int-snw-5700

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	1.018	6.82e-19	3.53e-04	9.29e-03

wolf-screen-ratio-mammosphere-adherent-int-snw-5700 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
ACO2	50	50	1.000	1.076	191	Yes	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
PSMD3	5709	57	0.986	1.106	146	Yes	-
PSMB7	5695	48	0.982	1.052	57	Yes	-
PSMA1	5682	61	0.996	1.052	123	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
[ PSMC1 ]	5700	14	0.840	1.018	137	Yes	-

Interactions (22)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ACTB	60	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast
PSMA1	5682	PSMC1	5700	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct_Fly, YeastMedium, IntAct
PSMA2	5683	PSMC1	5700	pp	--	int.I2D: BioGrid_Yeast, IntAct_Fly, YeastLow
PSMB7	5695	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PSMB7	5695	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PSMA1	5682	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastMedium
PSMA1	5682	PSMB7	5695	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
PSMC1	5700	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
ACTB	60	PSMC1	5700	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMB7	5695	pp	--	int.I2D: BioGrid_Yeast
PSMB7	5695	PSMC1	5700	pp	--	int.I2D: BioGrid_Yeast
PSMA2	5683	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMD3	5709	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
PSMA2	5683	PSMB7	5695	pp	--	int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
ACO2	50	PSMC1	5700	pp	--	int.I2D: YeastLow
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	PSMA1	5682	pp	--	int.I2D: BioGrid_Yeast
PSMC1	5700	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, MINT_Yeast, YeastHigh, Krogan_Core
PSMA1	5682	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMA1	5682	PSMA2	5683	pp	--	int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid
ACO2	50	PSMD11	5717	pp	--	int.I2D: YeastLow

Related GO terms (100)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006521	regulation of cellular amino acid metabolic process	3.54e-14	5.11e-10	7.757	6	17	50
GO:0000502	proteasome complex	9.02e-14	1.30e-09	7.543	6	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	1.67e-13	2.41e-09	7.401	6	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.84e-13	2.65e-09	7.379	6	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.92e-13	4.21e-09	7.272	6	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	3.48e-13	5.01e-09	7.231	6	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.12e-13	5.94e-09	7.192	6	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	4.48e-13	6.46e-09	7.172	6	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	6.18e-13	8.91e-09	7.097	6	23	79
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	1.58e-12	2.28e-08	6.877	6	21	92
GO:0000209	protein polyubiquitination	6.57e-12	9.47e-08	6.543	6	20	116
GO:0000082	G1/S transition of mitotic cell cycle	3.02e-11	4.36e-07	6.182	6	32	149
GO:0042981	regulation of apoptotic process	3.15e-11	4.54e-07	6.172	6	24	150
GO:0034641	cellular nitrogen compound metabolic process	6.99e-11	1.01e-06	5.983	6	20	171
GO:0016071	mRNA metabolic process	3.49e-10	5.03e-06	5.600	6	31	223
GO:0016070	RNA metabolic process	6.46e-10	9.32e-06	5.453	6	32	247
GO:0000278	mitotic cell cycle	1.02e-08	1.47e-04	4.790	6	48	391
GO:0043066	negative regulation of apoptotic process	1.66e-08	2.39e-04	4.673	6	31	424
GO:0005838	proteasome regulatory particle	2.46e-08	3.55e-04	8.816	3	7	12
GO:0016032	viral process	6.59e-08	9.50e-04	4.340	6	55	534
GO:0022624	proteasome accessory complex	7.59e-08	1.09e-03	8.314	3	8	17
GO:0006915	apoptotic process	8.29e-08	1.20e-03	4.285	6	33	555
GO:0005839	proteasome core complex	9.10e-08	1.31e-03	8.231	3	8	18
GO:0005654	nucleoplasm	9.82e-08	1.42e-03	3.544	7	76	1082
GO:0004298	threonine-type endopeptidase activity	1.08e-07	1.56e-03	8.153	3	8	19
GO:0044281	small molecule metabolic process	2.15e-07	3.10e-03	3.381	7	58	1211
GO:0010467	gene expression	2.52e-07	3.63e-03	4.015	6	59	669
GO:0019773	proteasome core complex, alpha-subunit complex	7.53e-06	1.09e-01	8.816	2	4	8
GO:0005829	cytosol	3.14e-05	4.52e-01	2.338	7	132	2496
GO:0070062	extracellular vesicular exosome	4.35e-04	1.00e+00	2.172	6	104	2400
GO:0003994	aconitate hydratase activity	1.11e-03	1.00e+00	9.816	1	1	2
GO:0051538	3 iron, 4 sulfur cluster binding	1.11e-03	1.00e+00	9.816	1	1	2
GO:0005634	nucleus	1.82e-03	1.00e+00	1.469	7	136	4559
GO:0043248	proteasome assembly	2.77e-03	1.00e+00	8.494	1	1	5
GO:0006102	isocitrate metabolic process	2.77e-03	1.00e+00	8.494	1	1	5
GO:0006101	citrate metabolic process	3.32e-03	1.00e+00	8.231	1	1	6
GO:0030957	Tat protein binding	3.32e-03	1.00e+00	8.231	1	3	6
GO:0070688	MLL5-L complex	4.43e-03	1.00e+00	7.816	1	1	8
GO:0030234	enzyme regulator activity	7.19e-03	1.00e+00	7.116	1	3	13
GO:0035267	NuA4 histone acetyltransferase complex	7.74e-03	1.00e+00	7.009	1	4	14
GO:0005730	nucleolus	8.01e-03	1.00e+00	2.136	4	69	1641
GO:0016020	membrane	8.74e-03	1.00e+00	2.101	4	90	1681
GO:0050998	nitric-oxide synthase binding	8.84e-03	1.00e+00	6.816	1	1	16
GO:0042176	regulation of protein catabolic process	8.84e-03	1.00e+00	6.816	1	3	16
GO:0017025	TBP-class protein binding	9.39e-03	1.00e+00	6.729	1	3	17
GO:0048863	stem cell differentiation	1.05e-02	1.00e+00	6.568	1	1	19
GO:0030863	cortical cytoskeleton	1.21e-02	1.00e+00	6.357	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.21e-02	1.00e+00	6.357	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.27e-02	1.00e+00	6.293	1	4	23
GO:0005844	polysome	1.27e-02	1.00e+00	6.293	1	4	23
GO:0031492	nucleosomal DNA binding	1.49e-02	1.00e+00	6.061	1	4	27
GO:0006099	tricarboxylic acid cycle	1.54e-02	1.00e+00	6.009	1	4	28
GO:0019894	kinesin binding	1.54e-02	1.00e+00	6.009	1	1	28
GO:0001895	retina homeostasis	1.87e-02	1.00e+00	5.729	1	1	34
GO:0051539	4 iron, 4 sulfur cluster binding	1.93e-02	1.00e+00	5.687	1	3	35
GO:0034332	adherens junction organization	1.98e-02	1.00e+00	5.646	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.03e-02	1.00e+00	5.607	1	4	37
GO:0070527	platelet aggregation	2.09e-02	1.00e+00	5.568	1	2	38
GO:0021762	substantia nigra development	2.42e-02	1.00e+00	5.357	1	2	44
GO:0006091	generation of precursor metabolites and energy	2.74e-02	1.00e+00	5.172	1	3	50
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.90e-02	1.00e+00	5.088	1	5	53
GO:0045216	cell-cell junction organization	2.96e-02	1.00e+00	5.061	1	2	54
GO:0000932	cytoplasmic mRNA processing body	2.96e-02	1.00e+00	5.061	1	3	54
GO:0034329	cell junction assembly	3.71e-02	1.00e+00	4.729	1	1	68
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.03e-02	1.00e+00	4.607	1	6	74
GO:0005200	structural constituent of cytoskeleton	4.94e-02	1.00e+00	4.308	1	8	91
GO:0006928	cellular component movement	4.94e-02	1.00e+00	4.308	1	7	91
GO:0014069	postsynaptic density	5.68e-02	1.00e+00	4.102	1	3	105
GO:0005506	iron ion binding	5.68e-02	1.00e+00	4.102	1	4	105
GO:0015630	microtubule cytoskeleton	5.94e-02	1.00e+00	4.035	1	4	110
GO:0072562	blood microparticle	5.99e-02	1.00e+00	4.022	1	3	111
GO:0030529	ribonucleoprotein complex	6.05e-02	1.00e+00	4.009	1	8	112
GO:0005515	protein binding	6.16e-02	1.00e+00	0.845	6	184	6024
GO:0044237	cellular metabolic process	6.31e-02	1.00e+00	3.946	1	5	117
GO:0006325	chromatin organization	6.36e-02	1.00e+00	3.933	1	5	118
GO:0006511	ubiquitin-dependent protein catabolic process	6.78e-02	1.00e+00	3.839	1	5	126
GO:0009615	response to virus	6.78e-02	1.00e+00	3.839	1	5	126
GO:0000790	nuclear chromatin	6.94e-02	1.00e+00	3.805	1	9	129
GO:0016887	ATPase activity	7.51e-02	1.00e+00	3.687	1	7	140
GO:0006457	protein folding	7.66e-02	1.00e+00	3.656	1	7	143
GO:0061024	membrane organization	7.77e-02	1.00e+00	3.636	1	7	145
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	8.80e-02	1.00e+00	3.450	1	7	165
GO:0030424	axon	8.85e-02	1.00e+00	3.441	1	4	166
GO:0005759	mitochondrial matrix	1.20e-01	1.00e+00	2.983	1	14	228
GO:0005856	cytoskeleton	1.50e-01	1.00e+00	2.631	1	12	291
GO:0006200	ATP catabolic process	1.51e-01	1.00e+00	2.626	1	15	292
GO:0043234	protein complex	1.52e-01	1.00e+00	2.612	1	18	295
GO:0005524	ATP binding	1.58e-01	1.00e+00	1.474	2	60	1298
GO:0019901	protein kinase binding	1.63e-01	1.00e+00	2.508	1	21	317
GO:0007411	axon guidance	1.64e-01	1.00e+00	2.499	1	13	319
GO:0005813	centrosome	1.67e-01	1.00e+00	2.467	1	14	326
GO:0003723	RNA binding	1.75e-01	1.00e+00	2.398	1	20	342
GO:0005925	focal adhesion	1.86e-01	1.00e+00	2.300	1	19	366
GO:0007596	blood coagulation	2.26e-01	1.00e+00	1.986	1	18	455
GO:0044267	cellular protein metabolic process	2.35e-01	1.00e+00	1.927	1	29	474
GO:0045087	innate immune response	2.87e-01	1.00e+00	1.597	1	24	596
GO:0005737	cytoplasm	3.49e-01	1.00e+00	0.522	3	110	3767
GO:0005615	extracellular space	4.23e-01	1.00e+00	0.914	1	17	957
GO:0005739	mitochondrion	4.37e-01	1.00e+00	0.853	1	28	998
GO:0044822	poly(A) RNA binding	4.56e-01	1.00e+00	0.772	1	49	1056

Wolf-ratios-Mammosphere-Adherent

int-snw-5700

Statistics

Genes (8)

Interactions (22)

Related GO terms (100)