reg-snw-158

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.934	1.18e-08	2.65e-04	6.55e-04

wolf-screen-ratio-mammosphere-adherent-reg-snw-158 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	Transcription factor	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
POLR2F	5435	14	0.891	0.956	5	-	Yes	-
RBX1	9978	8	1.185	0.934	9	TF	Yes	-
EFTUD2	9343	17	0.883	0.956	30	-	Yes	-
PSMB7	5695	10	0.982	0.934	33	-	Yes	-
HNRNPC	3183	40	1.812	0.973	62	-	Yes	-
PSMB2	5690	23	0.877	0.956	52	-	Yes	-
[ ADSL ]	158	1	0.107	0.934	26	-	-	-
TUBG1	7283	39	0.974	0.973	36	-	Yes	-
RUVBL2	10856	20	0.693	0.956	187	TF	Yes	-

Interactions (8)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMB2	5690	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
ADSL	158	RBX1	9978	pd	<	reg.ITFP.txt: no annot
HNRNPC	3183	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
PSMB7	5695	RBX1	9978	pd	<	reg.ITFP.txt: no annot
ADSL	158	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
POLR2F	5435	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
EFTUD2	9343	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
TUBG1	7283	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot

Related GO terms (158)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005654	nucleoplasm	1.40e-06	1.37e-02	3.116	7	55	876
GO:0010467	gene expression	5.08e-05	4.96e-01	3.342	5	31	535
GO:0005839	proteasome core complex	9.00e-05	8.79e-01	7.083	2	9	16
GO:0004298	threonine-type endopeptidase activity	1.02e-04	9.96e-01	6.996	2	9	17
GO:0005829	cytosol	1.73e-04	1.00e+00	2.088	7	58	1787
GO:0000398	mRNA splicing, via spliceosome	1.74e-04	1.00e+00	4.668	3	8	128
GO:0005730	nucleolus	2.22e-04	1.00e+00	2.419	6	41	1217
GO:0008380	RNA splicing	3.69e-04	1.00e+00	4.302	3	7	165
GO:0016032	viral process	3.85e-04	1.00e+00	3.342	4	32	428
GO:0006521	regulation of cellular amino acid metabolic process	6.08e-04	1.00e+00	5.726	2	16	41
GO:0006281	DNA repair	6.78e-04	1.00e+00	4.003	3	19	203
GO:0000502	proteasome complex	7.99e-04	1.00e+00	5.529	2	17	47
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	8.68e-04	1.00e+00	5.469	2	3	49
GO:0070626	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity	9.22e-04	1.00e+00	10.083	1	1	1
GO:0004018	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	9.22e-04	1.00e+00	10.083	1	1	1
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	9.78e-04	1.00e+00	5.383	2	17	52
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	1.02e-03	1.00e+00	5.356	2	17	53
GO:0005681	spliceosomal complex	1.09e-03	1.00e+00	5.302	2	2	55
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.13e-03	1.00e+00	5.276	2	17	56
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	1.17e-03	1.00e+00	5.251	2	16	57
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.30e-03	1.00e+00	5.177	2	17	60
GO:0071013	catalytic step 2 spliceosome	1.34e-03	1.00e+00	5.153	2	5	61
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	1.34e-03	1.00e+00	5.153	2	16	61
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	1.52e-03	1.00e+00	5.061	2	17	65
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	1.77e-03	1.00e+00	4.954	2	16	70
GO:0030891	VCB complex	1.84e-03	1.00e+00	9.083	1	1	2
GO:0031467	Cul7-RING ubiquitin ligase complex	1.84e-03	1.00e+00	9.083	1	1	2
GO:0044208	'de novo' AMP biosynthetic process	1.84e-03	1.00e+00	9.083	1	1	2
GO:0000278	mitotic cell cycle	2.39e-03	1.00e+00	3.374	3	35	314
GO:0071733	transcriptional activation by promoter-enhancer looping	2.76e-03	1.00e+00	8.499	1	1	3
GO:0043141	ATP-dependent 5'-3' DNA helicase activity	2.76e-03	1.00e+00	8.499	1	1	3
GO:0006167	AMP biosynthetic process	2.76e-03	1.00e+00	8.499	1	1	3
GO:0071899	negative regulation of estrogen receptor binding	2.76e-03	1.00e+00	8.499	1	1	3
GO:0000209	protein polyubiquitination	3.03e-03	1.00e+00	4.560	2	16	92
GO:0000212	meiotic spindle organization	3.68e-03	1.00e+00	8.083	1	1	4
GO:0031461	cullin-RING ubiquitin ligase complex	3.68e-03	1.00e+00	8.083	1	2	4
GO:0071169	establishment of protein localization to chromatin	3.68e-03	1.00e+00	8.083	1	1	4
GO:0019788	NEDD8 ligase activity	3.68e-03	1.00e+00	8.083	1	1	4
GO:0034641	cellular nitrogen compound metabolic process	3.92e-03	1.00e+00	4.369	2	18	105
GO:0042981	regulation of apoptotic process	4.45e-03	1.00e+00	4.276	2	18	112
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	4.60e-03	1.00e+00	7.762	1	2	5
GO:0006189	'de novo' IMP biosynthetic process	4.60e-03	1.00e+00	7.762	1	1	5
GO:0005827	polar microtubule	4.60e-03	1.00e+00	7.762	1	1	5
GO:0000930	gamma-tubulin complex	4.60e-03	1.00e+00	7.762	1	1	5
GO:0003924	GTPase activity	5.01e-03	1.00e+00	4.189	2	3	119
GO:0001055	RNA polymerase II activity	5.52e-03	1.00e+00	7.499	1	2	6
GO:0000082	G1/S transition of mitotic cell cycle	5.52e-03	1.00e+00	4.118	2	24	125
GO:0031462	Cul2-RING ubiquitin ligase complex	5.52e-03	1.00e+00	7.499	1	1	6
GO:0031466	Cul5-RING ubiquitin ligase complex	5.52e-03	1.00e+00	7.499	1	1	6
GO:0006184	GTP catabolic process	5.96e-03	1.00e+00	4.061	2	3	130
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	6.44e-03	1.00e+00	7.276	1	2	7
GO:0006164	purine nucleotide biosynthetic process	6.44e-03	1.00e+00	7.276	1	2	7
GO:0000812	Swr1 complex	6.44e-03	1.00e+00	7.276	1	2	7
GO:0045116	protein neddylation	6.44e-03	1.00e+00	7.276	1	1	7
GO:0031122	cytoplasmic microtubule organization	7.35e-03	1.00e+00	7.083	1	2	8
GO:0031011	Ino80 complex	7.35e-03	1.00e+00	7.083	1	2	8
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	8.27e-03	1.00e+00	6.914	1	1	9
GO:0008266	poly(U) RNA binding	8.27e-03	1.00e+00	6.914	1	1	9
GO:0005736	DNA-directed RNA polymerase I complex	9.18e-03	1.00e+00	6.762	1	2	10
GO:0043968	histone H2A acetylation	9.18e-03	1.00e+00	6.762	1	2	10
GO:0001054	RNA polymerase I activity	9.18e-03	1.00e+00	6.762	1	2	10
GO:0016071	mRNA metabolic process	1.00e-02	1.00e+00	3.674	2	21	170
GO:0007020	microtubule nucleation	1.01e-02	1.00e+00	6.624	1	1	11
GO:0070935	3'-UTR-mediated mRNA stabilization	1.01e-02	1.00e+00	6.624	1	2	11
GO:0045120	pronucleus	1.01e-02	1.00e+00	6.624	1	1	11
GO:0035267	NuA4 histone acetyltransferase complex	1.10e-02	1.00e+00	6.499	1	3	12
GO:0071392	cellular response to estradiol stimulus	1.19e-02	1.00e+00	6.383	1	1	13
GO:0005666	DNA-directed RNA polymerase III complex	1.19e-02	1.00e+00	6.383	1	2	13
GO:0005665	DNA-directed RNA polymerase II, core complex	1.19e-02	1.00e+00	6.383	1	2	13
GO:0001056	RNA polymerase III activity	1.19e-02	1.00e+00	6.383	1	2	13
GO:0035066	positive regulation of histone acetylation	1.19e-02	1.00e+00	6.383	1	1	13
GO:0016070	RNA metabolic process	1.21e-02	1.00e+00	3.529	2	21	188
GO:0006386	termination of RNA polymerase III transcription	1.28e-02	1.00e+00	6.276	1	2	14
GO:0010243	response to organonitrogen compound	1.28e-02	1.00e+00	6.276	1	1	14
GO:0006385	transcription elongation from RNA polymerase III promoter	1.28e-02	1.00e+00	6.276	1	2	14
GO:0005525	GTP binding	1.33e-02	1.00e+00	3.461	2	5	197
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.47e-02	1.00e+00	6.083	1	1	16
GO:0031463	Cul3-RING ubiquitin ligase complex	1.47e-02	1.00e+00	6.083	1	1	16
GO:0005719	nuclear euchromatin	1.47e-02	1.00e+00	6.083	1	1	16
GO:0006513	protein monoubiquitination	1.56e-02	1.00e+00	5.996	1	1	17
GO:0003678	DNA helicase activity	1.65e-02	1.00e+00	5.914	1	3	18
GO:0071339	MLL1 complex	1.65e-02	1.00e+00	5.914	1	2	18
GO:0000794	condensed nuclear chromosome	1.65e-02	1.00e+00	5.914	1	3	18
GO:0016020	membrane	1.75e-02	1.00e+00	1.846	4	38	1207
GO:0043044	ATP-dependent chromatin remodeling	1.83e-02	1.00e+00	5.762	1	2	20
GO:0019005	SCF ubiquitin ligase complex	1.83e-02	1.00e+00	5.762	1	1	20
GO:0043967	histone H4 acetylation	2.01e-02	1.00e+00	5.624	1	2	22
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	2.01e-02	1.00e+00	5.624	1	1	22
GO:0051262	protein tetramerization	2.10e-02	1.00e+00	5.560	1	2	23
GO:0006370	7-methylguanosine mRNA capping	2.19e-02	1.00e+00	5.499	1	2	24
GO:0006144	purine nucleobase metabolic process	2.19e-02	1.00e+00	5.499	1	2	24
GO:0004003	ATP-dependent DNA helicase activity	2.28e-02	1.00e+00	5.440	1	2	25
GO:0003730	mRNA 3'-UTR binding	2.28e-02	1.00e+00	5.440	1	2	25
GO:0031492	nucleosomal DNA binding	2.28e-02	1.00e+00	5.440	1	2	25
GO:0006360	transcription from RNA polymerase I promoter	2.46e-02	1.00e+00	5.329	1	2	27
GO:0034644	cellular response to UV	2.55e-02	1.00e+00	5.276	1	2	28
GO:0006383	transcription from RNA polymerase III promoter	2.64e-02	1.00e+00	5.225	1	2	29
GO:0031490	chromatin DNA binding	2.82e-02	1.00e+00	5.129	1	1	31
GO:0015030	Cajal body	2.91e-02	1.00e+00	5.083	1	2	32
GO:0014070	response to organic cyclic compound	3.09e-02	1.00e+00	4.996	1	1	34
GO:0050434	positive regulation of viral transcription	3.18e-02	1.00e+00	4.954	1	2	35
GO:0000226	microtubule cytoskeleton organization	3.27e-02	1.00e+00	4.914	1	2	36
GO:0043066	negative regulation of apoptotic process	3.35e-02	1.00e+00	2.753	2	20	322
GO:0040008	regulation of growth	3.36e-02	1.00e+00	4.874	1	2	37
GO:0005515	protein binding	3.44e-02	1.00e+00	0.881	7	76	4124
GO:0032508	DNA duplex unwinding	3.45e-02	1.00e+00	4.836	1	5	38
GO:0006283	transcription-coupled nucleotide-excision repair	3.63e-02	1.00e+00	4.762	1	6	40
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	3.63e-02	1.00e+00	4.762	1	2	40
GO:0044281	small molecule metabolic process	3.64e-02	1.00e+00	1.947	3	32	844
GO:0003684	damaged DNA binding	3.72e-02	1.00e+00	4.726	1	9	41
GO:0042802	identical protein binding	3.99e-02	1.00e+00	2.616	2	7	354
GO:0005634	nucleus	4.18e-02	1.00e+00	1.004	6	67	3246
GO:0032481	positive regulation of type I interferon production	4.34e-02	1.00e+00	4.499	1	5	48
GO:0006310	DNA recombination	4.52e-02	1.00e+00	4.440	1	6	50
GO:0055086	nucleobase-containing small molecule metabolic process	4.61e-02	1.00e+00	4.411	1	5	51
GO:0006368	transcription elongation from RNA polymerase II promoter	4.69e-02	1.00e+00	4.383	1	3	52
GO:0006289	nucleotide-excision repair	4.78e-02	1.00e+00	4.356	1	9	53
GO:0070062	extracellular vesicular exosome	4.92e-02	1.00e+00	1.403	4	43	1641
GO:0006338	chromatin remodeling	4.96e-02	1.00e+00	4.302	1	2	55
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.05e-02	1.00e+00	4.276	1	3	56
GO:0006915	apoptotic process	5.23e-02	1.00e+00	2.400	2	21	411
GO:0005200	structural constituent of cytoskeleton	6.10e-02	1.00e+00	3.996	1	2	68
GO:0051082	unfolded protein binding	6.27e-02	1.00e+00	3.954	1	4	70
GO:0006325	chromatin organization	6.27e-02	1.00e+00	3.954	1	3	70
GO:0016363	nuclear matrix	6.53e-02	1.00e+00	3.894	1	7	73
GO:0001649	osteoblast differentiation	6.62e-02	1.00e+00	3.874	1	2	74
GO:0015630	microtubule cytoskeleton	6.71e-02	1.00e+00	3.855	1	2	75
GO:0071456	cellular response to hypoxia	6.79e-02	1.00e+00	3.836	1	2	76
GO:0030529	ribonucleoprotein complex	7.31e-02	1.00e+00	3.726	1	4	82
GO:0007219	Notch signaling pathway	8.43e-02	1.00e+00	3.514	1	4	95
GO:0000086	G2/M transition of mitotic cell cycle	8.60e-02	1.00e+00	3.484	1	5	97
GO:0006457	protein folding	8.60e-02	1.00e+00	3.484	1	4	97
GO:0016887	ATPase activity	8.85e-02	1.00e+00	3.440	1	6	100
GO:0000790	nuclear chromatin	9.61e-02	1.00e+00	3.315	1	3	109
GO:0006397	mRNA processing	9.70e-02	1.00e+00	3.302	1	2	110
GO:0016607	nuclear speck	1.07e-01	1.00e+00	3.153	1	3	122
GO:0032403	protein complex binding	1.14e-01	1.00e+00	3.061	1	2	130
GO:0031625	ubiquitin protein ligase binding	1.20e-01	1.00e+00	2.975	1	5	138
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.24e-01	1.00e+00	2.934	1	2	142
GO:0005622	intracellular	1.26e-01	1.00e+00	2.904	1	1	145
GO:0006367	transcription initiation from RNA polymerase II promoter	1.39e-01	1.00e+00	2.753	1	4	161
GO:0000166	nucleotide binding	1.51e-01	1.00e+00	2.624	1	6	176
GO:0004842	ubiquitin-protein transferase activity	1.53e-01	1.00e+00	2.600	1	2	179
GO:0008152	metabolic process	1.56e-01	1.00e+00	2.576	1	3	182
GO:0016567	protein ubiquitination	1.61e-01	1.00e+00	2.529	1	3	188
GO:0044822	poly(A) RNA binding	1.64e-01	1.00e+00	1.441	2	25	799
GO:0043234	protein complex	1.78e-01	1.00e+00	2.369	1	8	210
GO:0005813	centrosome	1.83e-01	1.00e+00	2.322	1	8	217
GO:0006200	ATP catabolic process	1.85e-01	1.00e+00	2.309	1	8	219
GO:0003723	RNA binding	2.06e-01	1.00e+00	2.135	1	11	247
GO:0006366	transcription from RNA polymerase II promoter	2.74e-01	1.00e+00	1.670	1	6	341
GO:0045087	innate immune response	3.47e-01	1.00e+00	1.263	1	7	452
GO:0005737	cytoplasm	4.54e-01	1.00e+00	0.306	3	50	2633
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	4.59e-01	1.00e+00	0.753	1	8	644
GO:0008270	zinc ion binding	5.02e-01	1.00e+00	0.578	1	7	727
GO:0005524	ATP binding	5.78e-01	1.00e+00	0.283	1	23	892
GO:0003677	DNA binding	6.01e-01	1.00e+00	0.196	1	18	947
GO:0006351	transcription, DNA-templated	6.50e-01	1.00e+00	0.012	1	9	1076

Wolf-ratios-Mammosphere-Adherent

reg-snw-158

Statistics

Genes (9)

Interactions (8)

Related GO terms (158)