 | 464 |
GO:0055114 | oxidation-reduction process | 4.34e-01 | 1.00e+00 | 0.837 | 1 | 11 | 481 |
GO:0045893 | positive regulation of transcription, DNA-templated | 4.38e-01 | 1.00e+00 | 0.819 | 1 | 17 | 487 |
GO:0005737 | cytoplasm | 5.09e-01 | 1.00e+00 | 0.111 | 5 | 98 | 3976 |
GO:0045087 | innate immune response | 5.19e-01 | 1.00e+00 | 0.480 | 1 | 20 | 616 |
GO:0005794 | Golgi apparatus | 5.38e-01 | 1.00e+00 | 0.402 | 1 | 14 | 650 |
GO:0005615 | extracellular space | 7.03e-01 | 1.00e+00 | -0.234 | 1 | 17 | 1010 |
GO:0006355 | regulation of transcription, DNA-templated | 7.36e-01 | 1.00e+00 | -0.362 | 1 | 17 | 1104 |
GO:0005886 | plasma membrane | 9.73e-01 | 1.00e+00 | -1.722 | 1 | 38 | 2834 |