reg-snw-4869

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.828 9.35e-07 2.92e-03 5.55e-03
wolf-screen-ratio-mammosphere-adherent-reg-snw-4869 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree Transcription factor wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
CAD 790 250.8070.97367---
PHB2 11331 80.8290.95611-Yes-
POLR2F 5435 140.8910.9565-Yes-
DDX18 8886 30.6600.82842TFYes-
MCM5 4174 50.5780.830152TFYes-
EFTUD2 9343 170.8830.95630-Yes-
HNRNPC 3183 401.8120.97362-Yes-
TUBG1 7283 390.9740.97336-Yes-
PSMB2 5690 230.8770.95652-Yes-
[ NPM1 ] 4869 1-0.1120.82862-Yes-
RUVBL2 10856 200.6930.956187TFYes-
FBL 2091 90.8390.95614-Yes-
TACC3 10460 30.8060.83025-Yes-

Interactions (14)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
MCM5 4174 NPM1 4869 pd > reg.ITFP.txt: no annot
MCM5 4174 EFTUD2 9343 pd > reg.ITFP.txt: no annot
NPM1 4869 DDX18 8886 pd < reg.ITFP.txt: no annot
CAD 790 RUVBL2 10856 pd < reg.ITFP.txt: no annot
HNRNPC 3183 RUVBL2 10856 pd < reg.ITFP.txt: no annot
POLR2F 5435 RUVBL2 10856 pd < reg.ITFP.txt: no annot
CAD 790 MCM5 4174 pd < reg.ITFP.txt: no annot
PSMB2 5690 RUVBL2 10856 pd < reg.ITFP.txt: no annot
FBL 2091 RUVBL2 10856 pd < reg.ITFP.txt: no annot
NPM1 4869 RUVBL2 10856 pd < reg.ITFP.txt: no annot
MCM5 4174 TACC3 10460 pd > reg.ITFP.txt: no annot
RUVBL2 10856 PHB2 11331 pd > reg.ITFP.txt: no annot
TUBG1 7283 RUVBL2 10856 pd < reg.ITFP.txt: no annot
EFTUD2 9343 RUVBL2 10856 pd < reg.ITFP.txt: no annot

Related GO terms (220)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0016020membrane2.94e-062.87e-022.4869381207
GO:0005730nucleolus3.15e-063.08e-022.4749411217
GO:0005654nucleoplasm4.83e-054.72e-012.586755876
GO:0016363nuclear matrix1.09e-041.00e+004.9483773
GO:0003678DNA helicase activity2.47e-041.00e+006.3832318
GO:0000398mRNA splicing, via spliceosome5.72e-041.00e+004.13838128
GO:0015030Cajal body7.93e-041.00e+005.5532232
GO:0032508DNA duplex unwinding1.12e-031.00e+005.3052538
GO:0008380RNA splicing1.20e-031.00e+003.77237165
GO:1990259histone-glutamine methyltransferase activity1.33e-031.00e+009.553111
GO:0060735regulation of eIF2 alpha phosphorylation by dsRNA1.33e-031.00e+009.553111
GO:0060699regulation of endoribonuclease activity1.33e-031.00e+009.553111
GO:1990258histone glutamine methylation1.33e-031.00e+009.553111
GO:0004151dihydroorotase activity1.33e-031.00e+009.553111
GO:0004070aspartate carbamoyltransferase activity1.33e-031.00e+009.553111
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity1.33e-031.00e+009.553111
GO:0070335aspartate binding1.33e-031.00e+009.553111
GO:0016074snoRNA metabolic process1.33e-031.00e+009.553111
GO:0070409carbamoyl phosphate biosynthetic process1.33e-031.00e+009.553111
GO:0005634nucleus1.60e-031.00e+001.21010673246
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1.86e-031.00e+004.9382349
GO:0006281DNA repair2.17e-031.00e+003.473319203
GO:0005515protein binding2.23e-031.00e+001.00311764124
GO:0005681spliceosomal complex2.33e-031.00e+004.7722255
GO:0043234protein complex2.39e-031.00e+003.42438210
GO:0005813centrosome2.63e-031.00e+003.37638217
GO:0030953astral microtubule organization2.66e-031.00e+008.553112
GO:0032071regulation of endodeoxyribonuclease activity2.66e-031.00e+008.553112
GO:0044822poly(A) RNA binding2.67e-031.00e+002.233525799
GO:0071013catalytic step 2 spliceosome2.86e-031.00e+004.6222561
GO:0051082unfolded protein binding3.75e-031.00e+004.4242470
GO:0003723RNA binding3.79e-031.00e+003.190311247
GO:0071733transcriptional activation by promoter-enhancer looping3.99e-031.00e+007.968113
GO:0043141ATP-dependent 5'-3' DNA helicase activity3.99e-031.00e+007.968113
GO:0010826negative regulation of centrosome duplication3.99e-031.00e+007.968113
GO:0006543glutamine catabolic process3.99e-031.00e+007.968113
GO:0001652granular component3.99e-031.00e+007.968113
GO:0044205'de novo' UMP biosynthetic process3.99e-031.00e+007.968113
GO:0071899negative regulation of estrogen receptor binding3.99e-031.00e+007.968113
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process3.99e-031.00e+007.968113
GO:0031428box C/D snoRNP complex3.99e-031.00e+007.968113
GO:0001649osteoblast differentiation4.19e-031.00e+004.3442274
GO:0010467gene expression4.28e-031.00e+002.490431535
GO:0030529ribonucleoprotein complex5.12e-031.00e+004.1952482
GO:0051414response to cortisol5.32e-031.00e+007.553114
GO:0044387negative regulation of protein kinase activity by regulation of protein phosphorylation5.32e-031.00e+007.553114
GO:0000212meiotic spindle organization5.32e-031.00e+007.553114
GO:0071169establishment of protein localization to chromatin5.32e-031.00e+007.553114
GO:0006228UTP biosynthetic process5.32e-031.00e+007.553114
GO:0007098centrosome cycle5.32e-031.00e+007.553114
GO:0060762regulation of branching involved in mammary gland duct morphogenesis5.32e-031.00e+007.553114
GO:0030957Tat protein binding6.64e-031.00e+007.231125
GO:0042255ribosome assembly6.64e-031.00e+007.231115
GO:0033600negative regulation of mammary gland epithelial cell proliferation6.64e-031.00e+007.231115
GO:0046599regulation of centriole replication6.64e-031.00e+007.231115
GO:0014075response to amine6.64e-031.00e+007.231115
GO:0060744mammary gland branching involved in thelarche6.64e-031.00e+007.231115
GO:0005827polar microtubule6.64e-031.00e+007.231115
GO:0000930gamma-tubulin complex6.64e-031.00e+007.231115
GO:0043023ribosomal large subunit binding6.64e-031.00e+007.231125
GO:0031616spindle pole centrosome6.64e-031.00e+007.231115
GO:0000278mitotic cell cycle7.41e-031.00e+002.843335314
GO:0001055RNA polymerase II activity7.96e-031.00e+006.968126
GO:0046134pyrimidine nucleoside biosynthetic process7.96e-031.00e+006.968116
GO:0031000response to caffeine7.96e-031.00e+006.968116
GO:0042555MCM complex7.96e-031.00e+006.968116
GO:0022027interkinetic nuclear migration7.96e-031.00e+006.968116
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway9.28e-031.00e+006.746117
GO:0000812Swr1 complex9.28e-031.00e+006.746127
GO:0042802identical protein binding1.03e-021.00e+002.67037354
GO:0003924GTPase activity1.05e-021.00e+003.65823119
GO:0043024ribosomal small subunit binding1.06e-021.00e+006.553118
GO:0031122cytoplasmic microtubule organization1.06e-021.00e+006.553128
GO:0042994cytoplasmic sequestering of transcription factor1.06e-021.00e+006.553118
GO:0031011Ino80 complex1.06e-021.00e+006.553128
GO:0000082G1/S transition of mitotic cell cycle1.16e-021.00e+003.587224125
GO:0032886regulation of microtubule-based process1.19e-021.00e+006.383129
GO:0008266poly(U) RNA binding1.19e-021.00e+006.383119
GO:0006184GTP catabolic process1.25e-021.00e+003.53123130
GO:0070062extracellular vesicular exosome1.31e-021.00e+001.4586431641
GO:0005736DNA-directed RNA polymerase I complex1.32e-021.00e+006.2311210
GO:0006541glutamine metabolic process1.32e-021.00e+006.2311110
GO:0043968histone H2A acetylation1.32e-021.00e+006.2311210
GO:0001054RNA polymerase I activity1.32e-021.00e+006.2311210
GO:0007020microtubule nucleation1.46e-021.00e+006.0941111
GO:00709353'-UTR-mediated mRNA stabilization1.46e-021.00e+006.0941211
GO:0045120pronucleus1.46e-021.00e+006.0941111
GO:0035267NuA4 histone acetyltransferase complex1.59e-021.00e+005.9681312
GO:0071392cellular response to estradiol stimulus1.72e-021.00e+005.8531113
GO:0005666DNA-directed RNA polymerase III complex1.72e-021.00e+005.8531213
GO:0005665DNA-directed RNA polymerase II, core complex1.72e-021.00e+005.8531213
GO:0001056RNA polymerase III activity1.72e-021.00e+005.8531213
GO:0035066positive regulation of histone acetylation1.72e-021.00e+005.8531113
GO:0060749mammary gland alveolus development1.72e-021.00e+005.8531113
GO:0016032viral process1.72e-021.00e+002.396332428
GO:0006386termination of RNA polymerase III transcription1.85e-021.00e+005.7461214
GO:0010243response to organonitrogen compound1.85e-021.00e+005.7461114
GO:0006385transcription elongation from RNA polymerase III promoter1.85e-021.00e+005.7461214
GO:0004004ATP-dependent RNA helicase activity1.85e-021.00e+005.7461114
GO:0005829cytosol1.98e-021.00e+001.3356581787
GO:0004860protein kinase inhibitor activity1.98e-021.00e+005.6461115
GO:0005719nuclear euchromatin2.11e-021.00e+005.5531116
GO:0022008neurogenesis2.11e-021.00e+005.5531116
GO:0005839proteasome core complex2.11e-021.00e+005.5531916
GO:0006206pyrimidine nucleobase metabolic process2.24e-021.00e+005.4661217
GO:0051059NF-kappaB binding2.24e-021.00e+005.4661117
GO:0006270DNA replication initiation2.24e-021.00e+005.4661417
GO:0004298threonine-type endopeptidase activity2.24e-021.00e+005.4661917
GO:0071364cellular response to epidermal growth factor stimulus2.37e-021.00e+005.3831118
GO:0071339MLL1 complex2.37e-021.00e+005.3831218
GO:0033574response to testosterone2.37e-021.00e+005.3831118
GO:0000794condensed nuclear chromosome2.37e-021.00e+005.3831318
GO:0005524ATP binding2.53e-021.00e+001.752423892
GO:0043044ATP-dependent chromatin remodeling2.63e-021.00e+005.2311220
GO:0006913nucleocytoplasmic transport2.63e-021.00e+005.2311220
GO:0034080CENP-A containing nucleosome assembly2.63e-021.00e+005.2311220
GO:0005525GTP binding2.73e-021.00e+002.93125197
GO:0007569cell aging2.76e-021.00e+005.1611221
GO:0017144drug metabolic process2.76e-021.00e+005.1611121
GO:0030331estrogen receptor binding2.89e-021.00e+005.0941122
GO:0043967histone H4 acetylation2.89e-021.00e+005.0941222
GO:00063707-methylguanosine mRNA capping3.15e-021.00e+004.9681224
GO:0004003ATP-dependent DNA helicase activity3.28e-021.00e+004.9091225
GO:0008033tRNA processing3.28e-021.00e+004.9091125
GO:0003730mRNA 3'-UTR binding3.28e-021.00e+004.9091225
GO:0031492nucleosomal DNA binding3.28e-021.00e+004.9091225
GO:0006200ATP catabolic process3.32e-021.00e+002.77828219
GO:0006360transcription from RNA polymerase I promoter3.54e-021.00e+004.7981227
GO:0034644cellular response to UV3.67e-021.00e+004.7461228
GO:0006271DNA strand elongation involved in DNA replication3.79e-021.00e+004.6951829
GO:0051259protein oligomerization3.79e-021.00e+004.6951129
GO:0018107peptidyl-threonine phosphorylation3.79e-021.00e+004.6951229
GO:0006383transcription from RNA polymerase III promoter3.79e-021.00e+004.6951229
GO:0021987cerebral cortex development3.92e-021.00e+004.6461230
GO:0008104protein localization4.05e-021.00e+004.5991231
GO:0006950response to stress4.05e-021.00e+004.5991131
GO:0043195terminal bouton4.05e-021.00e+004.5991131
GO:0031490chromatin DNA binding4.05e-021.00e+004.5991131
GO:0007595lactation4.18e-021.00e+004.5531232
GO:0014070response to organic cyclic compound4.44e-021.00e+004.4661134
GO:0050434positive regulation of viral transcription4.56e-021.00e+004.4241235
GO:0045727positive regulation of translation4.56e-021.00e+004.4241235
GO:0000226microtubule cytoskeleton organization4.69e-021.00e+004.3831236
GO:0040008regulation of growth4.82e-021.00e+004.3441237
GO:0035690cellular response to drug4.95e-021.00e+004.3051238
GO:0006283transcription-coupled nucleotide-excision repair5.20e-021.00e+004.2311640
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding5.20e-021.00e+004.2311240
GO:0042995cell projection5.33e-021.00e+004.1951241
GO:0006521regulation of cellular amino acid metabolic process5.33e-021.00e+004.19511641
GO:0003684damaged DNA binding5.33e-021.00e+004.1951941
GO:0031100organ regeneration5.71e-021.00e+004.0941244
GO:0000502proteasome complex6.08e-021.00e+003.99811747
GO:0032481positive regulation of type I interferon production6.21e-021.00e+003.9681548
GO:0030097hemopoiesis6.21e-021.00e+003.9681348
GO:0006310DNA recombination6.46e-021.00e+003.9091650
GO:0006334nucleosome assembly6.58e-021.00e+003.8811451
GO:0055086nucleobase-containing small molecule metabolic process6.58e-021.00e+003.8811551
GO:0043066negative regulation of apoptotic process6.65e-021.00e+002.222220322
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.71e-021.00e+003.85311752
GO:0006368transcription elongation from RNA polymerase II promoter6.71e-021.00e+003.8531352
GO:0006289nucleotide-excision repair6.83e-021.00e+003.8251953
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest6.83e-021.00e+003.82511753
GO:0042393histone binding6.96e-021.00e+003.7981354
GO:0006338chromatin remodeling7.08e-021.00e+003.7721255
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.21e-021.00e+003.74611756
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent7.33e-021.00e+003.72011657
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.70e-021.00e+003.64611760
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I7.83e-021.00e+003.62211661
GO:0007565female pregnancy8.20e-021.00e+003.5531264
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process8.32e-021.00e+003.53111765
GO:0006364rRNA processing8.57e-021.00e+003.4871467
GO:0005200structural constituent of cytoskeleton8.69e-021.00e+003.4661268
GO:0006325chromatin organization8.93e-021.00e+003.4241370
GO:0002474antigen processing and presentation of peptide antigen via MHC class I8.93e-021.00e+003.42411670
GO:0001889liver development9.06e-021.00e+003.4031171
GO:0051726regulation of cell cycle9.30e-021.00e+003.3631273
GO:0051092positive regulation of NF-kappaB transcription factor activity1.12e-011.00e+003.0771189
GO:0006886intracellular protein transport1.12e-011.00e+003.0771289
GO:0000209protein polyubiquitination1.16e-011.00e+003.02911692
GO:0006260DNA replication1.18e-011.00e+002.99811194
GO:0000086G2/M transition of mitotic cell cycle1.22e-011.00e+002.9531597
GO:0006457protein folding1.22e-011.00e+002.9531497
GO:0016887ATPase activity1.25e-011.00e+002.90916100
GO:0034641cellular nitrogen compound metabolic process1.31e-011.00e+002.839118105
GO:0007507heart development1.32e-011.00e+002.82511106
GO:0046777protein autophosphorylation1.32e-011.00e+002.82512106
GO:0000790nuclear chromatin1.36e-011.00e+002.78513109
GO:0006397mRNA processing1.37e-011.00e+002.77212110
GO:0042981regulation of apoptotic process1.39e-011.00e+002.746118112
GO:0001666response to hypoxia1.44e-011.00e+002.69511116
GO:0016607nuclear speck1.51e-011.00e+002.62213122
GO:0004672protein kinase activity1.54e-011.00e+002.58712125
GO:0019904protein domain specific binding1.60e-011.00e+002.53112130
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.73e-011.00e+002.40312142
GO:0005622intracellular1.77e-011.00e+002.37311145
GO:0006367transcription initiation from RNA polymerase II promoter1.94e-011.00e+002.22214161
GO:0016071mRNA metabolic process2.04e-011.00e+002.144121170
GO:0043025neuronal cell body2.05e-011.00e+002.13513171
GO:0000166nucleotide binding2.11e-011.00e+002.09416176
GO:0003713transcription coactivator activity2.19e-011.00e+002.02915184
GO:0016070RNA metabolic process2.23e-011.00e+001.998121188
GO:0005743mitochondrial inner membrane2.33e-011.00e+001.93113197
GO:0019899enzyme binding2.46e-011.00e+001.83914210
GO:0005737cytoplasm2.58e-011.00e+000.5125502633
GO:0019901protein kinase binding2.69e-011.00e+001.695111232
GO:0046982protein heterodimerization activity3.01e-011.00e+001.50315265
GO:0044281small molecule metabolic process3.11e-011.00e+000.832232844
GO:0008285negative regulation of cell proliferation3.12e-011.00e+001.43914277
GO:0005925focal adhesion3.17e-011.00e+001.41314282
GO:0045892negative regulation of transcription, DNA-templated3.49e-011.00e+001.24517317
GO:0003677DNA binding3.64e-011.00e+000.666218947
GO:0006366transcription from RNA polymerase II promoter3.70e-011.00e+001.13916341
GO:0006915apoptotic process4.28e-011.00e+000.870121411
GO:0006351transcription, DNA-templated4.28e-011.00e+000.482291076
GO:0042803protein homodimerization activity4.42e-011.00e+000.81115428
GO:0045087innate immune response4.60e-011.00e+000.73317452
GO:0007165signal transduction5.73e-011.00e+000.28215618
GO:0045944positive regulation of transcription from RNA polymerase II promoter5.88e-011.00e+000.22218644
GO:0005739mitochondrion5.97e-011.00e+000.189111659
GO:0008270zinc ion binding6.34e-011.00e+000.04717727