int-snw-5062

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.931	2.26e-15	2.67e-03	4.24e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-5062 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
PSMD13	5719	16	0.848	1.029	104	Yes	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
MYLK	4638	1	-0.604	0.931	31	-	Yes
[ PAK2 ]	5062	1	-0.128	0.931	114	Yes	-
PSMB7	5695	48	0.982	1.052	57	Yes	-
PSMA1	5682	61	0.996	1.052	123	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-

Interactions (15)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMA2	5683	PSMB7	5695	pp	--	int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PAK2	5062	PSMA2	5683	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct
PSMA2	5683	PSMD13	5719	pp	--	int.I2D: YeastLow
PAK2	5062	PSMB7	5695	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct
ACTB	60	PSMA1	5682	pp	--	int.I2D: BioGrid_Yeast
PSMA1	5682	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct, YeastMedium, BioGrid, BioGrid_Yeast, IntAct_Yeast
ACTB	60	PSMD13	5719	pp	--	int.I2D: BioGrid_Yeast
PAK2	5062	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct
PAK2	5062	PSMA1	5682	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
PSMA1	5682	PSMB7	5695	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
ACTB	60	PSMB7	5695	pp	--	int.I2D: BioGrid_Yeast
PSMA1	5682	PSMA2	5683	pp	--	int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
MYLK	4638	PAK2	5062	pp	--	int.I2D: HPRD, INNATEDB, BCI; int.HPRD: in vitro, in vivo

Related GO terms (170)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0000082	G1/S transition of mitotic cell cycle	1.34e-08	1.93e-04	5.749	5	32	149
GO:0042981	regulation of apoptotic process	1.39e-08	2.00e-04	5.739	5	24	150
GO:0006521	regulation of cellular amino acid metabolic process	1.59e-08	2.29e-04	7.002	4	17	50
GO:0000502	proteasome complex	2.92e-08	4.21e-04	6.788	4	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.37e-08	6.30e-04	6.646	4	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.65e-08	6.71e-04	6.624	4	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.29e-08	9.08e-04	6.517	4	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	7.06e-08	1.02e-03	6.476	4	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.89e-08	1.14e-03	6.437	4	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	8.33e-08	1.20e-03	6.417	4	20	75
GO:0016071	mRNA metabolic process	1.01e-07	1.46e-03	5.167	5	31	223
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	1.03e-07	1.48e-03	6.342	4	23	79
GO:0005839	proteasome core complex	1.36e-07	1.97e-03	8.061	3	8	18
GO:0004298	threonine-type endopeptidase activity	1.62e-07	2.34e-03	7.983	3	8	19
GO:0016070	RNA metabolic process	1.69e-07	2.43e-03	5.020	5	32	247
GO:0016032	viral process	1.91e-07	2.76e-03	4.170	6	55	534
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	1.91e-07	2.75e-03	6.123	4	21	92
GO:0000209	protein polyubiquitination	4.85e-07	7.00e-03	5.788	4	20	116
GO:0000278	mitotic cell cycle	1.64e-06	2.37e-02	4.357	5	48	391
GO:0034641	cellular nitrogen compound metabolic process	2.29e-06	3.31e-02	5.228	4	20	171
GO:0043066	negative regulation of apoptotic process	2.45e-06	3.54e-02	4.240	5	31	424
GO:0005829	cytosol	6.07e-06	8.76e-02	2.361	8	132	2496
GO:0006915	apoptotic process	9.18e-06	1.32e-01	3.852	5	33	555
GO:0019773	proteasome core complex, alpha-subunit complex	9.67e-06	1.40e-01	8.646	2	4	8
GO:0005654	nucleoplasm	1.21e-05	1.75e-01	3.152	6	76	1082
GO:0010467	gene expression	2.28e-05	3.29e-01	3.582	5	59	669
GO:0070062	extracellular vesicular exosome	9.23e-05	1.00e+00	2.225	7	104	2400
GO:0014820	tonic smooth muscle contraction	6.24e-04	1.00e+00	10.646	1	1	1
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.25e-03	1.00e+00	9.646	1	1	2
GO:0005055	laminin receptor activity	1.25e-03	1.00e+00	9.646	1	1	2
GO:0006407	rRNA export from nucleus	1.25e-03	1.00e+00	9.646	1	1	2
GO:0007127	meiosis I	1.25e-03	1.00e+00	9.646	1	1	2
GO:0060414	aorta smooth muscle tissue morphogenesis	1.25e-03	1.00e+00	9.646	1	1	2
GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	1.87e-03	1.00e+00	9.061	1	1	3
GO:0004687	myosin light chain kinase activity	1.87e-03	1.00e+00	9.061	1	1	3
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.49e-03	1.00e+00	8.646	1	1	4
GO:0030686	90S preribosome	2.49e-03	1.00e+00	8.646	1	1	4
GO:0000730	DNA recombinase assembly	3.12e-03	1.00e+00	8.324	1	1	5
GO:2000001	regulation of DNA damage checkpoint	3.12e-03	1.00e+00	8.324	1	1	5
GO:0030957	Tat protein binding	3.74e-03	1.00e+00	8.061	1	3	6
GO:0071476	cellular hypotonic response	3.74e-03	1.00e+00	8.061	1	1	6
GO:0000028	ribosomal small subunit assembly	4.36e-03	1.00e+00	7.839	1	1	7
GO:0044281	small molecule metabolic process	4.42e-03	1.00e+00	2.404	4	58	1211
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0032060	bleb assembly	4.98e-03	1.00e+00	7.646	1	1	8
GO:0005515	protein binding	5.23e-03	1.00e+00	1.090	8	184	6024
GO:0030296	protein tyrosine kinase activator activity	5.60e-03	1.00e+00	7.476	1	1	9
GO:0005634	nucleus	5.94e-03	1.00e+00	1.299	7	136	4559
GO:0090303	positive regulation of wound healing	6.22e-03	1.00e+00	7.324	1	1	10
GO:0010569	regulation of double-strand break repair via homologous recombination	6.22e-03	1.00e+00	7.324	1	1	10
GO:0031571	mitotic G1 DNA damage checkpoint	6.85e-03	1.00e+00	7.187	1	4	11
GO:0005838	proteasome regulatory particle	7.47e-03	1.00e+00	7.061	1	7	12
GO:0005662	DNA replication factor A complex	8.09e-03	1.00e+00	6.946	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	8.70e-03	1.00e+00	6.839	1	4	14
GO:0050998	nitric-oxide synthase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0006939	smooth muscle contraction	1.06e-02	1.00e+00	6.559	1	1	17
GO:0022624	proteasome accessory complex	1.06e-02	1.00e+00	6.559	1	8	17
GO:0035861	site of double-strand break	1.12e-02	1.00e+00	6.476	1	1	18
GO:0004683	calmodulin-dependent protein kinase activity	1.18e-02	1.00e+00	6.398	1	1	19
GO:0006298	mismatch repair	1.24e-02	1.00e+00	6.324	1	3	20
GO:0061098	positive regulation of protein tyrosine kinase activity	1.30e-02	1.00e+00	6.254	1	1	21
GO:0032201	telomere maintenance via semi-conservative replication	1.30e-02	1.00e+00	6.254	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.30e-02	1.00e+00	6.254	1	4	21
GO:0005730	nucleolus	1.31e-02	1.00e+00	1.966	4	69	1641
GO:0006297	nucleotide-excision repair, DNA gap filling	1.36e-02	1.00e+00	6.187	1	3	22
GO:0030863	cortical cytoskeleton	1.36e-02	1.00e+00	6.187	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.36e-02	1.00e+00	6.187	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.43e-02	1.00e+00	6.123	1	4	23
GO:0005844	polysome	1.43e-02	1.00e+00	6.123	1	4	23
GO:0043236	laminin binding	1.43e-02	1.00e+00	6.123	1	1	23
GO:0000722	telomere maintenance via recombination	1.55e-02	1.00e+00	6.002	1	5	25
GO:0019901	protein kinase binding	1.57e-02	1.00e+00	3.338	2	21	317
GO:0007411	axon guidance	1.58e-02	1.00e+00	3.329	2	13	319
GO:0051928	positive regulation of calcium ion transport	1.61e-02	1.00e+00	5.946	1	1	26
GO:0050690	regulation of defense response to virus by virus	1.67e-02	1.00e+00	5.891	1	4	27
GO:0043022	ribosome binding	1.67e-02	1.00e+00	5.891	1	3	27
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	1.67e-02	1.00e+00	5.891	1	2	27
GO:0031492	nucleosomal DNA binding	1.67e-02	1.00e+00	5.891	1	4	27
GO:0019894	kinesin binding	1.73e-02	1.00e+00	5.839	1	1	28
GO:0006271	DNA strand elongation involved in DNA replication	1.86e-02	1.00e+00	5.739	1	7	30
GO:0001895	retina homeostasis	2.10e-02	1.00e+00	5.559	1	1	34
GO:0034332	adherens junction organization	2.22e-02	1.00e+00	5.476	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.29e-02	1.00e+00	5.437	1	4	37
GO:0007015	actin filament organization	2.29e-02	1.00e+00	5.437	1	2	37
GO:0006284	base-excision repair	2.29e-02	1.00e+00	5.437	1	3	37
GO:0070527	platelet aggregation	2.35e-02	1.00e+00	5.398	1	2	38
GO:0032154	cleavage furrow	2.35e-02	1.00e+00	5.398	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.41e-02	1.00e+00	5.361	1	4	39
GO:0000781	chromosome, telomeric region	2.41e-02	1.00e+00	5.361	1	3	39
GO:0021762	substantia nigra development	2.71e-02	1.00e+00	5.187	1	2	44
GO:0006283	transcription-coupled nucleotide-excision repair	2.83e-02	1.00e+00	5.123	1	7	46
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	2.90e-02	1.00e+00	5.092	1	5	47
GO:0003684	damaged DNA binding	3.02e-02	1.00e+00	5.031	1	7	49
GO:0040008	regulation of growth	3.08e-02	1.00e+00	5.002	1	5	50
GO:0006468	protein phosphorylation	3.15e-02	1.00e+00	2.801	2	18	460
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.26e-02	1.00e+00	4.918	1	5	53
GO:0045216	cell-cell junction organization	3.32e-02	1.00e+00	4.891	1	2	54
GO:0000932	cytoplasmic mRNA processing body	3.32e-02	1.00e+00	4.891	1	3	54
GO:0044267	cellular protein metabolic process	3.33e-02	1.00e+00	2.757	2	29	474
GO:0001725	stress fiber	3.38e-02	1.00e+00	4.865	1	2	55
GO:0000724	double-strand break repair via homologous recombination	3.38e-02	1.00e+00	4.865	1	3	55
GO:0000723	telomere maintenance	3.44e-02	1.00e+00	4.839	1	6	56
GO:0019903	protein phosphatase binding	3.80e-02	1.00e+00	4.692	1	4	62
GO:0006302	double-strand break repair	3.80e-02	1.00e+00	4.692	1	4	62
GO:0006469	negative regulation of protein kinase activity	3.98e-02	1.00e+00	4.624	1	4	65
GO:0031295	T cell costimulation	3.98e-02	1.00e+00	4.624	1	2	65
GO:0005524	ATP binding	4.04e-02	1.00e+00	1.889	3	60	1298
GO:0006289	nucleotide-excision repair	4.17e-02	1.00e+00	4.559	1	11	68
GO:0034329	cell junction assembly	4.17e-02	1.00e+00	4.559	1	1	68
GO:0003697	single-stranded DNA binding	4.17e-02	1.00e+00	4.559	1	5	68
GO:0018105	peptidyl-serine phosphorylation	4.23e-02	1.00e+00	4.538	1	5	69
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.53e-02	1.00e+00	4.437	1	6	74
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	4.59e-02	1.00e+00	4.417	1	3	75
GO:0019083	viral transcription	4.94e-02	1.00e+00	4.306	1	10	81
GO:0045087	innate immune response	5.06e-02	1.00e+00	2.427	2	24	596
GO:0050852	T cell receptor signaling pathway	5.18e-02	1.00e+00	4.237	1	4	85
GO:0047485	protein N-terminus binding	5.24e-02	1.00e+00	4.220	1	5	86
GO:0006415	translational termination	5.30e-02	1.00e+00	4.203	1	10	87
GO:0006936	muscle contraction	5.30e-02	1.00e+00	4.203	1	2	87
GO:0016605	PML body	5.36e-02	1.00e+00	4.187	1	3	88
GO:0016310	phosphorylation	5.48e-02	1.00e+00	4.154	1	4	90
GO:0006928	cellular component movement	5.54e-02	1.00e+00	4.138	1	7	91
GO:0005200	structural constituent of cytoskeleton	5.54e-02	1.00e+00	4.138	1	8	91
GO:0006414	translational elongation	5.66e-02	1.00e+00	4.107	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	6.31e-02	1.00e+00	3.946	1	10	104
GO:0014069	postsynaptic density	6.37e-02	1.00e+00	3.932	1	3	105
GO:0015630	microtubule cytoskeleton	6.66e-02	1.00e+00	3.865	1	4	110
GO:0072562	blood microparticle	6.72e-02	1.00e+00	3.852	1	3	111
GO:0030529	ribonucleoprotein complex	6.78e-02	1.00e+00	3.839	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.89e-02	1.00e+00	3.813	1	11	114
GO:0019058	viral life cycle	6.95e-02	1.00e+00	3.801	1	13	115
GO:0006325	chromatin organization	7.13e-02	1.00e+00	3.764	1	5	118
GO:0006260	DNA replication	7.30e-02	1.00e+00	3.727	1	9	121
GO:0030027	lamellipodium	7.54e-02	1.00e+00	3.680	1	4	125
GO:0009615	response to virus	7.60e-02	1.00e+00	3.669	1	5	126
GO:0030335	positive regulation of cell migration	7.65e-02	1.00e+00	3.657	1	7	127
GO:0016020	membrane	7.75e-02	1.00e+00	1.516	3	90	1681
GO:0000790	nuclear chromatin	7.77e-02	1.00e+00	3.635	1	9	129
GO:0006413	translational initiation	7.89e-02	1.00e+00	3.613	1	17	131
GO:0005911	cell-cell junction	8.18e-02	1.00e+00	3.559	1	4	136
GO:0003735	structural constituent of ribosome	8.23e-02	1.00e+00	3.548	1	10	137
GO:0006457	protein folding	8.58e-02	1.00e+00	3.486	1	7	143
GO:0061024	membrane organization	8.69e-02	1.00e+00	3.466	1	7	145
GO:0046777	protein autophosphorylation	9.44e-02	1.00e+00	3.342	1	7	158
GO:0005516	calmodulin binding	9.55e-02	1.00e+00	3.324	1	3	160
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	9.84e-02	1.00e+00	3.280	1	7	165
GO:0030424	axon	9.90e-02	1.00e+00	3.271	1	4	166
GO:0038095	Fc-epsilon receptor signaling pathway	1.00e-01	1.00e+00	3.254	1	12	168
GO:0004672	protein kinase activity	1.05e-01	1.00e+00	3.179	1	6	177
GO:0031625	ubiquitin protein ligase binding	1.06e-01	1.00e+00	3.170	1	14	178
GO:0006412	translation	1.35e-01	1.00e+00	2.801	1	20	230
GO:0006281	DNA repair	1.52e-01	1.00e+00	2.618	1	18	261
GO:0003779	actin binding	1.54e-01	1.00e+00	2.591	1	12	266
GO:0019899	enzyme binding	1.60e-01	1.00e+00	2.532	1	12	277
GO:0005856	cytoskeleton	1.68e-01	1.00e+00	2.461	1	12	291
GO:0043234	protein complex	1.70e-01	1.00e+00	2.442	1	18	295
GO:0004674	protein serine/threonine kinase activity	1.77e-01	1.00e+00	2.379	1	12	308
GO:0005813	centrosome	1.86e-01	1.00e+00	2.297	1	14	326
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.767	4	110	3767
GO:0003723	RNA binding	1.94e-01	1.00e+00	2.228	1	20	342
GO:0005925	focal adhesion	2.07e-01	1.00e+00	2.130	1	19	366
GO:0007155	cell adhesion	2.08e-01	1.00e+00	2.119	1	6	369
GO:0007596	blood coagulation	2.51e-01	1.00e+00	1.816	1	18	455
GO:0042802	identical protein binding	2.65e-01	1.00e+00	1.727	1	20	484
GO:0048471	perinuclear region of cytoplasm	2.73e-01	1.00e+00	1.675	1	13	502
GO:0007165	signal transduction	4.43e-01	1.00e+00	0.821	1	24	907
GO:0005615	extracellular space	4.61e-01	1.00e+00	0.744	1	17	957
GO:0044822	poly(A) RNA binding	4.96e-01	1.00e+00	0.602	1	49	1056
GO:0005886	plasma membrane	4.98e-01	1.00e+00	0.312	2	45	2582
GO:0046872	metal ion binding	5.75e-01	1.00e+00	0.294	1	25	1307

Wolf-ratios-Mammosphere-Adherent

int-snw-5062

Statistics

Genes (9)

Interactions (15)

Related GO terms (170)