reg-snw-28514

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.858	2.92e-07	1.56e-03	3.17e-03

wolf-screen-ratio-mammosphere-adherent-reg-snw-28514 subnetwork

Genes (12)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	Transcription factor	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
CAD	790	25	0.807	0.973	67	-	-	-
PSMB1	5689	5	0.688	0.901	28	-	Yes	-
RUVBL1	8607	24	0.720	0.973	126	TF	Yes	-
[ DLL1 ]	28514	1	0.279	0.858	9	TF	-	-
PHB2	11331	8	0.829	0.956	11	-	Yes	-
POLR2F	5435	14	0.891	0.956	5	-	Yes	-
EFTUD2	9343	17	0.883	0.956	30	-	Yes	-
HNRNPC	3183	40	1.812	0.973	62	-	Yes	-
TUBG1	7283	39	0.974	0.973	36	-	Yes	-
PSMB2	5690	23	0.877	0.956	52	-	Yes	-
RUVBL2	10856	20	0.693	0.956	187	TF	Yes	-
FBL	2091	9	0.839	0.956	14	-	Yes	-

Interactions (14)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMB2	5690	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
CAD	790	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
HNRNPC	3183	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
RUVBL2	10856	DLL1	28514	pd	>	reg.ITFP.txt: no annot
RUVBL1	8607	RUVBL2	10856	pd	<>	reg.ITFP.txt: no annot
FBL	2091	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
PSMB1	5689	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
CAD	790	RUVBL1	8607	pd	<	reg.ITFP.txt: no annot
POLR2F	5435	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
EFTUD2	9343	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
RUVBL2	10856	PHB2	11331	pd	>	reg.ITFP.txt: no annot
TUBG1	7283	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
HNRNPC	3183	RUVBL1	8607	pd	<	reg.ITFP.txt: no annot
TUBG1	7283	RUVBL1	8607	pd	<	reg.ITFP.txt: no annot

Related GO terms (207)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0016363	nuclear matrix	1.36e-06	1.33e-02	5.479	4	7	73
GO:0005654	nucleoplasm	2.42e-05	2.36e-01	2.701	7	55	876
GO:0000812	Swr1 complex	2.90e-05	2.83e-01	7.861	2	2	7
GO:0031011	Ino80 complex	3.86e-05	3.77e-01	7.668	2	2	8
GO:0043968	histone H2A acetylation	6.20e-05	6.05e-01	7.347	2	2	10
GO:0035267	NuA4 histone acetyltransferase complex	9.08e-05	8.86e-01	7.083	2	3	12
GO:0070062	extracellular vesicular exosome	1.63e-04	1.00e+00	1.988	8	43	1641
GO:0005839	proteasome core complex	1.65e-04	1.00e+00	6.668	2	9	16
GO:0004298	threonine-type endopeptidase activity	1.86e-04	1.00e+00	6.581	2	9	17
GO:0016020	membrane	1.95e-04	1.00e+00	2.239	7	38	1207
GO:0005730	nucleolus	2.06e-04	1.00e+00	2.227	7	41	1217
GO:0003678	DNA helicase activity	2.10e-04	1.00e+00	6.499	2	3	18
GO:0071339	MLL1 complex	2.10e-04	1.00e+00	6.499	2	2	18
GO:0010467	gene expression	2.78e-04	1.00e+00	2.927	5	31	535
GO:0043967	histone H4 acetylation	3.15e-04	1.00e+00	6.209	2	2	22
GO:0000398	mRNA splicing, via spliceosome	4.44e-04	1.00e+00	4.253	3	8	128
GO:0005634	nucleus	5.26e-04	1.00e+00	1.326	10	67	3246
GO:0015030	Cajal body	6.73e-04	1.00e+00	5.668	2	2	32
GO:0040008	regulation of growth	9.00e-04	1.00e+00	5.459	2	2	37
GO:0008380	RNA splicing	9.32e-04	1.00e+00	3.887	3	7	165
GO:0032508	DNA duplex unwinding	9.50e-04	1.00e+00	5.421	2	5	38
GO:0006521	regulation of cellular amino acid metabolic process	1.11e-03	1.00e+00	5.311	2	16	41
GO:1990259	histone-glutamine methyltransferase activity	1.23e-03	1.00e+00	9.668	1	1	1
GO:1990258	histone glutamine methylation	1.23e-03	1.00e+00	9.668	1	1	1
GO:0004151	dihydroorotase activity	1.23e-03	1.00e+00	9.668	1	1	1
GO:0004070	aspartate carbamoyltransferase activity	1.23e-03	1.00e+00	9.668	1	1	1
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	1.23e-03	1.00e+00	9.668	1	1	1
GO:0070335	aspartate binding	1.23e-03	1.00e+00	9.668	1	1	1
GO:0016074	snoRNA metabolic process	1.23e-03	1.00e+00	9.668	1	1	1
GO:0070409	carbamoyl phosphate biosynthetic process	1.23e-03	1.00e+00	9.668	1	1	1
GO:0000502	proteasome complex	1.45e-03	1.00e+00	5.114	2	17	47
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	1.58e-03	1.00e+00	5.054	2	3	49
GO:0006310	DNA recombination	1.64e-03	1.00e+00	5.025	2	6	50
GO:0006281	DNA repair	1.70e-03	1.00e+00	3.588	3	19	203
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.77e-03	1.00e+00	4.968	2	17	52
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	1.84e-03	1.00e+00	4.941	2	17	53
GO:0043234	protein complex	1.87e-03	1.00e+00	3.539	3	8	210
GO:0005681	spliceosomal complex	1.98e-03	1.00e+00	4.887	2	2	55
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.05e-03	1.00e+00	4.861	2	17	56
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	2.13e-03	1.00e+00	4.836	2	16	57
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.36e-03	1.00e+00	4.762	2	17	60
GO:0071013	catalytic step 2 spliceosome	2.43e-03	1.00e+00	4.738	2	5	61
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	2.43e-03	1.00e+00	4.738	2	16	61
GO:0072070	loop of Henle development	2.46e-03	1.00e+00	8.668	1	1	2
GO:0045608	negative regulation of auditory receptor cell differentiation	2.46e-03	1.00e+00	8.668	1	1	2
GO:0001757	somite specification	2.46e-03	1.00e+00	8.668	1	1	2
GO:0072014	proximal tubule development	2.46e-03	1.00e+00	8.668	1	1	2
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	2.76e-03	1.00e+00	4.646	2	17	65
GO:0006325	chromatin organization	3.19e-03	1.00e+00	4.539	2	3	70
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	3.19e-03	1.00e+00	4.539	2	16	70
GO:0001649	osteoblast differentiation	3.56e-03	1.00e+00	4.459	2	2	74
GO:0071733	transcriptional activation by promoter-enhancer looping	3.68e-03	1.00e+00	8.083	1	1	3
GO:0043141	ATP-dependent 5'-3' DNA helicase activity	3.68e-03	1.00e+00	8.083	1	1	3
GO:0007386	compartment pattern specification	3.68e-03	1.00e+00	8.083	1	1	3
GO:0006543	glutamine catabolic process	3.68e-03	1.00e+00	8.083	1	1	3
GO:0001652	granular component	3.68e-03	1.00e+00	8.083	1	1	3
GO:0044205	'de novo' UMP biosynthetic process	3.68e-03	1.00e+00	8.083	1	1	3
GO:0071899	negative regulation of estrogen receptor binding	3.68e-03	1.00e+00	8.083	1	1	3
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	3.68e-03	1.00e+00	8.083	1	1	3
GO:0031428	box C/D snoRNP complex	3.68e-03	1.00e+00	8.083	1	1	3
GO:0030529	ribonucleoprotein complex	4.35e-03	1.00e+00	4.311	2	4	82
GO:0005515	protein binding	4.51e-03	1.00e+00	0.981	10	76	4124
GO:0051414	response to cortisol	4.91e-03	1.00e+00	7.668	1	1	4
GO:0000212	meiotic spindle organization	4.91e-03	1.00e+00	7.668	1	1	4
GO:0071169	establishment of protein localization to chromatin	4.91e-03	1.00e+00	7.668	1	1	4
GO:0006228	UTP biosynthetic process	4.91e-03	1.00e+00	7.668	1	1	4
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	4.91e-03	1.00e+00	7.668	1	1	4
GO:0000209	protein polyubiquitination	5.45e-03	1.00e+00	4.145	2	16	92
GO:0000278	mitotic cell cycle	5.84e-03	1.00e+00	2.959	3	35	314
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	6.13e-03	1.00e+00	7.347	1	1	5
GO:0014075	response to amine	6.13e-03	1.00e+00	7.347	1	1	5
GO:0060744	mammary gland branching involved in thelarche	6.13e-03	1.00e+00	7.347	1	1	5
GO:0005827	polar microtubule	6.13e-03	1.00e+00	7.347	1	1	5
GO:0000930	gamma-tubulin complex	6.13e-03	1.00e+00	7.347	1	1	5
GO:0016887	ATPase activity	6.41e-03	1.00e+00	4.025	2	6	100
GO:0034641	cellular nitrogen compound metabolic process	7.05e-03	1.00e+00	3.954	2	18	105
GO:0001055	RNA polymerase II activity	7.35e-03	1.00e+00	7.083	1	2	6
GO:0046134	pyrimidine nucleoside biosynthetic process	7.35e-03	1.00e+00	7.083	1	1	6
GO:0031000	response to caffeine	7.35e-03	1.00e+00	7.083	1	1	6
GO:0042981	regulation of apoptotic process	7.98e-03	1.00e+00	3.861	2	18	112
GO:0042802	identical protein binding	8.14e-03	1.00e+00	2.786	3	7	354
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	8.57e-03	1.00e+00	6.861	1	1	7
GO:0003924	GTPase activity	8.97e-03	1.00e+00	3.774	2	3	119
GO:0031122	cytoplasmic microtubule organization	9.79e-03	1.00e+00	6.668	1	2	8
GO:0032693	negative regulation of interleukin-10 production	9.79e-03	1.00e+00	6.668	1	1	8
GO:0000082	G1/S transition of mitotic cell cycle	9.87e-03	1.00e+00	3.703	2	24	125
GO:0006184	GTP catabolic process	1.06e-02	1.00e+00	3.646	2	3	130
GO:0070986	left/right axis specification	1.10e-02	1.00e+00	6.499	1	1	9
GO:0008266	poly(U) RNA binding	1.10e-02	1.00e+00	6.499	1	1	9
GO:0005736	DNA-directed RNA polymerase I complex	1.22e-02	1.00e+00	6.347	1	2	10
GO:0006541	glutamine metabolic process	1.22e-02	1.00e+00	6.347	1	1	10
GO:0005112	Notch binding	1.22e-02	1.00e+00	6.347	1	1	10
GO:0001054	RNA polymerase I activity	1.22e-02	1.00e+00	6.347	1	2	10
GO:0005829	cytosol	1.26e-02	1.00e+00	1.450	6	58	1787
GO:0007020	microtubule nucleation	1.34e-02	1.00e+00	6.209	1	1	11
GO:0070935	3'-UTR-mediated mRNA stabilization	1.34e-02	1.00e+00	6.209	1	2	11
GO:0001709	cell fate determination	1.34e-02	1.00e+00	6.209	1	1	11
GO:0097150	neuronal stem cell maintenance	1.34e-02	1.00e+00	6.209	1	1	11
GO:0045120	pronucleus	1.34e-02	1.00e+00	6.209	1	1	11
GO:0016032	viral process	1.37e-02	1.00e+00	2.512	3	32	428
GO:0071392	cellular response to estradiol stimulus	1.59e-02	1.00e+00	5.968	1	1	13
GO:0005666	DNA-directed RNA polymerase III complex	1.59e-02	1.00e+00	5.968	1	2	13
GO:0005665	DNA-directed RNA polymerase II, core complex	1.59e-02	1.00e+00	5.968	1	2	13
GO:0001056	RNA polymerase III activity	1.59e-02	1.00e+00	5.968	1	2	13
GO:0035066	positive regulation of histone acetylation	1.59e-02	1.00e+00	5.968	1	1	13
GO:0060749	mammary gland alveolus development	1.59e-02	1.00e+00	5.968	1	1	13
GO:0006386	termination of RNA polymerase III transcription	1.71e-02	1.00e+00	5.861	1	2	14
GO:0010243	response to organonitrogen compound	1.71e-02	1.00e+00	5.861	1	1	14
GO:0006385	transcription elongation from RNA polymerase III promoter	1.71e-02	1.00e+00	5.861	1	2	14
GO:0016071	mRNA metabolic process	1.77e-02	1.00e+00	3.259	2	21	170
GO:0045638	negative regulation of myeloid cell differentiation	1.83e-02	1.00e+00	5.762	1	1	15
GO:0007220	Notch receptor processing	1.95e-02	1.00e+00	5.668	1	1	16
GO:0005719	nuclear euchromatin	1.95e-02	1.00e+00	5.668	1	1	16
GO:0006206	pyrimidine nucleobase metabolic process	2.07e-02	1.00e+00	5.581	1	2	17
GO:0016070	RNA metabolic process	2.14e-02	1.00e+00	3.114	2	21	188
GO:0071364	cellular response to epidermal growth factor stimulus	2.19e-02	1.00e+00	5.499	1	1	18
GO:0045747	positive regulation of Notch signaling pathway	2.19e-02	1.00e+00	5.499	1	1	18
GO:0033574	response to testosterone	2.19e-02	1.00e+00	5.499	1	1	18
GO:0000794	condensed nuclear chromosome	2.19e-02	1.00e+00	5.499	1	3	18
GO:0005525	GTP binding	2.34e-02	1.00e+00	3.046	2	5	197
GO:0043044	ATP-dependent chromatin remodeling	2.43e-02	1.00e+00	5.347	1	2	20
GO:0034080	CENP-A containing nucleosome assembly	2.43e-02	1.00e+00	5.347	1	2	20
GO:0017144	drug metabolic process	2.55e-02	1.00e+00	5.276	1	1	21
GO:0030331	estrogen receptor binding	2.67e-02	1.00e+00	5.209	1	1	22
GO:0006370	7-methylguanosine mRNA capping	2.91e-02	1.00e+00	5.083	1	2	24
GO:0048839	inner ear development	2.91e-02	1.00e+00	5.083	1	2	24
GO:0004003	ATP-dependent DNA helicase activity	3.03e-02	1.00e+00	5.025	1	2	25
GO:0008033	tRNA processing	3.03e-02	1.00e+00	5.025	1	1	25
GO:0003730	mRNA 3'-UTR binding	3.03e-02	1.00e+00	5.025	1	2	25
GO:0031492	nucleosomal DNA binding	3.03e-02	1.00e+00	5.025	1	2	25
GO:0007368	determination of left/right symmetry	3.15e-02	1.00e+00	4.968	1	1	26
GO:0006360	transcription from RNA polymerase I promoter	3.27e-02	1.00e+00	4.914	1	2	27
GO:0034644	cellular response to UV	3.39e-02	1.00e+00	4.861	1	2	28
GO:0030155	regulation of cell adhesion	3.39e-02	1.00e+00	4.861	1	1	28
GO:0018107	peptidyl-threonine phosphorylation	3.51e-02	1.00e+00	4.810	1	2	29
GO:0006383	transcription from RNA polymerase III promoter	3.51e-02	1.00e+00	4.810	1	2	29
GO:0003723	RNA binding	3.56e-02	1.00e+00	2.720	2	11	247
GO:0043195	terminal bouton	3.75e-02	1.00e+00	4.714	1	1	31
GO:0031490	chromatin DNA binding	3.75e-02	1.00e+00	4.714	1	1	31
GO:0007595	lactation	3.86e-02	1.00e+00	4.668	1	2	32
GO:0014070	response to organic cyclic compound	4.10e-02	1.00e+00	4.581	1	1	34
GO:0001947	heart looping	4.10e-02	1.00e+00	4.581	1	1	34
GO:0050434	positive regulation of viral transcription	4.22e-02	1.00e+00	4.539	1	2	35
GO:0000226	microtubule cytoskeleton organization	4.34e-02	1.00e+00	4.499	1	2	36
GO:0035690	cellular response to drug	4.57e-02	1.00e+00	4.421	1	2	38
GO:0006283	transcription-coupled nucleotide-excision repair	4.81e-02	1.00e+00	4.347	1	6	40
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	4.81e-02	1.00e+00	4.347	1	2	40
GO:0042995	cell projection	4.93e-02	1.00e+00	4.311	1	2	41
GO:0003684	damaged DNA binding	4.93e-02	1.00e+00	4.311	1	9	41
GO:0031100	organ regeneration	5.28e-02	1.00e+00	4.209	1	2	44
GO:0032481	positive regulation of type I interferon production	5.74e-02	1.00e+00	4.083	1	5	48
GO:0030097	hemopoiesis	5.74e-02	1.00e+00	4.083	1	3	48
GO:0043066	negative regulation of apoptotic process	5.75e-02	1.00e+00	2.338	2	20	322
GO:0006334	nucleosome assembly	6.09e-02	1.00e+00	3.996	1	4	51
GO:0055086	nucleobase-containing small molecule metabolic process	6.09e-02	1.00e+00	3.996	1	5	51
GO:0006368	transcription elongation from RNA polymerase II promoter	6.21e-02	1.00e+00	3.968	1	3	52
GO:0006289	nucleotide-excision repair	6.33e-02	1.00e+00	3.941	1	9	53
GO:0006338	chromatin remodeling	6.56e-02	1.00e+00	3.887	1	2	55
GO:0044822	poly(A) RNA binding	6.88e-02	1.00e+00	1.611	3	25	799
GO:0007565	female pregnancy	7.59e-02	1.00e+00	3.668	1	2	64
GO:0044281	small molecule metabolic process	7.85e-02	1.00e+00	1.532	3	32	844
GO:0006364	rRNA processing	7.93e-02	1.00e+00	3.602	1	4	67
GO:0005200	structural constituent of cytoskeleton	8.05e-02	1.00e+00	3.581	1	2	68
GO:0051082	unfolded protein binding	8.28e-02	1.00e+00	3.539	1	4	70
GO:0001889	liver development	8.39e-02	1.00e+00	3.519	1	1	71
GO:0031410	cytoplasmic vesicle	8.73e-02	1.00e+00	3.459	1	1	74
GO:0006915	apoptotic process	8.83e-02	1.00e+00	1.985	2	21	411
GO:0005524	ATP binding	8.96e-02	1.00e+00	1.453	3	23	892
GO:0005815	microtubule organizing center	9.07e-02	1.00e+00	3.402	1	1	77
GO:0007219	Notch signaling pathway	1.11e-01	1.00e+00	3.099	1	4	95
GO:0000086	G2/M transition of mitotic cell cycle	1.13e-01	1.00e+00	3.069	1	5	97
GO:0006457	protein folding	1.13e-01	1.00e+00	3.069	1	4	97
GO:0007507	heart development	1.23e-01	1.00e+00	2.941	1	1	106
GO:0046777	protein autophosphorylation	1.23e-01	1.00e+00	2.941	1	2	106
GO:0000790	nuclear chromatin	1.26e-01	1.00e+00	2.900	1	3	109
GO:0006397	mRNA processing	1.27e-01	1.00e+00	2.887	1	2	110
GO:0006351	transcription, DNA-templated	1.38e-01	1.00e+00	1.182	3	9	1076
GO:0016607	nuclear speck	1.40e-01	1.00e+00	2.738	1	3	122
GO:0004672	protein kinase activity	1.43e-01	1.00e+00	2.703	1	2	125
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.61e-01	1.00e+00	2.519	1	2	142
GO:0005622	intracellular	1.64e-01	1.00e+00	2.489	1	1	145
GO:0007267	cell-cell signaling	1.68e-01	1.00e+00	2.459	1	1	148
GO:0006367	transcription initiation from RNA polymerase II promoter	1.81e-01	1.00e+00	2.338	1	4	161
GO:0007067	mitotic nuclear division	1.85e-01	1.00e+00	2.302	1	8	165
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.85e-01	1.00e+00	1.338	2	8	644
GO:0007283	spermatogenesis	1.88e-01	1.00e+00	2.276	1	2	168
GO:0043025	neuronal cell body	1.91e-01	1.00e+00	2.251	1	3	171
GO:0000166	nucleotide binding	1.96e-01	1.00e+00	2.209	1	6	176
GO:0005743	mitochondrial inner membrane	2.17e-01	1.00e+00	2.046	1	3	197
GO:0006357	regulation of transcription from RNA polymerase II promoter	2.23e-01	1.00e+00	2.003	1	1	203
GO:0030154	cell differentiation	2.24e-01	1.00e+00	1.996	1	3	204
GO:0019899	enzyme binding	2.30e-01	1.00e+00	1.954	1	4	210
GO:0005813	centrosome	2.36e-01	1.00e+00	1.907	1	8	217
GO:0043231	intracellular membrane-bounded organelle	2.37e-01	1.00e+00	1.900	1	7	218
GO:0006200	ATP catabolic process	2.38e-01	1.00e+00	1.894	1	8	219
GO:0045892	negative regulation of transcription, DNA-templated	3.27e-01	1.00e+00	1.360	1	7	317
GO:0006366	transcription from RNA polymerase II promoter	3.47e-01	1.00e+00	1.255	1	6	341
GO:0005509	calcium ion binding	3.56e-01	1.00e+00	1.213	1	3	351
GO:0005794	Golgi apparatus	4.06e-01	1.00e+00	0.971	1	5	415
GO:0005737	cytoplasm	4.13e-01	1.00e+00	0.306	4	50	2633
GO:0045087	innate immune response	4.34e-01	1.00e+00	0.848	1	7	452
GO:0005887	integral component of plasma membrane	5.17e-01	1.00e+00	0.501	1	2	575
GO:0005739	mitochondrion	5.68e-01	1.00e+00	0.304	1	11	659
GO:0005576	extracellular region	5.70e-01	1.00e+00	0.296	1	5	663
GO:0008270	zinc ion binding	6.05e-01	1.00e+00	0.163	1	7	727
GO:0003677	DNA binding	7.06e-01	1.00e+00	-0.219	1	18	947
GO:0005886	plasma membrane	9.11e-01	1.00e+00	-1.132	1	11	1784

Wolf-ratios-Mammosphere-Adherent

reg-snw-28514

Statistics

Genes (12)

Interactions (14)

Related GO terms (207)