int-snw-1452

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.962	1.37e-16	1.35e-03	2.57e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-1452 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
RAN	5901	5	0.632	0.994	175	Yes	-
GNAI2	2771	3	-0.516	1.057	98	-	Yes
[ CSNK1A1 ]	1452	2	0.396	1.014	156	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
KPNB1	3837	6	0.613	1.017	296	Yes	-
HNRNPC	3183	20	1.812	1.026	119	Yes	-

Interactions (12)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
CSNK1A1	1452	GNAI2	2771	pp	--	int.I2D: Miller_WntLumier
KPNB1	3837	RAN	5901	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct, MGI, MIPS, BioGrid, BIND, BIND_Mouse, HPRD, INTEROLOG, YeastLow; int.HPRD: in vitro
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
CSNK1A1	1452	HNRNPC	3183	pp	--	int.I2D: BCI; int.HPRD: in vitro
ACTB	60	KPNB1	3837	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
CSNK1A1	1452	RAN	5901	pp	--	int.I2D: Miller_WntLumier
ACTB	60	GNAI2	2771	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
CSNK1A1	1452	KPNB1	3837	pp	--	int.I2D: HPRD; int.HPRD: in vitro
RPSA	3921	RAN	5901	pp	--	int.I2D: IntAct_Worm, BioGrid_Worm, BIND_Worm, CORE_2, MINT_Worm
ACTB	60	CSNK1A1	1452	pp	--	int.I2D: HPRD, BCI; int.HPRD: in vitro
ACTB	60	RAN	5901	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, NON_CORE

Related GO terms (188)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0016020	membrane	2.08e-06	3.00e-02	2.908	7	90	1681
GO:0019058	viral life cycle	2.69e-05	3.87e-01	5.556	3	13	115
GO:0005829	cytosol	3.14e-05	4.52e-01	2.338	7	132	2496
GO:0075733	intracellular transport of virus	3.65e-05	5.26e-01	7.729	2	3	17
GO:0043044	ATP-dependent chromatin remodeling	6.77e-05	9.77e-01	7.293	2	4	23
GO:0031492	nucleosomal DNA binding	9.38e-05	1.00e+00	7.061	2	4	27
GO:0005654	nucleoplasm	1.09e-04	1.00e+00	3.059	5	76	1082
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.66e-04	1.00e+00	6.088	2	5	53
GO:0005643	nuclear pore	4.23e-04	1.00e+00	5.983	2	4	57
GO:0070062	extracellular vesicular exosome	4.35e-04	1.00e+00	2.172	6	104	2400
GO:0005515	protein binding	9.24e-04	1.00e+00	1.260	8	184	6024
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.11e-03	1.00e+00	9.816	1	1	2
GO:0005055	laminin receptor activity	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006407	rRNA export from nucleus	1.11e-03	1.00e+00	9.816	1	1	2
GO:0044822	poly(A) RNA binding	1.57e-03	1.00e+00	2.772	4	49	1056
GO:0000056	ribosomal small subunit export from nucleus	1.66e-03	1.00e+00	9.231	1	1	3
GO:0000790	nuclear chromatin	2.15e-03	1.00e+00	4.805	2	9	129
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.22e-03	1.00e+00	8.816	1	1	4
GO:0030686	90S preribosome	2.22e-03	1.00e+00	8.816	1	1	4
GO:0000055	ribosomal large subunit export from nucleus	2.22e-03	1.00e+00	8.816	1	1	4
GO:0050805	negative regulation of synaptic transmission	2.22e-03	1.00e+00	8.816	1	1	4
GO:0006610	ribosomal protein import into nucleus	2.22e-03	1.00e+00	8.816	1	1	4
GO:0071782	endoplasmic reticulum tubular network	2.22e-03	1.00e+00	8.816	1	1	4
GO:0016032	viral process	2.46e-03	1.00e+00	3.340	3	55	534
GO:0000730	DNA recombinase assembly	2.77e-03	1.00e+00	8.494	1	1	5
GO:2000001	regulation of DNA damage checkpoint	2.77e-03	1.00e+00	8.494	1	1	5
GO:0030957	Tat protein binding	3.32e-03	1.00e+00	8.231	1	3	6
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	3.48e-03	1.00e+00	4.450	2	7	165
GO:0000028	ribosomal small subunit assembly	3.88e-03	1.00e+00	8.009	1	1	7
GO:0019904	protein domain specific binding	4.08e-03	1.00e+00	4.332	2	6	179
GO:0070688	MLL5-L complex	4.43e-03	1.00e+00	7.816	1	1	8
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4.43e-03	1.00e+00	7.816	1	1	8
GO:0010467	gene expression	4.67e-03	1.00e+00	3.015	3	59	669
GO:0003924	GTPase activity	4.92e-03	1.00e+00	4.194	2	12	197
GO:0008139	nuclear localization sequence binding	4.98e-03	1.00e+00	7.646	1	3	9
GO:0001973	adenosine receptor signaling pathway	4.98e-03	1.00e+00	7.646	1	1	9
GO:0010569	regulation of double-strand break repair via homologous recombination	5.53e-03	1.00e+00	7.494	1	1	10
GO:0006184	GTP catabolic process	5.78e-03	1.00e+00	4.075	2	12	214
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway	6.09e-03	1.00e+00	7.357	1	1	11
GO:0031571	mitotic G1 DNA damage checkpoint	6.09e-03	1.00e+00	7.357	1	4	11
GO:0045120	pronucleus	6.09e-03	1.00e+00	7.357	1	2	11
GO:0007067	mitotic nuclear division	6.49e-03	1.00e+00	3.990	2	14	227
GO:0070935	3'-UTR-mediated mRNA stabilization	6.64e-03	1.00e+00	7.231	1	2	12
GO:0005662	DNA replication factor A complex	7.19e-03	1.00e+00	7.116	1	1	13
GO:0008266	poly(U) RNA binding	7.19e-03	1.00e+00	7.116	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	7.74e-03	1.00e+00	7.009	1	4	14
GO:0006607	NLS-bearing protein import into nucleus	7.74e-03	1.00e+00	7.009	1	3	14
GO:0005730	nucleolus	8.01e-03	1.00e+00	2.136	4	69	1641
GO:0050998	nitric-oxide synthase binding	8.84e-03	1.00e+00	6.816	1	1	16
GO:0006309	apoptotic DNA fragmentation	9.39e-03	1.00e+00	6.729	1	1	17
GO:0019899	enzyme binding	9.53e-03	1.00e+00	3.702	2	12	277
GO:0035861	site of double-strand break	9.94e-03	1.00e+00	6.646	1	1	18
GO:0006259	DNA metabolic process	1.05e-02	1.00e+00	6.568	1	2	19
GO:0007214	gamma-aminobutyric acid signaling pathway	1.05e-02	1.00e+00	6.568	1	1	19
GO:0043234	protein complex	1.08e-02	1.00e+00	3.612	2	18	295
GO:0007165	signal transduction	1.09e-02	1.00e+00	2.576	3	24	907
GO:0006298	mismatch repair	1.10e-02	1.00e+00	6.494	1	3	20
GO:0007194	negative regulation of adenylate cyclase activity	1.16e-02	1.00e+00	6.424	1	1	21
GO:0031683	G-protein beta/gamma-subunit complex binding	1.16e-02	1.00e+00	6.424	1	1	21
GO:0032201	telomere maintenance via semi-conservative replication	1.16e-02	1.00e+00	6.424	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.16e-02	1.00e+00	6.424	1	4	21
GO:0005525	GTP binding	1.18e-02	1.00e+00	3.540	2	12	310
GO:0006297	nucleotide-excision repair, DNA gap filling	1.21e-02	1.00e+00	6.357	1	3	22
GO:0051924	regulation of calcium ion transport	1.21e-02	1.00e+00	6.357	1	1	22
GO:0030863	cortical cytoskeleton	1.21e-02	1.00e+00	6.357	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.21e-02	1.00e+00	6.357	1	4	22
GO:0007052	mitotic spindle organization	1.21e-02	1.00e+00	6.357	1	2	22
GO:0043236	laminin binding	1.27e-02	1.00e+00	6.293	1	1	23
GO:0005813	centrosome	1.30e-02	1.00e+00	3.467	2	14	326
GO:0000060	protein import into nucleus, translocation	1.32e-02	1.00e+00	6.231	1	5	24
GO:0008536	Ran GTPase binding	1.38e-02	1.00e+00	6.172	1	1	25
GO:0006611	protein export from nucleus	1.38e-02	1.00e+00	6.172	1	3	25
GO:0000722	telomere maintenance via recombination	1.38e-02	1.00e+00	6.172	1	5	25
GO:0003730	mRNA 3'-UTR binding	1.43e-02	1.00e+00	6.116	1	2	26
GO:0043022	ribosome binding	1.49e-02	1.00e+00	6.061	1	3	27
GO:0005634	nucleus	1.49e-02	1.00e+00	1.247	6	136	4559
GO:0019894	kinesin binding	1.54e-02	1.00e+00	6.009	1	1	28
GO:0006606	protein import into nucleus	1.65e-02	1.00e+00	5.909	1	2	30
GO:0006271	DNA strand elongation involved in DNA replication	1.65e-02	1.00e+00	5.909	1	7	30
GO:0001895	retina homeostasis	1.87e-02	1.00e+00	5.729	1	1	34
GO:0005834	heterotrimeric G-protein complex	1.87e-02	1.00e+00	5.729	1	1	34
GO:0034332	adherens junction organization	1.98e-02	1.00e+00	5.646	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.03e-02	1.00e+00	5.607	1	4	37
GO:0006284	base-excision repair	2.03e-02	1.00e+00	5.607	1	3	37
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	2.09e-02	1.00e+00	5.568	1	1	38
GO:0032092	positive regulation of protein binding	2.09e-02	1.00e+00	5.568	1	3	38
GO:0070527	platelet aggregation	2.09e-02	1.00e+00	5.568	1	2	38
GO:0050681	androgen receptor binding	2.09e-02	1.00e+00	5.568	1	3	38
GO:0001664	G-protein coupled receptor binding	2.09e-02	1.00e+00	5.568	1	1	38
GO:0022627	cytosolic small ribosomal subunit	2.14e-02	1.00e+00	5.531	1	4	39
GO:0000781	chromosome, telomeric region	2.14e-02	1.00e+00	5.531	1	3	39
GO:0007286	spermatid development	2.25e-02	1.00e+00	5.459	1	1	41
GO:0030521	androgen receptor signaling pathway	2.25e-02	1.00e+00	5.459	1	1	41
GO:0021762	substantia nigra development	2.42e-02	1.00e+00	5.357	1	2	44
GO:0007596	blood coagulation	2.45e-02	1.00e+00	2.986	2	18	455
GO:0006283	transcription-coupled nucleotide-excision repair	2.52e-02	1.00e+00	5.293	1	7	46
GO:0019003	GDP binding	2.58e-02	1.00e+00	5.261	1	2	47
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	2.58e-02	1.00e+00	5.261	1	5	47
GO:0044267	cellular protein metabolic process	2.65e-02	1.00e+00	2.927	2	29	474
GO:0003684	damaged DNA binding	2.69e-02	1.00e+00	5.201	1	7	49
GO:0045216	cell-cell junction organization	2.96e-02	1.00e+00	5.061	1	2	54
GO:0000186	activation of MAPKK activity	2.96e-02	1.00e+00	5.061	1	1	54
GO:0000724	double-strand break repair via homologous recombination	3.01e-02	1.00e+00	5.035	1	3	55
GO:0008565	protein transporter activity	3.06e-02	1.00e+00	5.009	1	5	56
GO:0000723	telomere maintenance	3.06e-02	1.00e+00	5.009	1	6	56
GO:0005737	cytoplasm	3.28e-02	1.00e+00	1.259	5	110	3767
GO:0019903	protein phosphatase binding	3.39e-02	1.00e+00	4.862	1	4	62
GO:0006302	double-strand break repair	3.39e-02	1.00e+00	4.862	1	4	62
GO:0006289	nucleotide-excision repair	3.71e-02	1.00e+00	4.729	1	11	68
GO:0034329	cell junction assembly	3.71e-02	1.00e+00	4.729	1	1	68
GO:0003697	single-stranded DNA binding	3.71e-02	1.00e+00	4.729	1	5	68
GO:0000777	condensed chromosome kinetochore	3.71e-02	1.00e+00	4.729	1	4	68
GO:0007584	response to nutrient	3.87e-02	1.00e+00	4.666	1	4	71
GO:0000785	chromatin	3.98e-02	1.00e+00	4.626	1	4	73
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.03e-02	1.00e+00	4.607	1	6	74
GO:0071013	catalytic step 2 spliceosome	4.25e-02	1.00e+00	4.531	1	4	78
GO:0051301	cell division	4.41e-02	1.00e+00	4.476	1	5	81
GO:0019083	viral transcription	4.41e-02	1.00e+00	4.476	1	10	81
GO:0005681	spliceosomal complex	4.51e-02	1.00e+00	4.441	1	4	83
GO:0047485	protein N-terminus binding	4.67e-02	1.00e+00	4.390	1	5	86
GO:0006415	translational termination	4.73e-02	1.00e+00	4.373	1	10	87
GO:0016605	PML body	4.78e-02	1.00e+00	4.357	1	3	88
GO:0042470	melanosome	4.94e-02	1.00e+00	4.308	1	9	91
GO:0006928	cellular component movement	4.94e-02	1.00e+00	4.308	1	7	91
GO:0005200	structural constituent of cytoskeleton	4.94e-02	1.00e+00	4.308	1	8	91
GO:0001649	osteoblast differentiation	4.99e-02	1.00e+00	4.293	1	6	92
GO:0006414	translational elongation	5.04e-02	1.00e+00	4.277	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	5.63e-02	1.00e+00	4.116	1	10	104
GO:0014069	postsynaptic density	5.68e-02	1.00e+00	4.102	1	3	105
GO:0030496	midbody	5.84e-02	1.00e+00	4.061	1	5	108
GO:0072562	blood microparticle	5.99e-02	1.00e+00	4.022	1	3	111
GO:0030529	ribonucleoprotein complex	6.05e-02	1.00e+00	4.009	1	8	112
GO:0005635	nuclear envelope	6.10e-02	1.00e+00	3.996	1	6	113
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.15e-02	1.00e+00	3.983	1	11	114
GO:0006325	chromatin organization	6.36e-02	1.00e+00	3.933	1	5	118
GO:0006260	DNA replication	6.52e-02	1.00e+00	3.897	1	9	121
GO:0006413	translational initiation	7.04e-02	1.00e+00	3.783	1	17	131
GO:0031982	vesicle	7.04e-02	1.00e+00	3.783	1	9	131
GO:0003735	structural constituent of ribosome	7.35e-02	1.00e+00	3.718	1	10	137
GO:0016055	Wnt signaling pathway	7.40e-02	1.00e+00	3.708	1	7	138
GO:0006457	protein folding	7.66e-02	1.00e+00	3.656	1	7	143
GO:0061024	membrane organization	7.77e-02	1.00e+00	3.636	1	7	145
GO:0007166	cell surface receptor signaling pathway	7.87e-02	1.00e+00	3.616	1	3	147
GO:0000082	G1/S transition of mitotic cell cycle	7.97e-02	1.00e+00	3.597	1	32	149
GO:0045121	membrane raft	8.33e-02	1.00e+00	3.531	1	8	156
GO:0000398	mRNA splicing, via spliceosome	8.74e-02	1.00e+00	3.459	1	8	164
GO:0030424	axon	8.85e-02	1.00e+00	3.441	1	4	166
GO:0031965	nuclear membrane	8.95e-02	1.00e+00	3.424	1	3	168
GO:0016607	nuclear speck	9.15e-02	1.00e+00	3.390	1	3	172
GO:0007049	cell cycle	9.26e-02	1.00e+00	3.373	1	2	174
GO:0004672	protein kinase activity	9.41e-02	1.00e+00	3.348	1	6	177
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	14	178
GO:0030168	platelet activation	1.08e-01	1.00e+00	3.137	1	10	205
GO:0004871	signal transducer activity	1.10e-01	1.00e+00	3.116	1	4	208
GO:0019221	cytokine-mediated signaling pathway	1.16e-01	1.00e+00	3.028	1	9	221
GO:0016071	mRNA metabolic process	1.17e-01	1.00e+00	3.015	1	31	223
GO:0008380	RNA splicing	1.20e-01	1.00e+00	2.983	1	11	228
GO:0006412	translation	1.21e-01	1.00e+00	2.971	1	20	230
GO:0003713	transcription coactivator activity	1.24e-01	1.00e+00	2.927	1	10	237
GO:0016070	RNA metabolic process	1.29e-01	1.00e+00	2.868	1	32	247
GO:0000166	nucleotide binding	1.35e-01	1.00e+00	2.799	1	5	259
GO:0006281	DNA repair	1.36e-01	1.00e+00	2.788	1	18	261
GO:0044281	small molecule metabolic process	1.41e-01	1.00e+00	1.574	2	58	1211
GO:0007264	small GTPase mediated signal transduction	1.45e-01	1.00e+00	2.692	1	4	279
GO:0005856	cytoskeleton	1.50e-01	1.00e+00	2.631	1	12	291
GO:0007186	G-protein coupled receptor signaling pathway	1.50e-01	1.00e+00	2.641	1	7	289
GO:0035556	intracellular signal transduction	1.56e-01	1.00e+00	2.573	1	9	303
GO:0005524	ATP binding	1.58e-01	1.00e+00	1.474	2	60	1298
GO:0004674	protein serine/threonine kinase activity	1.59e-01	1.00e+00	2.549	1	12	308
GO:0019901	protein kinase binding	1.63e-01	1.00e+00	2.508	1	21	317
GO:0007411	axon guidance	1.64e-01	1.00e+00	2.499	1	13	319
GO:0003682	chromatin binding	1.68e-01	1.00e+00	2.463	1	11	327
GO:0008283	cell proliferation	1.68e-01	1.00e+00	2.459	1	14	328
GO:0007268	synaptic transmission	1.70e-01	1.00e+00	2.441	1	6	332
GO:0003723	RNA binding	1.75e-01	1.00e+00	2.398	1	20	342
GO:0005925	focal adhesion	1.86e-01	1.00e+00	2.300	1	19	366
GO:0007155	cell adhesion	1.87e-01	1.00e+00	2.289	1	6	369
GO:0008284	positive regulation of cell proliferation	1.93e-01	1.00e+00	2.239	1	8	382
GO:0000278	mitotic cell cycle	1.97e-01	1.00e+00	2.205	1	48	391
GO:0006468	protein phosphorylation	2.28e-01	1.00e+00	1.971	1	18	460
GO:0045893	positive regulation of transcription, DNA-templated	2.36e-01	1.00e+00	1.915	1	13	478
GO:0042802	identical protein binding	2.39e-01	1.00e+00	1.897	1	20	484
GO:0006915	apoptotic process	2.69e-01	1.00e+00	1.700	1	33	555
GO:0045087	innate immune response	2.87e-01	1.00e+00	1.597	1	24	596
GO:0005615	extracellular space	4.23e-01	1.00e+00	0.914	1	17	957
GO:0005886	plasma membrane	4.34e-01	1.00e+00	0.482	2	45	2582
GO:0008270	zinc ion binding	4.36e-01	1.00e+00	0.855	1	12	997
GO:0046872	metal ion binding	5.32e-01	1.00e+00	0.464	1	25	1307

Wolf-ratios-Mammosphere-Adherent

int-snw-1452

Statistics

Genes (8)

Interactions (12)

Related GO terms (188)