Subnetwork | Dataset | Score | p-value 1 | p-value 2 | p-value 3 | Size | Highlighted genes |
---|---|---|---|---|---|---|---|
reg-snw-56655 | wolf-screen-ratio-mammosphere-adherent | 0.828 | 9.29e-07 | 2.91e-03 | 5.53e-03 | 8 | 7 |
int-snw-10454 | wolf-screen-ratio-mammosphere-adherent | 0.950 | 4.20e-16 | 1.77e-03 | 3.15e-02 | 12 | 12 |
Gene Symbol | Entrez Gene ID | Frequency | wolf-screen-ratio-mammosphere-adherent gene score | Best subnetwork score | Degree | wolf adherent-list Hits GI | wolf mammosphere no adherent-list Hits GI |
---|---|---|---|---|---|---|---|
PSMA2 | 5683 | 112 | 1.093 | 1.106 | 108 | Yes | - |
RBX1 | 9978 | 115 | 1.185 | 0.934 | 148 | Yes | - |
PSMB7 | 5695 | 118 | 0.982 | 0.934 | 90 | Yes | - |
VARS | 7407 | 86 | 0.549 | 1.002 | 204 | Yes | - |
POLE4 | 56655 | 63 | 0.177 | 0.828 | 56 | - | - |
PSMB3 | 5691 | 64 | 0.668 | 0.901 | 19 | Yes | - |
PGD | 5226 | 89 | 1.201 | 1.106 | 152 | Yes | - |
RSL24D1 | 51187 | 38 | 1.300 | 1.020 | 59 | Yes | - |
RPL10 | 6134 | 2 | 0.748 | 0.950 | 159 | Yes | - |
RUVBL1 | 8607 | 95 | 0.720 | 0.973 | 469 | Yes | - |
PPP2R1A | 5518 | 19 | 0.644 | 0.985 | 249 | Yes | - |
RPL14 | 9045 | 49 | 1.250 | 1.113 | 166 | Yes | - |
PSMB2 | 5690 | 116 | 0.877 | 0.956 | 169 | Yes | - |
ACTB | 60 | 134 | 1.153 | 1.151 | 610 | Yes | - |
PSMD11 | 5717 | 124 | 1.095 | 1.106 | 218 | Yes | - |
TAB1 | 10454 | 2 | 0.338 | 0.950 | 90 | Yes | - |
CFL1 | 1072 | 18 | 0.674 | 1.020 | 203 | Yes | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
PSMD11 | 5717 | RUVBL1 | 8607 | pp | -- | int.I2D: YeastLow |
PPP2R1A | 5518 | PSMB3 | 5691 | pp | -- | int.I2D: IntAct_Mouse |
ACTB | 60 | RUVBL1 | 8607 | pp | -- | int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast |
PSMA2 | 5683 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast |
PSMB2 | 5690 | POLE4 | 56655 | pd | < | reg.ITFP.txt: no annot |
RPL10 | 6134 | RPL14 | 9045 | pp | -- | int.I2D: BioGrid_Yeast |
PPP2R1A | 5518 | TAB1 | 10454 | pp | -- | int.Intact: MI:0915(physical association) |
PSMA2 | 5683 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
ACTB | 60 | PSMB2 | 5690 | pp | -- | int.I2D: BioGrid_Yeast |
PPP2R1A | 5518 | RUVBL1 | 8607 | pp | -- | int.I2D: YeastLow |
ACTB | 60 | RBX1 | 9978 | pp | -- | int.I2D: BioGrid_Yeast |
ACTB | 60 | CFL1 | 1072 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, MINT_Yeast, MIPS, BioGrid, BIND_Yeast, HPRD, IntAct, IntAct_Yeast, MINT, VidalHuman_core, YeastLow, Yu_GoldStd; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid |
CFL1 | 1072 | TAB1 | 10454 | pp | -- | int.I2D: BioGrid, MINT; int.Mint: MI:0915(physical association) |
PPP2R1A | 5518 | PSMB2 | 5690 | pp | -- | int.I2D: IntAct_Mouse |
ACTB | 60 | PPP2R1A | 5518 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB7 | 5695 | RBX1 | 9978 | pd | < | reg.ITFP.txt: no annot |
PGD | 5226 | PSMD11 | 5717 | pp | -- | int.I2D: YeastLow |
RUVBL1 | 8607 | TAB1 | 10454 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: MINT, IntAct; int.Mint: MI:0915(physical association) |
VARS | 7407 | POLE4 | 56655 | pd | <> | reg.ITFP.txt: no annot |
PSMA2 | 5683 | PSMB3 | 5691 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, INTEROLOG, Krogan_Core, MINT_Yeast, YeastHigh, Yu_GoldStd |
PPP2R1A | 5518 | PSMB7 | 5695 | pp | -- | int.I2D: IntAct_Mouse |
PSMB7 | 5695 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
PSMA2 | 5683 | POLE4 | 56655 | pd | < | reg.ITFP.txt: no annot |
VARS | 7407 | RUVBL1 | 8607 | pd | <> | reg.ITFP.txt: no annot |
ACTB | 60 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB7 | 5695 | POLE4 | 56655 | pd | < | reg.ITFP.txt: no annot |
CFL1 | 1072 | PGD | 5226 | pp | -- | int.I2D: YeastLow |
PSMB2 | 5690 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct |
RPL10 | 6134 | TAB1 | 10454 | pp | -- | int.I2D: BioGrid, MINT; int.Mint: MI:0915(physical association) |
PSMB3 | 5691 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: BCI, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Yeast, YeastHigh, HPRD, Krogan_Core, MINT_Yeast, MIPS; int.HPRD: yeast 2-hybrid |
PGD | 5226 | PPP2R1A | 5518 | pp | -- | int.I2D: YeastLow |
ACTB | 60 | PSMB7 | 5695 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB2 | 5690 | PSMB3 | 5691 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct, INTEROLOG, MINT, Yu_GoldStd, BCI, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid |
PSMB3 | 5691 | POLE4 | 56655 | pd | < | reg.ITFP.txt: no annot |
RBX1 | 9978 | TAB1 | 10454 | pp | -- | int.I2D: BioGrid, MINT; int.Mint: MI:0915(physical association) |
PPP2R1A | 5518 | PSMA2 | 5683 | pp | -- | int.I2D: IntAct_Mouse |
CFL1 | 1072 | RSL24D1 | 51187 | pp | -- | int.I2D: YeastLow |
PSMB2 | 5690 | PSMD11 | 5717 | pd | < | reg.ITFP.txt: no annot |
PSMB2 | 5690 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
PSMB2 | 5690 | VARS | 7407 | pd | < | reg.ITFP.txt: no annot |
CFL1 | 1072 | VARS | 7407 | pp | -- | int.I2D: YeastLow |
PSMB3 | 5691 | PSMD11 | 5717 | pp | -- | int.I2D: YeastLow |
CFL1 | 1072 | RUVBL1 | 8607 | pp | -- | int.I2D: YeastLow |
PSMA2 | 5683 | PSMB2 | 5690 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0016071 | mRNA metabolic process | 2.34e-11 | 3.82e-07 | 5.106 | 8 | 34 | 223 |
GO:0016070 | RNA metabolic process | 5.31e-11 | 8.67e-07 | 4.959 | 8 | 34 | 247 |
GO:0006521 | regulation of cellular amino acid metabolic process | 1.32e-09 | 2.16e-05 | 6.585 | 5 | 21 | 50 |
GO:0005839 | proteasome core complex | 2.44e-09 | 3.99e-05 | 7.737 | 4 | 11 | 18 |
GO:0000502 | proteasome complex | 2.85e-09 | 4.64e-05 | 6.371 | 5 | 22 | 58 |
GO:0004298 | threonine-type endopeptidase activity | 3.86e-09 | 6.30e-05 | 7.585 | 4 | 11 | 20 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.11e-09 | 8.34e-05 | 6.207 | 5 | 24 | 65 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 5.11e-09 | 8.34e-05 | 6.207 | 5 | 22 | 65 |
GO:0010467 | gene expression | 5.61e-09 | 9.15e-05 | 3.691 | 9 | 58 | 669 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 7.46e-09 | 1.22e-04 | 6.100 | 5 | 24 | 70 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 9.24e-09 | 1.51e-04 | 6.039 | 5 | 23 | 73 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 9.91e-09 | 1.62e-04 | 6.019 | 5 | 24 | 74 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 1.21e-08 | 1.98e-04 | 5.962 | 5 | 23 | 77 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 1.38e-08 | 2.26e-04 | 5.925 | 5 | 25 | 79 |
GO:0016032 | viral process | 2.55e-08 | 4.16e-04 | 3.830 | 8 | 55 | 540 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 3.33e-08 | 5.44e-04 | 5.674 | 5 | 23 | 94 |
GO:0005829 | cytosol | 4.36e-08 | 7.11e-04 | 2.284 | 13 | 125 | 2562 |
GO:0000209 | protein polyubiquitination | 9.61e-08 | 1.57e-03 | 5.371 | 5 | 21 | 116 |
GO:0000082 | G1/S transition of mitotic cell cycle | 3.47e-07 | 5.67e-03 | 5.000 | 5 | 33 | 150 |
GO:0042981 | regulation of apoptotic process | 3.59e-07 | 5.86e-03 | 4.991 | 5 | 26 | 151 |
GO:0034641 | cellular nitrogen compound metabolic process | 7.89e-07 | 1.29e-02 | 4.761 | 5 | 25 | 177 |
GO:0000278 | mitotic cell cycle | 2.00e-06 | 3.26e-02 | 3.855 | 6 | 52 | 398 |
GO:0043066 | negative regulation of apoptotic process | 3.25e-06 | 5.31e-02 | 3.734 | 6 | 30 | 433 |
GO:0005654 | nucleoplasm | 5.63e-06 | 9.20e-02 | 2.810 | 8 | 83 | 1095 |
GO:0070062 | extracellular vesicular exosome | 5.73e-06 | 9.35e-02 | 2.069 | 11 | 98 | 2516 |
GO:0006915 | apoptotic process | 1.59e-05 | 2.59e-01 | 3.335 | 6 | 34 | 571 |
GO:0035267 | NuA4 histone acetyltransferase complex | 9.22e-05 | 1.00e+00 | 7.100 | 2 | 4 | 14 |
GO:0016020 | membrane | 1.69e-04 | 1.00e+00 | 2.137 | 8 | 80 | 1746 |
GO:0005515 | protein binding | 2.05e-04 | 1.00e+00 | 1.133 | 14 | 172 | 6127 |
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 2.10e-04 | 1.00e+00 | 4.659 | 3 | 10 | 114 |
GO:0070262 | peptidyl-serine dephosphorylation | 1.04e-03 | 1.00e+00 | 9.907 | 1 | 1 | 1 |
GO:0019521 | D-gluconate metabolic process | 1.04e-03 | 1.00e+00 | 9.907 | 1 | 1 | 1 |
GO:0022625 | cytosolic large ribosomal subunit | 1.17e-03 | 1.00e+00 | 5.292 | 2 | 5 | 49 |
GO:0040008 | regulation of growth | 1.26e-03 | 1.00e+00 | 5.235 | 2 | 3 | 51 |
GO:0044281 | small molecule metabolic process | 1.42e-03 | 1.00e+00 | 2.153 | 6 | 57 | 1295 |
GO:0004832 | valine-tRNA ligase activity | 2.08e-03 | 1.00e+00 | 8.907 | 1 | 1 | 2 |
GO:0019322 | pentose biosynthetic process | 2.08e-03 | 1.00e+00 | 8.907 | 1 | 1 | 2 |
GO:0006438 | valyl-tRNA aminoacylation | 2.08e-03 | 1.00e+00 | 8.907 | 1 | 1 | 2 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 2.85e-03 | 1.00e+00 | 4.640 | 2 | 5 | 77 |
GO:0005634 | nucleus | 2.85e-03 | 1.00e+00 | 1.129 | 11 | 131 | 4828 |
GO:0009051 | pentose-phosphate shunt, oxidative branch | 3.12e-03 | 1.00e+00 | 8.322 | 1 | 1 | 3 |
GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity | 3.12e-03 | 1.00e+00 | 8.322 | 1 | 1 | 3 |
GO:0019083 | viral transcription | 3.15e-03 | 1.00e+00 | 4.567 | 2 | 8 | 81 |
GO:0006415 | translational termination | 3.63e-03 | 1.00e+00 | 4.464 | 2 | 8 | 87 |
GO:0016363 | nuclear matrix | 4.05e-03 | 1.00e+00 | 4.383 | 2 | 11 | 92 |
GO:0006414 | translational elongation | 4.13e-03 | 1.00e+00 | 4.368 | 2 | 11 | 93 |
GO:0001842 | neural fold formation | 4.16e-03 | 1.00e+00 | 7.907 | 1 | 1 | 4 |
GO:0031467 | Cul7-RING ubiquitin ligase complex | 4.16e-03 | 1.00e+00 | 7.907 | 1 | 1 | 4 |
GO:0019788 | NEDD8 ligase activity | 4.16e-03 | 1.00e+00 | 7.907 | 1 | 1 | 4 |
GO:0048273 | mitogen-activated protein kinase p38 binding | 4.16e-03 | 1.00e+00 | 7.907 | 1 | 1 | 4 |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 5.14e-03 | 1.00e+00 | 4.207 | 2 | 8 | 104 |
GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex | 5.20e-03 | 1.00e+00 | 7.585 | 1 | 2 | 5 |
GO:0031461 | cullin-RING ubiquitin ligase complex | 5.20e-03 | 1.00e+00 | 7.585 | 1 | 1 | 5 |
GO:0019932 | second-messenger-mediated signaling | 5.20e-03 | 1.00e+00 | 7.585 | 1 | 1 | 5 |
GO:0043248 | proteasome assembly | 5.20e-03 | 1.00e+00 | 7.585 | 1 | 1 | 5 |
GO:0042518 | negative regulation of tyrosine phosphorylation of Stat3 protein | 5.20e-03 | 1.00e+00 | 7.585 | 1 | 1 | 5 |
GO:0030891 | VCB complex | 5.20e-03 | 1.00e+00 | 7.585 | 1 | 2 | 5 |
GO:0008622 | epsilon DNA polymerase complex | 5.20e-03 | 1.00e+00 | 7.585 | 1 | 1 | 5 |
GO:0015630 | microtubule cytoskeleton | 5.93e-03 | 1.00e+00 | 4.100 | 2 | 5 | 112 |
GO:0030529 | ribonucleoprotein complex | 6.14e-03 | 1.00e+00 | 4.074 | 2 | 8 | 114 |
GO:0030957 | Tat protein binding | 6.23e-03 | 1.00e+00 | 7.322 | 1 | 4 | 6 |
GO:0019209 | kinase activator activity | 6.23e-03 | 1.00e+00 | 7.322 | 1 | 1 | 6 |
GO:0031466 | Cul5-RING ubiquitin ligase complex | 6.23e-03 | 1.00e+00 | 7.322 | 1 | 1 | 6 |
GO:0019058 | viral life cycle | 6.25e-03 | 1.00e+00 | 4.061 | 2 | 10 | 115 |
GO:0006325 | chromatin organization | 7.12e-03 | 1.00e+00 | 3.964 | 2 | 4 | 123 |
GO:0030836 | positive regulation of actin filament depolymerization | 7.27e-03 | 1.00e+00 | 7.100 | 1 | 2 | 7 |
GO:0002161 | aminoacyl-tRNA editing activity | 7.27e-03 | 1.00e+00 | 7.100 | 1 | 2 | 7 |
GO:0031462 | Cul2-RING ubiquitin ligase complex | 7.27e-03 | 1.00e+00 | 7.100 | 1 | 2 | 7 |
GO:0006413 | translational initiation | 8.04e-03 | 1.00e+00 | 3.874 | 2 | 12 | 131 |
GO:0009615 | response to virus | 8.15e-03 | 1.00e+00 | 3.863 | 2 | 6 | 132 |
GO:0019773 | proteasome core complex, alpha-subunit complex | 8.30e-03 | 1.00e+00 | 6.907 | 1 | 5 | 8 |
GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex | 8.30e-03 | 1.00e+00 | 6.907 | 1 | 2 | 8 |
GO:0070688 | MLL5-L complex | 8.30e-03 | 1.00e+00 | 6.907 | 1 | 1 | 8 |
GO:0030042 | actin filament depolymerization | 8.30e-03 | 1.00e+00 | 6.907 | 1 | 2 | 8 |
GO:0000812 | Swr1 complex | 8.30e-03 | 1.00e+00 | 6.907 | 1 | 3 | 8 |
GO:0045116 | protein neddylation | 8.30e-03 | 1.00e+00 | 6.907 | 1 | 2 | 8 |
GO:0003735 | structural constituent of ribosome | 9.26e-03 | 1.00e+00 | 3.767 | 2 | 8 | 141 |
GO:0000185 | activation of MAPKKK activity | 9.34e-03 | 1.00e+00 | 6.737 | 1 | 2 | 9 |
GO:0006450 | regulation of translational fidelity | 1.04e-02 | 1.00e+00 | 6.585 | 1 | 2 | 10 |
GO:0007084 | mitotic nuclear envelope reassembly | 1.04e-02 | 1.00e+00 | 6.585 | 1 | 1 | 10 |
GO:0006098 | pentose-phosphate shunt | 1.14e-02 | 1.00e+00 | 6.448 | 1 | 3 | 11 |
GO:0061001 | regulation of dendritic spine morphogenesis | 1.14e-02 | 1.00e+00 | 6.448 | 1 | 2 | 11 |
GO:0006275 | regulation of DNA replication | 1.24e-02 | 1.00e+00 | 6.322 | 1 | 2 | 12 |
GO:0030111 | regulation of Wnt signaling pathway | 1.24e-02 | 1.00e+00 | 6.322 | 1 | 1 | 12 |
GO:0043968 | histone H2A acetylation | 1.24e-02 | 1.00e+00 | 6.322 | 1 | 3 | 12 |
GO:0005838 | proteasome regulatory particle | 1.24e-02 | 1.00e+00 | 6.322 | 1 | 7 | 12 |
GO:0042273 | ribosomal large subunit biogenesis | 1.35e-02 | 1.00e+00 | 6.207 | 1 | 4 | 13 |
GO:0044267 | cellular protein metabolic process | 1.37e-02 | 1.00e+00 | 2.541 | 3 | 24 | 495 |
GO:0031011 | Ino80 complex | 1.45e-02 | 1.00e+00 | 6.100 | 1 | 3 | 14 |
GO:0006672 | ceramide metabolic process | 1.55e-02 | 1.00e+00 | 6.000 | 1 | 1 | 15 |
GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | 1.55e-02 | 1.00e+00 | 6.000 | 1 | 1 | 15 |
GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | 1.55e-02 | 1.00e+00 | 6.000 | 1 | 2 | 15 |
GO:0032403 | protein complex binding | 1.55e-02 | 1.00e+00 | 3.376 | 2 | 7 | 185 |
GO:0050998 | nitric-oxide synthase binding | 1.65e-02 | 1.00e+00 | 5.907 | 1 | 1 | 16 |
GO:0010243 | response to organonitrogen compound | 1.76e-02 | 1.00e+00 | 5.820 | 1 | 2 | 17 |
GO:0022624 | proteasome accessory complex | 1.76e-02 | 1.00e+00 | 5.820 | 1 | 9 | 17 |
GO:0031258 | lamellipodium membrane | 1.76e-02 | 1.00e+00 | 5.820 | 1 | 2 | 17 |
GO:0022604 | regulation of cell morphogenesis | 1.76e-02 | 1.00e+00 | 5.820 | 1 | 1 | 17 |
GO:0003678 | DNA helicase activity | 1.96e-02 | 1.00e+00 | 5.659 | 1 | 3 | 19 |
GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 1.96e-02 | 1.00e+00 | 5.659 | 1 | 1 | 19 |
GO:0048863 | stem cell differentiation | 1.96e-02 | 1.00e+00 | 5.659 | 1 | 1 | 19 |
GO:0008601 | protein phosphatase type 2A regulator activity | 2.06e-02 | 1.00e+00 | 5.585 | 1 | 3 | 20 |
GO:0000159 | protein phosphatase type 2A complex | 2.06e-02 | 1.00e+00 | 5.585 | 1 | 2 | 20 |
GO:0030010 | establishment of cell polarity | 2.17e-02 | 1.00e+00 | 5.515 | 1 | 2 | 21 |
GO:0045595 | regulation of cell differentiation | 2.17e-02 | 1.00e+00 | 5.515 | 1 | 1 | 21 |
GO:0000281 | mitotic cytokinesis | 2.17e-02 | 1.00e+00 | 5.515 | 1 | 2 | 21 |
GO:0030863 | cortical cytoskeleton | 2.27e-02 | 1.00e+00 | 5.448 | 1 | 1 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 2.27e-02 | 1.00e+00 | 5.448 | 1 | 4 | 22 |
GO:0043044 | ATP-dependent chromatin remodeling | 2.37e-02 | 1.00e+00 | 5.383 | 1 | 4 | 23 |
GO:0031463 | Cul3-RING ubiquitin ligase complex | 2.37e-02 | 1.00e+00 | 5.383 | 1 | 2 | 23 |
GO:0043200 | response to amino acid | 2.37e-02 | 1.00e+00 | 5.383 | 1 | 1 | 23 |
GO:0006513 | protein monoubiquitination | 2.37e-02 | 1.00e+00 | 5.383 | 1 | 1 | 23 |
GO:0006412 | translation | 2.44e-02 | 1.00e+00 | 3.030 | 2 | 15 | 235 |
GO:0045087 | innate immune response | 2.45e-02 | 1.00e+00 | 2.225 | 3 | 20 | 616 |
GO:0005730 | nucleolus | 2.50e-02 | 1.00e+00 | 1.511 | 5 | 70 | 1684 |
GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway | 2.57e-02 | 1.00e+00 | 5.263 | 1 | 2 | 25 |
GO:0030864 | cortical actin cytoskeleton | 2.57e-02 | 1.00e+00 | 5.263 | 1 | 1 | 25 |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 2.68e-02 | 1.00e+00 | 5.207 | 1 | 2 | 26 |
GO:0034080 | CENP-A containing nucleosome assembly | 2.78e-02 | 1.00e+00 | 5.152 | 1 | 2 | 27 |
GO:0000188 | inactivation of MAPK activity | 2.78e-02 | 1.00e+00 | 5.152 | 1 | 1 | 27 |
GO:0071339 | MLL1 complex | 2.78e-02 | 1.00e+00 | 5.152 | 1 | 3 | 27 |
GO:0003823 | antigen binding | 2.88e-02 | 1.00e+00 | 5.100 | 1 | 1 | 28 |
GO:0010033 | response to organic substance | 2.88e-02 | 1.00e+00 | 5.100 | 1 | 2 | 28 |
GO:0043967 | histone H4 acetylation | 2.88e-02 | 1.00e+00 | 5.100 | 1 | 3 | 28 |
GO:0031492 | nucleosomal DNA binding | 2.88e-02 | 1.00e+00 | 5.100 | 1 | 4 | 28 |
GO:0019894 | kinesin binding | 2.88e-02 | 1.00e+00 | 5.100 | 1 | 1 | 28 |
GO:0019005 | SCF ubiquitin ligase complex | 2.98e-02 | 1.00e+00 | 5.049 | 1 | 1 | 29 |
GO:0003887 | DNA-directed DNA polymerase activity | 2.98e-02 | 1.00e+00 | 5.049 | 1 | 3 | 29 |
GO:0071897 | DNA biosynthetic process | 2.98e-02 | 1.00e+00 | 5.049 | 1 | 2 | 29 |
GO:0006281 | DNA repair | 3.02e-02 | 1.00e+00 | 2.863 | 2 | 22 | 264 |
GO:0001755 | neural crest cell migration | 3.08e-02 | 1.00e+00 | 5.000 | 1 | 2 | 30 |
GO:0042254 | ribosome biogenesis | 3.08e-02 | 1.00e+00 | 5.000 | 1 | 1 | 30 |
GO:0050661 | NADP binding | 3.28e-02 | 1.00e+00 | 4.907 | 1 | 1 | 32 |
GO:0003007 | heart morphogenesis | 3.48e-02 | 1.00e+00 | 4.820 | 1 | 1 | 34 |
GO:0034332 | adherens junction organization | 3.69e-02 | 1.00e+00 | 4.737 | 1 | 1 | 36 |
GO:0001895 | retina homeostasis | 3.69e-02 | 1.00e+00 | 4.737 | 1 | 1 | 36 |
GO:0051084 | 'de novo' posttranslational protein folding | 3.79e-02 | 1.00e+00 | 4.698 | 1 | 4 | 37 |
GO:0043234 | protein complex | 3.82e-02 | 1.00e+00 | 2.678 | 2 | 17 | 300 |
GO:0070527 | platelet aggregation | 3.89e-02 | 1.00e+00 | 4.659 | 1 | 2 | 38 |
GO:0008047 | enzyme activator activity | 3.99e-02 | 1.00e+00 | 4.622 | 1 | 1 | 39 |
GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 4.19e-02 | 1.00e+00 | 4.549 | 1 | 1 | 41 |
GO:0006418 | tRNA aminoacylation for protein translation | 4.29e-02 | 1.00e+00 | 4.515 | 1 | 5 | 42 |
GO:0004722 | protein serine/threonine phosphatase activity | 4.29e-02 | 1.00e+00 | 4.515 | 1 | 1 | 42 |
GO:0030155 | regulation of cell adhesion | 4.29e-02 | 1.00e+00 | 4.515 | 1 | 3 | 42 |
GO:0032508 | DNA duplex unwinding | 4.29e-02 | 1.00e+00 | 4.515 | 1 | 4 | 42 |
GO:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | 4.39e-02 | 1.00e+00 | 4.481 | 1 | 2 | 43 |
GO:0014070 | response to organic cyclic compound | 4.39e-02 | 1.00e+00 | 4.481 | 1 | 3 | 43 |
GO:0007411 | axon guidance | 4.46e-02 | 1.00e+00 | 2.554 | 2 | 9 | 327 |
GO:0043966 | histone H3 acetylation | 4.59e-02 | 1.00e+00 | 4.415 | 1 | 2 | 45 |
GO:0021762 | substantia nigra development | 4.69e-02 | 1.00e+00 | 4.383 | 1 | 1 | 46 |
GO:0007266 | Rho protein signal transduction | 4.89e-02 | 1.00e+00 | 4.322 | 1 | 2 | 48 |
GO:0007254 | JNK cascade | 5.18e-02 | 1.00e+00 | 4.235 | 1 | 2 | 51 |
GO:0000775 | chromosome, centromeric region | 5.28e-02 | 1.00e+00 | 4.207 | 1 | 2 | 52 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 5.48e-02 | 1.00e+00 | 4.152 | 1 | 5 | 54 |
GO:0051403 | stress-activated MAPK cascade | 5.48e-02 | 1.00e+00 | 4.152 | 1 | 1 | 54 |
GO:0005925 | focal adhesion | 5.57e-02 | 1.00e+00 | 2.376 | 2 | 18 | 370 |
GO:0003824 | catalytic activity | 5.68e-02 | 1.00e+00 | 4.100 | 1 | 1 | 56 |
GO:0000932 | cytoplasmic mRNA processing body | 5.68e-02 | 1.00e+00 | 4.100 | 1 | 3 | 56 |
GO:0045216 | cell-cell junction organization | 5.97e-02 | 1.00e+00 | 4.024 | 1 | 2 | 59 |
GO:0046982 | protein heterodimerization activity | 6.37e-02 | 1.00e+00 | 2.267 | 2 | 11 | 399 |
GO:0007059 | chromosome segregation | 6.46e-02 | 1.00e+00 | 3.907 | 1 | 3 | 64 |
GO:0034146 | toll-like receptor 5 signaling pathway | 6.56e-02 | 1.00e+00 | 3.885 | 1 | 1 | 65 |
GO:0034166 | toll-like receptor 10 signaling pathway | 6.56e-02 | 1.00e+00 | 3.885 | 1 | 1 | 65 |
GO:0006310 | DNA recombination | 6.76e-02 | 1.00e+00 | 3.841 | 1 | 4 | 67 |
GO:0038123 | toll-like receptor TLR1:TLR2 signaling pathway | 7.15e-02 | 1.00e+00 | 3.757 | 1 | 1 | 71 |
GO:0034329 | cell junction assembly | 7.15e-02 | 1.00e+00 | 3.757 | 1 | 1 | 71 |
GO:0038124 | toll-like receptor TLR6:TLR2 signaling pathway | 7.15e-02 | 1.00e+00 | 3.757 | 1 | 1 | 71 |
GO:0032587 | ruffle membrane | 7.24e-02 | 1.00e+00 | 3.737 | 1 | 4 | 72 |
GO:0034162 | toll-like receptor 9 signaling pathway | 7.24e-02 | 1.00e+00 | 3.737 | 1 | 1 | 72 |
GO:0034134 | toll-like receptor 2 signaling pathway | 7.34e-02 | 1.00e+00 | 3.717 | 1 | 1 | 73 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 7.63e-02 | 1.00e+00 | 3.659 | 1 | 3 | 76 |
GO:0030324 | lung development | 7.63e-02 | 1.00e+00 | 3.659 | 1 | 1 | 76 |
GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | 7.63e-02 | 1.00e+00 | 3.659 | 1 | 2 | 76 |
GO:0002756 | MyD88-independent toll-like receptor signaling pathway | 7.82e-02 | 1.00e+00 | 3.622 | 1 | 2 | 78 |
GO:0006334 | nucleosome assembly | 7.92e-02 | 1.00e+00 | 3.603 | 1 | 4 | 79 |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | 8.02e-02 | 1.00e+00 | 3.585 | 1 | 2 | 80 |
GO:0034138 | toll-like receptor 3 signaling pathway | 8.02e-02 | 1.00e+00 | 3.585 | 1 | 2 | 80 |
GO:0002576 | platelet degranulation | 8.21e-02 | 1.00e+00 | 3.549 | 1 | 4 | 82 |
GO:0007596 | blood coagulation | 8.28e-02 | 1.00e+00 | 2.049 | 2 | 14 | 464 |
GO:0000187 | activation of MAPK activity | 8.98e-02 | 1.00e+00 | 3.415 | 1 | 4 | 90 |
GO:0005739 | mitochondrion | 9.12e-02 | 1.00e+00 | 1.461 | 3 | 24 | 1046 |
GO:0006928 | cellular component movement | 9.17e-02 | 1.00e+00 | 3.383 | 1 | 7 | 92 |
GO:0005200 | structural constituent of cytoskeleton | 9.26e-02 | 1.00e+00 | 3.368 | 1 | 7 | 93 |
GO:0006364 | rRNA processing | 9.55e-02 | 1.00e+00 | 3.322 | 1 | 5 | 96 |
GO:0007010 | cytoskeleton organization | 9.55e-02 | 1.00e+00 | 3.322 | 1 | 2 | 96 |
GO:0034142 | toll-like receptor 4 signaling pathway | 9.55e-02 | 1.00e+00 | 3.322 | 1 | 2 | 96 |
GO:0071456 | cellular response to hypoxia | 9.74e-02 | 1.00e+00 | 3.292 | 1 | 4 | 98 |
GO:0006470 | protein dephosphorylation | 9.83e-02 | 1.00e+00 | 3.278 | 1 | 1 | 99 |
GO:0014069 | postsynaptic density | 1.05e-01 | 1.00e+00 | 3.179 | 1 | 1 | 106 |
GO:0002224 | toll-like receptor signaling pathway | 1.08e-01 | 1.00e+00 | 3.139 | 1 | 2 | 109 |
GO:0005815 | microtubule organizing center | 1.09e-01 | 1.00e+00 | 3.126 | 1 | 4 | 110 |
GO:0006461 | protein complex assembly | 1.10e-01 | 1.00e+00 | 3.113 | 1 | 6 | 111 |
GO:0030308 | negative regulation of cell growth | 1.11e-01 | 1.00e+00 | 3.087 | 1 | 6 | 113 |
GO:0072562 | blood microparticle | 1.14e-01 | 1.00e+00 | 3.049 | 1 | 4 | 116 |
GO:0007219 | Notch signaling pathway | 1.23e-01 | 1.00e+00 | 2.941 | 1 | 4 | 125 |
GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 1.23e-01 | 1.00e+00 | 2.941 | 1 | 4 | 125 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 1.24e-01 | 1.00e+00 | 2.918 | 1 | 5 | 127 |
GO:0030036 | actin cytoskeleton organization | 1.26e-01 | 1.00e+00 | 2.896 | 1 | 5 | 129 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 1.27e-01 | 1.00e+00 | 2.885 | 1 | 3 | 130 |
GO:0000790 | nuclear chromatin | 1.30e-01 | 1.00e+00 | 2.852 | 1 | 7 | 133 |
GO:0031982 | vesicle | 1.31e-01 | 1.00e+00 | 2.841 | 1 | 10 | 134 |
GO:0000086 | G2/M transition of mitotic cell cycle | 1.34e-01 | 1.00e+00 | 2.809 | 1 | 7 | 137 |
GO:0005911 | cell-cell junction | 1.38e-01 | 1.00e+00 | 2.757 | 1 | 3 | 142 |
GO:0016887 | ATPase activity | 1.40e-01 | 1.00e+00 | 2.737 | 1 | 7 | 144 |
GO:0061024 | membrane organization | 1.42e-01 | 1.00e+00 | 2.717 | 1 | 5 | 146 |
GO:0006457 | protein folding | 1.44e-01 | 1.00e+00 | 2.688 | 1 | 8 | 149 |
GO:0005794 | Golgi apparatus | 1.45e-01 | 1.00e+00 | 1.563 | 2 | 14 | 650 |
GO:0010008 | endosome membrane | 1.52e-01 | 1.00e+00 | 2.612 | 1 | 6 | 157 |
GO:0008543 | fibroblast growth factor receptor signaling pathway | 1.53e-01 | 1.00e+00 | 2.594 | 1 | 4 | 159 |
GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 1.61e-01 | 1.00e+00 | 2.515 | 1 | 5 | 168 |
GO:0005524 | ATP binding | 1.62e-01 | 1.00e+00 | 1.089 | 3 | 46 | 1354 |
GO:0038095 | Fc-epsilon receptor signaling pathway | 1.64e-01 | 1.00e+00 | 2.489 | 1 | 7 | 171 |
GO:0030424 | axon | 1.65e-01 | 1.00e+00 | 2.481 | 1 | 3 | 172 |
GO:0031625 | ubiquitin protein ligase binding | 1.72e-01 | 1.00e+00 | 2.415 | 1 | 13 | 180 |
GO:0015629 | actin cytoskeleton | 1.75e-01 | 1.00e+00 | 2.391 | 1 | 5 | 183 |
GO:0030168 | platelet activation | 1.93e-01 | 1.00e+00 | 2.227 | 1 | 9 | 205 |
GO:0001701 | in utero embryonic development | 1.98e-01 | 1.00e+00 | 2.193 | 1 | 6 | 210 |
GO:0005737 | cytoplasm | 2.15e-01 | 1.00e+00 | 0.535 | 6 | 98 | 3976 |
GO:0007067 | mitotic nuclear division | 2.15e-01 | 1.00e+00 | 2.055 | 1 | 13 | 231 |
GO:0008380 | RNA splicing | 2.16e-01 | 1.00e+00 | 2.049 | 1 | 13 | 232 |
GO:0004842 | ubiquitin-protein transferase activity | 2.36e-01 | 1.00e+00 | 1.907 | 1 | 4 | 256 |
GO:0005975 | carbohydrate metabolic process | 2.50e-01 | 1.00e+00 | 1.809 | 1 | 5 | 274 |
GO:0003779 | actin binding | 2.51e-01 | 1.00e+00 | 1.804 | 1 | 7 | 275 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 2.51e-01 | 1.00e+00 | 1.804 | 1 | 6 | 275 |
GO:0007283 | spermatogenesis | 2.52e-01 | 1.00e+00 | 1.798 | 1 | 6 | 276 |
GO:0016567 | protein ubiquitination | 2.70e-01 | 1.00e+00 | 1.683 | 1 | 5 | 299 |
GO:0005856 | cytoskeleton | 2.79e-01 | 1.00e+00 | 1.626 | 1 | 8 | 311 |
GO:0005615 | extracellular space | 2.84e-01 | 1.00e+00 | 0.927 | 2 | 17 | 1010 |
GO:0019901 | protein kinase binding | 2.86e-01 | 1.00e+00 | 1.585 | 1 | 21 | 320 |
GO:0043231 | intracellular membrane-bounded organelle | 2.95e-01 | 1.00e+00 | 1.532 | 1 | 8 | 332 |
GO:0044822 | poly(A) RNA binding | 3.11e-01 | 1.00e+00 | 0.833 | 2 | 50 | 1078 |
GO:0003723 | RNA binding | 3.12e-01 | 1.00e+00 | 1.435 | 1 | 19 | 355 |
GO:0043565 | sequence-specific DNA binding | 3.19e-01 | 1.00e+00 | 1.395 | 1 | 4 | 365 |
GO:0006468 | protein phosphorylation | 3.90e-01 | 1.00e+00 | 1.040 | 1 | 10 | 467 |
GO:0055114 | oxidation-reduction process | 3.99e-01 | 1.00e+00 | 0.997 | 1 | 11 | 481 |
GO:0005783 | endoplasmic reticulum | 4.77e-01 | 1.00e+00 | 0.654 | 1 | 9 | 610 |
GO:0008270 | zinc ion binding | 6.83e-01 | 1.00e+00 | -0.152 | 1 | 12 | 1067 |
GO:0006355 | regulation of transcription, DNA-templated | 6.96e-01 | 1.00e+00 | -0.202 | 1 | 17 | 1104 |
GO:0006351 | transcription, DNA-templated | 8.24e-01 | 1.00e+00 | -0.723 | 1 | 25 | 1585 |