int-snw-3092

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.940	1.07e-15	2.23e-03	3.72e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-3092 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
[ HIP1 ]	3092	1	0.340	0.940	32	-	-
ACTB	60	167	1.153	1.151	587	Yes	-
RSL24D1	51187	36	1.300	1.020	59	Yes	-
ACO2	50	50	1.000	1.076	191	Yes	-
EIF6	3692	14	0.700	1.013	267	Yes	-
EIF2S2	8894	27	1.075	1.138	81	Yes	-
CASP8	841	8	0.804	1.041	141	-	-
CLTC	1213	35	0.884	1.138	247	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (9)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
CLTC	1213	HIP1	3092	pp	--	int.I2D: BioGrid, BIND, HPRD, MINT; int.Mint: MI:0915(physical association); int.HPRD: in vitro, in vivo, yeast 2-hybrid
EIF6	3692	PGD	5226	pp	--	int.I2D: YeastLow
HIP1	3092	EIF6	3692	pp	--	int.I2D: HPRD, BioGrid, StelzlHigh; int.HPRD: yeast 2-hybrid
ACO2	50	PGD	5226	pp	--	int.I2D: YeastLow
EIF6	3692	RSL24D1	51187	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	CLTC	1213	pp	--	int.I2D: IntAct_Yeast
CLTC	1213	EIF2S2	8894	pp	--	int.I2D: YeastLow
ACO2	50	EIF6	3692	pp	--	int.I2D: YeastLow
CASP8	841	HIP1	3092	pp	--	int.I2D: BioGrid, HPRD; int.HPRD: in vivo

Related GO terms (192)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0030136	clathrin-coated vesicle	2.94e-04	1.00e+00	6.254	2	4	42
GO:0003743	translation initiation factor activity	4.01e-04	1.00e+00	6.031	2	8	49
GO:0005856	cytoskeleton	6.24e-04	1.00e+00	4.046	3	12	291
GO:0030690	Noc1p-Noc2p complex	6.24e-04	1.00e+00	10.646	1	1	1
GO:0070243	regulation of thymocyte apoptotic process	6.24e-04	1.00e+00	10.646	1	1	1
GO:0000054	ribosomal subunit export from nucleus	6.24e-04	1.00e+00	10.646	1	1	1
GO:0019521	D-gluconate metabolic process	6.24e-04	1.00e+00	10.646	1	1	1
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	9.89e-04	1.00e+00	5.379	2	7	77
GO:0051538	3 iron, 4 sulfur cluster binding	1.25e-03	1.00e+00	9.646	1	1	2
GO:0002176	male germ cell proliferation	1.25e-03	1.00e+00	9.646	1	1	2
GO:0019322	pentose biosynthetic process	1.25e-03	1.00e+00	9.646	1	2	2
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	1.25e-03	1.00e+00	9.646	1	1	2
GO:0003994	aconitate hydratase activity	1.25e-03	1.00e+00	9.646	1	1	2
GO:0005200	structural constituent of cytoskeleton	1.38e-03	1.00e+00	5.138	2	8	91
GO:0005850	eukaryotic translation initiation factor 2 complex	1.87e-03	1.00e+00	9.061	1	1	3
GO:1900126	negative regulation of hyaluronan biosynthetic process	1.87e-03	1.00e+00	9.061	1	2	3
GO:0060715	syncytiotrophoblast cell differentiation involved in labyrinthine layer development	1.87e-03	1.00e+00	9.061	1	1	3
GO:0036462	TRAIL-activated apoptotic signaling pathway	1.87e-03	1.00e+00	9.061	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	1.87e-03	1.00e+00	9.061	1	2	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	1.87e-03	1.00e+00	9.061	1	1	3
GO:0071439	clathrin complex	1.87e-03	1.00e+00	9.061	1	2	3
GO:0097190	apoptotic signaling pathway	2.11e-03	1.00e+00	4.826	2	6	113
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	2.49e-03	1.00e+00	8.646	1	1	4
GO:0035877	death effector domain binding	2.49e-03	1.00e+00	8.646	1	1	4
GO:0032051	clathrin light chain binding	2.49e-03	1.00e+00	8.646	1	1	4
GO:1903077	negative regulation of protein localization to plasma membrane	2.49e-03	1.00e+00	8.646	1	1	4
GO:0006413	translational initiation	2.83e-03	1.00e+00	4.613	2	17	131
GO:0042256	mature ribosome assembly	3.12e-03	1.00e+00	8.324	1	1	5
GO:0006102	isocitrate metabolic process	3.12e-03	1.00e+00	8.324	1	1	5
GO:0005638	lamin filament	3.12e-03	1.00e+00	8.324	1	1	5
GO:0043023	ribosomal large subunit binding	3.12e-03	1.00e+00	8.324	1	1	5
GO:0032025	response to cobalt ion	3.12e-03	1.00e+00	8.324	1	1	5
GO:0061024	membrane organization	3.45e-03	1.00e+00	4.466	2	7	145
GO:0031265	CD95 death-inducing signaling complex	3.74e-03	1.00e+00	8.061	1	1	6
GO:0030130	clathrin coat of trans-Golgi network vesicle	3.74e-03	1.00e+00	8.061	1	3	6
GO:0030957	Tat protein binding	3.74e-03	1.00e+00	8.061	1	3	6
GO:0031264	death-inducing signaling complex	3.74e-03	1.00e+00	8.061	1	1	6
GO:0006101	citrate metabolic process	3.74e-03	1.00e+00	8.061	1	1	6
GO:0030118	clathrin coat	3.74e-03	1.00e+00	8.061	1	2	6
GO:0060546	negative regulation of necroptotic process	4.36e-03	1.00e+00	7.839	1	1	7
GO:0030132	clathrin coat of coated pit	4.36e-03	1.00e+00	7.839	1	2	7
GO:0097342	ripoptosome	4.36e-03	1.00e+00	7.839	1	1	7
GO:0097202	activation of cysteine-type endopeptidase activity	4.98e-03	1.00e+00	7.646	1	1	8
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0097284	hepatocyte apoptotic process	5.60e-03	1.00e+00	7.476	1	3	9
GO:0006098	pentose-phosphate shunt	6.22e-03	1.00e+00	7.324	1	4	10
GO:0001841	neural tube formation	6.22e-03	1.00e+00	7.324	1	1	10
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand	6.85e-03	1.00e+00	7.187	1	1	11
GO:0045651	positive regulation of macrophage differentiation	6.85e-03	1.00e+00	7.187	1	1	11
GO:0042273	ribosomal large subunit biogenesis	8.09e-03	1.00e+00	6.946	1	4	13
GO:0048268	clathrin coat assembly	8.09e-03	1.00e+00	6.946	1	1	13
GO:0048260	positive regulation of receptor-mediated endocytosis	8.09e-03	1.00e+00	6.946	1	2	13
GO:0030665	clathrin-coated vesicle membrane	8.09e-03	1.00e+00	6.946	1	2	13
GO:0035267	NuA4 histone acetyltransferase complex	8.70e-03	1.00e+00	6.839	1	4	14
GO:0030225	macrophage differentiation	9.32e-03	1.00e+00	6.739	1	1	15
GO:0005123	death receptor binding	9.32e-03	1.00e+00	6.739	1	1	15
GO:0050998	nitric-oxide synthase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0030101	natural killer cell activation	9.94e-03	1.00e+00	6.646	1	1	16
GO:0051603	proteolysis involved in cellular protein catabolic process	9.94e-03	1.00e+00	6.646	1	2	16
GO:0005829	cytosol	1.05e-02	1.00e+00	1.683	5	132	2496
GO:0097194	execution phase of apoptosis	1.18e-02	1.00e+00	6.398	1	1	19
GO:0030276	clathrin binding	1.24e-02	1.00e+00	6.324	1	2	20
GO:0045862	positive regulation of proteolysis	1.30e-02	1.00e+00	6.254	1	1	21
GO:0030863	cortical cytoskeleton	1.36e-02	1.00e+00	6.187	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.36e-02	1.00e+00	6.187	1	4	22
GO:0043234	protein complex	1.37e-02	1.00e+00	3.442	2	18	295
GO:0043044	ATP-dependent chromatin remodeling	1.43e-02	1.00e+00	6.123	1	4	23
GO:0008135	translation factor activity, nucleic acid binding	1.49e-02	1.00e+00	6.061	1	7	24
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	1.55e-02	1.00e+00	6.002	1	3	25
GO:0042113	B cell activation	1.55e-02	1.00e+00	6.002	1	2	25
GO:0019901	protein kinase binding	1.57e-02	1.00e+00	3.338	2	21	317
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	1.61e-02	1.00e+00	5.946	1	4	26
GO:0009409	response to cold	1.61e-02	1.00e+00	5.946	1	2	26
GO:0043022	ribosome binding	1.67e-02	1.00e+00	5.891	1	3	27
GO:0050661	NADP binding	1.67e-02	1.00e+00	5.891	1	2	27
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	1.67e-02	1.00e+00	5.891	1	2	27
GO:0034612	response to tumor necrosis factor	1.67e-02	1.00e+00	5.891	1	2	27
GO:0031492	nucleosomal DNA binding	1.67e-02	1.00e+00	5.891	1	4	27
GO:0006099	tricarboxylic acid cycle	1.73e-02	1.00e+00	5.839	1	4	28
GO:0030669	clathrin-coated endocytic vesicle membrane	1.73e-02	1.00e+00	5.839	1	4	28
GO:0019894	kinesin binding	1.73e-02	1.00e+00	5.839	1	1	28
GO:0042254	ribosome biogenesis	1.86e-02	1.00e+00	5.739	1	1	30
GO:0033572	transferrin transport	1.86e-02	1.00e+00	5.739	1	5	30
GO:0005164	tumor necrosis factor receptor binding	1.86e-02	1.00e+00	5.739	1	2	30
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	1.86e-02	1.00e+00	5.739	1	1	30
GO:0031623	receptor internalization	1.92e-02	1.00e+00	5.692	1	2	31
GO:0046677	response to antibiotic	1.92e-02	1.00e+00	5.692	1	2	31
GO:0005925	focal adhesion	2.05e-02	1.00e+00	3.130	2	19	366
GO:0032588	trans-Golgi network membrane	2.10e-02	1.00e+00	5.559	1	2	34
GO:0001895	retina homeostasis	2.10e-02	1.00e+00	5.559	1	1	34
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	2.10e-02	1.00e+00	5.559	1	2	34
GO:0097110	scaffold protein binding	2.10e-02	1.00e+00	5.559	1	3	34
GO:0051539	4 iron, 4 sulfur cluster binding	2.16e-02	1.00e+00	5.517	1	3	35
GO:0034332	adherens junction organization	2.22e-02	1.00e+00	5.476	1	1	36
GO:0008234	cysteine-type peptidase activity	2.29e-02	1.00e+00	5.437	1	3	37
GO:0051084	'de novo' posttranslational protein folding	2.29e-02	1.00e+00	5.437	1	4	37
GO:0097191	extrinsic apoptotic signaling pathway	2.35e-02	1.00e+00	5.398	1	3	38
GO:0071407	cellular response to organic cyclic compound	2.35e-02	1.00e+00	5.398	1	2	38
GO:0070527	platelet aggregation	2.35e-02	1.00e+00	5.398	1	2	38
GO:0042110	T cell activation	2.59e-02	1.00e+00	5.254	1	3	42
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	2.65e-02	1.00e+00	5.220	1	4	43
GO:0006892	post-Golgi vesicle-mediated transport	2.65e-02	1.00e+00	5.220	1	3	43
GO:0021762	substantia nigra development	2.71e-02	1.00e+00	5.187	1	2	44
GO:0044297	cell body	2.83e-02	1.00e+00	5.123	1	2	46
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	2.90e-02	1.00e+00	5.092	1	5	47
GO:0006091	generation of precursor metabolites and energy	3.08e-02	1.00e+00	5.002	1	3	50
GO:0004197	cysteine-type endopeptidase activity	3.08e-02	1.00e+00	5.002	1	3	50
GO:0003725	double-stranded RNA binding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.26e-02	1.00e+00	4.918	1	5	53
GO:0008233	peptidase activity	3.32e-02	1.00e+00	4.891	1	2	54
GO:0045216	cell-cell junction organization	3.32e-02	1.00e+00	4.891	1	2	54
GO:0044267	cellular protein metabolic process	3.33e-02	1.00e+00	2.757	2	29	474
GO:0097193	intrinsic apoptotic signaling pathway	3.38e-02	1.00e+00	4.865	1	6	55
GO:0051291	protein heterooligomerization	3.44e-02	1.00e+00	4.839	1	2	56
GO:0035091	phosphatidylinositol binding	3.74e-02	1.00e+00	4.715	1	3	61
GO:0071260	cellular response to mechanical stimulus	3.98e-02	1.00e+00	4.624	1	5	65
GO:0034329	cell junction assembly	4.17e-02	1.00e+00	4.559	1	1	68
GO:0032355	response to estradiol	4.35e-02	1.00e+00	4.496	1	5	71
GO:0006915	apoptotic process	4.45e-02	1.00e+00	2.530	2	33	555
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.53e-02	1.00e+00	4.437	1	6	74
GO:0008584	male gonad development	4.59e-02	1.00e+00	4.417	1	3	75
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	4.64e-02	1.00e+00	4.398	1	3	76
GO:0002756	MyD88-independent toll-like receptor signaling pathway	4.76e-02	1.00e+00	4.361	1	3	78
GO:0070062	extracellular vesicular exosome	4.77e-02	1.00e+00	1.417	4	104	2400
GO:0034138	toll-like receptor 3 signaling pathway	4.82e-02	1.00e+00	4.342	1	3	79
GO:0045087	innate immune response	5.06e-02	1.00e+00	2.427	2	24	596
GO:0006898	receptor-mediated endocytosis	5.12e-02	1.00e+00	4.254	1	3	84
GO:0045471	response to ethanol	5.24e-02	1.00e+00	4.220	1	3	86
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	5.48e-02	1.00e+00	4.154	1	7	90
GO:0042470	melanosome	5.54e-02	1.00e+00	4.138	1	9	91
GO:0006928	cellular component movement	5.54e-02	1.00e+00	4.138	1	7	91
GO:0001649	osteoblast differentiation	5.60e-02	1.00e+00	4.123	1	6	92
GO:0034142	toll-like receptor 4 signaling pathway	5.83e-02	1.00e+00	4.061	1	3	96
GO:0014069	postsynaptic density	6.37e-02	1.00e+00	3.932	1	3	105
GO:0005506	iron ion binding	6.37e-02	1.00e+00	3.932	1	4	105
GO:0005741	mitochondrial outer membrane	6.37e-02	1.00e+00	3.932	1	7	105
GO:0006897	endocytosis	6.43e-02	1.00e+00	3.918	1	8	106
GO:0002224	toll-like receptor signaling pathway	6.60e-02	1.00e+00	3.878	1	3	109
GO:0005815	microtubule organizing center	6.60e-02	1.00e+00	3.878	1	5	109
GO:0072562	blood microparticle	6.72e-02	1.00e+00	3.852	1	3	111
GO:0030529	ribonucleoprotein complex	6.78e-02	1.00e+00	3.839	1	8	112
GO:0005819	spindle	6.78e-02	1.00e+00	3.839	1	7	112
GO:0044237	cellular metabolic process	7.07e-02	1.00e+00	3.776	1	5	117
GO:0006325	chromatin organization	7.13e-02	1.00e+00	3.764	1	5	118
GO:0005730	nucleolus	7.30e-02	1.00e+00	1.551	3	69	1641
GO:0032496	response to lipopolysaccharide	7.30e-02	1.00e+00	3.727	1	4	121
GO:0016020	membrane	7.75e-02	1.00e+00	1.516	3	90	1681
GO:0000790	nuclear chromatin	7.77e-02	1.00e+00	3.635	1	9	129
GO:0031982	vesicle	7.89e-02	1.00e+00	3.613	1	9	131
GO:0007507	heart development	8.35e-02	1.00e+00	3.527	1	7	139
GO:0006457	protein folding	8.58e-02	1.00e+00	3.486	1	7	143
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	8.69e-02	1.00e+00	3.466	1	4	145
GO:0005198	structural molecule activity	8.98e-02	1.00e+00	3.417	1	5	150
GO:0042981	regulation of apoptotic process	8.98e-02	1.00e+00	3.417	1	24	150
GO:0045121	membrane raft	9.33e-02	1.00e+00	3.361	1	8	156
GO:0043005	neuron projection	9.38e-02	1.00e+00	3.352	1	6	157
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	9.84e-02	1.00e+00	3.280	1	7	165
GO:0030424	axon	9.90e-02	1.00e+00	3.271	1	4	166
GO:0006886	intracellular protein transport	1.02e-01	1.00e+00	3.228	1	5	171
GO:0031625	ubiquitin protein ligase binding	1.06e-01	1.00e+00	3.170	1	14	178
GO:0032403	protein complex binding	1.09e-01	1.00e+00	3.130	1	10	183
GO:0001525	angiogenesis	1.13e-01	1.00e+00	3.069	1	4	191
GO:0001701	in utero embryonic development	1.19e-01	1.00e+00	2.995	1	8	201
GO:0005515	protein binding	1.20e-01	1.00e+00	0.675	6	184	6024
GO:0005634	nucleus	1.20e-01	1.00e+00	0.814	5	136	4559
GO:0005739	mitochondrion	1.25e-01	1.00e+00	1.683	2	28	998
GO:0007067	mitotic nuclear division	1.33e-01	1.00e+00	2.820	1	14	227
GO:0005759	mitochondrial matrix	1.34e-01	1.00e+00	2.813	1	14	228
GO:0006412	translation	1.35e-01	1.00e+00	2.801	1	20	230
GO:0044822	poly(A) RNA binding	1.37e-01	1.00e+00	1.602	2	49	1056
GO:0005975	carbohydrate metabolic process	1.47e-01	1.00e+00	2.663	1	9	253
GO:0003779	actin binding	1.54e-01	1.00e+00	2.591	1	12	266
GO:0044281	small molecule metabolic process	1.71e-01	1.00e+00	1.404	2	58	1211
GO:0030154	cell differentiation	1.73e-01	1.00e+00	2.413	1	5	301
GO:0043231	intracellular membrane-bounded organelle	1.82e-01	1.00e+00	2.333	1	9	318
GO:0007411	axon guidance	1.82e-01	1.00e+00	2.329	1	13	319
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.767	4	110	3767
GO:0003723	RNA binding	1.94e-01	1.00e+00	2.228	1	20	342
GO:0006508	proteolysis	2.13e-01	1.00e+00	2.084	1	9	378
GO:0046982	protein heterodimerization activity	2.14e-01	1.00e+00	2.076	1	13	380
GO:0055114	oxidation-reduction process	2.34e-01	1.00e+00	1.932	1	12	420
GO:0007596	blood coagulation	2.51e-01	1.00e+00	1.816	1	18	455
GO:0016032	viral process	2.88e-01	1.00e+00	1.585	1	55	534
GO:0005794	Golgi apparatus	3.22e-01	1.00e+00	1.393	1	15	610
GO:0010467	gene expression	3.48e-01	1.00e+00	1.260	1	59	669
GO:0005615	extracellular space	4.61e-01	1.00e+00	0.744	1	17	957
GO:0006355	regulation of transcription, DNA-templated	4.75e-01	1.00e+00	0.685	1	18	997
GO:0005654	nucleoplasm	5.04e-01	1.00e+00	0.567	1	76	1082
GO:0005524	ATP binding	5.72e-01	1.00e+00	0.304	1	60	1298
GO:0046872	metal ion binding	5.75e-01	1.00e+00	0.294	1	25	1307
GO:0006351	transcription, DNA-templated	6.14e-01	1.00e+00	0.148	1	31	1446
GO:0005886	plasma membrane	8.31e-01	1.00e+00	-0.688	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-3092

Statistics

Genes (9)

Interactions (9)

Related GO terms (192)