int-snw-3708

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.933	1.90e-15	2.56e-03	4.11e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-3708 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
ACO2	50	50	1.000	1.076	191	Yes	-
[ ITPR1 ]	3708	1	-0.243	0.933	49	-	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
OGDH	4967	13	0.847	1.076	113	Yes	-
HSPD1	3329	35	0.913	1.035	286	Yes	-
PSMC1	5700	14	0.840	1.018	137	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (14)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
OGDH	4967	PSMC1	5700	pp	--	int.I2D: YeastLow
ACO2	50	PSMC1	5700	pp	--	int.I2D: YeastLow
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
ACO2	50	ITPR1	3708	pp	--	int.I2D: IntAct_Mouse
OGDH	4967	PGD	5226	pp	--	int.I2D: YeastLow
HSPD1	3329	RPSA	3921	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
OGDH	4967	PSMD11	5717	pp	--	int.I2D: YeastLow
ACO2	50	HSPD1	3329	pp	--	int.I2D: IntAct_Yeast
HSPD1	3329	OGDH	4967	pp	--	int.I2D: YeastLow
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
PSMC1	5700	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
ACO2	50	OGDH	4967	pp	--	int.I2D: YeastLow
ACO2	50	PSMD11	5717	pp	--	int.I2D: YeastLow
ACO2	50	PGD	5226	pp	--	int.I2D: YeastLow

Related GO terms (175)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0044281	small molecule metabolic process	8.36e-06	1.21e-01	3.159	6	58	1211
GO:0005838	proteasome regulatory particle	1.77e-05	2.56e-01	8.231	2	7	12
GO:0022624	proteasome accessory complex	3.65e-05	5.26e-01	7.729	2	8	17
GO:0034641	cellular nitrogen compound metabolic process	8.78e-05	1.00e+00	4.983	3	20	171
GO:0006099	tricarboxylic acid cycle	1.01e-04	1.00e+00	7.009	2	4	28
GO:0016032	viral process	1.15e-04	1.00e+00	3.755	4	55	534
GO:0016071	mRNA metabolic process	1.93e-04	1.00e+00	4.600	3	31	223
GO:0005759	mitochondrial matrix	2.06e-04	1.00e+00	4.568	3	14	228
GO:0016070	RNA metabolic process	2.61e-04	1.00e+00	4.453	3	32	247
GO:0006091	generation of precursor metabolites and energy	3.25e-04	1.00e+00	6.172	2	3	50
GO:0006521	regulation of cellular amino acid metabolic process	3.25e-04	1.00e+00	6.172	2	17	50
GO:0000502	proteasome complex	4.38e-04	1.00e+00	5.958	2	17	58
GO:0051087	chaperone binding	4.53e-04	1.00e+00	5.933	2	6	59
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	5.33e-04	1.00e+00	5.816	2	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.50e-04	1.00e+00	5.794	2	22	65
GO:0002842	positive regulation of T cell mediated immune response to tumor cell	5.55e-04	1.00e+00	10.816	1	1	1
GO:0048291	isotype switching to IgG isotypes	5.55e-04	1.00e+00	10.816	1	1	1
GO:0019521	D-gluconate metabolic process	5.55e-04	1.00e+00	10.816	1	1	1
GO:0034602	oxoglutarate dehydrogenase (NAD+) activity	5.55e-04	1.00e+00	10.816	1	1	1
GO:0002368	B cell cytokine production	5.55e-04	1.00e+00	10.816	1	1	1
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.38e-04	1.00e+00	5.687	2	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	6.75e-04	1.00e+00	5.646	2	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.13e-04	1.00e+00	5.607	2	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	7.32e-04	1.00e+00	5.587	2	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	8.12e-04	1.00e+00	5.512	2	23	79
GO:0016020	membrane	8.83e-04	1.00e+00	2.423	5	90	1681
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	1.10e-03	1.00e+00	5.293	2	21	92
GO:0061034	olfactory bulb mitral cell layer development	1.11e-03	1.00e+00	9.816	1	1	2
GO:0045252	oxoglutarate dehydrogenase complex	1.11e-03	1.00e+00	9.816	1	2	2
GO:0051538	3 iron, 4 sulfur cluster binding	1.11e-03	1.00e+00	9.816	1	1	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.11e-03	1.00e+00	9.816	1	1	2
GO:0019322	pentose biosynthetic process	1.11e-03	1.00e+00	9.816	1	2	2
GO:0003994	aconitate hydratase activity	1.11e-03	1.00e+00	9.816	1	1	2
GO:0005055	laminin receptor activity	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006407	rRNA export from nucleus	1.11e-03	1.00e+00	9.816	1	1	2
GO:0043066	negative regulation of apoptotic process	1.27e-03	1.00e+00	3.673	3	31	424
GO:0006458	'de novo' protein folding	1.66e-03	1.00e+00	9.231	1	1	3
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	1.66e-03	1.00e+00	9.231	1	1	3
GO:0005218	intracellular ligand-gated calcium channel activity	1.66e-03	1.00e+00	9.231	1	1	3
GO:0050849	negative regulation of calcium-mediated signaling	1.66e-03	1.00e+00	9.231	1	1	3
GO:0015085	calcium ion transmembrane transporter activity	1.66e-03	1.00e+00	9.231	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	1.66e-03	1.00e+00	9.231	1	2	3
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	1.66e-03	1.00e+00	9.231	1	1	3
GO:0030135	coated vesicle	1.66e-03	1.00e+00	9.231	1	1	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	1.66e-03	1.00e+00	9.231	1	1	3
GO:0050882	voluntary musculoskeletal movement	1.66e-03	1.00e+00	9.231	1	1	3
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	1.66e-03	1.00e+00	9.231	1	1	3
GO:0031094	platelet dense tubular network	1.66e-03	1.00e+00	9.231	1	1	3
GO:0000209	protein polyubiquitination	1.74e-03	1.00e+00	4.958	2	20	116
GO:0044237	cellular metabolic process	1.77e-03	1.00e+00	4.946	2	5	117
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.22e-03	1.00e+00	8.816	1	1	4
GO:0030686	90S preribosome	2.22e-03	1.00e+00	8.816	1	1	4
GO:0006104	succinyl-CoA metabolic process	2.22e-03	1.00e+00	8.816	1	1	4
GO:0006734	NADH metabolic process	2.22e-03	1.00e+00	8.816	1	1	4
GO:0005955	calcineurin complex	2.22e-03	1.00e+00	8.816	1	2	4
GO:0016887	ATPase activity	2.52e-03	1.00e+00	4.687	2	7	140
GO:0031088	platelet dense granule membrane	2.77e-03	1.00e+00	8.494	1	1	5
GO:0043248	proteasome assembly	2.77e-03	1.00e+00	8.494	1	1	5
GO:0046696	lipopolysaccharide receptor complex	2.77e-03	1.00e+00	8.494	1	1	5
GO:0006102	isocitrate metabolic process	2.77e-03	1.00e+00	8.494	1	1	5
GO:0030976	thiamine pyrophosphate binding	2.77e-03	1.00e+00	8.494	1	1	5
GO:0000082	G1/S transition of mitotic cell cycle	2.85e-03	1.00e+00	4.597	2	32	149
GO:0042981	regulation of apoptotic process	2.89e-03	1.00e+00	4.587	2	24	150
GO:0003688	DNA replication origin binding	3.32e-03	1.00e+00	8.231	1	2	6
GO:0021695	cerebellar cortex development	3.32e-03	1.00e+00	8.231	1	2	6
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	3.32e-03	1.00e+00	8.231	1	1	6
GO:0006101	citrate metabolic process	3.32e-03	1.00e+00	8.231	1	1	6
GO:0021860	pyramidal neuron development	3.32e-03	1.00e+00	8.231	1	1	6
GO:0000028	ribosomal small subunit assembly	3.88e-03	1.00e+00	8.009	1	1	7
GO:0006554	lysine catabolic process	4.43e-03	1.00e+00	7.816	1	2	8
GO:0051604	protein maturation	4.43e-03	1.00e+00	7.816	1	1	8
GO:0010467	gene expression	4.67e-03	1.00e+00	3.015	3	59	669
GO:0031095	platelet dense tubular network membrane	4.98e-03	1.00e+00	7.646	1	1	9
GO:0048016	inositol phosphate-mediated signaling	4.98e-03	1.00e+00	7.646	1	1	9
GO:0005829	cytosol	5.45e-03	1.00e+00	1.853	5	132	2496
GO:0006098	pentose-phosphate shunt	5.53e-03	1.00e+00	7.494	1	4	10
GO:0043032	positive regulation of macrophage activation	5.53e-03	1.00e+00	7.494	1	1	10
GO:0019855	calcium channel inhibitor activity	5.53e-03	1.00e+00	7.494	1	1	10
GO:0021756	striatum development	5.53e-03	1.00e+00	7.494	1	1	10
GO:0021794	thalamus development	6.09e-03	1.00e+00	7.357	1	1	11
GO:0032727	positive regulation of interferon-alpha production	6.09e-03	1.00e+00	7.357	1	1	11
GO:0032469	endoplasmic reticulum calcium ion homeostasis	6.09e-03	1.00e+00	7.357	1	1	11
GO:0001530	lipopolysaccharide binding	7.19e-03	1.00e+00	7.116	1	3	13
GO:0051131	chaperone-mediated protein complex assembly	7.19e-03	1.00e+00	7.116	1	1	13
GO:0042026	protein refolding	8.29e-03	1.00e+00	6.909	1	2	15
GO:0006103	2-oxoglutarate metabolic process	8.84e-03	1.00e+00	6.816	1	1	16
GO:0017025	TBP-class protein binding	9.39e-03	1.00e+00	6.729	1	3	17
GO:0050870	positive regulation of T cell activation	9.39e-03	1.00e+00	6.729	1	1	17
GO:0032733	positive regulation of interleukin-10 production	1.05e-02	1.00e+00	6.568	1	1	19
GO:0048863	stem cell differentiation	1.05e-02	1.00e+00	6.568	1	1	19
GO:0006200	ATP catabolic process	1.06e-02	1.00e+00	3.626	2	15	292
GO:0042100	B cell proliferation	1.16e-02	1.00e+00	6.424	1	1	21
GO:0043236	laminin binding	1.27e-02	1.00e+00	6.293	1	1	23
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.27e-02	1.00e+00	6.293	1	2	23
GO:0005637	nuclear inner membrane	1.38e-02	1.00e+00	6.172	1	2	25
GO:0042113	B cell activation	1.38e-02	1.00e+00	6.172	1	2	25
GO:0032735	positive regulation of interleukin-12 production	1.38e-02	1.00e+00	6.172	1	1	25
GO:0005739	mitochondrion	1.42e-02	1.00e+00	2.438	3	28	998
GO:0051209	release of sequestered calcium ion into cytosol	1.43e-02	1.00e+00	6.116	1	1	26
GO:0043022	ribosome binding	1.49e-02	1.00e+00	6.061	1	3	27
GO:0050661	NADP binding	1.49e-02	1.00e+00	6.061	1	2	27
GO:0016529	sarcoplasmic reticulum	1.65e-02	1.00e+00	5.909	1	1	30
GO:0044822	poly(A) RNA binding	1.66e-02	1.00e+00	2.357	3	49	1056
GO:0031072	heat shock protein binding	1.82e-02	1.00e+00	5.772	1	1	33
GO:0000278	mitotic cell cycle	1.84e-02	1.00e+00	3.205	2	48	391
GO:0051539	4 iron, 4 sulfur cluster binding	1.93e-02	1.00e+00	5.687	1	3	35
GO:0032755	positive regulation of interleukin-6 production	1.98e-02	1.00e+00	5.646	1	2	36
GO:0021766	hippocampus development	2.09e-02	1.00e+00	5.568	1	4	38
GO:0006096	glycolytic process	2.09e-02	1.00e+00	5.568	1	4	38
GO:0032729	positive regulation of interferon-gamma production	2.14e-02	1.00e+00	5.531	1	2	39
GO:0022627	cytosolic small ribosomal subunit	2.14e-02	1.00e+00	5.531	1	4	39
GO:0042110	T cell activation	2.31e-02	1.00e+00	5.424	1	3	42
GO:0006986	response to unfolded protein	2.74e-02	1.00e+00	5.172	1	2	50
GO:0005905	coated pit	2.74e-02	1.00e+00	5.172	1	3	50
GO:0003725	double-stranded RNA binding	2.85e-02	1.00e+00	5.116	1	5	52
GO:0031966	mitochondrial membrane	3.01e-02	1.00e+00	5.035	1	1	55
GO:0007202	activation of phospholipase C activity	3.01e-02	1.00e+00	5.035	1	3	55
GO:0002039	p53 binding	3.01e-02	1.00e+00	5.035	1	7	55
GO:0070062	extracellular vesicular exosome	3.05e-02	1.00e+00	1.587	4	104	2400
GO:0035091	phosphatidylinositol binding	3.33e-02	1.00e+00	4.885	1	3	61
GO:0030141	secretory granule	3.39e-02	1.00e+00	4.862	1	2	62
GO:0006915	apoptotic process	3.55e-02	1.00e+00	2.700	2	33	555
GO:0003697	single-stranded DNA binding	3.71e-02	1.00e+00	4.729	1	5	68
GO:0006816	calcium ion transport	3.93e-02	1.00e+00	4.646	1	2	72
GO:0009791	post-embryonic development	3.98e-02	1.00e+00	4.626	1	2	73
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.03e-02	1.00e+00	4.607	1	6	74
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	4.19e-02	1.00e+00	4.549	1	7	77
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	4.35e-02	1.00e+00	4.494	1	3	80
GO:0050796	regulation of insulin secretion	4.41e-02	1.00e+00	4.476	1	4	81
GO:0019083	viral transcription	4.41e-02	1.00e+00	4.476	1	10	81
GO:0006415	translational termination	4.73e-02	1.00e+00	4.373	1	10	87
GO:0050821	protein stabilization	4.78e-02	1.00e+00	4.357	1	2	88
GO:0006414	translational elongation	5.04e-02	1.00e+00	4.277	1	13	93
GO:0051082	unfolded protein binding	5.04e-02	1.00e+00	4.277	1	5	93
GO:0070588	calcium ion transmembrane transport	5.15e-02	1.00e+00	4.246	1	2	95
GO:0006112	energy reserve metabolic process	5.15e-02	1.00e+00	4.246	1	3	95
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	5.63e-02	1.00e+00	4.116	1	10	104
GO:0014069	postsynaptic density	5.68e-02	1.00e+00	4.102	1	3	105
GO:0005506	iron ion binding	5.68e-02	1.00e+00	4.102	1	4	105
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.15e-02	1.00e+00	3.983	1	11	114
GO:0019058	viral life cycle	6.20e-02	1.00e+00	3.971	1	13	115
GO:0006511	ubiquitin-dependent protein catabolic process	6.78e-02	1.00e+00	3.839	1	5	126
GO:0006413	translational initiation	7.04e-02	1.00e+00	3.783	1	17	131
GO:0005634	nucleus	7.14e-02	1.00e+00	0.984	5	136	4559
GO:0003735	structural constituent of ribosome	7.35e-02	1.00e+00	3.718	1	10	137
GO:0001666	response to hypoxia	7.97e-02	1.00e+00	3.597	1	5	149
GO:0005769	early endosome	8.13e-02	1.00e+00	3.568	1	2	152
GO:0008543	fibroblast growth factor receptor signaling pathway	8.33e-02	1.00e+00	3.531	1	9	156
GO:0038095	Fc-epsilon receptor signaling pathway	8.95e-02	1.00e+00	3.424	1	12	168
GO:0007173	epidermal growth factor receptor signaling pathway	1.00e-01	1.00e+00	3.254	1	12	189
GO:0030168	platelet activation	1.08e-01	1.00e+00	3.137	1	10	205
GO:0005654	nucleoplasm	1.16e-01	1.00e+00	1.737	2	76	1082
GO:0006412	translation	1.21e-01	1.00e+00	2.971	1	20	230
GO:0005975	carbohydrate metabolic process	1.32e-01	1.00e+00	2.833	1	9	253
GO:0043065	positive regulation of apoptotic process	1.39e-01	1.00e+00	2.750	1	10	268
GO:0048011	neurotrophin TRK receptor signaling pathway	1.40e-01	1.00e+00	2.745	1	15	269
GO:0005743	mitochondrial inner membrane	1.44e-01	1.00e+00	2.702	1	8	277
GO:0043234	protein complex	1.52e-01	1.00e+00	2.612	1	18	295
GO:0005524	ATP binding	1.58e-01	1.00e+00	1.474	2	60	1298
GO:0007155	cell adhesion	1.87e-01	1.00e+00	2.289	1	6	369
GO:0005515	protein binding	2.02e-01	1.00e+00	0.582	5	184	6024
GO:0009986	cell surface	2.02e-01	1.00e+00	2.165	1	11	402
GO:0055114	oxidation-reduction process	2.11e-01	1.00e+00	2.102	1	12	420
GO:0007596	blood coagulation	2.26e-01	1.00e+00	1.986	1	18	455
GO:0005730	nucleolus	2.29e-01	1.00e+00	1.136	2	69	1641
GO:0044267	cellular protein metabolic process	2.35e-01	1.00e+00	1.927	1	29	474
GO:0005783	endoplasmic reticulum	2.70e-01	1.00e+00	1.697	1	10	556
GO:0005789	endoplasmic reticulum membrane	2.76e-01	1.00e+00	1.661	1	16	570
GO:0045087	innate immune response	2.87e-01	1.00e+00	1.597	1	24	596
GO:0005737	cytoplasm	3.49e-01	1.00e+00	0.522	3	110	3767
GO:0007165	signal transduction	4.05e-01	1.00e+00	0.991	1	24	907
GO:0005615	extracellular space	4.23e-01	1.00e+00	0.914	1	17	957
GO:0005886	plasma membrane	4.34e-01	1.00e+00	0.482	2	45	2582
GO:0046872	metal ion binding	5.32e-01	1.00e+00	0.464	1	25	1307
GO:0016021	integral component of membrane	6.94e-01	1.00e+00	-0.137	1	27	1982

Wolf-ratios-Mammosphere-Adherent

int-snw-3708

Statistics

Genes (8)

Interactions (14)

Related GO terms (175)