reg-snw-6462

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.841	5.68e-07	2.23e-03	4.37e-03

wolf-screen-ratio-mammosphere-adherent-reg-snw-6462 subnetwork

Genes (12)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	Transcription factor	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
LCAT	3931	1	0.549	0.841	9	-	-	-
CAD	790	25	0.807	0.973	67	-	-	-
PHB2	11331	8	0.829	0.956	11	-	Yes	-
POLR2F	5435	14	0.891	0.956	5	-	Yes	-
[ SHBG ]	6462	1	-0.200	0.841	89	TF	-	-
EFTUD2	9343	17	0.883	0.956	30	-	Yes	-
HNRNPC	3183	40	1.812	0.973	62	-	Yes	-
TUBG1	7283	39	0.974	0.973	36	-	Yes	-
PSMB2	5690	23	0.877	0.956	52	-	Yes	-
RUVBL2	10856	20	0.693	0.956	187	TF	Yes	-
FBL	2091	9	0.839	0.956	14	-	Yes	-
MASP2	10747	1	0.736	0.841	13	-	Yes	-

Interactions (11)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMB2	5690	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
CAD	790	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
HNRNPC	3183	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
LCAT	3931	SHBG	6462	pd	<	reg.ITFP.txt: no annot
SHBG	6462	MASP2	10747	pd	>	reg.ITFP.txt: no annot
FBL	2091	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
POLR2F	5435	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
RUVBL2	10856	PHB2	11331	pd	>	reg.ITFP.txt: no annot
EFTUD2	9343	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
TUBG1	7283	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
SHBG	6462	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot

Related GO terms (201)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0070062	extracellular vesicular exosome	1.42e-05	1.38e-01	2.158	9	43	1641
GO:0016363	nuclear matrix	8.40e-05	8.20e-01	5.064	3	7	73
GO:0000398	mRNA splicing, via spliceosome	4.44e-04	1.00e+00	4.253	3	8	128
GO:0015030	Cajal body	6.73e-04	1.00e+00	5.668	2	2	32
GO:0008380	RNA splicing	9.32e-04	1.00e+00	3.887	3	7	165
GO:1990259	histone-glutamine methyltransferase activity	1.23e-03	1.00e+00	9.668	1	1	1
GO:0007285	primary spermatocyte growth	1.23e-03	1.00e+00	9.668	1	1	1
GO:1990258	histone glutamine methylation	1.23e-03	1.00e+00	9.668	1	1	1
GO:0004151	dihydroorotase activity	1.23e-03	1.00e+00	9.668	1	1	1
GO:0090107	regulation of high-density lipoprotein particle assembly	1.23e-03	1.00e+00	9.668	1	1	1
GO:0004070	aspartate carbamoyltransferase activity	1.23e-03	1.00e+00	9.668	1	1	1
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	1.23e-03	1.00e+00	9.668	1	1	1
GO:0070335	aspartate binding	1.23e-03	1.00e+00	9.668	1	1	1
GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	1.23e-03	1.00e+00	9.668	1	1	1
GO:0016074	snoRNA metabolic process	1.23e-03	1.00e+00	9.668	1	1	1
GO:0070409	carbamoyl phosphate biosynthetic process	1.23e-03	1.00e+00	9.668	1	1	1
GO:0001855	complement component C4b binding	1.23e-03	1.00e+00	9.668	1	1	1
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	1.58e-03	1.00e+00	5.054	2	3	49
GO:0016020	membrane	1.68e-03	1.00e+00	2.016	6	38	1207
GO:0005730	nucleolus	1.75e-03	1.00e+00	2.004	6	41	1217
GO:0043234	protein complex	1.87e-03	1.00e+00	3.539	3	8	210
GO:0005681	spliceosomal complex	1.98e-03	1.00e+00	4.887	2	2	55
GO:0071013	catalytic step 2 spliceosome	2.43e-03	1.00e+00	4.738	2	5	61
GO:0034435	cholesterol esterification	2.46e-03	1.00e+00	8.668	1	1	2
GO:0005654	nucleoplasm	2.66e-03	1.00e+00	2.216	5	55	876
GO:0010467	gene expression	3.10e-03	1.00e+00	2.605	4	31	535
GO:0001649	osteoblast differentiation	3.56e-03	1.00e+00	4.459	2	2	74
GO:0071733	transcriptional activation by promoter-enhancer looping	3.68e-03	1.00e+00	8.083	1	1	3
GO:0043141	ATP-dependent 5'-3' DNA helicase activity	3.68e-03	1.00e+00	8.083	1	1	3
GO:0006543	glutamine catabolic process	3.68e-03	1.00e+00	8.083	1	1	3
GO:0005497	androgen binding	3.68e-03	1.00e+00	8.083	1	1	3
GO:0001652	granular component	3.68e-03	1.00e+00	8.083	1	1	3
GO:0034186	apolipoprotein A-I binding	3.68e-03	1.00e+00	8.083	1	1	3
GO:0044205	'de novo' UMP biosynthetic process	3.68e-03	1.00e+00	8.083	1	1	3
GO:0071899	negative regulation of estrogen receptor binding	3.68e-03	1.00e+00	8.083	1	1	3
GO:0001867	complement activation, lectin pathway	3.68e-03	1.00e+00	8.083	1	1	3
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	3.68e-03	1.00e+00	8.083	1	1	3
GO:0031428	box C/D snoRNP complex	3.68e-03	1.00e+00	8.083	1	1	3
GO:0051414	response to cortisol	4.91e-03	1.00e+00	7.668	1	1	4
GO:0000212	meiotic spindle organization	4.91e-03	1.00e+00	7.668	1	1	4
GO:0071169	establishment of protein localization to chromatin	4.91e-03	1.00e+00	7.668	1	1	4
GO:0006228	UTP biosynthetic process	4.91e-03	1.00e+00	7.668	1	1	4
GO:0042158	lipoprotein biosynthetic process	4.91e-03	1.00e+00	7.668	1	1	4
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	4.91e-03	1.00e+00	7.668	1	1	4
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	6.13e-03	1.00e+00	7.347	1	1	5
GO:0014075	response to amine	6.13e-03	1.00e+00	7.347	1	1	5
GO:0060744	mammary gland branching involved in thelarche	6.13e-03	1.00e+00	7.347	1	1	5
GO:0005827	polar microtubule	6.13e-03	1.00e+00	7.347	1	1	5
GO:0000930	gamma-tubulin complex	6.13e-03	1.00e+00	7.347	1	1	5
GO:0001055	RNA polymerase II activity	7.35e-03	1.00e+00	7.083	1	2	6
GO:0046134	pyrimidine nucleoside biosynthetic process	7.35e-03	1.00e+00	7.083	1	1	6
GO:0031000	response to caffeine	7.35e-03	1.00e+00	7.083	1	1	6
GO:0042802	identical protein binding	8.14e-03	1.00e+00	2.786	3	7	354
GO:0034372	very-low-density lipoprotein particle remodeling	8.57e-03	1.00e+00	6.861	1	1	7
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	8.57e-03	1.00e+00	6.861	1	1	7
GO:0000812	Swr1 complex	8.57e-03	1.00e+00	6.861	1	2	7
GO:0003924	GTPase activity	8.97e-03	1.00e+00	3.774	2	3	119
GO:0031122	cytoplasmic microtubule organization	9.79e-03	1.00e+00	6.668	1	2	8
GO:0031011	Ino80 complex	9.79e-03	1.00e+00	6.668	1	2	8
GO:0006184	GTP catabolic process	1.06e-02	1.00e+00	3.646	2	3	130
GO:0008266	poly(U) RNA binding	1.10e-02	1.00e+00	6.499	1	1	9
GO:0005736	DNA-directed RNA polymerase I complex	1.22e-02	1.00e+00	6.347	1	2	10
GO:0006541	glutamine metabolic process	1.22e-02	1.00e+00	6.347	1	1	10
GO:0043968	histone H2A acetylation	1.22e-02	1.00e+00	6.347	1	2	10
GO:0001054	RNA polymerase I activity	1.22e-02	1.00e+00	6.347	1	2	10
GO:0007020	microtubule nucleation	1.34e-02	1.00e+00	6.209	1	1	11
GO:0070935	3'-UTR-mediated mRNA stabilization	1.34e-02	1.00e+00	6.209	1	2	11
GO:0034375	high-density lipoprotein particle remodeling	1.34e-02	1.00e+00	6.209	1	1	11
GO:0030301	cholesterol transport	1.34e-02	1.00e+00	6.209	1	1	11
GO:0045120	pronucleus	1.34e-02	1.00e+00	6.209	1	1	11
GO:0035267	NuA4 histone acetyltransferase complex	1.47e-02	1.00e+00	6.083	1	3	12
GO:0071392	cellular response to estradiol stimulus	1.59e-02	1.00e+00	5.968	1	1	13
GO:0005666	DNA-directed RNA polymerase III complex	1.59e-02	1.00e+00	5.968	1	2	13
GO:0005665	DNA-directed RNA polymerase II, core complex	1.59e-02	1.00e+00	5.968	1	2	13
GO:0001056	RNA polymerase III activity	1.59e-02	1.00e+00	5.968	1	2	13
GO:0006656	phosphatidylcholine biosynthetic process	1.59e-02	1.00e+00	5.968	1	1	13
GO:0035066	positive regulation of histone acetylation	1.59e-02	1.00e+00	5.968	1	1	13
GO:0060749	mammary gland alveolus development	1.59e-02	1.00e+00	5.968	1	1	13
GO:0006386	termination of RNA polymerase III transcription	1.71e-02	1.00e+00	5.861	1	2	14
GO:0010243	response to organonitrogen compound	1.71e-02	1.00e+00	5.861	1	1	14
GO:0006385	transcription elongation from RNA polymerase III promoter	1.71e-02	1.00e+00	5.861	1	2	14
GO:0043691	reverse cholesterol transport	1.71e-02	1.00e+00	5.861	1	1	14
GO:0005634	nucleus	1.84e-02	1.00e+00	1.004	8	67	3246
GO:0005719	nuclear euchromatin	1.95e-02	1.00e+00	5.668	1	1	16
GO:0005839	proteasome core complex	1.95e-02	1.00e+00	5.668	1	9	16
GO:0006206	pyrimidine nucleobase metabolic process	2.07e-02	1.00e+00	5.581	1	2	17
GO:0034364	high-density lipoprotein particle	2.07e-02	1.00e+00	5.581	1	1	17
GO:0004298	threonine-type endopeptidase activity	2.07e-02	1.00e+00	5.581	1	9	17
GO:0071364	cellular response to epidermal growth factor stimulus	2.19e-02	1.00e+00	5.499	1	1	18
GO:0003678	DNA helicase activity	2.19e-02	1.00e+00	5.499	1	3	18
GO:0071339	MLL1 complex	2.19e-02	1.00e+00	5.499	1	2	18
GO:0033574	response to testosterone	2.19e-02	1.00e+00	5.499	1	1	18
GO:0000794	condensed nuclear chromosome	2.19e-02	1.00e+00	5.499	1	3	18
GO:0005515	protein binding	2.26e-02	1.00e+00	0.829	9	76	4124
GO:0005525	GTP binding	2.34e-02	1.00e+00	3.046	2	5	197
GO:0006956	complement activation	2.43e-02	1.00e+00	5.347	1	1	20
GO:0043044	ATP-dependent chromatin remodeling	2.43e-02	1.00e+00	5.347	1	2	20
GO:0006281	DNA repair	2.47e-02	1.00e+00	3.003	2	19	203
GO:0017144	drug metabolic process	2.55e-02	1.00e+00	5.276	1	1	21
GO:0030331	estrogen receptor binding	2.67e-02	1.00e+00	5.209	1	1	22
GO:0043967	histone H4 acetylation	2.67e-02	1.00e+00	5.209	1	2	22
GO:0006370	7-methylguanosine mRNA capping	2.91e-02	1.00e+00	5.083	1	2	24
GO:0004003	ATP-dependent DNA helicase activity	3.03e-02	1.00e+00	5.025	1	2	25
GO:0008033	tRNA processing	3.03e-02	1.00e+00	5.025	1	1	25
GO:0003730	mRNA 3'-UTR binding	3.03e-02	1.00e+00	5.025	1	2	25
GO:0031492	nucleosomal DNA binding	3.03e-02	1.00e+00	5.025	1	2	25
GO:0006360	transcription from RNA polymerase I promoter	3.27e-02	1.00e+00	4.914	1	2	27
GO:0006958	complement activation, classical pathway	3.27e-02	1.00e+00	4.914	1	1	27
GO:0008233	peptidase activity	3.39e-02	1.00e+00	4.861	1	1	28
GO:0034644	cellular response to UV	3.39e-02	1.00e+00	4.861	1	2	28
GO:0018107	peptidyl-threonine phosphorylation	3.51e-02	1.00e+00	4.810	1	2	29
GO:0006383	transcription from RNA polymerase III promoter	3.51e-02	1.00e+00	4.810	1	2	29
GO:0003723	RNA binding	3.56e-02	1.00e+00	2.720	2	11	247
GO:0043195	terminal bouton	3.75e-02	1.00e+00	4.714	1	1	31
GO:0031490	chromatin DNA binding	3.75e-02	1.00e+00	4.714	1	1	31
GO:0042157	lipoprotein metabolic process	3.86e-02	1.00e+00	4.668	1	1	32
GO:0007595	lactation	3.86e-02	1.00e+00	4.668	1	2	32
GO:0014070	response to organic cyclic compound	4.10e-02	1.00e+00	4.581	1	1	34
GO:0050434	positive regulation of viral transcription	4.22e-02	1.00e+00	4.539	1	2	35
GO:0005576	extracellular region	4.32e-02	1.00e+00	1.881	3	5	663
GO:0000226	microtubule cytoskeleton organization	4.34e-02	1.00e+00	4.499	1	2	36
GO:0048306	calcium-dependent protein binding	4.46e-02	1.00e+00	4.459	1	1	37
GO:0040008	regulation of growth	4.46e-02	1.00e+00	4.459	1	2	37
GO:0035690	cellular response to drug	4.57e-02	1.00e+00	4.421	1	2	38
GO:0032508	DNA duplex unwinding	4.57e-02	1.00e+00	4.421	1	5	38
GO:0042632	cholesterol homeostasis	4.69e-02	1.00e+00	4.383	1	1	39
GO:0006283	transcription-coupled nucleotide-excision repair	4.81e-02	1.00e+00	4.347	1	6	40
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	4.81e-02	1.00e+00	4.347	1	2	40
GO:0042995	cell projection	4.93e-02	1.00e+00	4.311	1	2	41
GO:0006521	regulation of cellular amino acid metabolic process	4.93e-02	1.00e+00	4.311	1	16	41
GO:0003684	damaged DNA binding	4.93e-02	1.00e+00	4.311	1	9	41
GO:0005829	cytosol	5.20e-02	1.00e+00	1.187	5	58	1787
GO:0031100	organ regeneration	5.28e-02	1.00e+00	4.209	1	2	44
GO:0000278	mitotic cell cycle	5.50e-02	1.00e+00	2.374	2	35	314
GO:0000502	proteasome complex	5.63e-02	1.00e+00	4.114	1	17	47
GO:0008203	cholesterol metabolic process	5.63e-02	1.00e+00	4.114	1	1	47
GO:0032481	positive regulation of type I interferon production	5.74e-02	1.00e+00	4.083	1	5	48
GO:0006310	DNA recombination	5.98e-02	1.00e+00	4.025	1	6	50
GO:0055086	nucleobase-containing small molecule metabolic process	6.09e-02	1.00e+00	3.996	1	5	51
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.21e-02	1.00e+00	3.968	1	17	52
GO:0006368	transcription elongation from RNA polymerase II promoter	6.21e-02	1.00e+00	3.968	1	3	52
GO:0006289	nucleotide-excision repair	6.33e-02	1.00e+00	3.941	1	9	53
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	6.33e-02	1.00e+00	3.941	1	17	53
GO:0006338	chromatin remodeling	6.56e-02	1.00e+00	3.887	1	2	55
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.67e-02	1.00e+00	3.861	1	17	56
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	6.79e-02	1.00e+00	3.836	1	16	57
GO:0044822	poly(A) RNA binding	6.88e-02	1.00e+00	1.611	3	25	799
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.13e-02	1.00e+00	3.762	1	17	60
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	7.25e-02	1.00e+00	3.738	1	16	61
GO:0007565	female pregnancy	7.59e-02	1.00e+00	3.668	1	2	64
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	7.71e-02	1.00e+00	3.646	1	17	65
GO:0044281	small molecule metabolic process	7.85e-02	1.00e+00	1.532	3	32	844
GO:0006364	rRNA processing	7.93e-02	1.00e+00	3.602	1	4	67
GO:0005200	structural constituent of cytoskeleton	8.05e-02	1.00e+00	3.581	1	2	68
GO:0006325	chromatin organization	8.28e-02	1.00e+00	3.539	1	3	70
GO:0051082	unfolded protein binding	8.28e-02	1.00e+00	3.539	1	4	70
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	8.28e-02	1.00e+00	3.539	1	16	70
GO:0001889	liver development	8.39e-02	1.00e+00	3.519	1	1	71
GO:0004252	serine-type endopeptidase activity	9.18e-02	1.00e+00	3.383	1	1	78
GO:0016032	viral process	9.46e-02	1.00e+00	1.927	2	32	428
GO:0030529	ribonucleoprotein complex	9.63e-02	1.00e+00	3.311	1	4	82
GO:0006644	phospholipid metabolic process	1.04e-01	1.00e+00	3.193	1	2	89
GO:0045087	innate immune response	1.04e-01	1.00e+00	1.848	2	7	452
GO:0000209	protein polyubiquitination	1.07e-01	1.00e+00	3.145	1	16	92
GO:0000086	G2/M transition of mitotic cell cycle	1.13e-01	1.00e+00	3.069	1	5	97
GO:0006457	protein folding	1.13e-01	1.00e+00	3.069	1	4	97
GO:0016887	ATPase activity	1.16e-01	1.00e+00	3.025	1	6	100
GO:0034641	cellular nitrogen compound metabolic process	1.22e-01	1.00e+00	2.954	1	18	105
GO:0007507	heart development	1.23e-01	1.00e+00	2.941	1	1	106
GO:0046777	protein autophosphorylation	1.23e-01	1.00e+00	2.941	1	2	106
GO:0000790	nuclear chromatin	1.26e-01	1.00e+00	2.900	1	3	109
GO:0006397	mRNA processing	1.27e-01	1.00e+00	2.887	1	2	110
GO:0042981	regulation of apoptotic process	1.29e-01	1.00e+00	2.861	1	18	112
GO:0016607	nuclear speck	1.40e-01	1.00e+00	2.738	1	3	122
GO:0004672	protein kinase activity	1.43e-01	1.00e+00	2.703	1	2	125
GO:0000082	G1/S transition of mitotic cell cycle	1.43e-01	1.00e+00	2.703	1	24	125
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.61e-01	1.00e+00	2.519	1	2	142
GO:0005622	intracellular	1.64e-01	1.00e+00	2.489	1	1	145
GO:0006367	transcription initiation from RNA polymerase II promoter	1.81e-01	1.00e+00	2.338	1	4	161
GO:0016071	mRNA metabolic process	1.90e-01	1.00e+00	2.259	1	21	170
GO:0043025	neuronal cell body	1.91e-01	1.00e+00	2.251	1	3	171
GO:0000166	nucleotide binding	1.96e-01	1.00e+00	2.209	1	6	176
GO:0016070	RNA metabolic process	2.08e-01	1.00e+00	2.114	1	21	188
GO:0005743	mitochondrial inner membrane	2.17e-01	1.00e+00	2.046	1	3	197
GO:0019899	enzyme binding	2.30e-01	1.00e+00	1.954	1	4	210
GO:0005813	centrosome	2.36e-01	1.00e+00	1.907	1	8	217
GO:0006200	ATP catabolic process	2.38e-01	1.00e+00	1.894	1	8	219
GO:0006508	proteolysis	2.80e-01	1.00e+00	1.624	1	3	264
GO:0005524	ATP binding	3.01e-01	1.00e+00	0.868	2	23	892
GO:0045892	negative regulation of transcription, DNA-templated	3.27e-01	1.00e+00	1.360	1	7	317
GO:0043066	negative regulation of apoptotic process	3.31e-01	1.00e+00	1.338	1	20	322
GO:0006366	transcription from RNA polymerase II promoter	3.47e-01	1.00e+00	1.255	1	6	341
GO:0005509	calcium ion binding	3.56e-01	1.00e+00	1.213	1	3	351
GO:0006351	transcription, DNA-templated	3.88e-01	1.00e+00	0.597	2	9	1076
GO:0006915	apoptotic process	4.03e-01	1.00e+00	0.985	1	21	411
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	5.59e-01	1.00e+00	0.338	1	8	644
GO:0005615	extracellular space	5.63e-01	1.00e+00	0.322	1	8	651
GO:0005739	mitochondrion	5.68e-01	1.00e+00	0.304	1	11	659
GO:0008270	zinc ion binding	6.05e-01	1.00e+00	0.163	1	7	727
GO:0005737	cytoplasm	6.68e-01	1.00e+00	-0.109	3	50	2633
GO:0003677	DNA binding	7.06e-01	1.00e+00	-0.219	1	18	947

Wolf-ratios-Mammosphere-Adherent

reg-snw-6462

Statistics

Genes (12)

Interactions (11)

Related GO terms (201)