int-snw-5036

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.930	2.60e-15	2.77e-03	4.34e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-5036 subnetwork

Genes (12)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
ACO2	50	50	1.000	1.076	191	Yes	-
RSL24D1	51187	36	1.300	1.020	59	Yes	-
[ PA2G4 ]	5036	1	-0.272	0.930	61	-	Yes
EIF6	3692	14	0.700	1.013	267	Yes	-
RPS11	6205	36	0.993	1.113	175	Yes	-
RPL14	9045	42	1.250	1.113	143	Yes	-
RPL8	6132	9	0.778	0.967	218	Yes	-
PSMB2	5690	18	0.877	1.026	117	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
HSPD1	3329	35	0.913	1.035	286	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-
RPL11	6135	9	0.718	1.017	200	Yes	-

Interactions (20)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
EIF6	3692	PA2G4	5036	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
HSPD1	3329	EIF6	3692	pp	--	int.I2D: BioGrid_Yeast
EIF6	3692	RPL8	6132	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
RPL8	6132	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast, YeastMedium
RPL11	6135	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast
PA2G4	5036	RPL11	6135	pp	--	int.Intact: MI:0914(association); int.I2D: BCI, IntAct
EIF6	3692	RSL24D1	51187	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMB2	5690	RPL8	6132	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMB2	5690	pp	--	int.I2D: BioGrid_Yeast
EIF6	3692	PGD	5226	pp	--	int.I2D: YeastLow
PA2G4	5036	RPL8	6132	pp	--	int.Intact: MI:0914(association); int.I2D: BCI, IntAct
ACO2	50	EIF6	3692	pp	--	int.I2D: YeastLow
RPL11	6135	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
RPL8	6132	RPL11	6135	pp	--	int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium, IntAct_Yeast
RPL8	6132	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
RPS11	6205	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
ACO2	50	PGD	5226	pp	--	int.I2D: YeastLow
ACO2	50	HSPD1	3329	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPL11	6135	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
ACTB	60	HSPD1	3329	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, YeastLow

Related GO terms (167)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006413	translational initiation	4.31e-08	6.21e-04	5.520	5	17	131
GO:0042273	ribosomal large subunit biogenesis	1.25e-07	1.81e-03	8.116	3	4	13
GO:0019083	viral transcription	4.42e-07	6.37e-03	5.891	4	10	81
GO:0006415	translational termination	5.89e-07	8.50e-03	5.788	4	10	87
GO:0016071	mRNA metabolic process	6.13e-07	8.84e-03	4.752	5	31	223
GO:0006414	translational elongation	7.71e-07	1.11e-02	5.692	4	13	93
GO:0016070	RNA metabolic process	1.02e-06	1.46e-02	4.605	5	32	247
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	1.21e-06	1.74e-02	5.531	4	10	104
GO:0019843	rRNA binding	1.27e-06	1.84e-02	7.061	3	3	27
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1.75e-06	2.52e-02	5.398	4	11	114
GO:0019058	viral life cycle	1.81e-06	2.61e-02	5.386	4	13	115
GO:0016032	viral process	1.91e-06	2.76e-02	3.755	6	55	534
GO:0003735	structural constituent of ribosome	3.64e-06	5.24e-02	5.133	4	10	137
GO:0022625	cytosolic large ribosomal subunit	7.93e-06	1.14e-01	6.201	3	6	49
GO:0016020	membrane	1.08e-05	1.55e-01	2.516	8	90	1681
GO:0070062	extracellular vesicular exosome	1.31e-05	1.89e-01	2.172	9	104	2400
GO:0044267	cellular protein metabolic process	2.46e-05	3.54e-01	3.664	5	29	474
GO:0006412	translation	2.82e-05	4.07e-01	4.386	4	20	230
GO:0006364	rRNA processing	5.65e-05	8.15e-01	5.261	3	6	94
GO:0044822	poly(A) RNA binding	9.55e-05	1.00e+00	2.772	6	49	1056
GO:0010467	gene expression	1.28e-04	1.00e+00	3.167	5	59	669
GO:0005829	cytosol	2.03e-04	1.00e+00	1.946	8	132	2496
GO:0002842	positive regulation of T cell mediated immune response to tumor cell	8.32e-04	1.00e+00	10.231	1	1	1
GO:0048291	isotype switching to IgG isotypes	8.32e-04	1.00e+00	10.231	1	1	1
GO:0019521	D-gluconate metabolic process	8.32e-04	1.00e+00	10.231	1	1	1
GO:0000054	ribosomal subunit export from nucleus	8.32e-04	1.00e+00	10.231	1	1	1
GO:0002368	B cell cytokine production	8.32e-04	1.00e+00	10.231	1	1	1
GO:0051538	3 iron, 4 sulfur cluster binding	1.66e-03	1.00e+00	9.231	1	1	2
GO:0019322	pentose biosynthetic process	1.66e-03	1.00e+00	9.231	1	2	2
GO:0003994	aconitate hydratase activity	1.66e-03	1.00e+00	9.231	1	1	2
GO:0003723	RNA binding	2.48e-03	1.00e+00	3.398	3	20	342
GO:0006458	'de novo' protein folding	2.49e-03	1.00e+00	8.646	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	2.49e-03	1.00e+00	8.646	1	2	3
GO:0030135	coated vesicle	2.49e-03	1.00e+00	8.646	1	1	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.49e-03	1.00e+00	8.646	1	1	3
GO:0005925	focal adhesion	3.01e-03	1.00e+00	3.300	3	19	366
GO:0030529	ribonucleoprotein complex	3.75e-03	1.00e+00	4.424	2	8	112
GO:0042256	mature ribosome assembly	4.15e-03	1.00e+00	7.909	1	1	5
GO:0046696	lipopolysaccharide receptor complex	4.15e-03	1.00e+00	7.909	1	1	5
GO:0006102	isocitrate metabolic process	4.15e-03	1.00e+00	7.909	1	1	5
GO:0005638	lamin filament	4.15e-03	1.00e+00	7.909	1	1	5
GO:0043023	ribosomal large subunit binding	4.15e-03	1.00e+00	7.909	1	1	5
GO:0003688	DNA replication origin binding	4.98e-03	1.00e+00	7.646	1	2	6
GO:0030957	Tat protein binding	4.98e-03	1.00e+00	7.646	1	3	6
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	4.98e-03	1.00e+00	7.646	1	1	6
GO:0006101	citrate metabolic process	4.98e-03	1.00e+00	7.646	1	1	6
GO:0070688	MLL5-L complex	6.64e-03	1.00e+00	7.231	1	1	8
GO:0051604	protein maturation	6.64e-03	1.00e+00	7.231	1	1	8
GO:0005730	nucleolus	7.54e-03	1.00e+00	1.873	5	69	1641
GO:0006098	pentose-phosphate shunt	8.29e-03	1.00e+00	6.909	1	4	10
GO:0043032	positive regulation of macrophage activation	8.29e-03	1.00e+00	6.909	1	1	10
GO:0032727	positive regulation of interferon-alpha production	9.12e-03	1.00e+00	6.772	1	1	11
GO:0001530	lipopolysaccharide binding	1.08e-02	1.00e+00	6.531	1	3	13
GO:0051131	chaperone-mediated protein complex assembly	1.08e-02	1.00e+00	6.531	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	1.16e-02	1.00e+00	6.424	1	4	14
GO:0042026	protein refolding	1.24e-02	1.00e+00	6.324	1	2	15
GO:0050998	nitric-oxide synthase binding	1.32e-02	1.00e+00	6.231	1	1	16
GO:0010243	response to organonitrogen compound	1.41e-02	1.00e+00	6.144	1	3	17
GO:0050870	positive regulation of T cell activation	1.41e-02	1.00e+00	6.144	1	1	17
GO:0005759	mitochondrial matrix	1.48e-02	1.00e+00	3.398	2	14	228
GO:0005839	proteasome core complex	1.49e-02	1.00e+00	6.061	1	8	18
GO:0032733	positive regulation of interleukin-10 production	1.57e-02	1.00e+00	5.983	1	1	19
GO:0004298	threonine-type endopeptidase activity	1.57e-02	1.00e+00	5.983	1	8	19
GO:0042100	B cell proliferation	1.73e-02	1.00e+00	5.839	1	1	21
GO:0030863	cortical cytoskeleton	1.82e-02	1.00e+00	5.772	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.82e-02	1.00e+00	5.772	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.90e-02	1.00e+00	5.708	1	4	23
GO:0042113	B cell activation	2.06e-02	1.00e+00	5.587	1	2	25
GO:0032735	positive regulation of interleukin-12 production	2.06e-02	1.00e+00	5.587	1	1	25
GO:0043022	ribosome binding	2.22e-02	1.00e+00	5.476	1	3	27
GO:0050661	NADP binding	2.22e-02	1.00e+00	5.476	1	2	27
GO:0031492	nucleosomal DNA binding	2.22e-02	1.00e+00	5.476	1	4	27
GO:0006099	tricarboxylic acid cycle	2.31e-02	1.00e+00	5.424	1	4	28
GO:0019894	kinesin binding	2.31e-02	1.00e+00	5.424	1	1	28
GO:0034504	protein localization to nucleus	2.31e-02	1.00e+00	5.424	1	2	28
GO:0043234	protein complex	2.40e-02	1.00e+00	3.027	2	18	295
GO:0042254	ribosome biogenesis	2.47e-02	1.00e+00	5.324	1	1	30
GO:0001895	retina homeostasis	2.79e-02	1.00e+00	5.144	1	1	34
GO:0006605	protein targeting	2.87e-02	1.00e+00	5.102	1	2	35
GO:0051539	4 iron, 4 sulfur cluster binding	2.87e-02	1.00e+00	5.102	1	3	35
GO:0034332	adherens junction organization	2.96e-02	1.00e+00	5.061	1	1	36
GO:0032755	positive regulation of interleukin-6 production	2.96e-02	1.00e+00	5.061	1	2	36
GO:0051084	'de novo' posttranslational protein folding	3.04e-02	1.00e+00	5.022	1	4	37
GO:0070527	platelet aggregation	3.12e-02	1.00e+00	4.983	1	2	38
GO:0032729	positive regulation of interferon-gamma production	3.20e-02	1.00e+00	4.946	1	2	39
GO:0022627	cytosolic small ribosomal subunit	3.20e-02	1.00e+00	4.946	1	4	39
GO:0042110	T cell activation	3.44e-02	1.00e+00	4.839	1	3	42
GO:0014070	response to organic cyclic compound	3.52e-02	1.00e+00	4.805	1	4	43
GO:0021762	substantia nigra development	3.60e-02	1.00e+00	4.772	1	2	44
GO:0003743	translation initiation factor activity	4.00e-02	1.00e+00	4.616	1	8	49
GO:0006091	generation of precursor metabolites and energy	4.08e-02	1.00e+00	4.587	1	3	50
GO:0006521	regulation of cellular amino acid metabolic process	4.08e-02	1.00e+00	4.587	1	17	50
GO:0006986	response to unfolded protein	4.08e-02	1.00e+00	4.587	1	2	50
GO:0005905	coated pit	4.08e-02	1.00e+00	4.587	1	3	50
GO:0003725	double-stranded RNA binding	4.24e-02	1.00e+00	4.531	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	4.32e-02	1.00e+00	4.503	1	5	53
GO:0045216	cell-cell junction organization	4.40e-02	1.00e+00	4.476	1	2	54
GO:0002039	p53 binding	4.48e-02	1.00e+00	4.450	1	7	55
GO:0043066	negative regulation of apoptotic process	4.68e-02	1.00e+00	2.503	2	31	424
GO:0005840	ribosome	4.72e-02	1.00e+00	4.373	1	1	58
GO:0000502	proteasome complex	4.72e-02	1.00e+00	4.373	1	17	58
GO:0051087	chaperone binding	4.80e-02	1.00e+00	4.348	1	6	59
GO:0030141	secretory granule	5.04e-02	1.00e+00	4.277	1	2	62
GO:0006417	regulation of translation	5.04e-02	1.00e+00	4.277	1	1	62
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	5.20e-02	1.00e+00	4.231	1	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.28e-02	1.00e+00	4.209	1	22	65
GO:0034329	cell junction assembly	5.52e-02	1.00e+00	4.144	1	1	68
GO:0003697	single-stranded DNA binding	5.52e-02	1.00e+00	4.144	1	5	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.67e-02	1.00e+00	4.102	1	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	5.83e-02	1.00e+00	4.061	1	20	72
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.99e-02	1.00e+00	4.022	1	6	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.99e-02	1.00e+00	4.022	1	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	6.07e-02	1.00e+00	4.002	1	20	75
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	6.22e-02	1.00e+00	3.964	1	7	77
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	6.38e-02	1.00e+00	3.927	1	23	79
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	6.46e-02	1.00e+00	3.909	1	3	80
GO:0050821	protein stabilization	7.08e-02	1.00e+00	3.772	1	2	88
GO:0006928	cellular component movement	7.32e-02	1.00e+00	3.723	1	7	91
GO:0005200	structural constituent of cytoskeleton	7.32e-02	1.00e+00	3.723	1	8	91
GO:0044281	small molecule metabolic process	7.33e-02	1.00e+00	1.574	3	58	1211
GO:0005515	protein binding	7.35e-02	1.00e+00	0.675	8	184	6024
GO:0001649	osteoblast differentiation	7.39e-02	1.00e+00	3.708	1	6	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	7.39e-02	1.00e+00	3.708	1	21	92
GO:0051082	unfolded protein binding	7.47e-02	1.00e+00	3.692	1	5	93
GO:0014069	postsynaptic density	8.40e-02	1.00e+00	3.517	1	3	105
GO:0005506	iron ion binding	8.40e-02	1.00e+00	3.517	1	4	105
GO:0072562	blood microparticle	8.86e-02	1.00e+00	3.437	1	3	111
GO:0000209	protein polyubiquitination	9.24e-02	1.00e+00	3.373	1	20	116
GO:0044237	cellular metabolic process	9.32e-02	1.00e+00	3.361	1	5	117
GO:0006325	chromatin organization	9.39e-02	1.00e+00	3.348	1	5	118
GO:0007050	cell cycle arrest	9.85e-02	1.00e+00	3.277	1	9	124
GO:0000790	nuclear chromatin	1.02e-01	1.00e+00	3.220	1	9	129
GO:0016887	ATPase activity	1.10e-01	1.00e+00	3.102	1	7	140
GO:0006457	protein folding	1.13e-01	1.00e+00	3.071	1	7	143
GO:0061024	membrane organization	1.14e-01	1.00e+00	3.051	1	7	145
GO:0000082	G1/S transition of mitotic cell cycle	1.17e-01	1.00e+00	3.012	1	32	149
GO:0042981	regulation of apoptotic process	1.18e-01	1.00e+00	3.002	1	24	150
GO:0005769	early endosome	1.19e-01	1.00e+00	2.983	1	2	152
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.29e-01	1.00e+00	2.865	1	7	165
GO:0030424	axon	1.30e-01	1.00e+00	2.856	1	4	166
GO:0034641	cellular nitrogen compound metabolic process	1.33e-01	1.00e+00	2.813	1	20	171
GO:0031625	ubiquitin protein ligase binding	1.38e-01	1.00e+00	2.755	1	14	178
GO:0005737	cytoplasm	1.81e-01	1.00e+00	0.674	5	110	3767
GO:0005615	extracellular space	1.87e-01	1.00e+00	1.329	2	17	957
GO:0005975	carbohydrate metabolic process	1.91e-01	1.00e+00	2.248	1	9	253
GO:0005739	mitochondrion	2.00e-01	1.00e+00	1.268	2	28	998
GO:0043065	positive regulation of apoptotic process	2.02e-01	1.00e+00	2.165	1	10	268
GO:0005743	mitochondrial inner membrane	2.08e-01	1.00e+00	2.117	1	8	277
GO:0005856	cytoskeleton	2.17e-01	1.00e+00	2.046	1	12	291
GO:0006200	ATP catabolic process	2.18e-01	1.00e+00	2.041	1	15	292
GO:0005654	nucleoplasm	2.26e-01	1.00e+00	1.152	2	76	1082
GO:0019901	protein kinase binding	2.34e-01	1.00e+00	1.923	1	21	317
GO:0007411	axon guidance	2.35e-01	1.00e+00	1.914	1	13	319
GO:0008283	cell proliferation	2.41e-01	1.00e+00	1.874	1	14	328
GO:0000278	mitotic cell cycle	2.81e-01	1.00e+00	1.620	1	48	391
GO:0009986	cell surface	2.88e-01	1.00e+00	1.580	1	11	402
GO:0045892	negative regulation of transcription, DNA-templated	2.94e-01	1.00e+00	1.541	1	15	413
GO:0005524	ATP binding	2.95e-01	1.00e+00	0.889	2	60	1298
GO:0055114	oxidation-reduction process	2.99e-01	1.00e+00	1.517	1	12	420
GO:0007596	blood coagulation	3.19e-01	1.00e+00	1.401	1	18	455
GO:0005634	nucleus	3.20e-01	1.00e+00	0.399	5	136	4559
GO:0006915	apoptotic process	3.76e-01	1.00e+00	1.115	1	33	555
GO:0045087	innate immune response	3.97e-01	1.00e+00	1.012	1	24	596
GO:0003700	sequence-specific DNA binding transcription factor activity	4.49e-01	1.00e+00	0.782	1	11	699
GO:0003677	DNA binding	6.53e-01	1.00e+00	-0.019	1	28	1218
GO:0006351	transcription, DNA-templated	7.19e-01	1.00e+00	-0.267	1	31	1446
GO:0005886	plasma membrane	9.06e-01	1.00e+00	-1.103	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-5036

Statistics

Genes (12)

Interactions (20)

Related GO terms (167)