reg-snw-57120

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
tai-screen-luciferase 4.450 1.33e-21 1.54e-03 2.29e-03
tai-screen-luciferase-reg-snw-57120 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency tai-screen-luciferase gene score Best subnetwork score Degree Transcription factor List-Gonzales GI Tai-Hits
HES4 57801 3-4.1534.45010---
RB1 5925 5-2.0854.707351TF--
EIF2S2 8894 11-4.3205.67222-Yes-
CDC42 998 5-6.9604.70711-YesYes
COPA 1314 25-9.3955.672170TFYesYes
PAFAH1B1 5048 3-2.5834.58655TFYes-
[ GOPC ] 57120 11.7494.45037---
TNFRSF8 943 3-4.1064.45015---
CUL4B 8450 6-2.8095.269142TF--
SERBP1 26135 10-4.6125.51643--Yes
CDC5L 988 15-3.4195.672155TF--
CKAP5 9793 20-7.2145.67289TFYesYes

Interactions (16)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RB1 5925 GOPC 57120 pd > reg.ITFP.txt: no annot
COPA 1314 RB1 5925 pd <> reg.ITFP.txt: no annot
RB1 5925 HES4 57801 pd > reg.pazar.txt: no annot
CDC5L 988 GOPC 57120 pd > reg.ITFP.txt: no annot
CDC5L 988 COPA 1314 pd <> reg.ITFP.txt: no annot
CDC5L 988 CUL4B 8450 pd <> reg.ITFP.txt: no annot
COPA 1314 CUL4B 8450 pd <> reg.ITFP.txt: no annot
COPA 1314 GOPC 57120 pd > reg.ITFP.txt: no annot
CDC5L 988 CKAP5 9793 pd <> reg.ITFP.txt: no annot
CDC42 998 RB1 5925 pd < reg.pazar.txt: no annot
PAFAH1B1 5048 GOPC 57120 pd > reg.ITFP.txt: no annot
CDC5L 988 EIF2S2 8894 pd > reg.ITFP.txt: no annot
CUL4B 8450 GOPC 57120 pd > reg.ITFP.txt: no annot
COPA 1314 PAFAH1B1 5048 pd <> reg.ITFP.txt: no annot
TNFRSF8 943 RB1 5925 pd < reg.pazar.txt: no annot
RB1 5925 SERBP1 26135 pd > reg.pazar.txt: no annot

Related GO terms (283)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0007097nuclear migration1.38e-051.35e-018.347225
GO:0051219phosphoprotein binding4.09e-041.00e+006.0252325
GO:0045556positive regulation of TRAIL biosynthetic process1.23e-031.00e+009.668111
GO:0051081nuclear envelope disassembly1.23e-031.00e+009.668111
GO:0000235astral microtubule1.23e-031.00e+009.668111
GO:0071987WD40-repeat domain binding1.23e-031.00e+009.668111
GO:0043004cytoplasmic sequestering of CFTR protein1.23e-031.00e+009.668111
GO:0036035osteoclast development1.23e-031.00e+009.668111
GO:0090230regulation of centromere complex assembly1.23e-031.00e+009.668111
GO:0051660establishment of centrosome localization1.23e-031.00e+009.668111
GO:0031134sister chromatid biorientation1.23e-031.00e+009.668111
GO:0046469platelet activating factor metabolic process1.23e-031.00e+009.668111
GO:0016020membrane1.68e-031.00e+002.0166251207
GO:0051683establishment of Golgi localization2.46e-031.00e+008.668112
GO:0071338positive regulation of hair follicle cell proliferation2.46e-031.00e+008.668112
GO:0002176male germ cell proliferation2.46e-031.00e+008.668112
GO:0060661submandibular salivary gland formation2.46e-031.00e+008.668112
GO:0030951establishment or maintenance of microtubule cytoskeleton polarity2.46e-031.00e+008.668112
GO:0072422signal transduction involved in DNA damage checkpoint2.46e-031.00e+008.668112
GO:0035088establishment or maintenance of apical/basal cell polarity2.46e-031.00e+008.668112
GO:0051835positive regulation of synapse structural plasticity2.46e-031.00e+008.668112
GO:0090135actin filament branching2.46e-031.00e+008.668112
GO:0034088maintenance of mitotic sister chromatid cohesion2.46e-031.00e+008.668112
GO:0072384organelle transport along microtubule2.46e-031.00e+008.668112
GO:0045505dynein intermediate chain binding2.46e-031.00e+008.668112
GO:0007070negative regulation of transcription from RNA polymerase II promoter during mitosis2.46e-031.00e+008.668112
GO:0006893Golgi to plasma membrane transport3.68e-031.00e+008.083113
GO:0003161cardiac conduction system development3.68e-031.00e+008.083113
GO:0071459protein localization to chromosome, centromeric region3.68e-031.00e+008.083113
GO:0005850eukaryotic translation initiation factor 2 complex3.68e-031.00e+008.083113
GO:0060684epithelial-mesenchymal cell signaling3.68e-031.00e+008.083113
GO:0071930negative regulation of transcription involved in G1/S transition of mitotic cell cycle3.68e-031.00e+008.083113
GO:0021540corpus callosum morphogenesis3.68e-031.00e+008.083113
GO:0050658RNA transport4.91e-031.00e+007.668114
GO:0071922regulation of cohesin localization to chromatin4.91e-031.00e+007.668124
GO:0034191apolipoprotein A-I receptor binding4.91e-031.00e+007.668114
GO:0036336dendritic cell migration4.91e-031.00e+007.668114
GO:0048664neuron fate determination4.91e-031.00e+007.668114
GO:0001667ameboidal-type cell migration4.91e-031.00e+007.668114
GO:0008090retrograde axon cargo transport4.91e-031.00e+007.668114
GO:0030157pancreatic juice secretion4.91e-031.00e+007.668114
GO:0090136epithelial cell-cell adhesion4.91e-031.00e+007.668124
GO:0043550regulation of lipid kinase activity4.91e-031.00e+007.668114
GO:0031256leading edge membrane4.91e-031.00e+007.668114
GO:0035189Rb-E2F complex4.91e-031.00e+007.668114
GO:0034349glial cell apoptotic process4.91e-031.00e+007.668114
GO:0048554positive regulation of metalloenzyme activity4.91e-031.00e+007.668114
GO:0030036actin cytoskeleton organization5.22e-031.00e+004.1772290
GO:0000278mitotic cell cycle5.84e-031.00e+002.95939314
GO:0000086G2/M transition of mitotic cell cycle6.04e-031.00e+004.0692397
GO:0031465Cul4B-RING E3 ubiquitin ligase complex6.13e-031.00e+007.347115
GO:0031274positive regulation of pseudopodium assembly6.13e-031.00e+007.347115
GO:0003334keratinocyte development6.13e-031.00e+007.347115
GO:0007289spermatid nucleus differentiation6.13e-031.00e+007.347115
GO:0045842positive regulation of mitotic metaphase/anaphase transition6.13e-031.00e+007.347115
GO:0031023microtubule organizing center organization6.13e-031.00e+007.347115
GO:0000974Prp19 complex6.13e-031.00e+007.347115
GO:0031512motile primary cilium6.13e-031.00e+007.347115
GO:0048667cell morphogenesis involved in neuron differentiation6.13e-031.00e+007.347115
GO:0034452dynactin binding6.13e-031.00e+007.347115
GO:0000930gamma-tubulin complex6.13e-031.00e+007.347115
GO:0043353enucleate erythrocyte differentiation7.35e-031.00e+007.083116
GO:0045176apical protein localization7.35e-031.00e+007.083116
GO:0070914UV-damage excision repair7.35e-031.00e+007.083116
GO:0001961positive regulation of cytokine-mediated signaling pathway7.35e-031.00e+007.083116
GO:0051489regulation of filopodium assembly7.35e-031.00e+007.083116
GO:0060789hair follicle placode formation7.35e-031.00e+007.083116
GO:0017145stem cell division7.35e-031.00e+007.083116
GO:0000075cell cycle checkpoint7.35e-031.00e+007.083116
GO:0060047heart contraction7.35e-031.00e+007.083116
GO:0043497regulation of protein heterodimerization activity7.35e-031.00e+007.083116
GO:0070062extracellular vesicular exosome8.22e-031.00e+001.5736281641
GO:0051988regulation of attachment of spindle microtubules to kinetochore8.57e-031.00e+006.861117
GO:0035518histone H2A monoubiquitination8.57e-031.00e+006.861117
GO:0001675acrosome assembly8.57e-031.00e+006.861117
GO:0032319regulation of Rho GTPase activity8.57e-031.00e+006.861117
GO:0030126COPI vesicle coat8.57e-031.00e+006.861117
GO:0021895cerebral cortex neuron differentiation8.57e-031.00e+006.861117
GO:0045502dynein binding9.79e-031.00e+006.668118
GO:0005662DNA replication factor A complex9.79e-031.00e+006.668118
GO:1900087positive regulation of G1/S transition of mitotic cell cycle9.79e-031.00e+006.668118
GO:0051233spindle midzone9.79e-031.00e+006.668118
GO:0042535positive regulation of tumor necrosis factor biosynthetic process9.79e-031.00e+006.668118
GO:0030140trans-Golgi network transport vesicle1.10e-021.00e+006.499119
GO:0031996thioesterase binding1.10e-021.00e+006.499119
GO:0097284hepatocyte apoptotic process1.10e-021.00e+006.499119
GO:0048854brain morphogenesis1.10e-021.00e+006.499119
GO:0031625ubiquitin protein ligase binding1.19e-021.00e+003.56022138
GO:0007051spindle organization1.22e-021.00e+006.3471110
GO:0042551neuron maturation1.22e-021.00e+006.3471110
GO:0045651positive regulation of macrophage differentiation1.22e-021.00e+006.3471110
GO:0043488regulation of mRNA stability1.22e-021.00e+006.3471110
GO:0009306protein secretion1.34e-021.00e+006.2091211
GO:0031333negative regulation of protein complex assembly1.34e-021.00e+006.2091111
GO:0030225macrophage differentiation1.34e-021.00e+006.2091111
GO:0047496vesicle transport along microtubule1.34e-021.00e+006.2091111
GO:0045773positive regulation of axon extension1.34e-021.00e+006.2091111
GO:0030742GTP-dependent protein binding1.34e-021.00e+006.2091111
GO:0090316positive regulation of intracellular protein transport1.34e-021.00e+006.2091111
GO:0021819layer formation in cerebral cortex1.34e-021.00e+006.2091111
GO:0051297centrosome organization1.47e-021.00e+006.0831112
GO:0051146striated muscle cell differentiation1.47e-021.00e+006.0831212
GO:0007088regulation of mitosis1.47e-021.00e+006.0831112
GO:0043274phospholipase binding1.47e-021.00e+006.0831112
GO:0048205COPI coating of Golgi vesicle1.47e-021.00e+006.0831112
GO:0000132establishment of mitotic spindle orientation1.47e-021.00e+006.0831212
GO:0035371microtubule plus-end1.59e-021.00e+005.9681113
GO:0045445myoblast differentiation1.59e-021.00e+005.9681113
GO:0016514SWI/SNF complex1.59e-021.00e+005.9681113
GO:0019226transmission of nerve impulse1.59e-021.00e+005.9681113
GO:0007067mitotic nuclear division1.68e-021.00e+003.30225165
GO:0046847filopodium assembly1.71e-021.00e+005.8611114
GO:0007405neuroblast proliferation1.71e-021.00e+005.8611114
GO:0042176regulation of protein catabolic process1.71e-021.00e+005.8611314
GO:0045859regulation of protein kinase activity1.71e-021.00e+005.8611114
GO:0043025neuronal cell body1.79e-021.00e+003.25123171
GO:2000134negative regulation of G1/S transition of mitotic cell cycle1.83e-021.00e+005.7621115
GO:0008135translation factor activity, nucleic acid binding1.83e-021.00e+005.7621415
GO:0045879negative regulation of smoothened signaling pathway1.83e-021.00e+005.7621115
GO:0051017actin filament bundle assembly1.83e-021.00e+005.7621115
GO:1900026positive regulation of substrate adhesion-dependent cell spreading1.95e-021.00e+005.6681116
GO:0032467positive regulation of cytokinesis1.95e-021.00e+005.6681116
GO:0006890retrograde vesicle-mediated transport, Golgi to ER2.07e-021.00e+005.5811117
GO:0005083small GTPase regulator activity2.07e-021.00e+005.5811117
GO:0007017microtubule-based process2.07e-021.00e+005.5811117
GO:0005737cytoplasm2.16e-021.00e+001.1137392633
GO:0031435mitogen-activated protein kinase kinase kinase binding2.19e-021.00e+005.4991118
GO:0031069hair follicle morphogenesis2.19e-021.00e+005.4991118
GO:0005515protein binding2.26e-021.00e+000.8299504124
GO:0046329negative regulation of JNK cascade2.31e-021.00e+005.4211119
GO:0048565digestive tract development2.31e-021.00e+005.4211119
GO:0036464cytoplasmic ribonucleoprotein granule2.31e-021.00e+005.4211419
GO:0007163establishment or maintenance of cell polarity2.43e-021.00e+005.3471220
GO:0072686mitotic spindle2.43e-021.00e+005.3471120
GO:0010977negative regulation of neuron projection development2.55e-021.00e+005.2761121
GO:0031647regulation of protein stability2.55e-021.00e+005.2761121
GO:0007346regulation of mitotic cell cycle2.55e-021.00e+005.2761121
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle2.55e-021.00e+005.2761121
GO:0008134transcription factor binding2.61e-021.00e+002.96125209
GO:0043234protein complex2.64e-021.00e+002.95428210
GO:0051149positive regulation of muscle cell differentiation2.67e-021.00e+005.2091222
GO:0005875microtubule associated complex2.67e-021.00e+005.2091122
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity2.67e-021.00e+005.2091122
GO:0002040sprouting angiogenesis2.67e-021.00e+005.2091122
GO:0031424keratinization2.79e-021.00e+005.1451123
GO:0045931positive regulation of mitotic cell cycle2.79e-021.00e+005.1451223
GO:0005813centrosome2.80e-021.00e+002.90726217
GO:0031252cell leading edge2.91e-021.00e+005.0831224
GO:0007611learning or memory2.91e-021.00e+005.0831124
GO:0007030Golgi organization3.03e-021.00e+005.0251225
GO:0007093mitotic cell cycle checkpoint3.03e-021.00e+005.0251225
GO:0003730mRNA 3'-UTR binding3.03e-021.00e+005.0251125
GO:0034613cellular protein localization3.15e-021.00e+004.9681226
GO:0016042lipid catabolic process3.15e-021.00e+004.9681126
GO:0034332adherens junction organization3.39e-021.00e+004.8611328
GO:0042692muscle cell differentiation3.39e-021.00e+004.8611228
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway3.39e-021.00e+004.8611228
GO:0050885neuromuscular process controlling balance3.39e-021.00e+004.8611128
GO:0051402neuron apoptotic process3.63e-021.00e+004.7621130
GO:0021987cerebral cortex development3.63e-021.00e+004.7621130
GO:0050681androgen receptor binding3.63e-021.00e+004.7621230
GO:0021766hippocampus development3.75e-021.00e+004.7141331
GO:0001102RNA polymerase II activating transcription factor binding3.75e-021.00e+004.7141131
GO:0005871kinesin complex3.75e-021.00e+004.7141131
GO:0019900kinase binding3.86e-021.00e+004.6681232
GO:0045740positive regulation of DNA replication3.86e-021.00e+004.6681132
GO:0035914skeletal muscle cell differentiation3.98e-021.00e+004.6241133
GO:0008344adult locomotory behavior3.98e-021.00e+004.6241133
GO:0021762substantia nigra development4.10e-021.00e+004.5811234
GO:0000139Golgi membrane4.10e-021.00e+002.60824267
GO:0046330positive regulation of JNK cascade4.10e-021.00e+004.5811134
GO:0045732positive regulation of protein catabolic process4.10e-021.00e+004.5811134
GO:0006888ER to Golgi vesicle-mediated transport4.10e-021.00e+004.5811134
GO:0030521androgen receptor signaling pathway4.22e-021.00e+004.5391335
GO:0000226microtubule cytoskeleton organization4.34e-021.00e+004.4991136
GO:0003743translation initiation factor activity4.46e-021.00e+004.4591537
GO:0030175filopodium4.46e-021.00e+004.4591237
GO:0050680negative regulation of epithelial cell proliferation4.69e-021.00e+004.3831139
GO:0043525positive regulation of neuron apoptotic process4.93e-021.00e+004.3111241
GO:0003684damaged DNA binding4.93e-021.00e+004.3111141
GO:0001047core promoter binding5.04e-021.00e+004.2761142
GO:0005886plasma membrane5.17e-021.00e+001.1895131784
GO:0005829cytosol5.20e-021.00e+001.1875331787
GO:0030141secretory granule5.28e-021.00e+004.2091244
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity5.39e-021.00e+004.1771145
GO:0050790regulation of catalytic activity5.39e-021.00e+004.1771145
GO:0033138positive regulation of peptidyl-serine phosphorylation5.74e-021.00e+004.0831148
GO:0006469negative regulation of protein kinase activity5.98e-021.00e+004.0251150
GO:0060070canonical Wnt signaling pathway6.09e-021.00e+003.9961251
GO:0031295T cell costimulation6.09e-021.00e+003.9961151
GO:0044325ion channel binding6.21e-021.00e+003.9681152
GO:0045177apical part of cell6.44e-021.00e+003.9141154
GO:0035264multicellular organism growth6.44e-021.00e+003.9141154
GO:0048471perinuclear region of cytoplasm6.47e-021.00e+002.24227344
GO:0071260cellular response to mechanical stimulus6.56e-021.00e+003.8871155
GO:0000776kinetochore6.56e-021.00e+003.8871155
GO:0006338chromatin remodeling6.56e-021.00e+003.8871255
GO:0031175neuron projection development6.56e-021.00e+003.8871255
GO:0008584male gonad development6.79e-021.00e+003.8361157
GO:0042802identical protein binding6.80e-021.00e+002.20122354
GO:0044822poly(A) RNA binding6.88e-021.00e+001.611325799
GO:0000785chromatin7.02e-021.00e+003.7861259
GO:0007265Ras protein signal transduction7.02e-021.00e+003.7861259
GO:0005179hormone activity7.13e-021.00e+003.7621160
GO:0071013catalytic step 2 spliceosome7.25e-021.00e+003.7381161
GO:0010629negative regulation of gene expression7.36e-021.00e+003.7141262
GO:0030426growth cone7.59e-021.00e+003.6681364
GO:0004888transmembrane signaling receptor activity7.93e-021.00e+003.6021167
GO:0001764neuron migration7.93e-021.00e+003.6021267
GO:0000922spindle pole8.05e-021.00e+003.5811368
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis8.28e-021.00e+003.5391370
GO:0030496midbody8.62e-021.00e+003.4791373
GO:0014069postsynaptic density8.62e-021.00e+003.4791273
GO:0015630microtubule cytoskeleton8.84e-021.00e+003.4401275
GO:0051056regulation of small GTPase mediated signal transduction8.95e-021.00e+003.4211176
GO:0005938cell cortex9.07e-021.00e+003.4021177
GO:0005815microtubule organizing center9.07e-021.00e+003.4021277
GO:0016605PML body9.29e-021.00e+003.3651179
GO:0005819spindle9.40e-021.00e+003.3471280
GO:0005635nuclear envelope9.74e-021.00e+003.2931283
GO:0051260protein homooligomerization1.02e-011.00e+003.2251187
GO:0003677DNA binding1.03e-011.00e+001.366312947
GO:0006886intracellular protein transport1.04e-011.00e+003.1931189
GO:0061024membrane organization1.04e-011.00e+003.1931389
GO:0008201heparin binding1.06e-011.00e+003.1611191
GO:0007050cell cycle arrest1.07e-011.00e+003.1451292
GO:0006511ubiquitin-dependent protein catabolic process1.07e-011.00e+003.1451192
GO:0046983protein dimerization activity1.10e-011.00e+003.1141294
GO:0008017microtubule binding1.13e-011.00e+003.0691197
GO:0006413translational initiation1.15e-011.00e+003.03911299
GO:0005198structural molecule activity1.17e-011.00e+003.01011101
GO:0005911cell-cell junction1.21e-011.00e+002.96812104
GO:0010628positive regulation of gene expression1.23e-011.00e+002.94112106
GO:0045211postsynaptic membrane1.27e-011.00e+002.88712110
GO:0042981regulation of apoptotic process1.29e-011.00e+002.86114112
GO:0043005neuron projection1.30e-011.00e+002.84812113
GO:0007049cell cycle1.33e-011.00e+002.82312115
GO:0003924GTPase activity1.37e-011.00e+002.77413119
GO:0006351transcription, DNA-templated1.38e-011.00e+001.1823151076
GO:0016607nuclear speck1.40e-011.00e+002.73812122
GO:0000082G1/S transition of mitotic cell cycle1.43e-011.00e+002.70316125
GO:0000398mRNA splicing, via spliceosome1.47e-011.00e+002.66812128
GO:0030424axon1.47e-011.00e+002.66814128
GO:0006184GTP catabolic process1.49e-011.00e+002.64613130
GO:0031965nuclear membrane1.49e-011.00e+002.64612130
GO:0007173epidermal growth factor receptor signaling pathway1.61e-011.00e+002.51913142
GO:0007399nervous system development1.72e-011.00e+002.42111152
GO:0001701in utero embryonic development1.74e-011.00e+002.40212154
GO:0030425dendrite1.86e-011.00e+002.29313166
GO:0007264small GTPase mediated signal transduction1.94e-011.00e+002.22514174
GO:0006412translation1.98e-011.00e+002.193113178
GO:0003713transcription coactivator activity2.04e-011.00e+002.14513184
GO:0005525GTP binding2.17e-011.00e+002.04613197
GO:0006355regulation of transcription, DNA-templated2.18e-011.00e+001.18729715
GO:0043065positive regulation of apoptotic process2.22e-011.00e+002.01013202
GO:0015031protein transport2.23e-011.00e+002.00312203
GO:0030154cell differentiation2.24e-011.00e+001.99612204
GO:0007268synaptic transmission2.34e-011.00e+001.92711214
GO:0030054cell junction2.37e-011.00e+001.90013218
GO:0019901protein kinase binding2.51e-011.00e+001.81018232
GO:0007411axon guidance2.55e-011.00e+001.78012237
GO:0003723RNA binding2.65e-011.00e+001.72016247
GO:0003682chromatin binding2.69e-011.00e+001.69113252
GO:0008285negative regulation of cell proliferation2.92e-011.00e+001.55513277
GO:0005925focal adhesion2.97e-011.00e+001.529112282
GO:0045892negative regulation of transcription, DNA-templated3.27e-011.00e+001.36011317
GO:0007596blood coagulation3.46e-011.00e+001.26314339
GO:0044267cellular protein metabolic process3.56e-011.00e+001.209113352
GO:0005634nucleus3.66e-011.00e+000.3265403246
GO:0045893positive regulation of transcription, DNA-templated3.77e-011.00e+001.11016377
GO:0005794Golgi apparatus4.06e-011.00e+000.97113415
GO:0042803protein homodimerization activity4.16e-011.00e+000.92714428
GO:0016032viral process4.16e-011.00e+000.927113428
GO:0045087innate immune response4.34e-011.00e+000.84816452
GO:0005730nucleolus4.52e-011.00e+000.4192211217
GO:0010467gene expression4.92e-011.00e+000.605117535
GO:0003700sequence-specific DNA binding transcription factor activity5.22e-011.00e+000.48419582
GO:0007165signal transduction5.44e-011.00e+000.39715618
GO:0045944positive regulation of transcription from RNA polymerase II promoter5.59e-011.00e+000.33818644
GO:0005615extracellular space5.63e-011.00e+000.32212651
GO:0005654nucleoplasm6.76e-011.00e+00-0.106116876
GO:0046872metal ion binding7.01e-011.00e+00-0.199110934
GO:0016021integral component of membrane8.70e-011.00e+00-0.907131526