int-snw-5719

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	1.029	2.42e-19	2.70e-04	7.55e-03

wolf-screen-ratio-mammosphere-adherent-int-snw-5719 subnetwork

Genes (6)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
PSMA1	5682	61	0.996	1.052	123	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
[ PSMD13 ]	5719	16	0.848	1.029	104	Yes	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
PSMD3	5709	57	0.986	1.106	146	Yes	-

Interactions (14)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMD3	5709	PSMD13	5719	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, MINT_Yeast, YeastHigh, BioGrid, BioGrid_Yeast, IntAct_Yeast, Krogan_Core
PSMD3	5709	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
PSMA1	5682	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastMedium
ACTB	60	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast
PSMD11	5717	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastHigh, BioGrid, INTEROLOG
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMA1	5682	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMA2	5683	PSMD13	5719	pp	--	int.I2D: YeastLow
PSMA1	5682	PSMA2	5683	pp	--	int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid
ACTB	60	PSMA1	5682	pp	--	int.I2D: BioGrid_Yeast
PSMA1	5682	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct, YeastMedium, BioGrid, BioGrid_Yeast, IntAct_Yeast
PSMA2	5683	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD13	5719	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (85)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006521	regulation of cellular amino acid metabolic process	2.44e-12	3.52e-08	7.909	5	17	50
GO:0000502	proteasome complex	5.27e-12	7.61e-08	7.695	5	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	8.77e-12	1.27e-07	7.553	5	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	9.50e-12	1.37e-07	7.531	5	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.39e-11	2.01e-07	7.424	5	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	1.61e-11	2.32e-07	7.383	5	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.85e-11	2.67e-07	7.344	5	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	1.98e-11	2.86e-07	7.324	5	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	2.59e-11	3.74e-07	7.249	5	23	79
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	5.65e-11	8.15e-07	7.029	5	21	92
GO:0000209	protein polyubiquitination	1.84e-10	2.65e-06	6.695	5	20	116
GO:0000082	G1/S transition of mitotic cell cycle	6.55e-10	9.44e-06	6.334	5	32	149
GO:0042981	regulation of apoptotic process	6.77e-10	9.77e-06	6.324	5	24	150
GO:0034641	cellular nitrogen compound metabolic process	1.31e-09	1.89e-05	6.135	5	20	171
GO:0016071	mRNA metabolic process	5.01e-09	7.22e-05	5.752	5	31	223
GO:0016070	RNA metabolic process	8.37e-09	1.21e-04	5.605	5	32	247
GO:0005838	proteasome regulatory particle	8.79e-09	1.27e-04	9.231	3	7	12
GO:0022624	proteasome accessory complex	2.71e-08	3.91e-04	8.729	3	8	17
GO:0000278	mitotic cell cycle	8.38e-08	1.21e-03	4.942	5	48	391
GO:0043066	negative regulation of apoptotic process	1.26e-07	1.81e-03	4.825	5	31	424
GO:0005654	nucleoplasm	1.76e-07	2.54e-03	3.737	6	76	1082
GO:0016032	viral process	3.97e-07	5.73e-03	4.492	5	55	534
GO:0006915	apoptotic process	4.82e-07	6.95e-03	4.437	5	33	555
GO:0010467	gene expression	1.22e-06	1.76e-02	4.167	5	59	669
GO:0019773	proteasome core complex, alpha-subunit complex	4.03e-06	5.82e-02	9.231	2	4	8
GO:0070062	extracellular vesicular exosome	2.11e-05	3.05e-01	2.587	6	104	2400
GO:0005839	proteasome core complex	2.20e-05	3.17e-01	8.061	2	8	18
GO:0044281	small molecule metabolic process	2.31e-05	3.33e-01	3.311	5	58	1211
GO:0004298	threonine-type endopeptidase activity	2.46e-05	3.55e-01	7.983	2	8	19
GO:0005829	cytosol	2.67e-05	3.86e-01	2.531	6	132	2496
GO:0007127	meiosis I	8.32e-04	1.00e+00	10.231	1	1	2
GO:0043248	proteasome assembly	2.08e-03	1.00e+00	8.909	1	1	5
GO:0016020	membrane	2.27e-03	1.00e+00	2.516	4	90	1681
GO:0030957	Tat protein binding	2.49e-03	1.00e+00	8.646	1	3	6
GO:0070688	MLL5-L complex	3.32e-03	1.00e+00	8.231	1	1	8
GO:0030234	enzyme regulator activity	5.40e-03	1.00e+00	7.531	1	3	13
GO:0035267	NuA4 histone acetyltransferase complex	5.81e-03	1.00e+00	7.424	1	4	14
GO:0050998	nitric-oxide synthase binding	6.64e-03	1.00e+00	7.231	1	1	16
GO:0042176	regulation of protein catabolic process	6.64e-03	1.00e+00	7.231	1	3	16
GO:0048863	stem cell differentiation	7.88e-03	1.00e+00	6.983	1	1	19
GO:0030863	cortical cytoskeleton	9.12e-03	1.00e+00	6.772	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	9.12e-03	1.00e+00	6.772	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	9.53e-03	1.00e+00	6.708	1	4	23
GO:0005844	polysome	9.53e-03	1.00e+00	6.708	1	4	23
GO:0031492	nucleosomal DNA binding	1.12e-02	1.00e+00	6.476	1	4	27
GO:0019894	kinesin binding	1.16e-02	1.00e+00	6.424	1	1	28
GO:0005634	nucleus	1.39e-02	1.00e+00	1.399	5	136	4559
GO:0001895	retina homeostasis	1.41e-02	1.00e+00	6.144	1	1	34
GO:0034332	adherens junction organization	1.49e-02	1.00e+00	6.061	1	1	36
GO:0051084	'de novo' posttranslational protein folding	1.53e-02	1.00e+00	6.022	1	4	37
GO:0070527	platelet aggregation	1.57e-02	1.00e+00	5.983	1	2	38
GO:0021762	substantia nigra development	1.82e-02	1.00e+00	5.772	1	2	44
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.19e-02	1.00e+00	5.503	1	5	53
GO:0045216	cell-cell junction organization	2.23e-02	1.00e+00	5.476	1	2	54
GO:0000932	cytoplasmic mRNA processing body	2.23e-02	1.00e+00	5.476	1	3	54
GO:0034329	cell junction assembly	2.80e-02	1.00e+00	5.144	1	1	68
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	3.04e-02	1.00e+00	5.022	1	6	74
GO:0005200	structural constituent of cytoskeleton	3.73e-02	1.00e+00	4.723	1	8	91
GO:0006928	cellular component movement	3.73e-02	1.00e+00	4.723	1	7	91
GO:0014069	postsynaptic density	4.29e-02	1.00e+00	4.517	1	3	105
GO:0072562	blood microparticle	4.53e-02	1.00e+00	4.437	1	3	111
GO:0030529	ribonucleoprotein complex	4.57e-02	1.00e+00	4.424	1	8	112
GO:0006325	chromatin organization	4.81e-02	1.00e+00	4.348	1	5	118
GO:0006511	ubiquitin-dependent protein catabolic process	5.13e-02	1.00e+00	4.254	1	5	126
GO:0009615	response to virus	5.13e-02	1.00e+00	4.254	1	5	126
GO:0000790	nuclear chromatin	5.25e-02	1.00e+00	4.220	1	9	129
GO:0006457	protein folding	5.80e-02	1.00e+00	4.071	1	7	143
GO:0061024	membrane organization	5.88e-02	1.00e+00	4.051	1	7	145
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	6.67e-02	1.00e+00	3.865	1	7	165
GO:0030424	axon	6.71e-02	1.00e+00	3.856	1	4	166
GO:0005856	cytoskeleton	1.15e-01	1.00e+00	3.046	1	12	291
GO:0043234	protein complex	1.17e-01	1.00e+00	3.027	1	18	295
GO:0019901	protein kinase binding	1.25e-01	1.00e+00	2.923	1	21	317
GO:0007411	axon guidance	1.26e-01	1.00e+00	2.914	1	13	319
GO:0005813	centrosome	1.28e-01	1.00e+00	2.882	1	14	326
GO:0003723	RNA binding	1.34e-01	1.00e+00	2.813	1	20	342
GO:0005730	nucleolus	1.42e-01	1.00e+00	1.551	2	69	1641
GO:0005925	focal adhesion	1.43e-01	1.00e+00	2.715	1	19	366
GO:0007596	blood coagulation	1.75e-01	1.00e+00	2.401	1	18	455
GO:0044267	cellular protein metabolic process	1.82e-01	1.00e+00	2.342	1	29	474
GO:0005515	protein binding	2.04e-01	1.00e+00	0.675	4	184	6024
GO:0045087	innate immune response	2.24e-01	1.00e+00	2.012	1	24	596
GO:0005615	extracellular space	3.38e-01	1.00e+00	1.329	1	17	957
GO:0005524	ATP binding	4.32e-01	1.00e+00	0.889	1	60	1298
GO:0005737	cytoplasm	4.92e-01	1.00e+00	0.352	2	110	3767

Wolf-ratios-Mammosphere-Adherent

int-snw-5719

Statistics

Genes (6)

Interactions (14)

Related GO terms (85)