meta-int-snw-122622

Interacting subnets

Subnetwork	Dataset	Score	p-value 1	p-value 2	p-value 3	Size	Highlighted genes
reg-snw-5682	chia-screen-data-Fav	2.230	2.01e-07	3.88e-02	2.97e-02	13	8
int-snw-122622	chia-screen-data-Fav	2.870	6.90e-16	3.15e-04	2.50e-03	16	12

chia-screen-data-Fav-meta-int-snw-122622 subnetwork

Genes (25)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
MED19	219541	4	-2.657	3.449	115	Yes	-
KARS	3735	2	-1.759	2.428	123	-	-
CENPA	1058	5	-2.185	2.393	205	Yes	-
PHB2	11331	6	-2.236	2.994	151	Yes	-
PHB	5245	12	-2.743	2.689	163	Yes	Yes
PSMA1	5682	2	-1.363	2.230	29	-	-
YAP1	10413	12	-4.256	3.538	53	Yes	-
POU5F1	5460	12	-5.148	3.538	179	Yes	Yes
GTF2A2	2958	2	-1.938	2.377	41	-	-
HAGH	3029	2	-1.562	2.870	32	-	-
ADSSL1	122622	2	-1.224	2.870	36	-	-
SON	6651	2	-3.844	3.108	9	Yes	Yes
PSMD2	5708	6	-4.172	3.157	389	Yes	Yes
LUC7L3	51747	4	-3.523	3.449	18	Yes	-
COPS3	8533	5	-1.873	2.435	118	-	-
POLR2E	5434	5	-2.037	2.644	316	Yes	-
GSPT1	2935	7	-2.313	2.503	47	Yes	Yes
HSPD1	3329	2	-1.852	2.870	325	-	-
HNRNPU	3192	12	-2.869	2.644	172	Yes	-
EIF2B3	8891	5	-2.546	2.435	13	Yes	Yes
GPS1	2873	10	-3.621	2.689	62	Yes	Yes
CDK12	51755	2	-2.714	2.944	15	Yes	-
DDIT3	1649	11	-2.825	3.504	343	Yes	Yes
PRPF40A	55660	4	-1.511	2.307	305	-	-
SF3A1	10291	2	-2.787	3.129	51	Yes	Yes

Interactions (38)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMA1	5682	COPS3	8533	pd	<	reg.ITFP.txt: no annot
GPS1	2873	PHB	5245	pd	>	reg.ITFP.txt: no annot
PHB	5245	ADSSL1	122622	pp	--	int.I2D: YeastMedium
SON	6651	PRPF40A	55660	pp	--	int.I2D: BIND, MINT, HPRD; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
CDK12	51755	PRPF40A	55660	pp	--	int.I2D: BioGrid, BIND, MINT, Pawson1, HPRD; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
POLR2E	5434	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
HSPD1	3329	PHB2	11331	pp	--	int.I2D: IntAct_Yeast
HSPD1	3329	ADSSL1	122622	pp	--	int.I2D: IntAct_Yeast
KARS	3735	PSMA1	5682	pd	>	reg.ITFP.txt: no annot
GSPT1	2935	KARS	3735	pd	<	reg.ITFP.txt: no annot
HSPD1	3329	PRPF40A	55660	pd	<	reg.ITFP.txt: no annot
PHB	5245	PHB2	11331	pp	--	int.I2D: BioGrid, BioGrid_Yeast, IntAct_Yeast
KARS	3735	PHB	5245	pd	>	reg.ITFP.txt: no annot
KARS	3735	PHB2	11331	pd	>	reg.ITFP.txt: no annot
KARS	3735	PHB2	11331	pp	--	int.I2D: BioGrid_Yeast
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
GTF2A2	2958	PSMA1	5682	pd	>	reg.ITFP.txt: no annot
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
KARS	3735	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
DDIT3	1649	HSPD1	3329	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
PHB2	11331	ADSSL1	122622	pp	--	int.I2D: YeastMedium
GPS1	2873	COPS3	8533	pp	--	int.Intact: MI:0915(physical association); int.I2D: HPRD, IntAct, INNATEDB, BioGrid, MGI; int.HPRD: in vitro, yeast 2-hybrid
POLR2E	5434	PRPF40A	55660	pd	<>	reg.ITFP.txt: no annot
HNRNPU	3192	PRPF40A	55660	pd	<	reg.ITFP.txt: no annot
HNRNPU	3192	PRPF40A	55660	pp	--	int.I2D: BioGrid, Pawson1
CENPA	1058	KARS	3735	pd	<>	reg.ITFP.txt: no annot
COPS3	8533	EIF2B3	8891	pd	>	reg.ITFP.txt: no annot
PSMD2	5708	ADSSL1	122622	pp	--	int.I2D: BioGrid_Yeast
PSMA1	5682	PSMD2	5708	pp	--	int.I2D: BioGrid, BioGrid_Yeast
HAGH	3029	ADSSL1	122622	pp	--	int.I2D: YeastLow
PSMA1	5682	PRPF40A	55660	pd	<	reg.ITFP.txt: no annot
HSPD1	3329	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
GPS1	2873	PHB2	11331	pd	>	reg.ITFP.txt: no annot
HNRNPU	3192	POLR2E	5434	pd	<	reg.ITFP.txt: no annot
GTF2A2	2958	PRPF40A	55660	pd	<>	reg.ITFP.txt: no annot
PRPF40A	55660	ADSSL1	122622	pp	--	int.I2D: BioGrid_Yeast, MINT_Yeast, IntAct_Yeast
SF3A1	10291	PRPF40A	55660	pp	--	int.I2D: BioGrid, Pawson1; int.Mint: MI:0915(physical association)
PSMD2	5708	PHB2	11331	pp	--	int.I2D: IntAct_Yeast

Related GO terms (310)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0008380	RNA splicing	4.14e-08	6.76e-04	4.300	7	14	232
GO:0005654	nucleoplasm	2.19e-07	3.58e-03	2.713	11	31	1095
GO:0005515	protein binding	2.59e-07	4.23e-03	1.229	22	77	6127
GO:0010467	gene expression	3.51e-07	5.72e-03	3.135	9	27	669
GO:0016032	viral process	1.19e-05	1.95e-01	3.081	7	16	540
GO:0005634	nucleus	1.44e-05	2.35e-01	1.283	18	55	4828
GO:0010388	cullin deneddylation	8.06e-05	1.00e+00	7.181	2	5	9
GO:0006397	mRNA processing	1.18e-04	1.00e+00	3.950	4	6	169
GO:0044212	transcription regulatory region DNA binding	1.24e-04	1.00e+00	3.933	4	5	171
GO:0016607	nuclear speck	1.35e-04	1.00e+00	3.899	4	6	175
GO:0044822	poly(A) RNA binding	1.39e-04	1.00e+00	2.276	8	27	1078
GO:0042789	mRNA transcription from RNA polymerase II promoter	1.74e-04	1.00e+00	6.650	2	2	13
GO:0005829	cytosol	7.29e-04	1.00e+00	1.487	11	38	2562
GO:0042594	response to starvation	1.09e-03	1.00e+00	5.351	2	3	32
GO:0008180	COP9 signalosome	1.23e-03	1.00e+00	5.263	2	6	34
GO:0000082	G1/S transition of mitotic cell cycle	1.51e-03	1.00e+00	3.707	3	4	150
GO:0006430	lysyl-tRNA aminoacylation	1.53e-03	1.00e+00	9.351	1	1	1
GO:0002842	positive regulation of T cell mediated immune response to tumor cell	1.53e-03	1.00e+00	9.351	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	1.53e-03	1.00e+00	9.351	1	1	1
GO:0048291	isotype switching to IgG isotypes	1.53e-03	1.00e+00	9.351	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	1.53e-03	1.00e+00	9.351	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	1.53e-03	1.00e+00	9.351	1	1	1
GO:0060795	cell fate commitment involved in formation of primary germ layer	1.53e-03	1.00e+00	9.351	1	1	1
GO:0004824	lysine-tRNA ligase activity	1.53e-03	1.00e+00	9.351	1	1	1
GO:0002368	B cell cytokine production	1.53e-03	1.00e+00	9.351	1	1	1
GO:0042981	regulation of apoptotic process	1.54e-03	1.00e+00	3.697	3	3	151
GO:0003723	RNA binding	1.94e-03	1.00e+00	2.879	4	15	355
GO:0000398	mRNA splicing, via spliceosome	1.98e-03	1.00e+00	3.569	3	9	165
GO:0006521	regulation of cellular amino acid metabolic process	2.64e-03	1.00e+00	4.707	2	2	50
GO:0006367	transcription initiation from RNA polymerase II promoter	2.70e-03	1.00e+00	3.412	3	5	184
GO:0006986	response to unfolded protein	2.74e-03	1.00e+00	4.678	2	2	51
GO:0060242	contact inhibition	3.06e-03	1.00e+00	8.351	1	1	2
GO:0004019	adenylosuccinate synthase activity	3.06e-03	1.00e+00	8.351	1	1	2
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	3.06e-03	1.00e+00	8.351	1	1	2
GO:0000939	condensed chromosome inner kinetochore	3.06e-03	1.00e+00	8.351	1	1	2
GO:0009786	regulation of asymmetric cell division	3.06e-03	1.00e+00	8.351	1	1	2
GO:0004416	hydroxyacylglutathione hydrolase activity	3.06e-03	1.00e+00	8.351	1	1	2
GO:0060965	negative regulation of gene silencing by miRNA	3.06e-03	1.00e+00	8.351	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	3.06e-03	1.00e+00	8.351	1	1	2
GO:0005684	U2-type spliceosomal complex	3.06e-03	1.00e+00	8.351	1	1	2
GO:0015966	diadenosine tetraphosphate biosynthetic process	3.06e-03	1.00e+00	8.351	1	1	2
GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly	3.06e-03	1.00e+00	8.351	1	1	2
GO:0002944	cyclin K-CDK12 complex	3.06e-03	1.00e+00	8.351	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	3.06e-03	1.00e+00	8.351	1	1	2
GO:0003677	DNA binding	3.33e-03	1.00e+00	1.758	7	16	1351
GO:0000502	proteasome complex	3.53e-03	1.00e+00	4.493	2	2	58
GO:0006366	transcription from RNA polymerase II promoter	3.72e-03	1.00e+00	2.619	4	14	425
GO:0043066	negative regulation of apoptotic process	3.97e-03	1.00e+00	2.592	4	5	433
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.42e-03	1.00e+00	4.328	2	3	65
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.42e-03	1.00e+00	4.328	2	3	65
GO:0071459	protein localization to chromosome, centromeric region	4.59e-03	1.00e+00	7.766	1	1	3
GO:0006458	'de novo' protein folding	4.59e-03	1.00e+00	7.766	1	1	3
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	4.59e-03	1.00e+00	7.766	1	1	3
GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	4.59e-03	1.00e+00	7.766	1	1	3
GO:0046040	IMP metabolic process	4.59e-03	1.00e+00	7.766	1	1	3
GO:0044208	'de novo' AMP biosynthetic process	4.59e-03	1.00e+00	7.766	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	4.59e-03	1.00e+00	7.766	1	1	3
GO:0030135	coated vesicle	4.59e-03	1.00e+00	7.766	1	1	3
GO:0006368	transcription elongation from RNA polymerase II promoter	4.69e-03	1.00e+00	4.284	2	3	67
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.10e-03	1.00e+00	4.221	2	4	70
GO:0005759	mitochondrial matrix	5.24e-03	1.00e+00	3.071	3	4	233
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	5.54e-03	1.00e+00	4.161	2	2	73
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.69e-03	1.00e+00	4.141	2	4	74
GO:0008134	transcription factor binding	6.09e-03	1.00e+00	2.993	3	6	246
GO:0051716	cellular response to stimulus	6.11e-03	1.00e+00	7.351	1	2	4
GO:0000778	condensed nuclear chromosome kinetochore	6.11e-03	1.00e+00	7.351	1	1	4
GO:0006167	AMP biosynthetic process	6.11e-03	1.00e+00	7.351	1	1	4
GO:0060913	cardiac cell fate determination	6.11e-03	1.00e+00	7.351	1	1	4
GO:0003747	translation release factor activity	6.11e-03	1.00e+00	7.351	1	2	4
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	6.14e-03	1.00e+00	4.084	2	2	77
GO:0071013	catalytic step 2 spliceosome	6.46e-03	1.00e+00	4.047	2	3	79
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	6.46e-03	1.00e+00	4.047	2	4	79
GO:0001714	endodermal cell fate specification	7.64e-03	1.00e+00	7.029	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	7.64e-03	1.00e+00	7.029	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	7.64e-03	1.00e+00	7.029	1	2	5
GO:0005672	transcription factor TFIIA complex	7.64e-03	1.00e+00	7.029	1	1	5
GO:0046696	lipopolysaccharide receptor complex	7.64e-03	1.00e+00	7.029	1	1	5
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	7.64e-03	1.00e+00	7.029	1	1	5
GO:0032057	negative regulation of translational initiation in response to stress	7.64e-03	1.00e+00	7.029	1	1	5
GO:0000389	mRNA 3'-splice site recognition	7.64e-03	1.00e+00	7.029	1	1	5
GO:0043405	regulation of MAP kinase activity	7.64e-03	1.00e+00	7.029	1	1	5
GO:0016363	nuclear matrix	8.67e-03	1.00e+00	3.827	2	5	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	9.03e-03	1.00e+00	3.796	2	2	94
GO:0050847	progesterone receptor signaling pathway	9.16e-03	1.00e+00	6.766	1	1	6
GO:0003688	DNA replication origin binding	9.16e-03	1.00e+00	6.766	1	1	6
GO:0006531	aspartate metabolic process	9.16e-03	1.00e+00	6.766	1	1	6
GO:0060744	mammary gland branching involved in thelarche	9.16e-03	1.00e+00	6.766	1	1	6
GO:0050733	RS domain binding	9.16e-03	1.00e+00	6.766	1	1	6
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	9.16e-03	1.00e+00	6.766	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	9.16e-03	1.00e+00	6.766	1	2	6
GO:0005851	eukaryotic translation initiation factor 2B complex	9.16e-03	1.00e+00	6.766	1	3	6
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	9.16e-03	1.00e+00	6.766	1	1	6
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	9.16e-03	1.00e+00	6.766	1	1	6
GO:0001649	osteoblast differentiation	9.22e-03	1.00e+00	3.781	2	3	95
GO:0005743	mitochondrial inner membrane	1.05e-02	1.00e+00	2.707	3	3	300
GO:0051726	regulation of cell cycle	1.06e-02	1.00e+00	3.678	2	4	102
GO:0005730	nucleolus	1.11e-02	1.00e+00	1.440	7	28	1684
GO:0001055	RNA polymerase II activity	1.22e-02	1.00e+00	6.351	1	1	8
GO:0001955	blood vessel maturation	1.22e-02	1.00e+00	6.351	1	1	8
GO:0019773	proteasome core complex, alpha-subunit complex	1.22e-02	1.00e+00	6.351	1	1	8
GO:0000780	condensed nuclear chromosome, centromeric region	1.22e-02	1.00e+00	6.351	1	1	8
GO:0016779	nucleotidyltransferase activity	1.22e-02	1.00e+00	6.351	1	1	8
GO:0000209	protein polyubiquitination	1.35e-02	1.00e+00	3.493	2	5	116
GO:0071354	cellular response to interleukin-6	1.37e-02	1.00e+00	6.181	1	1	9
GO:0014850	response to muscle activity	1.37e-02	1.00e+00	6.181	1	1	9
GO:0006983	ER overload response	1.37e-02	1.00e+00	6.181	1	1	9
GO:0043032	positive regulation of macrophage activation	1.52e-02	1.00e+00	6.029	1	1	10
GO:0051382	kinetochore assembly	1.52e-02	1.00e+00	6.029	1	1	10
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	1.52e-02	1.00e+00	6.029	1	2	10
GO:0010944	negative regulation of transcription by competitive promoter binding	1.52e-02	1.00e+00	6.029	1	1	10
GO:0051604	protein maturation	1.52e-02	1.00e+00	6.029	1	1	10
GO:0006750	glutathione biosynthetic process	1.52e-02	1.00e+00	6.029	1	1	10
GO:0032727	positive regulation of interferon-alpha production	1.67e-02	1.00e+00	5.891	1	1	11
GO:0071257	cellular response to electrical stimulus	1.67e-02	1.00e+00	5.891	1	1	11
GO:0045662	negative regulation of myoblast differentiation	1.67e-02	1.00e+00	5.891	1	1	11
GO:0001054	RNA polymerase I activity	1.67e-02	1.00e+00	5.891	1	2	11
GO:0035413	positive regulation of catenin import into nucleus	1.67e-02	1.00e+00	5.891	1	1	11
GO:0042301	phosphate ion binding	1.67e-02	1.00e+00	5.891	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	1.67e-02	1.00e+00	5.891	1	1	11
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	1.82e-02	1.00e+00	5.766	1	2	12
GO:0005736	DNA-directed RNA polymerase I complex	1.82e-02	1.00e+00	5.766	1	2	12
GO:0005838	proteasome regulatory particle	1.82e-02	1.00e+00	5.766	1	1	12
GO:0009416	response to light stimulus	1.97e-02	1.00e+00	5.650	1	1	13
GO:0060766	negative regulation of androgen receptor signaling pathway	1.97e-02	1.00e+00	5.650	1	1	13
GO:0030234	enzyme regulator activity	1.97e-02	1.00e+00	5.650	1	1	13
GO:0001530	lipopolysaccharide binding	1.97e-02	1.00e+00	5.650	1	1	13
GO:0035198	miRNA binding	1.97e-02	1.00e+00	5.650	1	1	13
GO:0051131	chaperone-mediated protein complex assembly	1.97e-02	1.00e+00	5.650	1	1	13
GO:0071480	cellular response to gamma radiation	2.12e-02	1.00e+00	5.543	1	1	14
GO:0005685	U1 snRNP	2.12e-02	1.00e+00	5.543	1	1	14
GO:0005095	GTPase inhibitor activity	2.12e-02	1.00e+00	5.543	1	1	14
GO:0032465	regulation of cytokinesis	2.12e-02	1.00e+00	5.543	1	1	14
GO:0000278	mitotic cell cycle	2.22e-02	1.00e+00	2.299	3	12	398
GO:0046982	protein heterodimerization activity	2.24e-02	1.00e+00	2.295	3	3	399
GO:0042026	protein refolding	2.27e-02	1.00e+00	5.444	1	1	15
GO:0006479	protein methylation	2.27e-02	1.00e+00	5.444	1	2	15
GO:0001824	blastocyst development	2.27e-02	1.00e+00	5.444	1	1	15
GO:0060749	mammary gland alveolus development	2.27e-02	1.00e+00	5.444	1	1	15
GO:0006376	mRNA splice site selection	2.27e-02	1.00e+00	5.444	1	1	15
GO:0006974	cellular response to DNA damage stimulus	2.41e-02	1.00e+00	3.047	2	4	158
GO:0042176	regulation of protein catabolic process	2.42e-02	1.00e+00	5.351	1	1	16
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	2.42e-02	1.00e+00	5.351	1	1	16
GO:0005665	DNA-directed RNA polymerase II, core complex	2.42e-02	1.00e+00	5.351	1	1	16
GO:0000132	establishment of mitotic spindle orientation	2.42e-02	1.00e+00	5.351	1	1	16
GO:0001056	RNA polymerase III activity	2.42e-02	1.00e+00	5.351	1	1	16
GO:0005737	cytoplasm	2.46e-02	1.00e+00	0.853	11	43	3976
GO:0005666	DNA-directed RNA polymerase III complex	2.57e-02	1.00e+00	5.263	1	1	17
GO:0050870	positive regulation of T cell activation	2.57e-02	1.00e+00	5.263	1	1	17
GO:0022624	proteasome accessory complex	2.57e-02	1.00e+00	5.263	1	1	17
GO:0045892	negative regulation of transcription, DNA-templated	2.62e-02	1.00e+00	2.208	3	7	424
GO:0030332	cyclin binding	2.72e-02	1.00e+00	5.181	1	1	18
GO:0006386	termination of RNA polymerase III transcription	2.72e-02	1.00e+00	5.181	1	1	18
GO:0017025	TBP-class protein binding	2.72e-02	1.00e+00	5.181	1	1	18
GO:0006541	glutamine metabolic process	2.72e-02	1.00e+00	5.181	1	1	18
GO:0070064	proline-rich region binding	2.72e-02	1.00e+00	5.181	1	1	18
GO:0006385	transcription elongation from RNA polymerase III promoter	2.72e-02	1.00e+00	5.181	1	1	18
GO:0005839	proteasome core complex	2.72e-02	1.00e+00	5.181	1	1	18
GO:0032733	positive regulation of interleukin-10 production	2.87e-02	1.00e+00	5.103	1	2	19
GO:0034641	cellular nitrogen compound metabolic process	2.98e-02	1.00e+00	2.883	2	3	177
GO:0007049	cell cycle	2.98e-02	1.00e+00	2.883	2	4	177
GO:0004298	threonine-type endopeptidase activity	3.02e-02	1.00e+00	5.029	1	1	20
GO:0016597	amino acid binding	3.02e-02	1.00e+00	5.029	1	1	20
GO:0014003	oligodendrocyte development	3.02e-02	1.00e+00	5.029	1	3	20
GO:0003714	transcription corepressor activity	3.04e-02	1.00e+00	2.867	2	5	179
GO:0032757	positive regulation of interleukin-8 production	3.17e-02	1.00e+00	4.958	1	1	21
GO:0016575	histone deacetylation	3.17e-02	1.00e+00	4.958	1	1	21
GO:0036464	cytoplasmic ribonucleoprotein granule	3.32e-02	1.00e+00	4.891	1	1	22
GO:0043484	regulation of RNA splicing	3.47e-02	1.00e+00	4.827	1	1	23
GO:0008135	translation factor activity, nucleic acid binding	3.61e-02	1.00e+00	4.766	1	2	24
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	3.61e-02	1.00e+00	4.766	1	1	24
GO:0042100	B cell proliferation	3.76e-02	1.00e+00	4.707	1	1	25
GO:0003899	DNA-directed RNA polymerase activity	3.76e-02	1.00e+00	4.707	1	1	25
GO:0005844	polysome	3.76e-02	1.00e+00	4.707	1	2	25
GO:0042113	B cell activation	3.76e-02	1.00e+00	4.707	1	1	25
GO:0032735	positive regulation of interleukin-12 production	3.76e-02	1.00e+00	4.707	1	2	25
GO:0003924	GTPase activity	3.83e-02	1.00e+00	2.685	2	2	203
GO:0035329	hippo signaling	3.91e-02	1.00e+00	4.650	1	1	26
GO:0051209	release of sequestered calcium ion into cytosol	3.91e-02	1.00e+00	4.650	1	2	26
GO:0000188	inactivation of MAPK activity	4.06e-02	1.00e+00	4.596	1	1	27
GO:0001103	RNA polymerase II repressing transcription factor binding	4.06e-02	1.00e+00	4.596	1	1	27
GO:0034080	CENP-A containing nucleosome assembly	4.06e-02	1.00e+00	4.596	1	2	27
GO:0030331	estrogen receptor binding	4.06e-02	1.00e+00	4.596	1	2	27
GO:0071897	DNA biosynthetic process	4.35e-02	1.00e+00	4.493	1	1	29
GO:0006184	GTP catabolic process	4.43e-02	1.00e+00	2.569	2	2	220
GO:0006370	7-methylguanosine mRNA capping	4.50e-02	1.00e+00	4.444	1	2	30
GO:0006360	transcription from RNA polymerase I promoter	4.50e-02	1.00e+00	4.444	1	1	30
GO:0016071	mRNA metabolic process	4.54e-02	1.00e+00	2.550	2	8	223
GO:0006144	purine nucleobase metabolic process	4.79e-02	1.00e+00	4.351	1	2	32
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	4.79e-02	1.00e+00	4.351	1	1	32
GO:1903507	negative regulation of nucleic acid-templated transcription	4.79e-02	1.00e+00	4.351	1	1	32
GO:0001104	RNA polymerase II transcription cofactor activity	4.94e-02	1.00e+00	4.306	1	3	33
GO:0003713	transcription coactivator activity	5.14e-02	1.00e+00	2.450	2	7	239
GO:0016592	mediator complex	5.23e-02	1.00e+00	4.221	1	5	35
GO:0000049	tRNA binding	5.37e-02	1.00e+00	4.181	1	1	36
GO:0032755	positive regulation of interleukin-6 production	5.37e-02	1.00e+00	4.181	1	2	36
GO:0016070	RNA metabolic process	5.45e-02	1.00e+00	2.402	2	8	247
GO:0002376	immune system process	5.52e-02	1.00e+00	4.141	1	1	37
GO:0008033	tRNA processing	5.81e-02	1.00e+00	4.065	1	1	39
GO:0006383	transcription from RNA polymerase III promoter	5.81e-02	1.00e+00	4.065	1	3	39
GO:0032729	positive regulation of interferon-gamma production	5.81e-02	1.00e+00	4.065	1	1	39
GO:0009408	response to heat	5.95e-02	1.00e+00	4.029	1	2	40
GO:0035019	somatic stem cell maintenance	5.95e-02	1.00e+00	4.029	1	2	40
GO:0006418	tRNA aminoacylation for protein translation	6.24e-02	1.00e+00	3.958	1	3	42
GO:0042110	T cell activation	6.39e-02	1.00e+00	3.924	1	2	43
GO:0050434	positive regulation of viral transcription	6.53e-02	1.00e+00	3.891	1	2	44
GO:0043525	positive regulation of neuron apoptotic process	6.82e-02	1.00e+00	3.827	1	2	46
GO:0006283	transcription-coupled nucleotide-excision repair	6.82e-02	1.00e+00	3.827	1	1	46
GO:0043434	response to peptide hormone	6.82e-02	1.00e+00	3.827	1	2	46
GO:0003743	translation initiation factor activity	7.25e-02	1.00e+00	3.736	1	5	49
GO:0005739	mitochondrion	7.25e-02	1.00e+00	1.320	4	16	1046
GO:0035690	cellular response to drug	7.39e-02	1.00e+00	3.707	1	2	50
GO:0005905	coated pit	7.53e-02	1.00e+00	3.678	1	1	51
GO:0000910	cytokinesis	7.53e-02	1.00e+00	3.678	1	1	51
GO:0007254	JNK cascade	7.53e-02	1.00e+00	3.678	1	2	51
GO:0043234	protein complex	7.66e-02	1.00e+00	2.122	2	4	300
GO:0000775	chromosome, centromeric region	7.67e-02	1.00e+00	3.650	1	3	52
GO:0034976	response to endoplasmic reticulum stress	7.67e-02	1.00e+00	3.650	1	1	52
GO:0045454	cell redox homeostasis	7.67e-02	1.00e+00	3.650	1	1	52
GO:0009611	response to wounding	7.82e-02	1.00e+00	3.623	1	1	53
GO:0003725	double-stranded RNA binding	7.96e-02	1.00e+00	3.596	1	1	54
GO:0000226	microtubule cytoskeleton organization	8.10e-02	1.00e+00	3.569	1	2	55
GO:0002039	p53 binding	8.10e-02	1.00e+00	3.569	1	3	55
GO:0006355	regulation of transcription, DNA-templated	8.48e-02	1.00e+00	1.242	4	13	1104
GO:0051087	chaperone binding	8.66e-02	1.00e+00	3.468	1	1	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	8.66e-02	1.00e+00	3.468	1	2	59
GO:0006396	RNA processing	8.80e-02	1.00e+00	3.444	1	4	60
GO:0005525	GTP binding	8.93e-02	1.00e+00	1.993	2	5	328
GO:0032481	positive regulation of type I interferon production	8.94e-02	1.00e+00	3.420	1	2	61
GO:0006987	activation of signaling protein activity involved in unfolded protein response	9.08e-02	1.00e+00	3.396	1	2	62
GO:0009749	response to glucose	9.36e-02	1.00e+00	3.351	1	2	64
GO:0030141	secretory granule	9.78e-02	1.00e+00	3.284	1	1	67
GO:0006289	nucleotide-excision repair	1.01e-01	1.00e+00	3.242	1	1	69
GO:0003697	single-stranded DNA binding	1.01e-01	1.00e+00	3.242	1	2	69
GO:0000786	nucleosome	1.02e-01	1.00e+00	3.221	1	1	70
GO:0010468	regulation of gene expression	1.05e-01	1.00e+00	3.181	1	1	72
GO:0003729	mRNA binding	1.06e-01	1.00e+00	3.161	1	3	73
GO:0055086	nucleobase-containing small molecule metabolic process	1.06e-01	1.00e+00	3.161	1	2	73
GO:0005085	guanyl-nucleotide exchange factor activity	1.07e-01	1.00e+00	3.141	1	2	74
GO:0042826	histone deacetylase binding	1.07e-01	1.00e+00	3.141	1	2	74
GO:0043565	sequence-specific DNA binding	1.07e-01	1.00e+00	1.839	2	3	365
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	1.10e-01	1.00e+00	3.103	1	2	76
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	1.12e-01	1.00e+00	3.084	1	2	77
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	1.12e-01	1.00e+00	3.084	1	2	77
GO:0006334	nucleosome assembly	1.14e-01	1.00e+00	3.047	1	3	79
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	1.16e-01	1.00e+00	3.029	1	3	80
GO:0030968	endoplasmic reticulum unfolded protein response	1.17e-01	1.00e+00	3.011	1	2	81
GO:0051301	cell division	1.17e-01	1.00e+00	3.011	1	2	81
GO:0005681	spliceosomal complex	1.20e-01	1.00e+00	2.976	1	1	83
GO:0016020	membrane	1.22e-01	1.00e+00	0.903	5	27	1746
GO:0009653	anatomical structure morphogenesis	1.25e-01	1.00e+00	2.908	1	1	87
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.25e-01	1.00e+00	1.272	3	13	811
GO:0006415	translational termination	1.25e-01	1.00e+00	2.908	1	2	87
GO:0090090	negative regulation of canonical Wnt signaling pathway	1.27e-01	1.00e+00	2.891	1	4	88
GO:0050821	protein stabilization	1.31e-01	1.00e+00	2.843	1	3	91
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	1.33e-01	1.00e+00	2.811	1	2	93
GO:0005770	late endosome	1.35e-01	1.00e+00	2.796	1	1	94
GO:0051082	unfolded protein binding	1.36e-01	1.00e+00	2.781	1	3	95
GO:0009986	cell surface	1.36e-01	1.00e+00	1.629	2	4	422
GO:0007010	cytoskeleton organization	1.37e-01	1.00e+00	2.766	1	1	96
GO:0051015	actin filament binding	1.39e-01	1.00e+00	2.751	1	1	97
GO:0005524	ATP binding	1.49e-01	1.00e+00	0.948	4	13	1354
GO:0008360	regulation of cell shape	1.50e-01	1.00e+00	2.623	1	1	106
GO:0015630	microtubule cytoskeleton	1.58e-01	1.00e+00	2.543	1	1	112
GO:0030308	negative regulation of cell growth	1.60e-01	1.00e+00	2.530	1	2	113
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1.61e-01	1.00e+00	2.518	1	3	114
GO:0030529	ribonucleoprotein complex	1.61e-01	1.00e+00	2.518	1	6	114
GO:0045893	positive regulation of transcription, DNA-templated	1.70e-01	1.00e+00	1.423	2	6	487
GO:0003676	nucleic acid binding	1.71e-01	1.00e+00	2.420	1	2	122
GO:0044267	cellular protein metabolic process	1.75e-01	1.00e+00	1.399	2	7	495
GO:0007050	cell cycle arrest	1.76e-01	1.00e+00	2.373	1	3	126
GO:0070062	extracellular vesicular exosome	1.77e-01	1.00e+00	0.639	6	15	2516
GO:0006413	translational initiation	1.83e-01	1.00e+00	2.317	1	4	131
GO:0016477	cell migration	1.83e-01	1.00e+00	2.317	1	2	131
GO:0016055	Wnt signaling pathway	1.95e-01	1.00e+00	2.211	1	3	141
GO:0016887	ATPase activity	1.99e-01	1.00e+00	2.181	1	1	144
GO:0005769	early endosome	2.16e-01	1.00e+00	2.047	1	1	158
GO:0046777	protein autophosphorylation	2.16e-01	1.00e+00	2.047	1	3	158
GO:0006915	apoptotic process	2.17e-01	1.00e+00	1.193	2	8	571
GO:0000287	magnesium ion binding	2.35e-01	1.00e+00	1.908	1	2	174
GO:0004672	protein kinase activity	2.40e-01	1.00e+00	1.875	1	1	178
GO:0005667	transcription factor complex	2.40e-01	1.00e+00	1.875	1	3	178
GO:0031625	ubiquitin protein ligase binding	2.42e-01	1.00e+00	1.859	1	2	180
GO:0042803	protein homodimerization activity	2.44e-01	1.00e+00	1.081	2	6	617
GO:0043547	positive regulation of GTPase activity	2.54e-01	1.00e+00	1.781	1	2	190
GO:0001701	in utero embryonic development	2.77e-01	1.00e+00	1.636	1	2	210
GO:0005622	intracellular	2.95e-01	1.00e+00	1.530	1	2	226
GO:0006412	translation	3.04e-01	1.00e+00	1.474	1	5	235
GO:0003700	sequence-specific DNA binding transcription factor activity	3.19e-01	1.00e+00	0.804	2	10	748
GO:0044281	small molecule metabolic process	3.19e-01	1.00e+00	0.597	3	12	1295
GO:0006281	DNA repair	3.35e-01	1.00e+00	1.306	1	4	264
GO:0043065	positive regulation of apoptotic process	3.45e-01	1.00e+00	1.253	1	3	274
GO:0006357	regulation of transcription from RNA polymerase II promoter	3.46e-01	1.00e+00	1.247	1	4	275
GO:0019899	enzyme binding	3.59e-01	1.00e+00	1.181	1	3	288
GO:0006200	ATP catabolic process	3.74e-01	1.00e+00	1.107	1	1	303
GO:0008283	cell proliferation	4.01e-01	1.00e+00	0.980	1	3	331
GO:0003682	chromatin binding	4.04e-01	1.00e+00	0.967	1	7	334
GO:0005813	centrosome	4.09e-01	1.00e+00	0.945	1	4	339
GO:0030054	cell junction	4.24e-01	1.00e+00	0.875	1	3	356
GO:0007165	signal transduction	4.32e-01	1.00e+00	0.459	2	8	950
GO:0008285	negative regulation of cell proliferation	4.34e-01	1.00e+00	0.831	1	4	367
GO:0005925	focal adhesion	4.37e-01	1.00e+00	0.819	1	2	370
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	6.01e-01	1.00e+00	0.148	1	10	589
GO:0045087	innate immune response	6.18e-01	1.00e+00	0.084	1	4	616
GO:0005887	integral component of plasma membrane	7.81e-01	1.00e+00	-0.558	1	1	961
GO:0005615	extracellular space	7.98e-01	1.00e+00	-0.630	1	4	1010
GO:0005576	extracellular region	8.10e-01	1.00e+00	-0.684	1	1	1049
GO:0008270	zinc ion binding	8.16e-01	1.00e+00	-0.709	1	11	1067
GO:0005886	plasma membrane	8.35e-01	1.00e+00	-0.533	3	14	2834
GO:0046872	metal ion binding	9.05e-01	1.00e+00	-1.166	1	6	1465
GO:0006351	transcription, DNA-templated	9.22e-01	1.00e+00	-1.280	1	17	1585

chia-Fav

meta-int-snw-122622

Interacting subnets

Genes (25)

Interactions (38)

Related GO terms (310)