int-snw-32

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.942	8.97e-16	2.14e-03	3.60e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-32 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
[ ACACB ]	32	5	0.656	1.002	184	Yes	-
PSMD1	5707	12	0.836	1.057	113	Yes	-
PSMD13	5719	16	0.848	1.029	104	Yes	-
EEF2	1938	27	0.890	1.043	301	Yes	-
PSMD3	5709	57	0.986	1.106	146	Yes	-
PSMB2	5690	18	0.877	1.026	117	Yes	-
HSPD1	3329	35	0.913	1.035	286	Yes	-
ATP6V1B2	526	44	0.881	1.076	278	-	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (22)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
EEF2	1938	HSPD1	3329	pp	--	int.I2D: YeastLow, YeastMedium
PSMD1	5707	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, MINT_Yeast, Krogan_Core
HSPD1	3329	RPSA	3921	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
EEF2	1938	PSMD13	5719	pp	--	int.I2D: YeastLow
ACACB	32	RPSA	3921	pp	--	int.I2D: IntAct_Yeast, YeastMedium
PSMD3	5709	PSMD13	5719	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, MINT_Yeast, YeastHigh, BioGrid, BioGrid_Yeast, IntAct_Yeast, Krogan_Core
ACACB	32	PSMD13	5719	pp	--	int.I2D: IntAct_Yeast
PSMD1	5707	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct, MINT_Yeast, BioGrid, BioGrid_Yeast, IntAct_Yeast, Krogan_Core
PGD	5226	PSMD3	5709	pp	--	int.I2D: YeastLow
PSMB2	5690	PSMD1	5707	pp	--	int.I2D: BioGrid_Yeast
EEF2	1938	PGD	5226	pp	--	int.I2D: BioGrid_Yeast
ACACB	32	ATP6V1B2	526	pp	--	int.I2D: IntAct_Yeast
PSMB2	5690	PSMD13	5719	pp	--	int.I2D: BioGrid_Yeast, YeastMedium
ATP6V1B2	526	RPSA	3921	pp	--	int.I2D: IntAct_Yeast
PSMB2	5690	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastMedium
ACACB	32	PSMD3	5709	pp	--	int.I2D: YeastLow
EEF2	1938	PSMD3	5709	pp	--	int.I2D: Krogan_NonCore
ACACB	32	HSPD1	3329	pp	--	int.I2D: IntAct_Yeast
ACACB	32	EEF2	1938	pp	--	int.I2D: IntAct_Yeast
ACACB	32	PSMD1	5707	pp	--	int.I2D: IntAct_Yeast
ACACB	32	PGD	5226	pp	--	int.I2D: YeastLow
ACACB	32	PSMB2	5690	pp	--	int.I2D: BioGrid_Yeast, YeastLow

Related GO terms (160)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005829	cytosol	2.37e-08	3.42e-04	2.531	10	132	2496
GO:0006521	regulation of cellular amino acid metabolic process	2.64e-08	3.81e-04	6.850	4	17	50
GO:0000502	proteasome complex	4.86e-08	7.00e-04	6.636	4	17	58
GO:0005838	proteasome regulatory particle	5.26e-08	7.59e-04	8.494	3	7	12
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	7.26e-08	1.05e-03	6.494	4	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.73e-08	1.11e-03	6.472	4	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.05e-07	1.51e-03	6.365	4	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	1.17e-07	1.69e-03	6.324	4	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.31e-07	1.89e-03	6.285	4	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	1.38e-07	1.99e-03	6.265	4	20	75
GO:0022624	proteasome accessory complex	1.62e-07	2.34e-03	7.992	3	8	17
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	1.71e-07	2.46e-03	6.190	4	23	79
GO:0016071	mRNA metabolic process	2.00e-07	2.88e-03	5.015	5	31	223
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	3.16e-07	4.56e-03	5.971	4	21	92
GO:0016070	RNA metabolic process	3.32e-07	4.79e-03	4.868	5	32	247
GO:0016032	viral process	4.63e-07	6.68e-03	4.018	6	55	534
GO:0000209	protein polyubiquitination	8.04e-07	1.16e-02	5.636	4	20	116
GO:0070062	extracellular vesicular exosome	8.22e-07	1.19e-02	2.435	9	104	2400
GO:0010467	gene expression	1.74e-06	2.51e-02	3.693	6	59	669
GO:0000082	G1/S transition of mitotic cell cycle	2.19e-06	3.16e-02	5.275	4	32	149
GO:0042981	regulation of apoptotic process	2.25e-06	3.24e-02	5.265	4	24	150
GO:0034641	cellular nitrogen compound metabolic process	3.79e-06	5.47e-02	5.076	4	20	171
GO:0043066	negative regulation of apoptotic process	4.78e-06	6.90e-02	4.088	5	31	424
GO:0016020	membrane	2.52e-05	3.63e-01	2.586	7	90	1681
GO:0030234	enzyme regulator activity	3.36e-05	4.85e-01	7.794	2	3	13
GO:0042176	regulation of protein catabolic process	5.17e-05	7.45e-01	7.494	2	3	16
GO:0044281	small molecule metabolic process	5.41e-05	7.80e-01	2.837	6	58	1211
GO:0000278	mitotic cell cycle	9.81e-05	1.00e+00	3.883	4	48	391
GO:0006915	apoptotic process	3.78e-04	1.00e+00	3.378	4	33	555
GO:0014070	response to organic cyclic compound	3.85e-04	1.00e+00	6.068	2	4	43
GO:0012505	endomembrane system	6.53e-04	1.00e+00	5.687	2	2	56
GO:0002842	positive regulation of T cell mediated immune response to tumor cell	6.93e-04	1.00e+00	10.494	1	1	1
GO:0048291	isotype switching to IgG isotypes	6.93e-04	1.00e+00	10.494	1	1	1
GO:0019521	D-gluconate metabolic process	6.93e-04	1.00e+00	10.494	1	1	1
GO:0002368	B cell cytokine production	6.93e-04	1.00e+00	10.494	1	1	1
GO:2001295	malonyl-CoA biosynthetic process	1.39e-03	1.00e+00	9.494	1	1	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.39e-03	1.00e+00	9.494	1	1	2
GO:0003989	acetyl-CoA carboxylase activity	1.39e-03	1.00e+00	9.494	1	1	2
GO:0019322	pentose biosynthetic process	1.39e-03	1.00e+00	9.494	1	2	2
GO:0005055	laminin receptor activity	1.39e-03	1.00e+00	9.494	1	1	2
GO:0006407	rRNA export from nucleus	1.39e-03	1.00e+00	9.494	1	1	2
GO:0007127	meiosis I	1.39e-03	1.00e+00	9.494	1	1	2
GO:0006414	translational elongation	1.79e-03	1.00e+00	4.955	2	13	93
GO:0006458	'de novo' protein folding	2.08e-03	1.00e+00	8.909	1	1	3
GO:0006084	acetyl-CoA metabolic process	2.08e-03	1.00e+00	8.909	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	2.08e-03	1.00e+00	8.909	1	2	3
GO:0030135	coated vesicle	2.08e-03	1.00e+00	8.909	1	1	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.08e-03	1.00e+00	8.909	1	1	3
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.77e-03	1.00e+00	8.494	1	1	4
GO:0030686	90S preribosome	2.77e-03	1.00e+00	8.494	1	1	4
GO:0046696	lipopolysaccharide receptor complex	3.46e-03	1.00e+00	8.172	1	1	5
GO:0004075	biotin carboxylase activity	3.46e-03	1.00e+00	8.172	1	1	5
GO:0009374	biotin binding	3.46e-03	1.00e+00	8.172	1	1	5
GO:0003688	DNA replication origin binding	4.15e-03	1.00e+00	7.909	1	2	6
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	4.15e-03	1.00e+00	7.909	1	1	6
GO:0005654	nucleoplasm	4.58e-03	1.00e+00	2.415	4	76	1082
GO:0033180	proton-transporting V-type ATPase, V1 domain	4.84e-03	1.00e+00	7.687	1	2	7
GO:0000028	ribosomal small subunit assembly	4.84e-03	1.00e+00	7.687	1	1	7
GO:0006853	carnitine shuttle	5.53e-03	1.00e+00	7.494	1	1	8
GO:0031325	positive regulation of cellular metabolic process	5.53e-03	1.00e+00	7.494	1	1	8
GO:0051604	protein maturation	5.53e-03	1.00e+00	7.494	1	1	8
GO:0006768	biotin metabolic process	6.22e-03	1.00e+00	7.324	1	1	9
GO:0008494	translation activator activity	6.22e-03	1.00e+00	7.324	1	1	9
GO:0006098	pentose-phosphate shunt	6.91e-03	1.00e+00	7.172	1	4	10
GO:0043032	positive regulation of macrophage activation	6.91e-03	1.00e+00	7.172	1	1	10
GO:0032727	positive regulation of interferon-alpha production	7.60e-03	1.00e+00	7.035	1	1	11
GO:0001530	lipopolysaccharide binding	8.98e-03	1.00e+00	6.794	1	3	13
GO:0051131	chaperone-mediated protein complex assembly	8.98e-03	1.00e+00	6.794	1	1	13
GO:0046961	proton-transporting ATPase activity, rotational mechanism	1.04e-02	1.00e+00	6.587	1	3	15
GO:0042026	protein refolding	1.04e-02	1.00e+00	6.587	1	2	15
GO:0046034	ATP metabolic process	1.04e-02	1.00e+00	6.587	1	1	15
GO:0006412	translation	1.05e-02	1.00e+00	3.649	2	20	230
GO:0010243	response to organonitrogen compound	1.17e-02	1.00e+00	6.407	1	3	17
GO:0050870	positive regulation of T cell activation	1.17e-02	1.00e+00	6.407	1	1	17
GO:0003746	translation elongation factor activity	1.17e-02	1.00e+00	6.407	1	3	17
GO:0005839	proteasome core complex	1.24e-02	1.00e+00	6.324	1	8	18
GO:0015078	hydrogen ion transmembrane transporter activity	1.31e-02	1.00e+00	6.246	1	3	19
GO:0032733	positive regulation of interleukin-10 production	1.31e-02	1.00e+00	6.246	1	1	19
GO:0004298	threonine-type endopeptidase activity	1.31e-02	1.00e+00	6.246	1	8	19
GO:0005634	nucleus	1.44e-02	1.00e+00	1.147	7	136	4559
GO:0042100	B cell proliferation	1.45e-02	1.00e+00	6.102	1	1	21
GO:0005844	polysome	1.58e-02	1.00e+00	5.971	1	4	23
GO:0043236	laminin binding	1.58e-02	1.00e+00	5.971	1	1	23
GO:0042113	B cell activation	1.72e-02	1.00e+00	5.850	1	2	25
GO:0032735	positive regulation of interleukin-12 production	1.72e-02	1.00e+00	5.850	1	1	25
GO:0015991	ATP hydrolysis coupled proton transport	1.79e-02	1.00e+00	5.794	1	4	26
GO:0043022	ribosome binding	1.86e-02	1.00e+00	5.739	1	3	27
GO:0050661	NADP binding	1.86e-02	1.00e+00	5.739	1	2	27
GO:0015992	proton transport	1.99e-02	1.00e+00	5.636	1	3	29
GO:0033572	transferrin transport	2.06e-02	1.00e+00	5.587	1	5	30
GO:0006633	fatty acid biosynthetic process	2.20e-02	1.00e+00	5.494	1	3	32
GO:0051701	interaction with host	2.20e-02	1.00e+00	5.494	1	4	32
GO:0090382	phagosome maturation	2.47e-02	1.00e+00	5.324	1	5	36
GO:0032755	positive regulation of interleukin-6 production	2.47e-02	1.00e+00	5.324	1	2	36
GO:0005902	microvillus	2.60e-02	1.00e+00	5.246	1	2	38
GO:0032729	positive regulation of interferon-gamma production	2.67e-02	1.00e+00	5.209	1	2	39
GO:0022627	cytosolic small ribosomal subunit	2.67e-02	1.00e+00	5.209	1	4	39
GO:0042110	T cell activation	2.88e-02	1.00e+00	5.102	1	3	42
GO:0045727	positive regulation of translation	3.01e-02	1.00e+00	5.035	1	3	44
GO:0044822	poly(A) RNA binding	3.18e-02	1.00e+00	2.035	3	49	1056
GO:0006986	response to unfolded protein	3.41e-02	1.00e+00	4.850	1	2	50
GO:0005905	coated pit	3.41e-02	1.00e+00	4.850	1	3	50
GO:0006879	cellular iron ion homeostasis	3.48e-02	1.00e+00	4.822	1	4	51
GO:0051289	protein homotetramerization	3.48e-02	1.00e+00	4.822	1	1	51
GO:0003725	double-stranded RNA binding	3.55e-02	1.00e+00	4.794	1	5	52
GO:0002244	hematopoietic progenitor cell differentiation	3.68e-02	1.00e+00	4.739	1	1	54
GO:0002039	p53 binding	3.75e-02	1.00e+00	4.713	1	7	55
GO:0051087	chaperone binding	4.02e-02	1.00e+00	4.612	1	6	59
GO:0044267	cellular protein metabolic process	4.07e-02	1.00e+00	2.605	2	29	474
GO:0030141	secretory granule	4.22e-02	1.00e+00	4.540	1	2	62
GO:0006767	water-soluble vitamin metabolic process	4.62e-02	1.00e+00	4.407	1	1	68
GO:0003697	single-stranded DNA binding	4.62e-02	1.00e+00	4.407	1	5	68
GO:0006766	vitamin metabolic process	4.82e-02	1.00e+00	4.344	1	1	71
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	5.21e-02	1.00e+00	4.227	1	7	77
GO:0005524	ATP binding	5.40e-02	1.00e+00	1.737	3	60	1298
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	5.41e-02	1.00e+00	4.172	1	3	80
GO:0001726	ruffle	5.41e-02	1.00e+00	4.172	1	4	80
GO:0019083	viral transcription	5.48e-02	1.00e+00	4.154	1	10	81
GO:0006415	translational termination	5.87e-02	1.00e+00	4.051	1	10	87
GO:0050821	protein stabilization	5.94e-02	1.00e+00	4.035	1	2	88
GO:0042470	melanosome	6.14e-02	1.00e+00	3.986	1	9	91
GO:0051082	unfolded protein binding	6.27e-02	1.00e+00	3.955	1	5	93
GO:0006112	energy reserve metabolic process	6.40e-02	1.00e+00	3.924	1	3	95
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	6.98e-02	1.00e+00	3.794	1	10	104
GO:0005741	mitochondrial outer membrane	7.05e-02	1.00e+00	3.780	1	7	105
GO:0030529	ribonucleoprotein complex	7.50e-02	1.00e+00	3.687	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	7.63e-02	1.00e+00	3.661	1	11	114
GO:0019058	viral life cycle	7.70e-02	1.00e+00	3.649	1	13	115
GO:0006413	translational initiation	8.72e-02	1.00e+00	3.461	1	17	131
GO:0044255	cellular lipid metabolic process	8.85e-02	1.00e+00	3.439	1	6	133
GO:0003735	structural constituent of ribosome	9.11e-02	1.00e+00	3.396	1	10	137
GO:0016887	ATPase activity	9.30e-02	1.00e+00	3.365	1	7	140
GO:0008286	insulin receptor signaling pathway	9.42e-02	1.00e+00	3.344	1	7	142
GO:0010628	positive regulation of gene expression	9.68e-02	1.00e+00	3.304	1	5	146
GO:0005769	early endosome	1.01e-01	1.00e+00	3.246	1	2	152
GO:0003924	GTPase activity	1.29e-01	1.00e+00	2.872	1	12	197
GO:0005765	lysosomal membrane	1.32e-01	1.00e+00	2.829	1	5	203
GO:0006184	GTP catabolic process	1.39e-01	1.00e+00	2.753	1	12	214
GO:0005759	mitochondrial matrix	1.47e-01	1.00e+00	2.661	1	14	228
GO:0005739	mitochondrion	1.49e-01	1.00e+00	1.531	2	28	998
GO:0005975	carbohydrate metabolic process	1.62e-01	1.00e+00	2.511	1	9	253
GO:0043065	positive regulation of apoptotic process	1.71e-01	1.00e+00	2.428	1	10	268
GO:0005743	mitochondrial inner membrane	1.76e-01	1.00e+00	2.380	1	8	277
GO:0042493	response to drug	1.80e-01	1.00e+00	2.344	1	13	284
GO:0006200	ATP catabolic process	1.85e-01	1.00e+00	2.304	1	15	292
GO:0043234	protein complex	1.87e-01	1.00e+00	2.290	1	18	295
GO:0005525	GTP binding	1.95e-01	1.00e+00	2.218	1	12	310
GO:0019901	protein kinase binding	1.99e-01	1.00e+00	2.186	1	21	317
GO:0043231	intracellular membrane-bounded organelle	2.00e-01	1.00e+00	2.181	1	9	318
GO:0007155	cell adhesion	2.28e-01	1.00e+00	1.967	1	6	369
GO:0009986	cell surface	2.46e-01	1.00e+00	1.843	1	11	402
GO:0055114	oxidation-reduction process	2.56e-01	1.00e+00	1.780	1	12	420
GO:0005886	plasma membrane	2.60e-01	1.00e+00	0.745	3	45	2582
GO:0055085	transmembrane transport	2.64e-01	1.00e+00	1.729	1	10	435
GO:0005730	nucleolus	3.18e-01	1.00e+00	0.814	2	69	1641
GO:0005515	protein binding	4.12e-01	1.00e+00	0.260	5	184	6024
GO:0005615	extracellular space	4.97e-01	1.00e+00	0.592	1	17	957
GO:0005737	cytoplasm	5.08e-01	1.00e+00	0.200	3	110	3767
GO:0046872	metal ion binding	6.13e-01	1.00e+00	0.142	1	25	1307
GO:0016021	integral component of membrane	7.72e-01	1.00e+00	-0.459	1	27	1982

Wolf-ratios-Mammosphere-Adherent

int-snw-32

Statistics

Genes (10)

Interactions (22)

Related GO terms (160)