int-snw-4738

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.936	1.48e-15	2.41e-03	3.94e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-4738 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
[ NEDD8 ]	4738	2	0.572	0.936	119	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
RPS11	6205	36	0.993	1.113	175	Yes	-
RPL8	6132	9	0.778	0.967	218	Yes	-
RPL14	9045	42	1.250	1.113	143	Yes	-
RPL6	6128	11	0.844	1.113	164	Yes	-
RPL30	6156	4	0.756	1.043	164	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
RPL11	6135	9	0.718	1.017	200	Yes	-

Interactions (22)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
RPL6	6128	RPL30	6156	pp	--	int.I2D: BioGrid_Yeast
NEDD8	4738	RPL30	6156	pp	--	int.I2D: BioGrid
RPL30	6156	RPS11	6205	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast
RPL6	6128	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
NEDD8	4738	RPL6	6128	pp	--	int.I2D: BioGrid
NEDD8	4738	RBX1	9978	pp	--	int.I2D: BioGrid
RPL6	6128	RPL11	6135	pp	--	int.I2D: BioGrid_Yeast
RPL11	6135	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
RPL30	6156	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
RPS11	6205	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
NEDD8	4738	RPS11	6205	pp	--	int.I2D: BioGrid
RPL6	6128	RPL8	6132	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
RPL8	6132	RPL30	6156	pp	--	int.I2D: BioGrid_Yeast
NEDD8	4738	RPL11	6135	pp	--	int.I2D: BioGrid, MINT; int.Mint: MI:0915(physical association)
RPL8	6132	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast, YeastMedium
RPL11	6135	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast
RPL11	6135	RPL30	6156	pp	--	int.I2D: BioGrid_Yeast
RPL6	6128	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
RPL8	6132	RPL11	6135	pp	--	int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium, IntAct_Yeast
NEDD8	4738	RPL8	6132	pp	--	int.I2D: BioGrid
RPL8	6132	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (78)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0019083	viral transcription	4.82e-15	6.96e-11	7.114	7	10	81
GO:0006415	translational termination	8.10e-15	1.17e-10	7.011	7	10	87
GO:0006414	translational elongation	1.31e-14	1.89e-10	6.914	7	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	2.94e-14	4.24e-10	6.753	7	10	104
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	5.68e-14	8.20e-10	6.621	7	11	114
GO:0019058	viral life cycle	6.05e-14	8.73e-10	6.608	7	13	115
GO:0006413	translational initiation	1.54e-13	2.22e-09	6.420	7	17	131
GO:0003735	structural constituent of ribosome	2.12e-13	3.06e-09	6.355	7	10	137
GO:0016071	mRNA metabolic process	6.74e-12	9.73e-08	5.653	7	31	223
GO:0006412	translation	8.39e-12	1.21e-07	5.608	7	20	230
GO:0016070	RNA metabolic process	1.39e-11	2.00e-07	5.505	7	32	247
GO:0016032	viral process	2.92e-11	4.22e-07	4.585	8	55	534
GO:0022625	cytosolic large ribosomal subunit	4.58e-11	6.60e-07	7.353	5	6	49
GO:0044267	cellular protein metabolic process	1.35e-09	1.94e-05	4.565	7	29	474
GO:0010467	gene expression	1.49e-08	2.14e-04	4.068	7	59	669
GO:0005829	cytosol	1.38e-07	1.98e-03	2.531	9	132	2496
GO:0044822	poly(A) RNA binding	3.49e-07	5.04e-03	3.409	7	49	1056
GO:0019843	rRNA binding	4.88e-07	7.04e-03	7.476	3	3	27
GO:0003723	RNA binding	8.48e-07	1.22e-02	4.550	5	20	342
GO:0016020	membrane	8.40e-06	1.21e-01	2.738	7	90	1681
GO:0045116	protein neddylation	9.67e-06	1.40e-01	8.646	2	2	8
GO:0042273	ribosomal large subunit biogenesis	2.69e-05	3.88e-01	7.946	2	4	13
GO:0005925	focal adhesion	4.65e-05	6.70e-01	4.130	4	19	366
GO:0022627	cytosolic small ribosomal subunit	2.53e-04	1.00e+00	6.361	2	4	39
GO:0070062	extracellular vesicular exosome	1.12e-03	1.00e+00	2.002	6	104	2400
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.25e-03	1.00e+00	9.646	1	1	2
GO:0005055	laminin receptor activity	1.25e-03	1.00e+00	9.646	1	1	2
GO:0006407	rRNA export from nucleus	1.25e-03	1.00e+00	9.646	1	1	2
GO:0006364	rRNA processing	1.47e-03	1.00e+00	5.092	2	6	94
GO:0019788	NEDD8 ligase activity	2.49e-03	1.00e+00	8.646	1	1	4
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.49e-03	1.00e+00	8.646	1	1	4
GO:0030686	90S preribosome	2.49e-03	1.00e+00	8.646	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	2.49e-03	1.00e+00	8.646	1	1	4
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	3.12e-03	1.00e+00	8.324	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	3.12e-03	1.00e+00	8.324	1	1	5
GO:0030891	VCB complex	3.12e-03	1.00e+00	8.324	1	2	5
GO:0031466	Cul5-RING ubiquitin ligase complex	3.74e-03	1.00e+00	8.061	1	1	6
GO:0031462	Cul2-RING ubiquitin ligase complex	4.36e-03	1.00e+00	7.839	1	2	7
GO:0000028	ribosomal small subunit assembly	4.36e-03	1.00e+00	7.839	1	1	7
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	4.98e-03	1.00e+00	7.646	1	2	8
GO:0031625	ubiquitin protein ligase binding	5.15e-03	1.00e+00	4.170	2	14	178
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.18e-02	1.00e+00	6.398	1	1	19
GO:0036464	cytoplasmic ribonucleoprotein granule	1.36e-02	1.00e+00	6.187	1	4	22
GO:0006513	protein monoubiquitination	1.43e-02	1.00e+00	6.123	1	1	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.43e-02	1.00e+00	6.123	1	3	23
GO:0043236	laminin binding	1.43e-02	1.00e+00	6.123	1	1	23
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.61e-02	1.00e+00	5.946	1	3	26
GO:0043022	ribosome binding	1.67e-02	1.00e+00	5.891	1	3	27
GO:0034504	protein localization to nucleus	1.73e-02	1.00e+00	5.839	1	2	28
GO:0019005	SCF ubiquitin ligase complex	1.80e-02	1.00e+00	5.788	1	1	29
GO:0006605	protein targeting	2.16e-02	1.00e+00	5.517	1	2	35
GO:0014070	response to organic cyclic compound	2.65e-02	1.00e+00	5.220	1	4	43
GO:0005515	protein binding	3.23e-02	1.00e+00	0.897	7	184	6024
GO:0008104	protein localization	3.44e-02	1.00e+00	4.839	1	3	56
GO:0005840	ribosome	3.56e-02	1.00e+00	4.788	1	1	58
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.59e-02	1.00e+00	4.417	1	2	75
GO:0009653	anatomical structure morphogenesis	5.06e-02	1.00e+00	4.271	1	3	83
GO:0006464	cellular protein modification process	5.12e-02	1.00e+00	4.254	1	2	84
GO:0001649	osteoblast differentiation	5.60e-02	1.00e+00	4.123	1	6	92
GO:0071456	cellular response to hypoxia	5.60e-02	1.00e+00	4.123	1	6	92
GO:0007219	Notch signaling pathway	7.25e-02	1.00e+00	3.739	1	5	120
GO:0006511	ubiquitin-dependent protein catabolic process	7.60e-02	1.00e+00	3.669	1	5	126
GO:0007179	transforming growth factor beta receptor signaling pathway	7.71e-02	1.00e+00	3.646	1	4	128
GO:0032403	protein complex binding	1.09e-01	1.00e+00	3.130	1	10	183
GO:0004842	ubiquitin-protein transferase activity	1.48e-01	1.00e+00	2.652	1	6	255
GO:0006281	DNA repair	1.52e-01	1.00e+00	2.618	1	18	261
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.53e-01	1.00e+00	2.602	1	8	264
GO:0016567	protein ubiquitination	1.70e-01	1.00e+00	2.442	1	5	295
GO:0007155	cell adhesion	2.08e-01	1.00e+00	2.119	1	6	369
GO:0006508	proteolysis	2.13e-01	1.00e+00	2.084	1	9	378
GO:0005634	nucleus	3.08e-01	1.00e+00	0.492	4	136	4559
GO:0005737	cytoplasm	4.31e-01	1.00e+00	0.352	3	110	3767
GO:0006355	regulation of transcription, DNA-templated	4.75e-01	1.00e+00	0.685	1	18	997
GO:0008270	zinc ion binding	4.75e-01	1.00e+00	0.685	1	12	997
GO:0005654	nucleoplasm	5.04e-01	1.00e+00	0.567	1	76	1082
GO:0003677	DNA binding	5.48e-01	1.00e+00	0.396	1	28	1218
GO:0005730	nucleolus	6.63e-01	1.00e+00	-0.034	1	69	1641
GO:0005886	plasma membrane	8.31e-01	1.00e+00	-0.688	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-4738

Statistics

Genes (9)

Interactions (22)

Related GO terms (78)