reg-snw-4609

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
tai-screen-luciferase 4.325 2.79e-20 2.52e-03 3.58e-03
tai-screen-luciferase-reg-snw-4609 subnetwork

Genes (14)

Gene Symbol Entrez Gene ID Frequency tai-screen-luciferase gene score Best subnetwork score Degree Transcription factor List-Gonzales GI Tai-Hits
EIF2S2 8894 11-4.3205.67222-Yes-
COPA 1314 25-9.3955.672170TFYesYes
THAP11 57215 1-3.6734.3253TF-Yes
[ MYC ] 4609 1-1.9204.32577TF--
HSF1 3297 8-4.1795.027138TF-Yes
NME2 4831 1-3.0344.3251TF--
TLK2 11011 8-4.0115.67214---
MRPS12 6183 13-5.4215.516307TFYes-
YBX1 4904 6-3.0335.516120TF--
RAN 5901 2-3.8094.32583-YesYes
ODC1 4953 1-2.5034.32512---
SERBP1 26135 10-4.6125.51643--Yes
CDC5L 988 15-3.4195.672155TF--
CKAP5 9793 20-7.2145.67289TFYesYes

Interactions (13)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CDC5L 988 TLK2 11011 pd > reg.ITFP.txt: no annot
MYC 4609 THAP11 57215 pd < reg.TRANSFAC.txt: no annot
MYC 4609 NME2 4831 pd < reg.TRANSFAC.txt: no annot
CDC5L 988 CKAP5 9793 pd <> reg.ITFP.txt: no annot
HSF1 3297 MRPS12 6183 pd <> reg.ITFP.txt: no annot
YBX1 4904 SERBP1 26135 pd > reg.ITFP.txt: no annot
MYC 4609 YBX1 4904 pd > reg.TRANSFAC.txt: no annot
CDC5L 988 EIF2S2 8894 pd > reg.ITFP.txt: no annot
CDC5L 988 COPA 1314 pd <> reg.ITFP.txt: no annot
CDC5L 988 YBX1 4904 pd <> reg.ITFP.txt: no annot
YBX1 4904 MRPS12 6183 pd <> reg.ITFP.txt: no annot
MYC 4609 ODC1 4953 pd > reg.TRANSFAC.txt: no annot
MYC 4609 RAN 5901 pd > reg.ITFP.txt: no annot

Related GO terms (215)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0044822poly(A) RNA binding4.99e-041.00e+002.389625799
GO:0050679positive regulation of epithelial cell proliferation1.04e-031.00e+005.3592234
GO:0005515protein binding1.09e-031.00e+001.02112504124
GO:0035690cellular response to drug1.30e-031.00e+005.1982238
GO:0090096positive regulation of metanephric cap mesenchymal cell proliferation1.43e-031.00e+009.446111
GO:0033387putrescine biosynthetic process from ornithine1.43e-031.00e+009.446111
GO:0004586ornithine decarboxylase activity1.43e-031.00e+009.446111
GO:0071987WD40-repeat domain binding1.43e-031.00e+009.446111
GO:0004673protein histidine kinase activity1.43e-031.00e+009.446111
GO:0018106peptidyl-histidine phosphorylation1.43e-031.00e+009.446111
GO:0005882intermediate filament1.44e-031.00e+005.1242240
GO:0002762negative regulation of myeloid leukocyte differentiation2.87e-031.00e+008.446112
GO:0032204regulation of telomere maintenance2.87e-031.00e+008.446112
GO:0044346fibroblast apoptotic process2.87e-031.00e+008.446112
GO:0001672regulation of chromatin assembly or disassembly2.87e-031.00e+008.446112
GO:0002176male germ cell proliferation2.87e-031.00e+008.446112
GO:0090231regulation of spindle checkpoint2.87e-031.00e+008.446112
GO:0030951establishment or maintenance of microtubule cytoskeleton polarity2.87e-031.00e+008.446112
GO:0072422signal transduction involved in DNA damage checkpoint2.87e-031.00e+008.446112
GO:0003697single-stranded DNA binding2.91e-031.00e+004.6132357
GO:0043234protein complex3.00e-031.00e+003.31738210
GO:0005737cytoplasm3.77e-031.00e+001.2539392633
GO:0005850eukaryotic translation initiation factor 2 complex4.30e-031.00e+007.861113
GO:0051154negative regulation of striated muscle cell differentiation4.30e-031.00e+007.861113
GO:0007143female meiotic division4.30e-031.00e+007.861113
GO:0000056ribosomal small subunit export from nucleus4.30e-031.00e+007.861113
GO:0045656negative regulation of monocyte differentiation4.30e-031.00e+007.861113
GO:0001162RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding4.30e-031.00e+007.861113
GO:0006183GTP biosynthetic process4.30e-031.00e+007.861113
GO:0016020membrane4.38e-031.00e+001.7946251207
GO:0003682chromatin binding5.01e-031.00e+003.05433252
GO:0050658RNA transport5.72e-031.00e+007.446114
GO:0045682regulation of epidermis development5.72e-031.00e+007.446114
GO:0030157pancreatic juice secretion5.72e-031.00e+007.446114
GO:0051782negative regulation of cell division5.72e-031.00e+007.446114
GO:0006228UTP biosynthetic process5.72e-031.00e+007.446114
GO:0019215intermediate filament binding5.72e-031.00e+007.446114
GO:0000055ribosomal large subunit export from nucleus5.72e-031.00e+007.446114
GO:0006241CTP biosynthetic process5.72e-031.00e+007.446114
GO:0010467gene expression5.74e-031.00e+002.383417535
GO:0000974Prp19 complex7.15e-031.00e+007.124115
GO:0070934CRD-mediated mRNA stabilization7.15e-031.00e+007.124115
GO:0014075response to amine7.15e-031.00e+007.124115
GO:0032873negative regulation of stress-activated MAPK cascade7.15e-031.00e+007.124115
GO:0071204histone pre-mRNA 3'end processing complex7.15e-031.00e+007.124115
GO:0000930gamma-tubulin complex7.15e-031.00e+007.124115
GO:0009142nucleoside triphosphate biosynthetic process7.15e-031.00e+007.124115
GO:0003700sequence-specific DNA binding transcription factor activity7.73e-031.00e+002.26149582
GO:0060136embryonic process involved in female pregnancy8.57e-031.00e+006.861116
GO:2001022positive regulation of response to DNA damage stimulus8.57e-031.00e+006.861116
GO:0070937CRD-mediated mRNA stability complex8.57e-031.00e+006.861116
GO:0006165nucleoside diphosphate phosphorylation1.00e-021.00e+006.639117
GO:0075733intracellular transport of virus1.00e-021.00e+006.639127
GO:0004550nucleoside diphosphate kinase activity1.00e-021.00e+006.639117
GO:0030126COPI vesicle coat1.00e-021.00e+006.639117
GO:0005662DNA replication factor A complex1.14e-021.00e+006.446118
GO:0006595polyamine metabolic process1.14e-021.00e+006.446118
GO:2000573positive regulation of DNA biosynthetic process1.14e-021.00e+006.446118
GO:0048471perinuclear region of cytoplasm1.18e-021.00e+002.60537344
GO:0006974cellular response to DNA damage stimulus1.26e-021.00e+003.52722121
GO:0045618positive regulation of keratinocyte differentiation1.28e-021.00e+006.276119
GO:0006351transcription, DNA-templated1.38e-021.00e+001.6975151076
GO:0000398mRNA splicing, via spliceosome1.40e-021.00e+003.44622128
GO:0071480cellular response to gamma radiation1.43e-021.00e+006.1241110
GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process1.43e-021.00e+006.1241110
GO:0007051spindle organization1.43e-021.00e+006.1241110
GO:0010507negative regulation of autophagy1.43e-021.00e+006.1241110
GO:0043015gamma-tubulin binding1.43e-021.00e+006.1241210
GO:0043488regulation of mRNA stability1.43e-021.00e+006.1241110
GO:0071398cellular response to fatty acid1.57e-021.00e+005.9871111
GO:0045120pronucleus1.57e-021.00e+005.9871111
GO:0006355regulation of transcription, DNA-templated1.58e-021.00e+001.96449715
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.70e-021.00e+003.29624142
GO:0005634nucleus1.70e-021.00e+000.9529403246
GO:0051297centrosome organization1.71e-021.00e+005.8611112
GO:0048205COPI coating of Golgi vesicle1.71e-021.00e+005.8611112
GO:0051276chromosome organization1.71e-021.00e+005.8611112
GO:0015935small ribosomal subunit1.71e-021.00e+005.8611412
GO:0015949nucleobase-containing small molecule interconversion1.71e-021.00e+005.8611112
GO:0035371microtubule plus-end1.85e-021.00e+005.7461113
GO:0070848response to growth factor1.85e-021.00e+005.7461113
GO:0015671oxygen transport1.85e-021.00e+005.7461113
GO:0001701in utero embryonic development1.99e-021.00e+003.17922154
GO:0006259DNA metabolic process1.99e-021.00e+005.6391114
GO:0042176regulation of protein catabolic process1.99e-021.00e+005.6391314
GO:0008135translation factor activity, nucleic acid binding2.13e-021.00e+005.5391415
GO:0007067mitotic nuclear division2.26e-021.00e+003.08025165
GO:0005730nucleolus2.27e-021.00e+001.5195211217
GO:0071944cell periphery2.41e-021.00e+005.3591117
GO:0007052mitotic spindle organization2.41e-021.00e+005.3591117
GO:0005689U12-type spliceosomal complex2.41e-021.00e+005.3591217
GO:0006890retrograde vesicle-mediated transport, Golgi to ER2.41e-021.00e+005.3591117
GO:0000122negative regulation of transcription from RNA polymerase II promoter2.51e-021.00e+002.19836456
GO:0006611protein export from nucleus2.55e-021.00e+005.2761118
GO:0048147negative regulation of fibroblast proliferation2.55e-021.00e+005.2761118
GO:0033574response to testosterone2.55e-021.00e+005.2761118
GO:0006412translation2.60e-021.00e+002.970213178
GO:0001892embryonic placenta development2.83e-021.00e+005.1241120
GO:0032720negative regulation of tumor necrosis factor production2.83e-021.00e+005.1241120
GO:0005761mitochondrial ribosome2.83e-021.00e+005.1241120
GO:0005829cytosol2.93e-021.00e+001.2286331787
GO:0051781positive regulation of cell division3.11e-021.00e+004.9871122
GO:0040018positive regulation of multicellular organism growth3.11e-021.00e+004.9871122
GO:0034605cellular response to heat3.11e-021.00e+004.9871122
GO:0007286spermatid development3.25e-021.00e+004.9221123
GO:0045171intercellular bridge3.25e-021.00e+004.9221123
GO:0070491repressing transcription factor binding3.25e-021.00e+004.9221123
GO:0070888E-box binding3.53e-021.00e+004.8021125
GO:0003730mRNA 3'-UTR binding3.53e-021.00e+004.8021125
GO:0002053positive regulation of mesenchymal cell proliferation3.67e-021.00e+004.7461126
GO:0010332response to gamma radiation3.67e-021.00e+004.7461226
GO:0010494cytoplasmic stress granule3.67e-021.00e+004.7461226
GO:0005813centrosome3.75e-021.00e+002.68426217
GO:0034644cellular response to UV3.94e-021.00e+004.6391128
GO:0003677DNA binding3.99e-021.00e+001.559412947
GO:0071333cellular response to glucose stimulus4.22e-021.00e+004.5391230
GO:0050681androgen receptor binding4.22e-021.00e+004.5391230
GO:0021766hippocampus development4.36e-021.00e+004.4921331
GO:0001658branching involved in ureteric bud morphogenesis4.36e-021.00e+004.4921131
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process4.49e-021.00e+004.4461232
GO:0051591response to cAMP4.49e-021.00e+004.4461132
GO:0003723RNA binding4.75e-021.00e+002.49826247
GO:0019003GDP binding4.77e-021.00e+004.3591134
GO:0032092positive regulation of protein binding4.77e-021.00e+004.3591134
GO:0048146positive regulation of fibroblast proliferation4.91e-021.00e+004.3171135
GO:0030521androgen receptor signaling pathway4.91e-021.00e+004.3171335
GO:0003743translation initiation factor activity5.18e-021.00e+004.2371537
GO:0006952defense response5.18e-021.00e+004.2371137
GO:0010976positive regulation of neuron projection development5.45e-021.00e+004.1611239
GO:0006879cellular iron ion homeostasis5.59e-021.00e+004.1241140
GO:0006521regulation of cellular amino acid metabolic process5.72e-021.00e+004.0881341
GO:0008284positive regulation of cell proliferation5.90e-021.00e+002.32223279
GO:0045944positive regulation of transcription from RNA polymerase II promoter6.02e-021.00e+001.70038644
GO:0010468regulation of gene expression6.67e-021.00e+003.8611148
GO:0006468protein phosphorylation6.75e-021.00e+002.21223301
GO:0007059chromosome segregation6.94e-021.00e+003.8021150
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription6.94e-021.00e+003.8021150
GO:0018105peptidyl-serine phosphorylation7.07e-021.00e+003.7741251
GO:0060070canonical Wnt signaling pathway7.07e-021.00e+003.7741251
GO:0005643nuclear pore7.07e-021.00e+003.7741151
GO:0055086nucleobase-containing small molecule metabolic process7.07e-021.00e+003.7741151
GO:0070062extracellular vesicular exosome7.09e-021.00e+001.0885281641
GO:0001822kidney development7.21e-021.00e+003.7461252
GO:0001726ruffle7.34e-021.00e+003.7181153
GO:0043066negative regulation of apoptotic process7.60e-021.00e+002.11526322
GO:0006338chromatin remodeling7.61e-021.00e+003.6651255
GO:0008584male gonad development7.87e-021.00e+003.6131157
GO:0000165MAPK cascade8.01e-021.00e+003.5881158
GO:0000785chromatin8.14e-021.00e+003.5631259
GO:0005179hormone activity8.27e-021.00e+003.5391160
GO:0071013catalytic step 2 spliceosome8.40e-021.00e+003.5151161
GO:0010629negative regulation of gene expression8.54e-021.00e+003.4921262
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding8.67e-021.00e+003.4691163
GO:0042470melanosome8.80e-021.00e+003.4461264
GO:0006112energy reserve metabolic process8.93e-021.00e+003.4241265
GO:0007229integrin-mediated signaling pathway9.06e-021.00e+003.4021166
GO:0000922spindle pole9.33e-021.00e+003.3591368
GO:0016568chromatin modification9.33e-021.00e+003.3591268
GO:0045893positive regulation of transcription, DNA-templated9.97e-021.00e+001.88826377
GO:0015630microtubule cytoskeleton1.02e-011.00e+003.2171275
GO:0019058viral life cycle1.06e-011.00e+003.1611878
GO:0030529ribonucleoprotein complex1.11e-011.00e+003.0881382
GO:0003690double-stranded DNA binding1.13e-011.00e+003.0711183
GO:0044281small molecule metabolic process1.14e-011.00e+001.31038844
GO:0030027lamellipodium1.19e-011.00e+002.9871388
GO:0061024membrane organization1.20e-011.00e+002.9701389
GO:0006886intracellular protein transport1.20e-011.00e+002.9701189
GO:0005654nucleoplasm1.24e-011.00e+001.256316876
GO:0007050cell cycle arrest1.24e-011.00e+002.9221292
GO:0032496response to lipopolysaccharide1.25e-011.00e+002.9071193
GO:0046983protein dimerization activity1.27e-011.00e+002.8911294
GO:0007219Notch signaling pathway1.28e-011.00e+002.8761295
GO:0000086G2/M transition of mitotic cell cycle1.31e-011.00e+002.8461397
GO:0009615response to virus1.31e-011.00e+002.8461297
GO:0006413translational initiation1.33e-011.00e+002.81711299
GO:0005198structural molecule activity1.36e-011.00e+002.78811101
GO:0034641cellular nitrogen compound metabolic process1.41e-011.00e+002.73213105
GO:0007179transforming growth factor beta receptor signaling pathway1.43e-011.00e+002.70512107
GO:0003735structural constituent of ribosome1.46e-011.00e+002.67818109
GO:0042981regulation of apoptotic process1.49e-011.00e+002.63914112
GO:0007049cell cycle1.53e-011.00e+002.60112115
GO:0003924GTPase activity1.58e-011.00e+002.55113119
GO:0016607nuclear speck1.61e-011.00e+002.51512122
GO:0031965nuclear membrane1.71e-011.00e+002.42412130
GO:0006184GTP catabolic process1.71e-011.00e+002.42413130
GO:0032403protein complex binding1.71e-011.00e+002.42412130
GO:0019904protein domain specific binding1.71e-011.00e+002.42411130
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription1.74e-011.00e+002.40212132
GO:0006367transcription initiation from RNA polymerase II promoter2.08e-011.00e+002.11513161
GO:0008380RNA splicing2.12e-011.00e+002.08014165
GO:0007283spermatogenesis2.16e-011.00e+002.05412168
GO:0007264small GTPase mediated signal transduction2.23e-011.00e+002.00314174
GO:0003713transcription coactivator activity2.34e-011.00e+001.92213184
GO:0005575cellular_component2.37e-011.00e+001.89912187
GO:0004674protein serine/threonine kinase activity2.48e-011.00e+001.82413197
GO:0005525GTP binding2.48e-011.00e+001.82413197
GO:0035556intracellular signal transduction2.51e-011.00e+001.80913199
GO:0008134transcription factor binding2.61e-011.00e+001.73915209
GO:0043231intracellular membrane-bounded organelle2.71e-011.00e+001.67811218
GO:0042493response to drug2.75e-011.00e+001.65211222
GO:0019901protein kinase binding2.86e-011.00e+001.58818232
GO:0007155cell adhesion2.98e-011.00e+001.51512244
GO:0008285negative regulation of cell proliferation3.32e-011.00e+001.33213277
GO:0005925focal adhesion3.37e-011.00e+001.306112282
GO:0000278mitotic cell cycle3.67e-011.00e+001.15119314
GO:0005524ATP binding3.70e-011.00e+000.645210892
GO:0006366transcription from RNA polymerase II promoter3.92e-011.00e+001.03212341
GO:0046872metal ion binding3.93e-011.00e+000.579210934
GO:0044267cellular protein metabolic process4.02e-011.00e+000.987113352
GO:0042803protein homodimerization activity4.66e-011.00e+000.70514428
GO:0016032viral process4.66e-011.00e+000.705113428
GO:0007165signal transduction6.00e-011.00e+000.17515618
GO:0005615extracellular space6.20e-011.00e+000.10012651
GO:0008270zinc ion binding6.62e-011.00e+00-0.06015727
GO:0005886plasma membrane9.41e-011.00e+00-1.3551131784