int-snw-1072

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	1.002	3.18e-18	5.23e-04	1.26e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-1072 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
ACTB	60	167	1.153	1.151	587	Yes	-
RSL24D1	51187	36	1.300	1.020	59	Yes	-
ACO2	50	50	1.000	1.076	191	Yes	-
ATP1A1	476	2	0.842	1.002	82	Yes	-
OGDH	4967	13	0.847	1.076	113	Yes	-
[ CFL1 ]	1072	12	0.674	1.020	203	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (9)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
CFL1	1072	OGDH	4967	pp	--	int.I2D: YeastLow
ACO2	50	CFL1	1072	pp	--	int.I2D: YeastLow
CFL1	1072	RSL24D1	51187	pp	--	int.I2D: YeastLow
OGDH	4967	PGD	5226	pp	--	int.I2D: YeastLow
ACTB	60	CFL1	1072	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, MINT_Yeast, MIPS, BioGrid, BIND_Yeast, HPRD, IntAct, IntAct_Yeast, MINT, VidalHuman_core, YeastLow, Yu_GoldStd; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
ACO2	50	OGDH	4967	pp	--	int.I2D: YeastLow
ATP1A1	476	CFL1	1072	pp	--	int.I2D: BCI, BioGrid_Rat, HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid
ACO2	50	PGD	5226	pp	--	int.I2D: YeastLow
CFL1	1072	PGD	5226	pp	--	int.I2D: YeastLow

Related GO terms (160)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006099	tricarboxylic acid cycle	7.59e-05	1.00e+00	7.201	2	4	28
GO:0006091	generation of precursor metabolites and energy	2.45e-04	1.00e+00	6.365	2	3	50
GO:0051087	chaperone binding	3.41e-04	1.00e+00	6.126	2	6	59
GO:0045989	positive regulation of striated muscle contraction	4.85e-04	1.00e+00	11.009	1	1	1
GO:0019521	D-gluconate metabolic process	4.85e-04	1.00e+00	11.009	1	1	1
GO:0034602	oxoglutarate dehydrogenase (NAD+) activity	4.85e-04	1.00e+00	11.009	1	1	1
GO:0031947	negative regulation of glucocorticoid biosynthetic process	4.85e-04	1.00e+00	11.009	1	1	1
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.36e-04	1.00e+00	5.799	2	6	74
GO:0061034	olfactory bulb mitral cell layer development	9.70e-04	1.00e+00	10.009	1	1	2
GO:0045252	oxoglutarate dehydrogenase complex	9.70e-04	1.00e+00	10.009	1	2	2
GO:0051538	3 iron, 4 sulfur cluster binding	9.70e-04	1.00e+00	10.009	1	1	2
GO:0019322	pentose biosynthetic process	9.70e-04	1.00e+00	10.009	1	2	2
GO:0003994	aconitate hydratase activity	9.70e-04	1.00e+00	10.009	1	1	2
GO:0044237	cellular metabolic process	1.33e-03	1.00e+00	5.138	2	5	117
GO:0001842	neural fold formation	1.46e-03	1.00e+00	9.424	1	1	3
GO:1990239	steroid hormone binding	1.46e-03	1.00e+00	9.424	1	1	3
GO:1903416	response to glycoside	1.46e-03	1.00e+00	9.424	1	1	3
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	1.46e-03	1.00e+00	9.424	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	1.46e-03	1.00e+00	9.424	1	2	3
GO:0031402	sodium ion binding	1.46e-03	1.00e+00	9.424	1	1	3
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	1.46e-03	1.00e+00	9.424	1	1	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	1.46e-03	1.00e+00	9.424	1	1	3
GO:0031982	vesicle	1.67e-03	1.00e+00	4.975	2	9	131
GO:0006104	succinyl-CoA metabolic process	1.94e-03	1.00e+00	9.009	1	1	4
GO:0006734	NADH metabolic process	1.94e-03	1.00e+00	9.009	1	1	4
GO:0006102	isocitrate metabolic process	2.42e-03	1.00e+00	8.687	1	1	5
GO:0030976	thiamine pyrophosphate binding	2.42e-03	1.00e+00	8.687	1	1	5
GO:0045823	positive regulation of heart contraction	2.42e-03	1.00e+00	8.687	1	1	5
GO:0021695	cerebellar cortex development	2.91e-03	1.00e+00	8.424	1	2	6
GO:0045822	negative regulation of heart contraction	2.91e-03	1.00e+00	8.424	1	1	6
GO:0030957	Tat protein binding	2.91e-03	1.00e+00	8.424	1	3	6
GO:0030836	positive regulation of actin filament depolymerization	2.91e-03	1.00e+00	8.424	1	2	6
GO:0006101	citrate metabolic process	2.91e-03	1.00e+00	8.424	1	1	6
GO:0021860	pyramidal neuron development	2.91e-03	1.00e+00	8.424	1	1	6
GO:0036376	sodium ion export from cell	2.91e-03	1.00e+00	8.424	1	1	6
GO:0086013	membrane repolarization during cardiac muscle cell action potential	3.39e-03	1.00e+00	8.201	1	1	7
GO:0030955	potassium ion binding	3.39e-03	1.00e+00	8.201	1	1	7
GO:0005391	sodium:potassium-exchanging ATPase activity	3.88e-03	1.00e+00	8.009	1	1	8
GO:0086009	membrane repolarization	3.88e-03	1.00e+00	8.009	1	1	8
GO:0070688	MLL5-L complex	3.88e-03	1.00e+00	8.009	1	1	8
GO:0030042	actin filament depolymerization	3.88e-03	1.00e+00	8.009	1	2	8
GO:0006554	lysine catabolic process	3.88e-03	1.00e+00	8.009	1	2	8
GO:0030007	cellular potassium ion homeostasis	4.36e-03	1.00e+00	7.839	1	2	9
GO:0006098	pentose-phosphate shunt	4.84e-03	1.00e+00	7.687	1	4	10
GO:0071383	cellular response to steroid hormone stimulus	4.84e-03	1.00e+00	7.687	1	1	10
GO:0086004	regulation of cardiac muscle cell contraction	4.84e-03	1.00e+00	7.687	1	1	10
GO:0005890	sodium:potassium-exchanging ATPase complex	4.84e-03	1.00e+00	7.687	1	1	10
GO:0021756	striatum development	4.84e-03	1.00e+00	7.687	1	1	10
GO:0005759	mitochondrial matrix	4.96e-03	1.00e+00	4.176	2	14	228
GO:0021794	thalamus development	5.33e-03	1.00e+00	7.549	1	1	11
GO:0061001	regulation of dendritic spine morphogenesis	5.33e-03	1.00e+00	7.549	1	2	11
GO:0086064	cell communication by electrical coupling involved in cardiac conduction	5.81e-03	1.00e+00	7.424	1	2	12
GO:0055119	relaxation of cardiac muscle	5.81e-03	1.00e+00	7.424	1	1	12
GO:0006883	cellular sodium ion homeostasis	5.81e-03	1.00e+00	7.424	1	1	12
GO:0060081	membrane hyperpolarization	5.81e-03	1.00e+00	7.424	1	1	12
GO:0010107	potassium ion import	6.29e-03	1.00e+00	7.308	1	1	13
GO:0002028	regulation of sodium ion transport	6.29e-03	1.00e+00	7.308	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	6.78e-03	1.00e+00	7.201	1	4	14
GO:0050998	nitric-oxide synthase binding	7.74e-03	1.00e+00	7.009	1	1	16
GO:0006103	2-oxoglutarate metabolic process	7.74e-03	1.00e+00	7.009	1	1	16
GO:0031258	lamellipodium membrane	7.74e-03	1.00e+00	7.009	1	2	16
GO:0022604	regulation of cell morphogenesis	7.74e-03	1.00e+00	7.009	1	1	16
GO:0043234	protein complex	8.18e-03	1.00e+00	3.804	2	18	295
GO:0002026	regulation of the force of heart contraction	8.22e-03	1.00e+00	6.921	1	1	17
GO:0006754	ATP biosynthetic process	8.71e-03	1.00e+00	6.839	1	1	18
GO:0016791	phosphatase activity	8.71e-03	1.00e+00	6.839	1	1	18
GO:0019901	protein kinase binding	9.40e-03	1.00e+00	3.700	2	21	317
GO:0007411	axon guidance	9.52e-03	1.00e+00	3.691	2	13	319
GO:0030506	ankyrin binding	9.67e-03	1.00e+00	6.687	1	1	20
GO:0043548	phosphatidylinositol 3-kinase binding	1.01e-02	1.00e+00	6.616	1	2	21
GO:0030010	establishment of cell polarity	1.01e-02	1.00e+00	6.616	1	2	21
GO:0000281	mitotic cytokinesis	1.01e-02	1.00e+00	6.616	1	1	21
GO:0030863	cortical cytoskeleton	1.06e-02	1.00e+00	6.549	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.06e-02	1.00e+00	6.549	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.11e-02	1.00e+00	6.485	1	4	23
GO:0030864	cortical actin cytoskeleton	1.11e-02	1.00e+00	6.485	1	1	23
GO:0043200	response to amino acid	1.11e-02	1.00e+00	6.485	1	1	23
GO:0005925	focal adhesion	1.24e-02	1.00e+00	3.493	2	19	366
GO:0050661	NADP binding	1.30e-02	1.00e+00	6.254	1	2	27
GO:0031492	nucleosomal DNA binding	1.30e-02	1.00e+00	6.254	1	4	27
GO:0001755	neural crest cell migration	1.35e-02	1.00e+00	6.201	1	2	28
GO:0043531	ADP binding	1.35e-02	1.00e+00	6.201	1	1	28
GO:0019894	kinesin binding	1.35e-02	1.00e+00	6.201	1	1	28
GO:0042254	ribosome biogenesis	1.45e-02	1.00e+00	6.102	1	1	30
GO:0031072	heat shock protein binding	1.59e-02	1.00e+00	5.964	1	1	33
GO:0044281	small molecule metabolic process	1.60e-02	1.00e+00	2.352	3	58	1211
GO:0001895	retina homeostasis	1.64e-02	1.00e+00	5.921	1	1	34
GO:0051539	4 iron, 4 sulfur cluster binding	1.69e-02	1.00e+00	5.879	1	3	35
GO:0034332	adherens junction organization	1.73e-02	1.00e+00	5.839	1	1	36
GO:0070062	extracellular vesicular exosome	1.75e-02	1.00e+00	1.780	4	104	2400
GO:0030315	T-tubule	1.78e-02	1.00e+00	5.799	1	1	37
GO:0051084	'de novo' posttranslational protein folding	1.78e-02	1.00e+00	5.799	1	4	37
GO:0021766	hippocampus development	1.83e-02	1.00e+00	5.761	1	4	38
GO:0006096	glycolytic process	1.83e-02	1.00e+00	5.761	1	4	38
GO:0070527	platelet aggregation	1.83e-02	1.00e+00	5.761	1	2	38
GO:0007596	blood coagulation	1.88e-02	1.00e+00	3.179	2	18	455
GO:0060048	cardiac muscle contraction	1.88e-02	1.00e+00	5.723	1	1	39
GO:0021762	substantia nigra development	2.12e-02	1.00e+00	5.549	1	2	44
GO:0007266	Rho protein signal transduction	2.26e-02	1.00e+00	5.454	1	2	47
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.54e-02	1.00e+00	5.281	1	5	53
GO:0045216	cell-cell junction organization	2.59e-02	1.00e+00	5.254	1	2	54
GO:0031966	mitochondrial membrane	2.64e-02	1.00e+00	5.227	1	1	55
GO:0008217	regulation of blood pressure	2.73e-02	1.00e+00	5.176	1	4	57
GO:0005901	caveola	2.97e-02	1.00e+00	5.055	1	5	62
GO:0071260	cellular response to mechanical stimulus	3.11e-02	1.00e+00	4.986	1	5	65
GO:0045087	innate immune response	3.12e-02	1.00e+00	2.790	2	24	596
GO:0034329	cell junction assembly	3.25e-02	1.00e+00	4.921	1	1	68
GO:0032587	ruffle membrane	3.35e-02	1.00e+00	4.879	1	3	70
GO:0042383	sarcolemma	3.40e-02	1.00e+00	4.859	1	3	71
GO:0016020	membrane	3.85e-02	1.00e+00	1.879	3	90	1681
GO:0002576	platelet degranulation	3.91e-02	1.00e+00	4.651	1	4	82
GO:0016311	dephosphorylation	4.05e-02	1.00e+00	4.599	1	3	85
GO:0007010	cytoskeleton organization	4.33e-02	1.00e+00	4.501	1	1	91
GO:0042470	melanosome	4.33e-02	1.00e+00	4.501	1	9	91
GO:0016363	nuclear matrix	4.33e-02	1.00e+00	4.501	1	12	91
GO:0006928	cellular component movement	4.33e-02	1.00e+00	4.501	1	7	91
GO:0005200	structural constituent of cytoskeleton	4.33e-02	1.00e+00	4.501	1	8	91
GO:0014069	postsynaptic density	4.99e-02	1.00e+00	4.294	1	3	105
GO:0005506	iron ion binding	4.99e-02	1.00e+00	4.294	1	4	105
GO:0072562	blood microparticle	5.27e-02	1.00e+00	4.214	1	3	111
GO:0030529	ribonucleoprotein complex	5.31e-02	1.00e+00	4.201	1	8	112
GO:0006325	chromatin organization	5.59e-02	1.00e+00	4.126	1	5	118
GO:0030036	actin cytoskeleton organization	5.82e-02	1.00e+00	4.066	1	5	123
GO:0009615	response to virus	5.96e-02	1.00e+00	4.031	1	5	126
GO:0000790	nuclear chromatin	6.10e-02	1.00e+00	3.998	1	9	129
GO:0016323	basolateral plasma membrane	6.37e-02	1.00e+00	3.932	1	4	135
GO:0005911	cell-cell junction	6.42e-02	1.00e+00	3.921	1	4	136
GO:0006457	protein folding	6.74e-02	1.00e+00	3.849	1	7	143
GO:0061024	membrane organization	6.83e-02	1.00e+00	3.829	1	7	145
GO:0034220	ion transmembrane transport	7.01e-02	1.00e+00	3.790	1	4	149
GO:0005615	extracellular space	7.39e-02	1.00e+00	2.106	2	17	957
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	7.74e-02	1.00e+00	3.642	1	7	165
GO:0030424	axon	7.79e-02	1.00e+00	3.634	1	4	166
GO:0005768	endosome	7.92e-02	1.00e+00	3.608	1	6	169
GO:0005739	mitochondrion	7.96e-02	1.00e+00	2.046	2	28	998
GO:0034641	cellular nitrogen compound metabolic process	8.01e-02	1.00e+00	3.591	1	20	171
GO:0019904	protein domain specific binding	8.37e-02	1.00e+00	3.525	1	6	179
GO:0016324	apical plasma membrane	9.27e-02	1.00e+00	3.372	1	5	199
GO:0030168	platelet activation	9.54e-02	1.00e+00	3.329	1	10	205
GO:0005975	carbohydrate metabolic process	1.17e-01	1.00e+00	3.026	1	9	253
GO:0003779	actin binding	1.22e-01	1.00e+00	2.953	1	12	266
GO:0005524	ATP binding	1.25e-01	1.00e+00	1.667	2	60	1298
GO:0042493	response to drug	1.30e-01	1.00e+00	2.859	1	13	284
GO:0005856	cytoskeleton	1.33e-01	1.00e+00	2.824	1	12	291
GO:0055114	oxidation-reduction process	1.87e-01	1.00e+00	2.294	1	12	420
GO:0043066	negative regulation of apoptotic process	1.89e-01	1.00e+00	2.281	1	31	424
GO:0055085	transmembrane transport	1.93e-01	1.00e+00	2.244	1	10	435
GO:0006468	protein phosphorylation	2.03e-01	1.00e+00	2.163	1	18	460
GO:0044267	cellular protein metabolic process	2.09e-01	1.00e+00	2.120	1	29	474
GO:0005783	endoplasmic reticulum	2.41e-01	1.00e+00	1.890	1	10	556
GO:0005794	Golgi apparatus	2.61e-01	1.00e+00	1.756	1	15	610
GO:0005829	cytosol	3.48e-01	1.00e+00	0.723	2	132	2496
GO:0005634	nucleus	3.90e-01	1.00e+00	0.439	3	136	4559
GO:0005654	nucleoplasm	4.21e-01	1.00e+00	0.929	1	76	1082
GO:0046872	metal ion binding	4.86e-01	1.00e+00	0.657	1	25	1307
GO:0005730	nucleolus	5.71e-01	1.00e+00	0.328	1	69	1641
GO:0005737	cytoplasm	5.83e-01	1.00e+00	0.130	2	110	3767
GO:0005515	protein binding	6.18e-01	1.00e+00	0.037	3	184	6024
GO:0016021	integral component of membrane	6.45e-01	1.00e+00	0.056	1	27	1982
GO:0005886	plasma membrane	7.49e-01	1.00e+00	-0.326	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-1072

Statistics

Genes (7)

Interactions (9)

Related GO terms (160)