meta-reg-snw-11051

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
int-snw-90019 chia-screen-data-Fav 2.833 1.75e-15 4.97e-04 3.45e-03 12 11
reg-snw-11051 chia-screen-data-Fav 2.307 7.93e-08 2.35e-02 1.87e-02 25 17
chia-screen-data-Fav-meta-reg-snw-11051 subnetwork

Genes (33)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
PHB 5245 12-2.7432.689163YesYes
MED28 80306 6-2.4042.44586Yes-
CBLL1 79872 6-1.8972.44538--
MED13L 23389 8-2.5502.30750Yes-
VARS 7407 8-2.3662.689204Yes-
APC 324 6-2.2933.004384Yes-
POU5F1 5460 12-5.1483.538179YesYes
ADA 100 2-2.4992.3078YesYes
FBXO22 26263 8-1.7392.459208--
EIF2S2 8894 9-2.9992.459103YesYes
HNRNPD 3184 3-2.1533.117123Yes-
ETF1 2107 7-2.8292.50377YesYes
CCT7 10574 10-2.3352.459173Yes-
HNRNPU 3192 12-2.8692.644172Yes-
CPSF3 51692 7-2.6862.50331YesYes
PRPF40A 55660 4-1.5112.307305--
NDUFA4L2 56901 10-2.4772.45921Yes-
AGPS 8540 6-2.4242.41027YesYes
NFIA 4774 2-1.4582.30780--
YAP1 10413 12-4.2563.53853Yes-
NFIB 4781 2-1.5052.30740--
MATR3 9782 2-1.5562.32947--
ULK2 9706 3-2.2923.197312YesYes
TPR 7175 3-2.6382.44564YesYes
NUDT21 11051 2-1.2732.30761--
NCBP1 4686 8-2.5102.45984YesYes
SYNCRIP 10492 8-2.4012.503247YesYes
EIF2S1 1965 2-1.8012.41063--
SRSF3 6428 5-2.9923.53854Yes-
GPS1 2873 10-3.6212.68962YesYes
POLH 5429 8-2.5862.45924YesYes
SYT8 90019 3-1.3822.8331--
DDIT3 1649 11-2.8253.504343YesYes

Interactions (59)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ETF1 2107 SYNCRIP 10492 pd < reg.ITFP.txt: no annot
NCBP1 4686 FBXO22 26263 pd < reg.ITFP.txt: no annot
PHB 5245 VARS 7407 pd < reg.ITFP.txt: no annot
GPS1 2873 PHB 5245 pd > reg.ITFP.txt: no annot
APC 324 CCT7 10574 pp -- int.I2D: Jorgensen_EphR, SOURAV_MAPK_LOW, IntAct
EIF2S1 1965 ETF1 2107 pd > reg.ITFP.txt: no annot
EIF2S1 1965 ETF1 2107 pp -- int.I2D: YeastLow
APC 324 PHB 5245 pp -- int.I2D: Jorgensen_EphR
NUDT21 11051 PRPF40A 55660 pd < reg.ITFP.txt: no annot
ULK2 9706 SYNCRIP 10492 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
NCBP1 4686 TPR 7175 pd < reg.ITFP.txt: no annot
POLH 5429 FBXO22 26263 pd < reg.ITFP.txt: no annot
HNRNPU 3192 MATR3 9782 pd < reg.ITFP.txt: no annot
APC 324 TPR 7175 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, IntAct, SOURAV_MAPK_HIGH
HNRNPD 3184 ULK2 9706 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
NCBP1 4686 CBLL1 79872 pd < reg.ITFP.txt: no annot
CCT7 10574 FBXO22 26263 pd < reg.ITFP.txt: no annot
CBLL1 79872 MED28 80306 pd > reg.ITFP.txt: no annot
EIF2S1 1965 SYNCRIP 10492 pd <> reg.ITFP.txt: no annot
ULK2 9706 MATR3 9782 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
POU5F1 5460 MATR3 9782 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU 3192 ULK2 9706 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
CCT7 10574 PRPF40A 55660 pp -- int.I2D: BioGrid, Pawson1
NFIB 4781 NUDT21 11051 pd > reg.ITFP.txt: no annot
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
DDIT3 1649 VARS 7407 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
NFIA 4774 NFIB 4781 pd <> reg.ITFP.txt: no annot
AGPS 8540 SYNCRIP 10492 pd < reg.ITFP.txt: no annot
MED13L 23389 MED28 80306 pp -- int.I2D: BioGrid
HNRNPD 3184 HNRNPU 3192 pp -- int.Mint: MI:0915(physical association)
ETF1 2107 EIF2S2 8894 pp -- int.I2D: BioGrid_Yeast, YeastLow
NFIA 4774 NUDT21 11051 pd > reg.ITFP.txt: no annot
YAP1 10413 MED28 80306 pp -- int.I2D: MINT;
int.Mint: MI:0915(physical association)
HNRNPU 3192 PRPF40A 55660 pd < reg.ITFP.txt: no annot
HNRNPU 3192 PRPF40A 55660 pp -- int.I2D: BioGrid, Pawson1
EIF2S1 1965 EIF2S2 8894 pp -- int.Intact: MI:0407(direct interaction);
int.I2D: BCI, BioGrid_Yeast, IntAct, IntAct_Yeast, MINT_Yeast, YeastHigh, Yu_GoldStd, HPRD;
int.HPRD: in vitro
SRSF3 6428 ULK2 9706 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
SYNCRIP 10492 CPSF3 51692 pd > reg.ITFP.txt: no annot
MATR3 9782 NUDT21 11051 pd > reg.ITFP.txt: no annot
NFIA 4774 MED13L 23389 pd > reg.ITFP.txt: no annot
SYNCRIP 10492 NUDT21 11051 pd > reg.ITFP.txt: no annot
NFIB 4781 AGPS 8540 pd > reg.ITFP.txt: no annot
TPR 7175 NUDT21 11051 pd > reg.ITFP.txt: no annot
NUDT21 11051 CBLL1 79872 pd < reg.ITFP.txt: no annot
NCBP1 4686 PRPF40A 55660 pp -- int.I2D: INTEROLOG
HNRNPD 3184 SYNCRIP 10492 pp -- int.I2D: HPRD, BCI;
int.HPRD: in vivo
VARS 7407 FBXO22 26263 pd <> reg.ITFP.txt: no annot
PHB 5245 FBXO22 26263 pd < reg.ITFP.txt: no annot
HNRNPU 3192 SYNCRIP 10492 pp -- int.Mint: MI:0915(physical association)
FBXO22 26263 NDUFA4L2 56901 pd > reg.ITFP.txt: no annot
APC 324 SYNCRIP 10492 pp -- int.I2D: Jorgensen_EphR
EIF2S1 1965 NUDT21 11051 pd > reg.ITFP.txt: no annot
ADA 100 NFIA 4774 pd < reg.pazar.txt: no annot
APC 324 MATR3 9782 pp -- int.I2D: Jorgensen_EphR
DDIT3 1649 HNRNPD 3184 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
EIF2S2 8894 FBXO22 26263 pd < reg.ITFP.txt: no annot
SYNCRIP 10492 SYT8 90019 pp -- int.I2D: BioGrid, HPRD;
int.HPRD: in vitro, in vivo
NUDT21 11051 FBXO22 26263 pd < reg.ITFP.txt: no annot

Related GO terms (446)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0008380RNA splicing1.51e-082.46e-044.092814232
GO:0003723RNA binding2.40e-083.91e-043.648915355
GO:0000398mRNA splicing, via spliceosome3.25e-085.31e-044.39179165
GO:0010467gene expression4.29e-087.00e-043.0241127669
GO:0044822poly(A) RNA binding7.00e-081.14e-032.57613271078
GO:0005654nucleoplasm8.42e-081.37e-032.55413311095
GO:0031124mRNA 3'-end processing1.47e-062.40e-025.5584442
GO:0006369termination of RNA polymerase II transcription1.95e-063.18e-025.4584445
GO:0030529ribonucleoprotein complex3.09e-065.04e-024.43956114
GO:0005515protein binding8.84e-061.44e-011.01325776127
GO:0005850eukaryotic translation initiation factor 2 complex1.19e-051.94e-018.365223
GO:0006366transcription from RNA polymerase II promoter1.84e-053.00e-013.026714425
GO:0070934CRD-mediated mRNA stabilization3.95e-056.45e-017.628225
GO:0070937CRD-mediated mRNA stability complex5.92e-059.66e-017.365226
GO:0006379mRNA cleavage1.77e-041.00e+006.6282210
GO:0006396RNA processing2.38e-041.00e+004.6283460
GO:0006406mRNA export from nucleus2.63e-041.00e+004.5813562
GO:0042789mRNA transcription from RNA polymerase II promoter3.05e-041.00e+006.2502213
GO:0044212transcription regulatory region DNA binding3.76e-041.00e+003.53245171
GO:0005829cytosol8.79e-041.00e+001.32713382562
GO:0006378mRNA polyadenylation8.93e-041.00e+005.4912222
GO:0001649osteoblast differentiation9.18e-041.00e+003.9653395
GO:0043022ribosome binding1.45e-031.00e+005.1432228
GO:0007094mitotic spindle assembly checkpoint1.78e-031.00e+004.9962331
GO:0042594response to starvation1.89e-031.00e+004.9502332
GO:1901673regulation of spindle assembly involved in mitosis2.02e-031.00e+008.950111
GO:0043578nuclear matrix organization2.02e-031.00e+008.950111
GO:2000016negative regulation of determination of dorsal identity2.02e-031.00e+008.950111
GO:2000795negative regulation of epithelial cell proliferation involved in lung morphogenesis2.02e-031.00e+008.950111
GO:0010965regulation of mitotic sister chromatid separation2.02e-031.00e+008.950111
GO:0008609alkylglycerone-phosphate synthase activity2.02e-031.00e+008.950111
GO:0006404RNA import into nucleus2.02e-031.00e+008.950111
GO:0090308regulation of methylation-dependent chromatin silencing2.02e-031.00e+008.950111
GO:0006157deoxyadenosine catabolic process2.02e-031.00e+008.950111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway2.02e-031.00e+008.950111
GO:0046111xanthine biosynthetic process2.02e-031.00e+008.950111
GO:0032261purine nucleotide salvage2.02e-031.00e+008.950111
GO:0042483negative regulation of odontogenesis2.02e-031.00e+008.950111
GO:0060169negative regulation of adenosine receptor signaling pathway2.02e-031.00e+008.950111
GO:0060795cell fate commitment involved in formation of primary germ layer2.02e-031.00e+008.950111
GO:0006260DNA replication2.02e-031.00e+003.56934125
GO:0051171regulation of nitrogen compound metabolic process2.02e-031.00e+008.950111
GO:0021740principal sensory nucleus of trigeminal nerve development2.02e-031.00e+008.950111
GO:0008079translation termination factor activity2.02e-031.00e+008.950111
GO:0060407negative regulation of penile erection2.02e-031.00e+008.950111
GO:0031453positive regulation of heterochromatin assembly2.02e-031.00e+008.950111
GO:0061141lung ciliated cell differentiation2.02e-031.00e+008.950111
GO:0000166nucleotide binding2.11e-031.00e+002.86346272
GO:0016592mediator complex2.26e-031.00e+004.8212535
GO:0005634nucleus2.35e-031.00e+000.88318554828
GO:0035019somatic stem cell maintenance2.95e-031.00e+004.6282240
GO:0044267cellular protein metabolic process2.96e-031.00e+002.32157495
GO:0006974cellular response to DNA damage stimulus3.92e-031.00e+003.23134158
GO:0004832valine-tRNA ligase activity4.04e-031.00e+007.950112
GO:0002314germinal center B cell differentiation4.04e-031.00e+007.950112
GO:0060242contact inhibition4.04e-031.00e+007.950112
GO:0031990mRNA export from nucleus in response to heat stress4.04e-031.00e+007.950112
GO:0044337canonical Wnt signaling pathway involved in positive regulation of apoptotic process4.04e-031.00e+007.950112
GO:0006154adenosine catabolic process4.04e-031.00e+007.950112
GO:0005846nuclear cap binding complex4.04e-031.00e+007.950112
GO:0002176male germ cell proliferation4.04e-031.00e+007.950112
GO:0006438valyl-tRNA aminoacylation4.04e-031.00e+007.950112
GO:0009786regulation of asymmetric cell division4.04e-031.00e+007.950112
GO:0070840dynein complex binding4.04e-031.00e+007.950112
GO:0046103inosine biosynthetic process4.04e-031.00e+007.950112
GO:0060965negative regulation of gene silencing by miRNA4.04e-031.00e+007.950112
GO:0046832negative regulation of RNA export from nucleus4.04e-031.00e+007.950112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress4.04e-031.00e+007.950112
GO:0001883purine nucleoside binding4.04e-031.00e+007.950112
GO:0000189MAPK import into nucleus4.04e-031.00e+007.950112
GO:0043558regulation of translational initiation in response to stress4.04e-031.00e+007.950112
GO:2000791negative regulation of mesenchymal cell proliferation involved in lung development4.04e-031.00e+007.950112
GO:0009798axis specification4.04e-031.00e+007.950112
GO:0070256negative regulation of mucus secretion4.04e-031.00e+007.950112
GO:0044324regulation of transcription involved in anterior/posterior axis specification4.04e-031.00e+007.950112
GO:0042323negative regulation of circadian sleep/wake cycle, non-REM sleep4.04e-031.00e+007.950112
GO:0003743translation initiation factor activity4.39e-031.00e+004.3352549
GO:0006355regulation of transcription, DNA-templated5.74e-031.00e+001.6497131104
GO:0043103hypoxanthine salvage6.05e-031.00e+007.365113
GO:0042306regulation of protein import into nucleus6.05e-031.00e+007.365113
GO:0016149translation release factor activity, codon specific6.05e-031.00e+007.365113
GO:0033632regulation of cell-cell adhesion mediated by integrin6.05e-031.00e+007.365113
GO:0046061dATP catabolic process6.05e-031.00e+007.365113
GO:0006405RNA export from nucleus6.05e-031.00e+007.365113
GO:0003130BMP signaling pathway involved in heart induction6.05e-031.00e+007.365113
GO:0060205cytoplasmic membrane-bounded vesicle lumen6.05e-031.00e+007.365113
GO:0016020membrane6.40e-031.00e+001.3509271746
GO:0006987activation of signaling protein activity involved in unfolded protein response6.95e-031.00e+003.9962262
GO:0000776kinetochore7.17e-031.00e+003.9732463
GO:0097452GAIT complex8.06e-031.00e+006.950124
GO:0034273ATG1/UKL1 signaling complex8.06e-031.00e+006.950114
GO:0060913cardiac cell fate determination8.06e-031.00e+006.950114
GO:0060486Clara cell differentiation8.06e-031.00e+006.950114
GO:0008611ether lipid biosynthetic process8.06e-031.00e+006.950114
GO:0051151negative regulation of smooth muscle cell differentiation8.06e-031.00e+006.950114
GO:0097167circadian regulation of translation8.06e-031.00e+006.950114
GO:0003747translation release factor activity8.06e-031.00e+006.950124
GO:0002636positive regulation of germinal center formation8.06e-031.00e+006.950114
GO:0006290pyrimidine dimer repair8.06e-031.00e+006.950114
GO:0002906negative regulation of mature B cell apoptotic process8.06e-031.00e+006.950114
GO:0006999nuclear pore organization8.06e-031.00e+006.950114
GO:0044615nuclear pore nuclear basket8.06e-031.00e+006.950114
GO:0019887protein kinase regulator activity8.06e-031.00e+006.950114
GO:0001821histamine secretion8.06e-031.00e+006.950114
GO:0003729mRNA binding9.53e-031.00e+003.7602373
GO:0042826histone deacetylase binding9.78e-031.00e+003.7412274
GO:0001714endodermal cell fate specification1.01e-021.00e+006.628115
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic process1.01e-021.00e+006.628115
GO:0043620regulation of DNA-templated transcription in response to stress1.01e-021.00e+006.628115
GO:0004000adenosine deaminase activity1.01e-021.00e+006.628115
GO:0005849mRNA cleavage factor complex1.01e-021.00e+006.628115
GO:0021960anterior commissure morphogenesis1.01e-021.00e+006.628115
GO:0002686negative regulation of leukocyte migration1.01e-021.00e+006.628115
GO:0048742regulation of skeletal muscle fiber development1.01e-021.00e+006.628115
GO:0006398histone mRNA 3'-end processing1.01e-021.00e+006.628115
GO:0045292mRNA cis splicing, via spliceosome1.01e-021.00e+006.628115
GO:0031442positive regulation of mRNA 3'-end processing1.01e-021.00e+006.628115
GO:0006449regulation of translational termination1.01e-021.00e+006.628115
GO:0010793regulation of mRNA export from nucleus1.01e-021.00e+006.628115
GO:0048671negative regulation of collateral sprouting1.01e-021.00e+006.628115
GO:0070849response to epidermal growth factor1.01e-021.00e+006.628115
GO:0016071mRNA metabolic process1.02e-021.00e+002.73438223
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity1.06e-021.00e+003.6832277
GO:0071013catalytic step 2 spliceosome1.11e-021.00e+003.6462379
GO:0030968endoplasmic reticulum unfolded protein response1.16e-021.00e+003.6102281
GO:0006412translation1.17e-021.00e+002.65835235
GO:0008762UDP-N-acetylmuramate dehydrogenase activity1.21e-021.00e+006.365116
GO:0030858positive regulation of epithelial cell differentiation1.21e-021.00e+006.365116
GO:0050847progesterone receptor signaling pathway1.21e-021.00e+006.365116
GO:0090267positive regulation of mitotic cell cycle spindle assembly checkpoint1.21e-021.00e+006.365116
GO:0060509Type I pneumocyte differentiation1.21e-021.00e+006.365116
GO:2000323negative regulation of glucocorticoid receptor signaling pathway1.21e-021.00e+006.365116
GO:0044300cerebellar mossy fiber1.21e-021.00e+006.365116
GO:0005851eukaryotic translation initiation factor 2B complex1.21e-021.00e+006.365136
GO:0071679commissural neuron axon guidance1.21e-021.00e+006.365116
GO:0071204histone pre-mRNA 3'end processing complex1.21e-021.00e+006.365116
GO:0042382paraspeckles1.21e-021.00e+006.365126
GO:0008134transcription factor binding1.32e-021.00e+002.59236246
GO:0016070RNA metabolic process1.34e-021.00e+002.58738247
GO:0090090negative regulation of canonical Wnt signaling pathway1.36e-021.00e+003.4912488
GO:0007091metaphase/anaphase transition of mitotic cell cycle1.41e-021.00e+006.143117
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland development1.41e-021.00e+006.143117
GO:0046825regulation of protein export from nucleus1.41e-021.00e+006.143127
GO:0051988regulation of attachment of spindle microtubules to kinetochore1.41e-021.00e+006.143117
GO:0002161aminoacyl-tRNA editing activity1.41e-021.00e+006.143117
GO:0004521endoribonuclease activity1.41e-021.00e+006.143117
GO:0050862positive regulation of T cell receptor signaling pathway1.41e-021.00e+006.143117
GO:0006301postreplication repair1.41e-021.00e+006.143117
GO:0060510Type II pneumocyte differentiation1.41e-021.00e+006.143117
GO:0006282regulation of DNA repair1.41e-021.00e+006.143117
GO:0016363nuclear matrix1.48e-021.00e+003.4262592
GO:0045670regulation of osteoclast differentiation1.61e-021.00e+005.950118
GO:0051292nuclear pore complex assembly1.61e-021.00e+005.950118
GO:0001955blood vessel maturation1.61e-021.00e+005.950118
GO:0000339RNA cap binding1.61e-021.00e+005.950118
GO:0035457cellular response to interferon-alpha1.61e-021.00e+005.950118
GO:0070244negative regulation of thymocyte apoptotic process1.61e-021.00e+005.950118
GO:0033089positive regulation of T cell differentiation in thymus1.61e-021.00e+005.950118
GO:0042405nuclear inclusion body1.81e-021.00e+005.780119
GO:0071354cellular response to interleukin-61.81e-021.00e+005.780119
GO:00084095'-3' exonuclease activity1.81e-021.00e+005.780119
GO:0033197response to vitamin E1.81e-021.00e+005.780119
GO:0010388cullin deneddylation1.81e-021.00e+005.780159
GO:0005847mRNA cleavage and polyadenylation specificity factor complex1.81e-021.00e+005.780119
GO:0046638positive regulation of alpha-beta T cell differentiation1.81e-021.00e+005.780119
GO:0006983ER overload response1.81e-021.00e+005.780119
GO:0043495protein anchor1.81e-021.00e+005.780119
GO:0048541Peyer's patch development1.81e-021.00e+005.780119
GO:0005832chaperonin-containing T-complex1.81e-021.00e+005.780119
GO:0008610lipid biosynthetic process2.00e-021.00e+005.6281110
GO:0002199zona pellucida receptor complex2.00e-021.00e+005.6281110
GO:0045667regulation of osteoblast differentiation2.00e-021.00e+005.6281110
GO:0031274positive regulation of pseudopodium assembly2.00e-021.00e+005.6281110
GO:0006450regulation of translational fidelity2.00e-021.00e+005.6281110
GO:0071949FAD binding2.00e-021.00e+005.6281110
GO:0043101purine-containing compound salvage2.00e-021.00e+005.6281110
GO:0010225response to UV-C2.00e-021.00e+005.6281210
GO:0000731DNA synthesis involved in DNA repair2.00e-021.00e+005.6281110
GO:0010944negative regulation of transcription by competitive promoter binding2.00e-021.00e+005.6281110
GO:0030877beta-catenin destruction complex2.00e-021.00e+005.6281110
GO:0005845mRNA cap binding complex2.20e-021.00e+005.4911111
GO:0051010microtubule plus-end binding2.20e-021.00e+005.4911211
GO:0007340acrosome reaction2.20e-021.00e+005.4911111
GO:0045662negative regulation of myoblast differentiation2.20e-021.00e+005.4911111
GO:0031116positive regulation of microtubule polymerization2.20e-021.00e+005.4911111
GO:0035413positive regulation of catenin import into nucleus2.20e-021.00e+005.4911111
GO:2000060positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process2.20e-021.00e+005.4911111
GO:0042162telomeric DNA binding2.20e-021.00e+005.4911111
GO:0060391positive regulation of SMAD protein import into nucleus2.20e-021.00e+005.4911111
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay2.22e-021.00e+003.11723114
GO:0009168purine ribonucleoside monophosphate biosynthetic process2.40e-021.00e+005.3651212
GO:0032886regulation of microtubule-based process2.40e-021.00e+005.3651112
GO:0045947negative regulation of translational initiation2.40e-021.00e+005.3651112
GO:0008334histone mRNA metabolic process2.40e-021.00e+005.3651112
GO:0045295gamma-catenin binding2.40e-021.00e+005.3651112
GO:0019079viral genome replication2.40e-021.00e+005.3651112
GO:0034045pre-autophagosomal structure membrane2.40e-021.00e+005.3651112
GO:0008143poly(A) binding2.40e-021.00e+005.3651212
GO:0034399nuclear periphery2.40e-021.00e+005.3651112
GO:0043488regulation of mRNA stability2.60e-021.00e+005.2501113
GO:0010001glial cell differentiation2.60e-021.00e+005.2501113
GO:0060766negative regulation of androgen receptor signaling pathway2.60e-021.00e+005.2501113
GO:0010460positive regulation of heart rate2.60e-021.00e+005.2501113
GO:0044295axonal growth cone2.60e-021.00e+005.2501113
GO:0051019mitogen-activated protein kinase binding2.60e-021.00e+005.2501213
GO:0043409negative regulation of MAPK cascade2.60e-021.00e+005.2501213
GO:0005868cytoplasmic dynein complex2.60e-021.00e+005.2501113
GO:0035198miRNA binding2.60e-021.00e+005.2501113
GO:0046827positive regulation of protein export from nucleus2.60e-021.00e+005.2501113
GO:0007050cell cycle arrest2.67e-021.00e+002.97323126
GO:0035371microtubule plus-end2.79e-021.00e+005.1431114
GO:0071480cellular response to gamma radiation2.79e-021.00e+005.1431114
GO:0048566embryonic digestive tract development2.79e-021.00e+005.1431114
GO:0005095GTPase inhibitor activity2.79e-021.00e+005.1431114
GO:0045807positive regulation of endocytosis2.79e-021.00e+005.1431114
GO:0032465regulation of cytokinesis2.79e-021.00e+005.1431114
GO:0005487nucleocytoplasmic transporter activity2.79e-021.00e+005.1431214
GO:0030335positive regulation of cell migration2.83e-021.00e+002.92822130
GO:0006413translational initiation2.87e-021.00e+002.91724131
GO:0016477cell migration2.87e-021.00e+002.91722131
GO:0042307positive regulation of protein import into nucleus2.99e-021.00e+005.0431215
GO:0017091AU-rich element binding2.99e-021.00e+005.0431215
GO:0006479protein methylation2.99e-021.00e+005.0431215
GO:0001824blastocyst development2.99e-021.00e+005.0431115
GO:0006401RNA catabolic process2.99e-021.00e+005.0431115
GO:0045987positive regulation of smooth muscle contraction2.99e-021.00e+005.0431115
GO:0032839dendrite cytoplasm3.19e-021.00e+004.9501116
GO:0007026negative regulation of microtubule depolymerization3.19e-021.00e+004.9501216
GO:0030902hindbrain development3.19e-021.00e+004.9501116
GO:0046716muscle cell cellular homeostasis3.19e-021.00e+004.9501116
GO:0051276chromosome organization3.19e-021.00e+004.9501216
GO:0001829trophectodermal cell differentiation3.38e-021.00e+004.8631217
GO:0043274phospholipase binding3.38e-021.00e+004.8631117
GO:0005215transporter activity3.46e-021.00e+002.77022145
GO:0070064proline-rich region binding3.58e-021.00e+004.7801118
GO:0031122cytoplasmic microtubule organization3.58e-021.00e+004.7801118
GO:0090316positive regulation of intracellular protein transport3.58e-021.00e+004.7801118
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription3.72e-021.00e+002.71222151
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity3.77e-021.00e+004.7021219
GO:0050850positive regulation of calcium-mediated signaling3.97e-021.00e+004.6281120
GO:0046777protein autophosphorylation4.04e-021.00e+002.64623158
GO:0048675axon extension4.16e-021.00e+004.5581121
GO:0032757positive regulation of interleukin-8 production4.16e-021.00e+004.5581121
GO:0009954proximal/distal pattern formation4.16e-021.00e+004.5581121
GO:0043278response to morphine4.16e-021.00e+004.5581121
GO:0016575histone deacetylation4.16e-021.00e+004.5581121
GO:0000281mitotic cytokinesis4.16e-021.00e+004.5581121
GO:0001106RNA polymerase II transcription corepressor activity4.36e-021.00e+004.4911122
GO:0036464cytoplasmic ribonucleoprotein granule4.36e-021.00e+004.4911122
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding4.52e-021.00e+002.55823168
GO:0010506regulation of autophagy4.55e-021.00e+004.4261123
GO:0071346cellular response to interferon-gamma4.55e-021.00e+004.4261223
GO:0034660ncRNA metabolic process4.55e-021.00e+004.4261123
GO:0006397mRNA processing4.56e-021.00e+002.54926169
GO:0008135translation factor activity, nucleic acid binding4.74e-021.00e+004.3651224
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress4.74e-021.00e+004.3651124
GO:0016607nuclear speck4.86e-021.00e+002.49926175
GO:0006611protein export from nucleus4.94e-021.00e+004.3061125
GO:0030864cortical actin cytoskeleton4.94e-021.00e+004.3061125
GO:0005844polysome4.94e-021.00e+004.3061225
GO:0045296cadherin binding4.94e-021.00e+004.3061125
GO:0007049cell cycle4.96e-021.00e+002.48224177
GO:0003714transcription corepressor activity5.06e-021.00e+002.46625179
GO:0035329hippo signaling5.13e-021.00e+004.2501126
GO:0031047gene silencing by RNA5.13e-021.00e+004.2501226
GO:0000045autophagic vacuole assembly5.13e-021.00e+004.2501126
GO:0051209release of sequestered calcium ion into cytosol5.13e-021.00e+004.2501226
GO:0006913nucleocytoplasmic transport5.32e-021.00e+004.1951127
GO:0000188inactivation of MAPK activity5.32e-021.00e+004.1951127
GO:0043392negative regulation of DNA binding5.32e-021.00e+004.1951127
GO:0000387spliceosomal snRNP assembly5.32e-021.00e+004.1951127
GO:0007339binding of sperm to zona pellucida5.32e-021.00e+004.1951127
GO:0005637nuclear inner membrane5.51e-021.00e+004.1431128
GO:0015631tubulin binding5.71e-021.00e+004.0921129
GO:0005913cell-cell adherens junction5.71e-021.00e+004.0921129
GO:0005739mitochondrion5.71e-021.00e+001.2415161046
GO:0003887DNA-directed DNA polymerase activity5.71e-021.00e+004.0921129
GO:0034605cellular response to heat5.71e-021.00e+004.0921129
GO:0072686mitotic spindle5.71e-021.00e+004.0921129
GO:0071897DNA biosynthetic process5.71e-021.00e+004.0921129
GO:0006606protein import into nucleus5.90e-021.00e+004.0431130
GO:00063707-methylguanosine mRNA capping5.90e-021.00e+004.0431230
GO:0031647regulation of protein stability5.90e-021.00e+004.0431230
GO:0051262protein tetramerization5.90e-021.00e+004.0431130
GO:0010494cytoplasmic stress granule5.90e-021.00e+004.0431230
GO:0010827regulation of glucose transport6.09e-021.00e+003.9961331
GO:0005782peroxisomal matrix6.09e-021.00e+003.9961131
GO:0009953dorsal/ventral pattern formation6.28e-021.00e+003.9501132
GO:0006144purine nucleobase metabolic process6.28e-021.00e+003.9501232
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic6.28e-021.00e+003.9501132
GO:0002062chondrocyte differentiation6.28e-021.00e+003.9501232
GO:1903507negative regulation of nucleic acid-templated transcription6.28e-021.00e+003.9501132
GO:0033077T cell differentiation in thymus6.47e-021.00e+003.9061133
GO:0007162negative regulation of cell adhesion6.47e-021.00e+003.9061133
GO:0031072heat shock protein binding6.47e-021.00e+003.9061133
GO:0001104RNA polymerase II transcription cofactor activity6.47e-021.00e+003.9061333
GO:0070830tight junction assembly6.47e-021.00e+003.9061133
GO:0008180COP9 signalosome6.66e-021.00e+003.8631634
GO:0001890placenta development6.66e-021.00e+003.8631134
GO:0048286lung alveolus development6.66e-021.00e+003.8631134
GO:0001942hair follicle development6.85e-021.00e+003.8211135
GO:0030890positive regulation of B cell proliferation6.85e-021.00e+003.8211135
GO:0009267cellular response to starvation7.03e-021.00e+003.7801136
GO:0048538thymus development7.03e-021.00e+003.7801136
GO:0006446regulation of translational initiation7.03e-021.00e+003.7801236
GO:0007077mitotic nuclear envelope disassembly7.22e-021.00e+003.7411337
GO:0051084'de novo' posttranslational protein folding7.22e-021.00e+003.7411137
GO:0042752regulation of circadian rhythm7.22e-021.00e+003.7411337
GO:0045893positive regulation of transcription, DNA-templated7.45e-021.00e+001.60736487
GO:0051781positive regulation of cell division7.60e-021.00e+003.6651139
GO:0042542response to hydrogen peroxide7.79e-021.00e+003.6281140
GO:0045944positive regulation of transcription from RNA polymerase II promoter7.92e-021.00e+001.286413811
GO:0005881cytoplasmic microtubule7.97e-021.00e+003.5921241
GO:0045785positive regulation of cell adhesion7.97e-021.00e+003.5921141
GO:0017148negative regulation of translation7.97e-021.00e+003.5921341
GO:0006418tRNA aminoacylation for protein translation8.16e-021.00e+003.5581342
GO:0008645hexose transport8.16e-021.00e+003.5581342
GO:0042110T cell activation8.35e-021.00e+003.5241243
GO:0014070response to organic cyclic compound8.35e-021.00e+003.5241143
GO:0005737cytoplasm8.39e-021.00e+000.57812433976
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process8.53e-021.00e+003.4911144
GO:0050434positive regulation of viral transcription8.53e-021.00e+003.4911244
GO:0016328lateral plasma membrane8.90e-021.00e+003.4261146
GO:0044297cell body8.90e-021.00e+003.4261146
GO:0043525positive regulation of neuron apoptotic process8.90e-021.00e+003.4261246
GO:0019898extrinsic component of membrane8.90e-021.00e+003.4261146
GO:0045727positive regulation of translation8.90e-021.00e+003.4261246
GO:0006921cellular component disassembly involved in execution phase of apoptosis9.09e-021.00e+003.3951147
GO:0019827stem cell maintenance9.27e-021.00e+003.3651248
GO:0004842ubiquitin-protein transferase activity9.42e-021.00e+001.95025256
GO:0016032viral process9.47e-021.00e+001.458316540
GO:0005778peroxisomal membrane9.64e-021.00e+003.3061250
GO:0006986response to unfolded protein9.82e-021.00e+003.2781251
GO:0001669acrosomal vesicle9.82e-021.00e+003.2781151
GO:0007254JNK cascade9.82e-021.00e+003.2781251
GO:0003684damaged DNA binding9.82e-021.00e+003.2781151
GO:0045732positive regulation of protein catabolic process9.82e-021.00e+003.2781151
GO:0034976response to endoplasmic reticulum stress1.00e-011.00e+003.2501152
GO:0045454cell redox homeostasis1.00e-011.00e+003.2501152
GO:0009611response to wounding1.02e-011.00e+003.2221153
GO:0060041retina development in camera-type eye1.02e-011.00e+003.2221153
GO:0048306calcium-dependent protein binding1.09e-011.00e+003.1171157
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity1.13e-011.00e+003.0671259
GO:0015758glucose transport1.13e-011.00e+003.0671359
GO:0005643nuclear pore1.13e-011.00e+003.0671359
GO:0050728negative regulation of inflammatory response1.15e-011.00e+003.0431160
GO:0000122negative regulation of transcription from RNA polymerase II promoter1.15e-011.00e+001.333310589
GO:0008013beta-catenin binding1.15e-011.00e+003.0431460
GO:0005730nucleolus1.19e-011.00e+000.8176281684
GO:0000151ubiquitin ligase complex1.20e-011.00e+002.9731263
GO:0007409axonogenesis1.25e-011.00e+002.9061166
GO:0006368transcription elongation from RNA polymerase II promoter1.27e-011.00e+002.8841367
GO:0016787hydrolase activity1.32e-011.00e+002.8211170
GO:0032587ruffle membrane1.36e-011.00e+002.7801172
GO:0010468regulation of gene expression1.36e-011.00e+002.7801172
GO:0008021synaptic vesicle1.38e-011.00e+002.7601273
GO:0055086nucleobase-containing small molecule metabolic process1.38e-011.00e+002.7601273
GO:0060070canonical Wnt signaling pathway1.41e-011.00e+002.7211275
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process1.43e-011.00e+002.7021276
GO:0008584male gonad development1.45e-011.00e+002.6831177
GO:0001822kidney development1.48e-011.00e+002.6461279
GO:0005813centrosome1.49e-011.00e+001.54524339
GO:0051301cell division1.52e-011.00e+002.6101281
GO:0001889liver development1.53e-011.00e+002.5921282
GO:0009952anterior/posterior pattern specification1.57e-011.00e+002.5581284
GO:0009653anatomical structure morphogenesis1.62e-011.00e+002.5071187
GO:0006415translational termination1.62e-011.00e+002.5071287
GO:0006464cellular protein modification process1.65e-011.00e+002.4741189
GO:0005777peroxisome1.67e-011.00e+002.4581190
GO:0043565sequence-specific DNA binding1.68e-011.00e+001.43823365
GO:0008285negative regulation of cell proliferation1.69e-011.00e+001.43024367
GO:0003690double-stranded DNA binding1.69e-011.00e+002.4421191
GO:0016337single organismal cell-cell adhesion1.70e-011.00e+002.4261192
GO:0005923tight junction1.70e-011.00e+002.4261192
GO:0005770late endosome1.74e-011.00e+002.3951194
GO:0051082unfolded protein binding1.75e-011.00e+002.3801395
GO:0007010cytoskeleton organization1.77e-011.00e+002.3651196
GO:0030018Z disc1.80e-011.00e+002.3351298
GO:0007155cell adhesion1.82e-011.00e+001.36522384
GO:0003700sequence-specific DNA binding transcription factor activity1.91e-011.00e+000.988310748
GO:0008360regulation of cell shape1.94e-011.00e+002.22211106
GO:0030659cytoplasmic vesicle membrane1.95e-011.00e+002.20911107
GO:0006461protein complex assembly2.02e-011.00e+002.15612111
GO:0030308negative regulation of cell growth2.05e-011.00e+002.13012113
GO:0000209protein polyubiquitination2.10e-011.00e+002.09215116
GO:0005635nuclear envelope2.10e-011.00e+002.09213116
GO:0009986cell surface2.10e-011.00e+001.22924422
GO:0045892negative regulation of transcription, DNA-templated2.11e-011.00e+001.22227424
GO:0007568aging2.21e-011.00e+002.00812123
GO:0006511ubiquitin-dependent protein catabolic process2.27e-011.00e+001.96113127
GO:0030027lamellipodium2.32e-011.00e+001.92811130
GO:0044255cellular lipid metabolic process2.48e-011.00e+001.82111140
GO:0016055Wnt signaling pathway2.49e-011.00e+001.81013141
GO:0042802identical protein binding2.61e-011.00e+001.01026491
GO:0006457protein folding2.61e-011.00e+001.73111149
GO:0008017microtubule binding2.63e-011.00e+001.72114150
GO:0001666response to hypoxia2.63e-011.00e+001.72113150
GO:0042981regulation of apoptotic process2.64e-011.00e+001.71213151
GO:0005198structural molecule activity2.76e-011.00e+001.63711159
GO:0003677DNA binding2.90e-011.00e+000.5504161351
GO:0005524ATP binding2.91e-011.00e+000.5474131354
GO:0031965nuclear membrane3.01e-011.00e+001.49111176
GO:0005667transcription factor complex3.04e-011.00e+001.47413178
GO:0031625ubiquitin protein ligase binding3.07e-011.00e+001.45812180
GO:0005764lysosome3.10e-011.00e+001.44211182
GO:0009897external side of plasma membrane3.11e-011.00e+001.43411183
GO:0006367transcription initiation from RNA polymerase II promoter3.12e-011.00e+001.42615184
GO:0001701in utero embryonic development3.48e-011.00e+001.23612210
GO:0042803protein homodimerization activity3.56e-011.00e+000.68126617
GO:0008270zinc ion binding3.67e-011.00e+000.4763111067
GO:0016874ligase activity3.67e-011.00e+001.14314224
GO:0019221cytokine-mediated signaling pathway3.74e-011.00e+001.10513230
GO:0007067mitotic nuclear division3.76e-011.00e+001.09814231
GO:0003713transcription coactivator activity3.86e-011.00e+001.04917239
GO:0043025neuronal cell body4.04e-011.00e+000.96113254
GO:0005874microtubule4.09e-011.00e+000.93913258
GO:0006281DNA repair4.16e-011.00e+000.90614264
GO:0005975carbohydrate metabolic process4.28e-011.00e+000.85213274
GO:0043065positive regulation of apoptotic process4.28e-011.00e+000.85213274
GO:0003779actin binding4.30e-011.00e+000.84711275
GO:0006357regulation of transcription from RNA polymerase II promoter4.30e-011.00e+000.84714275
GO:0042493response to drug4.45e-011.00e+000.78011288
GO:0019899enzyme binding4.45e-011.00e+000.78013288
GO:0016567protein ubiquitination4.57e-011.00e+000.72615299
GO:0005743mitochondrial inner membrane4.58e-011.00e+000.72113300
GO:0004674protein serine/threonine kinase activity4.71e-011.00e+000.66512312
GO:0019901protein kinase binding4.80e-011.00e+000.62814320
GO:0008283cell proliferation4.92e-011.00e+000.57913331
GO:0044281small molecule metabolic process4.93e-011.00e+000.1963121295
GO:0043231intracellular membrane-bounded organelle4.93e-011.00e+000.57511332
GO:0003682chromatin binding4.95e-011.00e+000.56617334
GO:0030054cell junction5.17e-011.00e+000.47413356
GO:0000278mitotic cell cycle5.58e-011.00e+000.313112398
GO:0046982protein heterodimerization activity5.59e-011.00e+000.31013399
GO:0046872metal ion binding5.79e-011.00e+000.018361465
GO:0007165signal transduction5.80e-011.00e+000.05828950
GO:0055114oxidation-reduction process6.28e-011.00e+000.04012481
GO:0006351transcription, DNA-templated6.34e-011.00e+00-0.0953171585
GO:0055085transmembrane transport6.53e-011.00e+00-0.05615514
GO:0006915apoptotic process6.92e-011.00e+00-0.20718571
GO:0005783endoplasmic reticulum7.16e-011.00e+00-0.30312610
GO:0070062extracellular vesicular exosome7.71e-011.00e+00-0.3474152516
GO:0005886plasma membrane8.49e-011.00e+00-0.5194142834
GO:0005887integral component of plasma membrane8.65e-011.00e+00-0.95811961
GO:0005615extracellular space8.79e-011.00e+00-1.030141010
GO:0016021integral component of membrane9.96e-011.00e+00-2.328172483