int-snw-3839

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	1.017	7.69e-19	3.64e-04	9.52e-03

wolf-screen-ratio-mammosphere-adherent-int-snw-3839 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
ACTB	60	167	1.153	1.151	587	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
[ KPNA3 ]	3839	1	0.025	1.017	31	-	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
KPNB1	3837	6	0.613	1.017	296	Yes	-
HNRNPC	3183	20	1.812	1.026	119	Yes	-

Interactions (9)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
KPNB1	3837	KPNA3	3839	pp	--	int.I2D: BioGrid, HPRD; int.Mint: MI:0915(physical association); int.HPRD: in vitro
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
KPNB1	3837	PSMA2	5683	pp	--	int.I2D: Krogan_NonCore, YeastLow
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ACTB	60	KPNB1	3837	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
HNRNPC	3183	KPNA3	3839	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid, VidalHuman_core, MINT, IntAct; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
KPNB1	3837	PSMD11	5717	pp	--	int.I2D: Krogan_NonCore

Related GO terms (134)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005654	nucleoplasm	1.15e-06	1.66e-02	3.514	6	76	1082
GO:0005829	cytosol	4.62e-06	6.66e-02	2.531	7	132	2496
GO:0008139	nuclear localization sequence binding	7.26e-06	1.05e-01	8.839	2	3	9
GO:0006607	NLS-bearing protein import into nucleus	1.83e-05	2.64e-01	8.201	2	3	14
GO:0043044	ATP-dependent chromatin remodeling	5.08e-05	7.33e-01	7.485	2	4	23
GO:0016032	viral process	5.95e-05	8.58e-01	3.948	4	55	534
GO:0031492	nucleosomal DNA binding	7.05e-05	1.00e+00	7.254	2	4	27
GO:0016071	mRNA metabolic process	1.22e-04	1.00e+00	4.793	3	31	223
GO:0070062	extracellular vesicular exosome	1.27e-04	1.00e+00	2.365	6	104	2400
GO:0010467	gene expression	1.44e-04	1.00e+00	3.623	4	59	669
GO:0016070	RNA metabolic process	1.65e-04	1.00e+00	4.645	3	32	247
GO:0006521	regulation of cellular amino acid metabolic process	2.45e-04	1.00e+00	6.365	2	17	50
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.75e-04	1.00e+00	6.281	2	5	53
GO:0008565	protein transporter activity	3.07e-04	1.00e+00	6.201	2	5	56
GO:0005643	nuclear pore	3.18e-04	1.00e+00	6.176	2	4	57
GO:0000502	proteasome complex	3.29e-04	1.00e+00	6.151	2	17	58
GO:0016020	membrane	3.67e-04	1.00e+00	2.616	5	90	1681
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.01e-04	1.00e+00	6.009	2	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.14e-04	1.00e+00	5.986	2	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.80e-04	1.00e+00	5.879	2	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	5.08e-04	1.00e+00	5.839	2	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.36e-04	1.00e+00	5.799	2	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.51e-04	1.00e+00	5.780	2	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	6.11e-04	1.00e+00	5.705	2	23	79
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	8.28e-04	1.00e+00	5.485	2	21	92
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9.70e-04	1.00e+00	10.009	1	1	2
GO:0005055	laminin receptor activity	9.70e-04	1.00e+00	10.009	1	1	2
GO:0006407	rRNA export from nucleus	9.70e-04	1.00e+00	10.009	1	1	2
GO:0075732	viral penetration into host nucleus	9.70e-04	1.00e+00	10.009	1	1	2
GO:0019058	viral life cycle	1.29e-03	1.00e+00	5.163	2	13	115
GO:0000209	protein polyubiquitination	1.31e-03	1.00e+00	5.151	2	20	116
GO:0000790	nuclear chromatin	1.62e-03	1.00e+00	4.998	2	9	129
GO:0006915	apoptotic process	1.77e-03	1.00e+00	3.477	3	33	555
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.94e-03	1.00e+00	9.009	1	1	4
GO:0030686	90S preribosome	1.94e-03	1.00e+00	9.009	1	1	4
GO:0006610	ribosomal protein import into nucleus	1.94e-03	1.00e+00	9.009	1	1	4
GO:0071782	endoplasmic reticulum tubular network	1.94e-03	1.00e+00	9.009	1	1	4
GO:0000082	G1/S transition of mitotic cell cycle	2.15e-03	1.00e+00	4.790	2	32	149
GO:0042981	regulation of apoptotic process	2.18e-03	1.00e+00	4.780	2	24	150
GO:0005515	protein binding	2.21e-03	1.00e+00	1.260	7	184	6024
GO:0043248	proteasome assembly	2.42e-03	1.00e+00	8.687	1	1	5
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	2.63e-03	1.00e+00	4.642	2	7	165
GO:0034641	cellular nitrogen compound metabolic process	2.82e-03	1.00e+00	4.591	2	20	171
GO:0030957	Tat protein binding	2.91e-03	1.00e+00	8.424	1	3	6
GO:0000028	ribosomal small subunit assembly	3.39e-03	1.00e+00	8.201	1	1	7
GO:0019773	proteasome core complex, alpha-subunit complex	3.88e-03	1.00e+00	8.009	1	4	8
GO:0070688	MLL5-L complex	3.88e-03	1.00e+00	8.009	1	1	8
GO:0019221	cytokine-mediated signaling pathway	4.67e-03	1.00e+00	4.221	2	9	221
GO:0045120	pronucleus	5.33e-03	1.00e+00	7.549	1	2	11
GO:0070935	3'-UTR-mediated mRNA stabilization	5.81e-03	1.00e+00	7.424	1	2	12
GO:0005838	proteasome regulatory particle	5.81e-03	1.00e+00	7.424	1	7	12
GO:0008266	poly(U) RNA binding	6.29e-03	1.00e+00	7.308	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	6.78e-03	1.00e+00	7.201	1	4	14
GO:0050998	nitric-oxide synthase binding	7.74e-03	1.00e+00	7.009	1	1	16
GO:0043234	protein complex	8.18e-03	1.00e+00	3.804	2	18	295
GO:0075733	intracellular transport of virus	8.22e-03	1.00e+00	6.921	1	3	17
GO:0006309	apoptotic DNA fragmentation	8.22e-03	1.00e+00	6.921	1	1	17
GO:0022624	proteasome accessory complex	8.22e-03	1.00e+00	6.921	1	8	17
GO:0046718	viral entry into host cell	8.71e-03	1.00e+00	6.839	1	2	18
GO:0005839	proteasome core complex	8.71e-03	1.00e+00	6.839	1	8	18
GO:0048863	stem cell differentiation	9.19e-03	1.00e+00	6.761	1	1	19
GO:0004298	threonine-type endopeptidase activity	9.19e-03	1.00e+00	6.761	1	8	19
GO:0030863	cortical cytoskeleton	1.06e-02	1.00e+00	6.549	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.06e-02	1.00e+00	6.549	1	4	22
GO:0044822	poly(A) RNA binding	1.10e-02	1.00e+00	2.549	3	49	1056
GO:0043236	laminin binding	1.11e-02	1.00e+00	6.485	1	1	23
GO:0000060	protein import into nucleus, translocation	1.16e-02	1.00e+00	6.424	1	5	24
GO:0008536	Ran GTPase binding	1.21e-02	1.00e+00	6.365	1	1	25
GO:0003730	mRNA 3'-UTR binding	1.26e-02	1.00e+00	6.308	1	2	26
GO:0043022	ribosome binding	1.30e-02	1.00e+00	6.254	1	3	27
GO:0019894	kinesin binding	1.35e-02	1.00e+00	6.201	1	1	28
GO:0000278	mitotic cell cycle	1.41e-02	1.00e+00	3.398	2	48	391
GO:0006606	protein import into nucleus	1.45e-02	1.00e+00	6.102	1	2	30
GO:0044281	small molecule metabolic process	1.60e-02	1.00e+00	2.352	3	58	1211
GO:0001895	retina homeostasis	1.64e-02	1.00e+00	5.921	1	1	34
GO:0043066	negative regulation of apoptotic process	1.64e-02	1.00e+00	3.281	2	31	424
GO:0034332	adherens junction organization	1.73e-02	1.00e+00	5.839	1	1	36
GO:0051084	'de novo' posttranslational protein folding	1.78e-02	1.00e+00	5.799	1	4	37
GO:0070527	platelet aggregation	1.83e-02	1.00e+00	5.761	1	2	38
GO:0022627	cytosolic small ribosomal subunit	1.88e-02	1.00e+00	5.723	1	4	39
GO:0044267	cellular protein metabolic process	2.03e-02	1.00e+00	3.120	2	29	474
GO:0021762	substantia nigra development	2.12e-02	1.00e+00	5.549	1	2	44
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	2.26e-02	1.00e+00	5.454	1	5	47
GO:0045216	cell-cell junction organization	2.59e-02	1.00e+00	5.254	1	2	54
GO:0000932	cytoplasmic mRNA processing body	2.59e-02	1.00e+00	5.254	1	3	54
GO:0034329	cell junction assembly	3.25e-02	1.00e+00	4.921	1	1	68
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	3.54e-02	1.00e+00	4.799	1	6	74
GO:0005634	nucleus	3.60e-02	1.00e+00	1.176	5	136	4559
GO:0071013	catalytic step 2 spliceosome	3.73e-02	1.00e+00	4.723	1	4	78
GO:0019083	viral transcription	3.87e-02	1.00e+00	4.669	1	10	81
GO:0005681	spliceosomal complex	3.96e-02	1.00e+00	4.634	1	4	83
GO:0006415	translational termination	4.15e-02	1.00e+00	4.566	1	10	87
GO:0006928	cellular component movement	4.33e-02	1.00e+00	4.501	1	7	91
GO:0005200	structural constituent of cytoskeleton	4.33e-02	1.00e+00	4.501	1	8	91
GO:0001649	osteoblast differentiation	4.38e-02	1.00e+00	4.485	1	6	92
GO:0006414	translational elongation	4.43e-02	1.00e+00	4.470	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	4.94e-02	1.00e+00	4.308	1	10	104
GO:0014069	postsynaptic density	4.99e-02	1.00e+00	4.294	1	3	105
GO:0006461	protein complex assembly	5.27e-02	1.00e+00	4.214	1	6	111
GO:0072562	blood microparticle	5.27e-02	1.00e+00	4.214	1	3	111
GO:0030529	ribonucleoprotein complex	5.31e-02	1.00e+00	4.201	1	8	112
GO:0005635	nuclear envelope	5.36e-02	1.00e+00	4.189	1	6	113
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	5.40e-02	1.00e+00	4.176	1	11	114
GO:0006325	chromatin organization	5.59e-02	1.00e+00	4.126	1	5	118
GO:0006511	ubiquitin-dependent protein catabolic process	5.96e-02	1.00e+00	4.031	1	5	126
GO:0009615	response to virus	5.96e-02	1.00e+00	4.031	1	5	126
GO:0006413	translational initiation	6.19e-02	1.00e+00	3.975	1	17	131
GO:0003735	structural constituent of ribosome	6.46e-02	1.00e+00	3.911	1	10	137
GO:0006457	protein folding	6.74e-02	1.00e+00	3.849	1	7	143
GO:0061024	membrane organization	6.83e-02	1.00e+00	3.829	1	7	145
GO:0008022	protein C-terminus binding	7.56e-02	1.00e+00	3.678	1	5	161
GO:0000398	mRNA splicing, via spliceosome	7.69e-02	1.00e+00	3.651	1	8	164
GO:0030424	axon	7.79e-02	1.00e+00	3.634	1	4	166
GO:0031965	nuclear membrane	7.88e-02	1.00e+00	3.616	1	3	168
GO:0019904	protein domain specific binding	8.37e-02	1.00e+00	3.525	1	6	179
GO:0008380	RNA splicing	1.06e-01	1.00e+00	3.176	1	11	228
GO:0006412	translation	1.06e-01	1.00e+00	3.163	1	20	230
GO:0000166	nucleotide binding	1.19e-01	1.00e+00	2.992	1	5	259
GO:0019899	enzyme binding	1.27e-01	1.00e+00	2.895	1	12	277
GO:0005856	cytoskeleton	1.33e-01	1.00e+00	2.824	1	12	291
GO:0019901	protein kinase binding	1.44e-01	1.00e+00	2.700	1	21	317
GO:0007411	axon guidance	1.45e-01	1.00e+00	2.691	1	13	319
GO:0003723	RNA binding	1.55e-01	1.00e+00	2.591	1	20	342
GO:0005925	focal adhesion	1.65e-01	1.00e+00	2.493	1	19	366
GO:0007155	cell adhesion	1.66e-01	1.00e+00	2.481	1	6	369
GO:0005730	nucleolus	1.85e-01	1.00e+00	1.328	2	69	1641
GO:0007596	blood coagulation	2.01e-01	1.00e+00	2.179	1	18	455
GO:0042802	identical protein binding	2.13e-01	1.00e+00	2.090	1	20	484
GO:0045087	innate immune response	2.56e-01	1.00e+00	1.790	1	24	596
GO:0005737	cytoplasm	2.67e-01	1.00e+00	0.714	3	110	3767
GO:0005615	extracellular space	3.82e-01	1.00e+00	1.106	1	17	957
GO:0008270	zinc ion binding	3.94e-01	1.00e+00	1.047	1	12	997
GO:0005524	ATP binding	4.83e-01	1.00e+00	0.667	1	60	1298
GO:0005886	plasma membrane	7.49e-01	1.00e+00	-0.326	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-3839

Statistics

Genes (7)

Interactions (9)

Related GO terms (134)