reg-snw-84290

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.817 1.42e-06 3.64e-03 6.76e-03
wolf-screen-ratio-mammosphere-adherent-reg-snw-84290 subnetwork

Genes (15)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree Transcription factor wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
CAD 790 250.8070.97367---
PSMB1 5689 50.6880.90128-Yes-
RUVBL1 8607 240.7200.973126TFYes-
POLR2F 5435 140.8910.9565-Yes-
PHB2 11331 80.8290.95611-Yes-
MCM5 4174 50.5780.830152TFYes-
EFTUD2 9343 170.8830.95630-Yes-
HNRNPC 3183 401.8120.97362-Yes-
TUBG1 7283 390.9740.97336-Yes-
PSMB2 5690 230.8770.95652-Yes-
ANP32B 10541 20.7090.82321-Yes-
RUVBL2 10856 200.6930.956187TFYes-
FBL 2091 90.8390.95614-Yes-
[ CAPNS2 ] 84290 10.1450.81731---
TACC3 10460 30.8060.83025-Yes-

Interactions (19)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMB2 5690 RUVBL2 10856 pd < reg.ITFP.txt: no annot
FBL 2091 RUVBL2 10856 pd < reg.ITFP.txt: no annot
RUVBL2 10856 CAPNS2 84290 pd > reg.ITFP.txt: no annot
MCM5 4174 EFTUD2 9343 pd > reg.ITFP.txt: no annot
MCM5 4174 CAPNS2 84290 pd > reg.ITFP.txt: no annot
MCM5 4174 TACC3 10460 pd > reg.ITFP.txt: no annot
RUVBL2 10856 PHB2 11331 pd > reg.ITFP.txt: no annot
TUBG1 7283 RUVBL2 10856 pd < reg.ITFP.txt: no annot
HNRNPC 3183 RUVBL1 8607 pd < reg.ITFP.txt: no annot
TUBG1 7283 RUVBL1 8607 pd < reg.ITFP.txt: no annot
CAD 790 RUVBL2 10856 pd < reg.ITFP.txt: no annot
HNRNPC 3183 RUVBL2 10856 pd < reg.ITFP.txt: no annot
RUVBL1 8607 RUVBL2 10856 pd <> reg.ITFP.txt: no annot
CAD 790 RUVBL1 8607 pd < reg.ITFP.txt: no annot
PSMB1 5689 RUVBL2 10856 pd < reg.ITFP.txt: no annot
MCM5 4174 ANP32B 10541 pd > reg.ITFP.txt: no annot
POLR2F 5435 RUVBL2 10856 pd < reg.ITFP.txt: no annot
EFTUD2 9343 RUVBL2 10856 pd < reg.ITFP.txt: no annot
CAD 790 MCM5 4174 pd < reg.ITFP.txt: no annot

Related GO terms (208)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0003678DNA helicase activity2.36e-062.30e-026.7623318
GO:0016363nuclear matrix3.69e-063.60e-025.1574773
GO:0005654nucleoplasm1.48e-051.44e-012.572855876
GO:0005730nucleolus1.75e-051.70e-012.2679411217
GO:0032508DNA duplex unwinding2.40e-052.34e-015.6843538
GO:0000812Swr1 complex4.60e-054.50e-017.539227
GO:0031011Ino80 complex6.13e-055.99e-017.347228
GO:0043968histone H2A acetylation9.84e-059.61e-017.0252210
GO:0035267NuA4 histone acetyltransferase complex1.44e-041.00e+006.7622312
GO:0016020membrane1.53e-041.00e+002.1098381207
GO:0070062extracellular vesicular exosome1.98e-041.00e+001.8369431641
GO:0005839proteasome core complex2.61e-041.00e+006.3472916
GO:0005634nucleus2.74e-041.00e+001.26712673246
GO:0004298threonine-type endopeptidase activity2.96e-041.00e+006.2592917
GO:0071339MLL1 complex3.32e-041.00e+006.1772218
GO:0043967histone H4 acetylation5.00e-041.00e+005.8872222
GO:0000082G1/S transition of mitotic cell cycle8.33e-041.00e+003.966324125
GO:0000398mRNA splicing, via spliceosome8.92e-041.00e+003.93138128
GO:0010467gene expression9.19e-041.00e+002.605531535
GO:0015030Cajal body1.06e-031.00e+005.3472232
GO:0000278mitotic cell cycle1.08e-031.00e+003.052435314
GO:0040008regulation of growth1.42e-031.00e+005.1372237
GO:1990259histone-glutamine methyltransferase activity1.54e-031.00e+009.347111
GO:1990258histone glutamine methylation1.54e-031.00e+009.347111
GO:0004151dihydroorotase activity1.54e-031.00e+009.347111
GO:0004070aspartate carbamoyltransferase activity1.54e-031.00e+009.347111
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity1.54e-031.00e+009.347111
GO:0070335aspartate binding1.54e-031.00e+009.347111
GO:0016074snoRNA metabolic process1.54e-031.00e+009.347111
GO:0070409carbamoyl phosphate biosynthetic process1.54e-031.00e+009.347111
GO:0006521regulation of cellular amino acid metabolic process1.74e-031.00e+004.98921641
GO:0008380RNA splicing1.86e-031.00e+003.56537165
GO:0000502proteasome complex2.29e-031.00e+004.79221747
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding2.48e-031.00e+004.7322349
GO:0006310DNA recombination2.59e-031.00e+004.7032650
GO:0006334nucleosome assembly2.69e-031.00e+004.6742451
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.79e-031.00e+004.64621752
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest2.90e-031.00e+004.61921753
GO:0030953astral microtubule organization3.07e-031.00e+008.347112
GO:0005681spliceosomal complex3.12e-031.00e+004.5652255
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.23e-031.00e+004.53921756
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent3.35e-031.00e+004.51421657
GO:0006281DNA repair3.35e-031.00e+003.266319203
GO:0043234protein complex3.69e-031.00e+003.21738210
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.70e-031.00e+004.44021760
GO:0071013catalytic step 2 spliceosome3.83e-031.00e+004.4162561
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I3.83e-031.00e+004.41621661
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process4.33e-031.00e+004.32421765
GO:0071733transcriptional activation by promoter-enhancer looping4.60e-031.00e+007.762113
GO:0043141ATP-dependent 5'-3' DNA helicase activity4.60e-031.00e+007.762113
GO:0006543glutamine catabolic process4.60e-031.00e+007.762113
GO:0001652granular component4.60e-031.00e+007.762113
GO:0044205'de novo' UMP biosynthetic process4.60e-031.00e+007.762113
GO:0071899negative regulation of estrogen receptor binding4.60e-031.00e+007.762113
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process4.60e-031.00e+007.762113
GO:0031428box C/D snoRNP complex4.60e-031.00e+007.762113
GO:0006325chromatin organization5.01e-031.00e+004.2172370
GO:0002474antigen processing and presentation of peptide antigen via MHC class I5.01e-031.00e+004.21721670
GO:0001649osteoblast differentiation5.58e-031.00e+004.1372274
GO:0051414response to cortisol6.13e-031.00e+007.347114
GO:0000212meiotic spindle organization6.13e-031.00e+007.347114
GO:0071169establishment of protein localization to chromatin6.13e-031.00e+007.347114
GO:0006228UTP biosynthetic process6.13e-031.00e+007.347114
GO:0060762regulation of branching involved in mammary gland duct morphogenesis6.13e-031.00e+007.347114
GO:0030529ribonucleoprotein complex6.81e-031.00e+003.9892482
GO:0033600negative regulation of mammary gland epithelial cell proliferation7.66e-031.00e+007.025115
GO:0014075response to amine7.66e-031.00e+007.025115
GO:0060744mammary gland branching involved in thelarche7.66e-031.00e+007.025115
GO:0005827polar microtubule7.66e-031.00e+007.025115
GO:0000930gamma-tubulin complex7.66e-031.00e+007.025115
GO:0000209protein polyubiquitination8.51e-031.00e+003.82321692
GO:0001055RNA polymerase II activity9.18e-031.00e+006.762126
GO:0046134pyrimidine nucleoside biosynthetic process9.18e-031.00e+006.762116
GO:0031000response to caffeine9.18e-031.00e+006.762116
GO:0042555MCM complex9.18e-031.00e+006.762116
GO:0022027interkinetic nuclear migration9.18e-031.00e+006.762116
GO:0016887ATPase activity1.00e-021.00e+003.70326100
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway1.07e-021.00e+006.539117
GO:0070063RNA polymerase binding1.07e-021.00e+006.539117
GO:0034641cellular nitrogen compound metabolic process1.10e-021.00e+003.632218105
GO:0004198calcium-dependent cysteine-type endopeptidase activity1.22e-021.00e+006.347118
GO:0031122cytoplasmic microtubule organization1.22e-021.00e+006.347128
GO:0042994cytoplasmic sequestering of transcription factor1.22e-021.00e+006.347118
GO:0042981regulation of apoptotic process1.24e-021.00e+003.539218112
GO:0032886regulation of microtubule-based process1.37e-021.00e+006.177129
GO:0021591ventricular system development1.37e-021.00e+006.177119
GO:0008266poly(U) RNA binding1.37e-021.00e+006.177119
GO:0003924GTPase activity1.39e-021.00e+003.45223119
GO:0005515protein binding1.49e-021.00e+000.79611764124
GO:0005736DNA-directed RNA polymerase I complex1.53e-021.00e+006.0251210
GO:0006541glutamine metabolic process1.53e-021.00e+006.0251110
GO:0001054RNA polymerase I activity1.53e-021.00e+006.0251210
GO:0042802identical protein binding1.55e-021.00e+002.46437354
GO:0006184GTP catabolic process1.65e-021.00e+003.32423130
GO:0007020microtubule nucleation1.68e-021.00e+005.8871111
GO:00709353'-UTR-mediated mRNA stabilization1.68e-021.00e+005.8871211
GO:0045120pronucleus1.68e-021.00e+005.8871111
GO:0046827positive regulation of protein export from nucleus1.68e-021.00e+005.8871111
GO:0071392cellular response to estradiol stimulus1.98e-021.00e+005.6461113
GO:0005666DNA-directed RNA polymerase III complex1.98e-021.00e+005.6461213
GO:0005665DNA-directed RNA polymerase II, core complex1.98e-021.00e+005.6461213
GO:0001056RNA polymerase III activity1.98e-021.00e+005.6461213
GO:0035066positive regulation of histone acetylation1.98e-021.00e+005.6461113
GO:0060749mammary gland alveolus development1.98e-021.00e+005.6461113
GO:0006386termination of RNA polymerase III transcription2.13e-021.00e+005.5391214
GO:0010243response to organonitrogen compound2.13e-021.00e+005.5391114
GO:0006385transcription elongation from RNA polymerase III promoter2.13e-021.00e+005.5391214
GO:0005719nuclear euchromatin2.43e-021.00e+005.3471116
GO:0022008neurogenesis2.43e-021.00e+005.3471116
GO:0016032viral process2.57e-021.00e+002.190332428
GO:0006206pyrimidine nucleobase metabolic process2.58e-021.00e+005.2591217
GO:0001944vasculature development2.58e-021.00e+005.2591117
GO:0006270DNA replication initiation2.58e-021.00e+005.2591417
GO:0071364cellular response to epidermal growth factor stimulus2.73e-021.00e+005.1771118
GO:0016071mRNA metabolic process2.73e-021.00e+002.937221170
GO:0033574response to testosterone2.73e-021.00e+005.1771118
GO:0000794condensed nuclear chromosome2.73e-021.00e+005.1771318
GO:0043044ATP-dependent chromatin remodeling3.03e-021.00e+005.0251220
GO:0034080CENP-A containing nucleosome assembly3.03e-021.00e+005.0251220
GO:0045596negative regulation of cell differentiation3.03e-021.00e+005.0251120
GO:0017144drug metabolic process3.18e-021.00e+004.9541121
GO:0016070RNA metabolic process3.28e-021.00e+002.792221188
GO:0030331estrogen receptor binding3.33e-021.00e+004.8871122
GO:0005525GTP binding3.58e-021.00e+002.72425197
GO:00063707-methylguanosine mRNA capping3.63e-021.00e+004.7621224
GO:0048839inner ear development3.63e-021.00e+004.7621224
GO:0004003ATP-dependent DNA helicase activity3.77e-021.00e+004.7031225
GO:0008033tRNA processing3.77e-021.00e+004.7031125
GO:0003730mRNA 3'-UTR binding3.77e-021.00e+004.7031225
GO:0031492nucleosomal DNA binding3.77e-021.00e+004.7031225
GO:0006360transcription from RNA polymerase I promoter4.07e-021.00e+004.5921227
GO:0005829cytosol4.15e-021.00e+001.1286581787
GO:0005524ATP binding4.17e-021.00e+001.546423892
GO:0034644cellular response to UV4.22e-021.00e+004.5391228
GO:0005813centrosome4.27e-021.00e+002.58528217
GO:0006271DNA strand elongation involved in DNA replication4.37e-021.00e+004.4891829
GO:0018107peptidyl-threonine phosphorylation4.37e-021.00e+004.4891229
GO:0006383transcription from RNA polymerase III promoter4.37e-021.00e+004.4891229
GO:0021987cerebral cortex development4.51e-021.00e+004.4401230
GO:0043195terminal bouton4.66e-021.00e+004.3921131
GO:0031490chromatin DNA binding4.66e-021.00e+004.3921131
GO:0007595lactation4.81e-021.00e+004.3471232
GO:0014070response to organic cyclic compound5.10e-021.00e+004.2591134
GO:0050434positive regulation of viral transcription5.25e-021.00e+004.2171235
GO:0000226microtubule cytoskeleton organization5.39e-021.00e+004.1771236
GO:0003723RNA binding5.39e-021.00e+002.398211247
GO:0035690cellular response to drug5.68e-021.00e+004.0991238
GO:0006283transcription-coupled nucleotide-excision repair5.98e-021.00e+004.0251640
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding5.98e-021.00e+004.0251240
GO:0042995cell projection6.12e-021.00e+003.9891241
GO:0003684damaged DNA binding6.12e-021.00e+003.9891941
GO:0031100organ regeneration6.55e-021.00e+003.8871244
GO:0060021palate development6.99e-021.00e+003.7921147
GO:0032481positive regulation of type I interferon production7.13e-021.00e+003.7621548
GO:0030097hemopoiesis7.13e-021.00e+003.7621348
GO:0055086nucleobase-containing small molecule metabolic process7.56e-021.00e+003.6741551
GO:0006368transcription elongation from RNA polymerase II promoter7.70e-021.00e+003.6461352
GO:0006289nucleotide-excision repair7.84e-021.00e+003.6191953
GO:0042393histone binding7.99e-021.00e+003.5921354
GO:0005737cytoplasm8.10e-021.00e+000.7917502633
GO:0006338chromatin remodeling8.13e-021.00e+003.5651255
GO:0043066negative regulation of apoptotic process8.58e-021.00e+002.016220322
GO:0007565female pregnancy9.40e-021.00e+003.3471264
GO:0006364rRNA processing9.82e-021.00e+003.2801467
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process9.82e-021.00e+003.2801267
GO:0005200structural constituent of cytoskeleton9.96e-021.00e+003.2591268
GO:0051082unfolded protein binding1.02e-011.00e+003.2171470
GO:0001889liver development1.04e-011.00e+003.1971171
GO:0051726regulation of cell cycle1.07e-011.00e+003.1571273
GO:0005815microtubule organizing center1.12e-011.00e+003.0801177
GO:0044822poly(A) RNA binding1.19e-011.00e+001.289325799
GO:0006915apoptotic process1.29e-011.00e+001.664221411
GO:0044281small molecule metabolic process1.34e-011.00e+001.210332844
GO:0006260DNA replication1.35e-011.00e+002.79211194
GO:0000086G2/M transition of mitotic cell cycle1.39e-011.00e+002.7471597
GO:0006457protein folding1.39e-011.00e+002.7471497
GO:0007507heart development1.51e-011.00e+002.61911106
GO:0046777protein autophosphorylation1.51e-011.00e+002.61912106
GO:0000790nuclear chromatin1.55e-011.00e+002.57813109
GO:0006397mRNA processing1.56e-011.00e+002.56512110
GO:0001666response to hypoxia1.64e-011.00e+002.48911116
GO:0016607nuclear speck1.72e-011.00e+002.41613122
GO:0004672protein kinase activity1.76e-011.00e+002.38112125
GO:0019904protein domain specific binding1.82e-011.00e+002.32412130
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.97e-011.00e+002.19712142
GO:0005622intracellular2.01e-011.00e+002.16711145
GO:0006367transcription initiation from RNA polymerase II promoter2.21e-011.00e+002.01614161
GO:0006351transcription, DNA-templated2.24e-011.00e+000.860391076
GO:0007067mitotic nuclear division2.26e-011.00e+001.98018165
GO:0007283spermatogenesis2.29e-011.00e+001.95412168
GO:0043025neuronal cell body2.33e-011.00e+001.92913171
GO:0000166nucleotide binding2.39e-011.00e+001.88716176
GO:0005743mitochondrial inner membrane2.64e-011.00e+001.72413197
GO:0006357regulation of transcription from RNA polymerase II promoter2.70e-011.00e+001.68111203
GO:0019899enzyme binding2.78e-011.00e+001.63214210
GO:0043231intracellular membrane-bounded organelle2.87e-011.00e+001.57817218
GO:0006200ATP catabolic process2.89e-011.00e+001.57218219
GO:0006508proteolysis3.37e-011.00e+001.30213264
GO:0045892negative regulation of transcription, DNA-templated3.91e-011.00e+001.03817317
GO:0006366transcription from RNA polymerase II promoter4.13e-011.00e+000.93316341
GO:0005509calcium ion binding4.23e-011.00e+000.89113351
GO:0003677DNA binding4.35e-011.00e+000.459218947
GO:0005794Golgi apparatus4.79e-011.00e+000.65015415
GO:0045087innate immune response5.09e-011.00e+000.52617452
GO:0045944positive regulation of transcription from RNA polymerase II promoter6.41e-011.00e+000.01618644
GO:0005739mitochondrion6.50e-011.00e+00-0.018111659
GO:0008270zinc ion binding6.87e-011.00e+00-0.15917727
GO:0005886plasma membrane9.52e-011.00e+00-1.4541111784