Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
wolf-screen-ratio-mammosphere-adherent | 0.923 | 4.44e-15 | 3.15e-03 | 4.76e-02 |
Gene Symbol | Entrez Gene ID | Frequency | wolf-screen-ratio-mammosphere-adherent gene score | Best subnetwork score | Degree | wolf adherent-list Hits GI | wolf mammosphere no adherent-list Hits GI |
---|---|---|---|---|---|---|---|
ACO2 | 50 | 50 | 1.000 | 1.076 | 191 | Yes | - |
EEF2 | 1938 | 27 | 0.890 | 1.043 | 301 | Yes | - |
PHB2 | 11331 | 9 | 0.829 | 1.076 | 140 | Yes | - |
PSMA2 | 5683 | 60 | 1.093 | 1.106 | 89 | Yes | - |
PPP2R1A | 5518 | 9 | 0.644 | 0.985 | 249 | Yes | - |
PSMB7 | 5695 | 48 | 0.982 | 1.052 | 57 | Yes | - |
PSMA1 | 5682 | 61 | 0.996 | 1.052 | 123 | Yes | - |
PSMB2 | 5690 | 18 | 0.877 | 1.026 | 117 | Yes | - |
ACTB | 60 | 167 | 1.153 | 1.151 | 587 | Yes | - |
EIF4A1 | 1973 | 3 | 0.866 | 0.981 | 71 | Yes | - |
OGDH | 4967 | 13 | 0.847 | 1.076 | 113 | Yes | - |
HSPD1 | 3329 | 35 | 0.913 | 1.035 | 286 | Yes | - |
[ PPP2R2C ] | 5522 | 1 | -0.234 | 0.923 | 19 | - | - |
RPSA | 3921 | 156 | 1.327 | 1.151 | 152 | Yes | - |
PGD | 5226 | 75 | 1.201 | 1.106 | 138 | Yes | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
OGDH | 4967 | PGD | 5226 | pp | -- | int.I2D: YeastLow |
ACTB | 60 | PSMB2 | 5690 | pp | -- | int.I2D: BioGrid_Yeast |
EIF4A1 | 1973 | PPP2R1A | 5518 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
EEF2 | 1938 | PPP2R1A | 5518 | pp | -- | int.Intact: MI:0914(association); int.I2D: YeastLow, BioGrid, HPRD, IntAct; int.HPRD: in vivo |
ACTB | 60 | PSMB7 | 5695 | pp | -- | int.I2D: BioGrid_Yeast |
PPP2R1A | 5518 | PPP2R2C | 5522 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct |
PSMA1 | 5682 | PSMA2 | 5683 | pp | -- | int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid |
EEF2 | 1938 | PGD | 5226 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB2 | 5690 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct |
PPP2R1A | 5518 | PSMB2 | 5690 | pp | -- | int.I2D: IntAct_Mouse |
PPP2R1A | 5518 | PSMA1 | 5682 | pp | -- | int.I2D: IntAct_Mouse |
ACO2 | 50 | OGDH | 4967 | pp | -- | int.I2D: YeastLow |
ACTB | 60 | PPP2R1A | 5518 | pp | -- | int.I2D: BioGrid_Yeast |
PPP2R1A | 5518 | PSMA2 | 5683 | pp | -- | int.I2D: IntAct_Mouse |
HSPD1 | 3329 | PHB2 | 11331 | pp | -- | int.I2D: IntAct_Yeast |
PPP2R1A | 5518 | PSMB7 | 5695 | pp | -- | int.I2D: IntAct_Mouse |
PSMA2 | 5683 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast |
RPSA | 3921 | PHB2 | 11331 | pp | -- | int.I2D: IntAct_Yeast |
ACTB | 60 | PSMA1 | 5682 | pp | -- | int.I2D: BioGrid_Yeast |
EEF2 | 1938 | HSPD1 | 3329 | pp | -- | int.I2D: YeastLow, YeastMedium |
HSPD1 | 3329 | RPSA | 3921 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast |
PGD | 5226 | PPP2R1A | 5518 | pp | -- | int.I2D: YeastLow |
ACTB | 60 | EEF2 | 1938 | pp | -- | int.I2D: YeastLow, IntAct_Yeast |
ACTB | 60 | RPSA | 3921 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct |
PSMA2 | 5683 | PSMB2 | 5690 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core |
ACO2 | 50 | PGD | 5226 | pp | -- | int.I2D: YeastLow |
EEF2 | 1938 | PHB2 | 11331 | pp | -- | int.I2D: IntAct_Yeast |
ACTB | 60 | PHB2 | 11331 | pp | -- | int.I2D: IntAct_Yeast |
HSPD1 | 3329 | PPP2R2C | 5522 | pp | -- | int.I2D: BioGrid |
ACO2 | 50 | HSPD1 | 3329 | pp | -- | int.I2D: IntAct_Yeast |
PSMA1 | 5682 | PSMB2 | 5690 | pp | -- | int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid |
PSMA1 | 5682 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast |
HSPD1 | 3329 | PPP2R1A | 5518 | pp | -- | int.Intact: MI:0914(association); int.I2D: HPRD, IntAct; int.HPRD: in vivo |
PPP2R1A | 5518 | PHB2 | 11331 | pp | -- | int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct |
ACTB | 60 | HSPD1 | 3329 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct, YeastLow |
HSPD1 | 3329 | OGDH | 4967 | pp | -- | int.I2D: YeastLow |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0016071 | mRNA metabolic process | 1.11e-09 | 1.61e-05 | 4.916 | 7 | 31 | 223 |
GO:0016070 | RNA metabolic process | 2.27e-09 | 3.28e-05 | 4.768 | 7 | 32 | 247 |
GO:0005839 | proteasome core complex | 2.30e-09 | 3.31e-05 | 7.739 | 4 | 8 | 18 |
GO:0004298 | threonine-type endopeptidase activity | 2.91e-09 | 4.20e-05 | 7.661 | 4 | 8 | 19 |
GO:0010467 | gene expression | 9.90e-08 | 1.43e-03 | 3.523 | 8 | 59 | 669 |
GO:0070062 | extracellular vesicular exosome | 1.22e-07 | 1.76e-03 | 2.265 | 12 | 104 | 2400 |
GO:0006521 | regulation of cellular amino acid metabolic process | 1.70e-07 | 2.45e-03 | 6.265 | 4 | 17 | 50 |
GO:0000502 | proteasome complex | 3.11e-07 | 4.48e-03 | 6.051 | 4 | 17 | 58 |
GO:0016032 | viral process | 4.56e-07 | 6.57e-03 | 3.656 | 7 | 55 | 534 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 4.64e-07 | 6.69e-03 | 5.909 | 4 | 19 | 64 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 4.94e-07 | 7.12e-03 | 5.887 | 4 | 22 | 65 |
GO:0034641 | cellular nitrogen compound metabolic process | 6.03e-07 | 8.69e-03 | 4.813 | 5 | 20 | 171 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 6.67e-07 | 9.62e-03 | 5.780 | 4 | 22 | 70 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 7.47e-07 | 1.08e-02 | 5.739 | 4 | 20 | 72 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 8.35e-07 | 1.20e-02 | 5.700 | 4 | 22 | 74 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 8.81e-07 | 1.27e-02 | 5.680 | 4 | 20 | 75 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 1.09e-06 | 1.57e-02 | 5.605 | 4 | 23 | 79 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 2.01e-06 | 2.89e-02 | 5.386 | 4 | 21 | 92 |
GO:0005829 | cytosol | 2.81e-06 | 4.06e-02 | 2.083 | 11 | 132 | 2496 |
GO:0000209 | protein polyubiquitination | 5.06e-06 | 7.30e-02 | 5.051 | 4 | 20 | 116 |
GO:0000082 | G1/S transition of mitotic cell cycle | 1.37e-05 | 1.97e-01 | 4.690 | 4 | 32 | 149 |
GO:0042981 | regulation of apoptotic process | 1.40e-05 | 2.02e-01 | 4.680 | 4 | 24 | 150 |
GO:0019773 | proteasome core complex, alpha-subunit complex | 2.82e-05 | 4.06e-01 | 7.909 | 2 | 4 | 8 |
GO:0000278 | mitotic cell cycle | 3.42e-05 | 4.94e-01 | 3.620 | 5 | 48 | 391 |
GO:0043066 | negative regulation of apoptotic process | 5.05e-05 | 7.28e-01 | 3.503 | 5 | 31 | 424 |
GO:0044281 | small molecule metabolic process | 1.02e-04 | 1.00e+00 | 2.475 | 7 | 58 | 1211 |
GO:0006915 | apoptotic process | 1.80e-04 | 1.00e+00 | 3.115 | 5 | 33 | 555 |
GO:0008601 | protein phosphatase type 2A regulator activity | 1.90e-04 | 1.00e+00 | 6.587 | 2 | 2 | 20 |
GO:0000159 | protein phosphatase type 2A complex | 1.90e-04 | 1.00e+00 | 6.587 | 2 | 2 | 20 |
GO:0005844 | polysome | 2.52e-04 | 1.00e+00 | 6.386 | 2 | 4 | 23 |
GO:0006099 | tricarboxylic acid cycle | 3.76e-04 | 1.00e+00 | 6.102 | 2 | 4 | 28 |
GO:0016020 | membrane | 7.94e-04 | 1.00e+00 | 2.001 | 7 | 90 | 1681 |
GO:0002842 | positive regulation of T cell mediated immune response to tumor cell | 1.04e-03 | 1.00e+00 | 9.909 | 1 | 1 | 1 |
GO:0070262 | peptidyl-serine dephosphorylation | 1.04e-03 | 1.00e+00 | 9.909 | 1 | 1 | 1 |
GO:0048291 | isotype switching to IgG isotypes | 1.04e-03 | 1.00e+00 | 9.909 | 1 | 1 | 1 |
GO:0019521 | D-gluconate metabolic process | 1.04e-03 | 1.00e+00 | 9.909 | 1 | 1 | 1 |
GO:0034602 | oxoglutarate dehydrogenase (NAD+) activity | 1.04e-03 | 1.00e+00 | 9.909 | 1 | 1 | 1 |
GO:0002368 | B cell cytokine production | 1.04e-03 | 1.00e+00 | 9.909 | 1 | 1 | 1 |
GO:0044267 | cellular protein metabolic process | 1.18e-03 | 1.00e+00 | 3.020 | 4 | 29 | 474 |
GO:0006091 | generation of precursor metabolites and energy | 1.20e-03 | 1.00e+00 | 5.265 | 2 | 3 | 50 |
GO:0003725 | double-stranded RNA binding | 1.30e-03 | 1.00e+00 | 5.209 | 2 | 5 | 52 |
GO:0005759 | mitochondrial matrix | 1.54e-03 | 1.00e+00 | 3.661 | 3 | 14 | 228 |
GO:0006412 | translation | 1.58e-03 | 1.00e+00 | 3.649 | 3 | 20 | 230 |
GO:0051087 | chaperone binding | 1.67e-03 | 1.00e+00 | 5.027 | 2 | 6 | 59 |
GO:0061034 | olfactory bulb mitral cell layer development | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 1 | 2 |
GO:0045252 | oxoglutarate dehydrogenase complex | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 2 | 2 |
GO:0051538 | 3 iron, 4 sulfur cluster binding | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 1 | 2 |
GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 1 | 2 |
GO:0019322 | pentose biosynthetic process | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 2 | 2 |
GO:0003994 | aconitate hydratase activity | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 1 | 2 |
GO:0005055 | laminin receptor activity | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 1 | 2 |
GO:0006407 | rRNA export from nucleus | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 1 | 2 |
GO:0005739 | mitochondrion | 2.63e-03 | 1.00e+00 | 2.268 | 5 | 28 | 998 |
GO:0005515 | protein binding | 2.98e-03 | 1.00e+00 | 0.938 | 12 | 184 | 6024 |
GO:0006458 | 'de novo' protein folding | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 1 | 3 |
GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 1 | 3 |
GO:0009051 | pentose-phosphate shunt, oxidative branch | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 2 | 3 |
GO:0022028 | tangential migration from the subventricular zone to the olfactory bulb | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 1 | 3 |
GO:0030135 | coated vesicle | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 1 | 3 |
GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 1 | 3 |
GO:0043234 | protein complex | 3.21e-03 | 1.00e+00 | 3.290 | 3 | 18 | 295 |
GO:0005654 | nucleoplasm | 3.74e-03 | 1.00e+00 | 2.152 | 5 | 76 | 1082 |
GO:0006414 | translational elongation | 4.09e-03 | 1.00e+00 | 4.370 | 2 | 13 | 93 |
GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 4 |
GO:0030686 | 90S preribosome | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 4 |
GO:0006104 | succinyl-CoA metabolic process | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 4 |
GO:0006734 | NADH metabolic process | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 4 |
GO:0019932 | second-messenger-mediated signaling | 5.19e-03 | 1.00e+00 | 7.587 | 1 | 1 | 5 |
GO:0046696 | lipopolysaccharide receptor complex | 5.19e-03 | 1.00e+00 | 7.587 | 1 | 1 | 5 |
GO:0042518 | negative regulation of tyrosine phosphorylation of Stat3 protein | 5.19e-03 | 1.00e+00 | 7.587 | 1 | 1 | 5 |
GO:0006102 | isocitrate metabolic process | 5.19e-03 | 1.00e+00 | 7.587 | 1 | 1 | 5 |
GO:0033600 | negative regulation of mammary gland epithelial cell proliferation | 5.19e-03 | 1.00e+00 | 7.587 | 1 | 1 | 5 |
GO:0030976 | thiamine pyrophosphate binding | 5.19e-03 | 1.00e+00 | 7.587 | 1 | 1 | 5 |
GO:0005634 | nucleus | 5.55e-03 | 1.00e+00 | 1.077 | 10 | 136 | 4559 |
GO:0015630 | microtubule cytoskeleton | 5.67e-03 | 1.00e+00 | 4.128 | 2 | 4 | 110 |
GO:0030529 | ribonucleoprotein complex | 5.87e-03 | 1.00e+00 | 4.102 | 2 | 8 | 112 |
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 6.08e-03 | 1.00e+00 | 4.076 | 2 | 11 | 114 |
GO:0003688 | DNA replication origin binding | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 2 | 6 |
GO:0021695 | cerebellar cortex development | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 2 | 6 |
GO:0030957 | Tat protein binding | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 3 | 6 |
GO:0060744 | mammary gland branching involved in thelarche | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 1 | 6 |
GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 1 | 6 |
GO:0006101 | citrate metabolic process | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 1 | 6 |
GO:0021860 | pyramidal neuron development | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 1 | 6 |
GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 1 | 6 |
GO:0044237 | cellular metabolic process | 6.39e-03 | 1.00e+00 | 4.039 | 2 | 5 | 117 |
GO:0000028 | ribosomal small subunit assembly | 7.26e-03 | 1.00e+00 | 7.102 | 1 | 1 | 7 |
GO:0006413 | translational initiation | 7.96e-03 | 1.00e+00 | 3.876 | 2 | 17 | 131 |
GO:0000339 | RNA cap binding | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 8 |
GO:0070688 | MLL5-L complex | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 8 |
GO:0006554 | lysine catabolic process | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 2 | 8 |
GO:0051604 | protein maturation | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 8 |
GO:0016281 | eukaryotic translation initiation factor 4F complex | 9.32e-03 | 1.00e+00 | 6.739 | 1 | 2 | 9 |
GO:0008494 | translation activator activity | 9.32e-03 | 1.00e+00 | 6.739 | 1 | 1 | 9 |
GO:0006098 | pentose-phosphate shunt | 1.04e-02 | 1.00e+00 | 6.587 | 1 | 4 | 10 |
GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway | 1.04e-02 | 1.00e+00 | 6.587 | 1 | 1 | 10 |
GO:0007084 | mitotic nuclear envelope reassembly | 1.04e-02 | 1.00e+00 | 6.587 | 1 | 1 | 10 |
GO:0043032 | positive regulation of macrophage activation | 1.04e-02 | 1.00e+00 | 6.587 | 1 | 1 | 10 |
GO:0021756 | striatum development | 1.04e-02 | 1.00e+00 | 6.587 | 1 | 1 | 10 |
GO:0021794 | thalamus development | 1.14e-02 | 1.00e+00 | 6.450 | 1 | 1 | 11 |
GO:0032727 | positive regulation of interferon-alpha production | 1.14e-02 | 1.00e+00 | 6.450 | 1 | 1 | 11 |
GO:0006275 | regulation of DNA replication | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 2 | 12 |
GO:0030111 | regulation of Wnt signaling pathway | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 1 | 12 |
GO:0006672 | ceramide metabolic process | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 1 | 13 |
GO:0001530 | lipopolysaccharide binding | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 3 | 13 |
GO:0051131 | chaperone-mediated protein complex assembly | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 1 | 13 |
GO:0035267 | NuA4 histone acetyltransferase complex | 1.45e-02 | 1.00e+00 | 6.102 | 1 | 4 | 14 |
GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | 1.55e-02 | 1.00e+00 | 6.002 | 1 | 2 | 15 |
GO:0060749 | mammary gland alveolus development | 1.55e-02 | 1.00e+00 | 6.002 | 1 | 2 | 15 |
GO:0042026 | protein refolding | 1.55e-02 | 1.00e+00 | 6.002 | 1 | 2 | 15 |
GO:0050998 | nitric-oxide synthase binding | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 16 |
GO:0006103 | 2-oxoglutarate metabolic process | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 16 |
GO:0010243 | response to organonitrogen compound | 1.75e-02 | 1.00e+00 | 5.822 | 1 | 3 | 17 |
GO:0050870 | positive regulation of T cell activation | 1.75e-02 | 1.00e+00 | 5.822 | 1 | 1 | 17 |
GO:0003746 | translation elongation factor activity | 1.75e-02 | 1.00e+00 | 5.822 | 1 | 3 | 17 |
GO:0032733 | positive regulation of interleukin-10 production | 1.96e-02 | 1.00e+00 | 5.661 | 1 | 1 | 19 |
GO:0044822 | poly(A) RNA binding | 2.03e-02 | 1.00e+00 | 1.865 | 4 | 49 | 1056 |
GO:0042100 | B cell proliferation | 2.16e-02 | 1.00e+00 | 5.517 | 1 | 1 | 21 |
GO:0045595 | regulation of cell differentiation | 2.16e-02 | 1.00e+00 | 5.517 | 1 | 1 | 21 |
GO:0003823 | antigen binding | 2.26e-02 | 1.00e+00 | 5.450 | 1 | 1 | 22 |
GO:0030863 | cortical cytoskeleton | 2.26e-02 | 1.00e+00 | 5.450 | 1 | 1 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 2.26e-02 | 1.00e+00 | 5.450 | 1 | 4 | 22 |
GO:0043044 | ATP-dependent chromatin remodeling | 2.37e-02 | 1.00e+00 | 5.386 | 1 | 4 | 23 |
GO:0043236 | laminin binding | 2.37e-02 | 1.00e+00 | 5.386 | 1 | 1 | 23 |
GO:0008135 | translation factor activity, nucleic acid binding | 2.47e-02 | 1.00e+00 | 5.324 | 1 | 7 | 24 |
GO:0042113 | B cell activation | 2.57e-02 | 1.00e+00 | 5.265 | 1 | 2 | 25 |
GO:0032735 | positive regulation of interleukin-12 production | 2.57e-02 | 1.00e+00 | 5.265 | 1 | 1 | 25 |
GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening | 2.57e-02 | 1.00e+00 | 5.265 | 1 | 1 | 25 |
GO:0030331 | estrogen receptor binding | 2.77e-02 | 1.00e+00 | 5.154 | 1 | 2 | 27 |
GO:0010033 | response to organic substance | 2.77e-02 | 1.00e+00 | 5.154 | 1 | 2 | 27 |
GO:0043022 | ribosome binding | 2.77e-02 | 1.00e+00 | 5.154 | 1 | 3 | 27 |
GO:0050661 | NADP binding | 2.77e-02 | 1.00e+00 | 5.154 | 1 | 2 | 27 |
GO:0000188 | inactivation of MAPK activity | 2.77e-02 | 1.00e+00 | 5.154 | 1 | 1 | 27 |
GO:0031492 | nucleosomal DNA binding | 2.77e-02 | 1.00e+00 | 5.154 | 1 | 4 | 27 |
GO:0019894 | kinesin binding | 2.87e-02 | 1.00e+00 | 5.102 | 1 | 1 | 28 |
GO:0005743 | mitochondrial inner membrane | 3.27e-02 | 1.00e+00 | 2.795 | 2 | 8 | 277 |
GO:0031072 | heat shock protein binding | 3.38e-02 | 1.00e+00 | 4.865 | 1 | 1 | 33 |
GO:0001895 | retina homeostasis | 3.48e-02 | 1.00e+00 | 4.822 | 1 | 1 | 34 |
GO:0051539 | 4 iron, 4 sulfur cluster binding | 3.58e-02 | 1.00e+00 | 4.780 | 1 | 3 | 35 |
GO:0006200 | ATP catabolic process | 3.61e-02 | 1.00e+00 | 2.719 | 2 | 15 | 292 |
GO:0034332 | adherens junction organization | 3.68e-02 | 1.00e+00 | 4.739 | 1 | 1 | 36 |
GO:0032755 | positive regulation of interleukin-6 production | 3.68e-02 | 1.00e+00 | 4.739 | 1 | 2 | 36 |
GO:0051084 | 'de novo' posttranslational protein folding | 3.78e-02 | 1.00e+00 | 4.700 | 1 | 4 | 37 |
GO:0021766 | hippocampus development | 3.88e-02 | 1.00e+00 | 4.661 | 1 | 4 | 38 |
GO:0006096 | glycolytic process | 3.88e-02 | 1.00e+00 | 4.661 | 1 | 4 | 38 |
GO:0070527 | platelet aggregation | 3.88e-02 | 1.00e+00 | 4.661 | 1 | 2 | 38 |
GO:0032729 | positive regulation of interferon-gamma production | 3.98e-02 | 1.00e+00 | 4.624 | 1 | 2 | 39 |
GO:0022627 | cytosolic small ribosomal subunit | 3.98e-02 | 1.00e+00 | 4.624 | 1 | 4 | 39 |
GO:0008026 | ATP-dependent helicase activity | 3.98e-02 | 1.00e+00 | 4.624 | 1 | 3 | 39 |
GO:0019901 | protein kinase binding | 4.19e-02 | 1.00e+00 | 2.601 | 2 | 21 | 317 |
GO:0042110 | T cell activation | 4.28e-02 | 1.00e+00 | 4.517 | 1 | 3 | 42 |
GO:0004722 | protein serine/threonine phosphatase activity | 4.28e-02 | 1.00e+00 | 4.517 | 1 | 1 | 42 |
GO:0030155 | regulation of cell adhesion | 4.28e-02 | 1.00e+00 | 4.517 | 1 | 2 | 42 |
GO:0014070 | response to organic cyclic compound | 4.38e-02 | 1.00e+00 | 4.483 | 1 | 4 | 43 |
GO:0021762 | substantia nigra development | 4.48e-02 | 1.00e+00 | 4.450 | 1 | 2 | 44 |
GO:0045727 | positive regulation of translation | 4.48e-02 | 1.00e+00 | 4.450 | 1 | 3 | 44 |
GO:0003743 | translation initiation factor activity | 4.98e-02 | 1.00e+00 | 4.294 | 1 | 8 | 49 |
GO:0006986 | response to unfolded protein | 5.08e-02 | 1.00e+00 | 4.265 | 1 | 2 | 50 |
GO:0000775 | chromosome, centromeric region | 5.08e-02 | 1.00e+00 | 4.265 | 1 | 2 | 50 |
GO:0031100 | organ regeneration | 5.08e-02 | 1.00e+00 | 4.265 | 1 | 4 | 50 |
GO:0005905 | coated pit | 5.08e-02 | 1.00e+00 | 4.265 | 1 | 3 | 50 |
GO:0040008 | regulation of growth | 5.08e-02 | 1.00e+00 | 4.265 | 1 | 5 | 50 |
GO:0004386 | helicase activity | 5.28e-02 | 1.00e+00 | 4.209 | 1 | 2 | 52 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 5.38e-02 | 1.00e+00 | 4.181 | 1 | 5 | 53 |
GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 5.38e-02 | 1.00e+00 | 4.181 | 1 | 1 | 53 |
GO:0002244 | hematopoietic progenitor cell differentiation | 5.47e-02 | 1.00e+00 | 4.154 | 1 | 1 | 54 |
GO:0045216 | cell-cell junction organization | 5.47e-02 | 1.00e+00 | 4.154 | 1 | 2 | 54 |
GO:0000932 | cytoplasmic mRNA processing body | 5.47e-02 | 1.00e+00 | 4.154 | 1 | 3 | 54 |
GO:0031966 | mitochondrial membrane | 5.57e-02 | 1.00e+00 | 4.128 | 1 | 1 | 55 |
GO:0002039 | p53 binding | 5.57e-02 | 1.00e+00 | 4.128 | 1 | 7 | 55 |
GO:0007059 | chromosome segregation | 6.26e-02 | 1.00e+00 | 3.955 | 1 | 4 | 62 |
GO:0030141 | secretory granule | 6.26e-02 | 1.00e+00 | 3.955 | 1 | 2 | 62 |
GO:0034329 | cell junction assembly | 6.85e-02 | 1.00e+00 | 3.822 | 1 | 1 | 68 |
GO:0003697 | single-stranded DNA binding | 6.85e-02 | 1.00e+00 | 3.822 | 1 | 5 | 68 |
GO:0050790 | regulation of catalytic activity | 6.94e-02 | 1.00e+00 | 3.801 | 1 | 2 | 69 |
GO:0003729 | mRNA binding | 7.24e-02 | 1.00e+00 | 3.739 | 1 | 3 | 72 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 7.43e-02 | 1.00e+00 | 3.700 | 1 | 6 | 74 |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 7.72e-02 | 1.00e+00 | 3.642 | 1 | 7 | 77 |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | 8.01e-02 | 1.00e+00 | 3.587 | 1 | 3 | 80 |
GO:0019083 | viral transcription | 8.10e-02 | 1.00e+00 | 3.569 | 1 | 10 | 81 |
GO:0006415 | translational termination | 8.68e-02 | 1.00e+00 | 3.466 | 1 | 10 | 87 |
GO:0050821 | protein stabilization | 8.78e-02 | 1.00e+00 | 3.450 | 1 | 2 | 88 |
GO:0016363 | nuclear matrix | 9.06e-02 | 1.00e+00 | 3.401 | 1 | 12 | 91 |
GO:0006928 | cellular component movement | 9.06e-02 | 1.00e+00 | 3.401 | 1 | 7 | 91 |
GO:0005200 | structural constituent of cytoskeleton | 9.06e-02 | 1.00e+00 | 3.401 | 1 | 8 | 91 |
GO:0051082 | unfolded protein binding | 9.25e-02 | 1.00e+00 | 3.370 | 1 | 5 | 93 |
GO:0006470 | protein dephosphorylation | 9.73e-02 | 1.00e+00 | 3.294 | 1 | 1 | 98 |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 1.03e-01 | 1.00e+00 | 3.209 | 1 | 10 | 104 |
GO:0014069 | postsynaptic density | 1.04e-01 | 1.00e+00 | 3.195 | 1 | 3 | 105 |
GO:0005506 | iron ion binding | 1.04e-01 | 1.00e+00 | 3.195 | 1 | 4 | 105 |
GO:0006461 | protein complex assembly | 1.09e-01 | 1.00e+00 | 3.115 | 1 | 6 | 111 |
GO:0072562 | blood microparticle | 1.09e-01 | 1.00e+00 | 3.115 | 1 | 3 | 111 |
GO:0030308 | negative regulation of cell growth | 1.09e-01 | 1.00e+00 | 3.128 | 1 | 6 | 110 |
GO:0019058 | viral life cycle | 1.13e-01 | 1.00e+00 | 3.064 | 1 | 13 | 115 |
GO:0006325 | chromatin organization | 1.16e-01 | 1.00e+00 | 3.027 | 1 | 5 | 118 |
GO:0009615 | response to virus | 1.23e-01 | 1.00e+00 | 2.932 | 1 | 5 | 126 |
GO:0000790 | nuclear chromatin | 1.26e-01 | 1.00e+00 | 2.898 | 1 | 9 | 129 |
GO:0003735 | structural constituent of ribosome | 1.33e-01 | 1.00e+00 | 2.811 | 1 | 10 | 137 |
GO:0000086 | G2/M transition of mitotic cell cycle | 1.33e-01 | 1.00e+00 | 2.822 | 1 | 9 | 136 |
GO:0016887 | ATPase activity | 1.36e-01 | 1.00e+00 | 2.780 | 1 | 7 | 140 |
GO:0006457 | protein folding | 1.39e-01 | 1.00e+00 | 2.749 | 1 | 7 | 143 |
GO:0061024 | membrane organization | 1.41e-01 | 1.00e+00 | 2.729 | 1 | 7 | 145 |
GO:0010628 | positive regulation of gene expression | 1.42e-01 | 1.00e+00 | 2.719 | 1 | 5 | 146 |
GO:0005769 | early endosome | 1.47e-01 | 1.00e+00 | 2.661 | 1 | 2 | 152 |
GO:0005524 | ATP binding | 1.47e-01 | 1.00e+00 | 1.152 | 3 | 60 | 1298 |
GO:0008543 | fibroblast growth factor receptor signaling pathway | 1.51e-01 | 1.00e+00 | 2.624 | 1 | 9 | 156 |
GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 1.59e-01 | 1.00e+00 | 2.543 | 1 | 7 | 165 |
GO:0030424 | axon | 1.59e-01 | 1.00e+00 | 2.534 | 1 | 4 | 166 |
GO:0003924 | GTPase activity | 1.86e-01 | 1.00e+00 | 2.287 | 1 | 12 | 197 |
GO:0006184 | GTP catabolic process | 2.01e-01 | 1.00e+00 | 2.168 | 1 | 12 | 214 |
GO:0019221 | cytokine-mediated signaling pathway | 2.07e-01 | 1.00e+00 | 2.121 | 1 | 9 | 221 |
GO:0008380 | RNA splicing | 2.13e-01 | 1.00e+00 | 2.076 | 1 | 11 | 228 |
GO:0005975 | carbohydrate metabolic process | 2.33e-01 | 1.00e+00 | 1.926 | 1 | 9 | 253 |
GO:0005730 | nucleolus | 2.39e-01 | 1.00e+00 | 0.814 | 3 | 69 | 1641 |
GO:0043065 | positive regulation of apoptotic process | 2.45e-01 | 1.00e+00 | 1.843 | 1 | 10 | 268 |
GO:0005615 | extracellular space | 2.62e-01 | 1.00e+00 | 1.007 | 2 | 17 | 957 |
GO:0005856 | cytoskeleton | 2.64e-01 | 1.00e+00 | 1.724 | 1 | 12 | 291 |
GO:0005525 | GTP binding | 2.78e-01 | 1.00e+00 | 1.633 | 1 | 12 | 310 |
GO:0007411 | axon guidance | 2.85e-01 | 1.00e+00 | 1.592 | 1 | 13 | 319 |
GO:0005813 | centrosome | 2.90e-01 | 1.00e+00 | 1.560 | 1 | 14 | 326 |
GO:0003723 | RNA binding | 3.02e-01 | 1.00e+00 | 1.491 | 1 | 20 | 342 |
GO:0005925 | focal adhesion | 3.20e-01 | 1.00e+00 | 1.393 | 1 | 19 | 366 |
GO:0007155 | cell adhesion | 3.22e-01 | 1.00e+00 | 1.382 | 1 | 6 | 369 |
GO:0046982 | protein heterodimerization activity | 3.30e-01 | 1.00e+00 | 1.339 | 1 | 13 | 380 |
GO:0009986 | cell surface | 3.46e-01 | 1.00e+00 | 1.258 | 1 | 11 | 402 |
GO:0045892 | negative regulation of transcription, DNA-templated | 3.53e-01 | 1.00e+00 | 1.219 | 1 | 15 | 413 |
GO:0055114 | oxidation-reduction process | 3.58e-01 | 1.00e+00 | 1.195 | 1 | 12 | 420 |
GO:0007596 | blood coagulation | 3.82e-01 | 1.00e+00 | 1.079 | 1 | 18 | 455 |
GO:0045087 | innate immune response | 4.69e-01 | 1.00e+00 | 0.690 | 1 | 24 | 596 |
GO:0007165 | signal transduction | 6.23e-01 | 1.00e+00 | 0.084 | 1 | 24 | 907 |
GO:0006355 | regulation of transcription, DNA-templated | 6.59e-01 | 1.00e+00 | -0.052 | 1 | 18 | 997 |
GO:0046872 | metal ion binding | 7.60e-01 | 1.00e+00 | -0.443 | 1 | 25 | 1307 |
GO:0005886 | plasma membrane | 7.79e-01 | 1.00e+00 | -0.425 | 2 | 45 | 2582 |
GO:0005737 | cytoplasm | 7.93e-01 | 1.00e+00 | -0.385 | 3 | 110 | 3767 |
GO:0006351 | transcription, DNA-templated | 7.95e-01 | 1.00e+00 | -0.589 | 1 | 31 | 1446 |