TP53

Genes (1)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree Transcription factor wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
TP53 7157 20.4320.833101TF--

Gene info in the NCBI database: TP53

Subnetworks (2)

Subnetwork ID wolf-screen-ratio-mammosphere-adherent score Size Highlighted genes
reg-snw-4800 0.833 7 5
reg-snw-324 0.819 6 4

Related GO terms (137)

Accession number Name Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005515protein binding764124
GO:0045892negative regulation of transcription, DNA-templated7317
GO:0051262protein tetramerization223
GO:2001244positive regulation of intrinsic apoptotic signaling pathway128
GO:0003682chromatin binding6252
GO:0030308negative regulation of cell growth270
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation156
GO:2000379positive regulation of reactive oxygen species metabolic process121
GO:0090343positive regulation of cell aging11
GO:0019903protein phosphatase binding347
GO:0034103regulation of tissue remodeling11
GO:0000060protein import into nucleus, translocation119
GO:0003700sequence-specific DNA binding transcription factor activity6582
GO:0010165response to X-ray117
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription130
GO:0008104protein localization231
GO:0016604nuclear body123
GO:1901525negative regulation of macromitophagy12
GO:0005669transcription factor TFIID complex118
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator114
GO:0002039p53 binding245
GO:0044212transcription regulatory region DNA binding2143
GO:0002931response to ischemia113
GO:0035264multicellular organism growth154
GO:0090399replicative senescence27
GO:0007275multicellular organismal development4214
GO:0007265Ras protein signal transduction359
GO:0070245positive regulation of thymocyte apoptotic process14
GO:0006461protein complex assembly391
GO:1902108regulation of mitochondrial membrane permeability involved in apoptotic process13
GO:0005759mitochondrial matrix5139
GO:0035035histone acetyltransferase binding117
GO:0097252oligodendrocyte apoptotic process11
GO:0001085RNA polymerase II transcription factor binding131
GO:0008283cell proliferation6239
GO:0071456cellular response to hypoxia276
GO:0048568embryonic organ development111
GO:0003684damaged DNA binding941
GO:0001756somitogenesis127
GO:0009651response to salt stress110
GO:0002326B cell lineage commitment14
GO:0009303rRNA transcription18
GO:0031065positive regulation of histone deacetylation19
GO:0019901protein kinase binding11232
GO:0006355regulation of transcription, DNA-templated7715
GO:0097193intrinsic apoptotic signaling pathway149
GO:0016605PML body479
GO:0010332response to gamma radiation126
GO:0000790nuclear chromatin3109
GO:0007050cell cycle arrest392
GO:0005657replication fork216
GO:0005654nucleoplasm55876
GO:0030971receptor tyrosine kinase binding126
GO:0035033histone deacetylase regulator activity13
GO:0030330DNA damage response, signal transduction by p53 class mediator113
GO:0046677response to antibiotic124
GO:0016032viral process32428
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator114
GO:0007369gastrulation117
GO:0002020protease binding150
GO:2000378negative regulation of reactive oxygen species metabolic process112
GO:0071850mitotic cell cycle arrest110
GO:0071158positive regulation of cell cycle arrest115
GO:0043234protein complex8210
GO:0005634nucleus673246
GO:0034644cellular response to UV228
GO:0001701in utero embryonic development3154
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding240
GO:0042802identical protein binding7354
GO:0005737cytoplasm502633
GO:0000733DNA strand renaturation28
GO:0006974cellular response to DNA damage stimulus3121
GO:0021549cerebellum development119
GO:0006284base-excision repair832
GO:0031625ubiquitin protein ligase binding5138
GO:0005783endoplasmic reticulum3381
GO:0008340determination of adult lifespan111
GO:0005829cytosol581787
GO:0043066negative regulation of apoptotic process20322
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator124
GO:0002360T cell lineage commitment13
GO:0005739mitochondrion11659
GO:0008156negative regulation of DNA replication113
GO:0035794positive regulation of mitochondrial membrane permeability12
GO:0045893positive regulation of transcription, DNA-templated10377
GO:0008285negative regulation of cell proliferation4277
GO:0010666positive regulation of cardiac muscle cell apoptotic process13
GO:0035690cellular response to drug238
GO:0016363nuclear matrix773
GO:0042981regulation of apoptotic process18112
GO:0042149cellular response to glucose starvation111
GO:0000785chromatin559
GO:0002309T cell proliferation involved in immune response15
GO:0007179transforming growth factor beta receptor signaling pathway1107
GO:0005524ATP binding23892
GO:0045944positive regulation of transcription from RNA polymerase II promoter8644
GO:0051097negative regulation of helicase activity13
GO:0006983ER overload response16
GO:0031497chromatin assembly16
GO:0090403oxidative stress-induced premature senescence12
GO:0006302double-strand break repair852
GO:0031571mitotic G1 DNA damage checkpoint29
GO:0033077T cell differentiation in thymus226
GO:0006915apoptotic process21411
GO:0046902regulation of mitochondrial membrane permeability19
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1753
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway153
GO:0006289nucleotide-excision repair953
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription1132
GO:0030154cell differentiation3204
GO:0051402neuron apoptotic process230
GO:0046982protein heterodimerization activity5265
GO:0007406negative regulation of neuroblast proliferation16
GO:0032461positive regulation of protein oligomerization110
GO:0051721protein phosphatase 2A binding114
GO:0007596blood coagulation4339
GO:0005730nucleolus411217
GO:0001836release of cytochrome c from mitochondria122
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway124
GO:0047485protein N-terminus binding265
GO:0070266necroptotic process19
GO:0071479cellular response to ionizing radiation124
GO:0051087chaperone binding345
GO:0008270zinc ion binding7727
GO:0005507copper ion binding129
GO:0043065positive regulation of apoptotic process3202
GO:0007219Notch signaling pathway495
GO:0097371MDM2/MDM4 family protein binding15
GO:0043525positive regulation of neuron apoptotic process141
GO:0048147negative regulation of fibroblast proliferation118
GO:0090200positive regulation of release of cytochrome c from mitochondria118
GO:0000122negative regulation of transcription from RNA polymerase II promoter4456
GO:0003677DNA binding18947
GO:0007569cell aging221
GO:0019899enzyme binding4210
GO:0008134transcription factor binding4209
GO:0034613cellular protein localization126