int-snw-6233

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
tai-screen-luciferase	8.389	3.07e-257	1.78e-14	1.14e-06

tai-screen-luciferase-int-snw-6233 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	tai-screen-luciferase gene score	Best subnetwork score	Degree	List-Gonzales GI	Tai-Hits
RPS24	6229	21	-7.034	8.389	217	Yes	-
COPZ1	22818	32	-8.301	9.063	13	Yes	Yes
COPA	1314	32	-9.395	9.063	170	Yes	Yes
CDC42	998	11	-6.960	8.389	265	Yes	Yes
[ RPS27A ]	6233	15	-5.631	8.389	342	Yes	-
ARCN1	372	32	-8.232	9.063	118	Yes	Yes
COPB2	9276	32	-13.168	9.063	41	Yes	Yes

Interactions (8)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
CDC42	998	RPS27A	6233	pp	--	int.I2D: SOURAV_MAPK_HIGH
COPA	1314	RPS27A	6233	pp	--	int.I2D: YeastLow
ARCN1	372	COPA	1314	pp	--	int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core; int.HPRD: in vivo
ARCN1	372	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
COPA	1314	COPB2	9276	pp	--	int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vivo
ARCN1	372	COPB2	9276	pp	--	int.I2D: HPRD, BCI; int.HPRD: in vivo
COPA	1314	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
RPS24	6229	RPS27A	6233	pp	--	int.I2D: YeastMedium

Related GO terms (202)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0030126	COPI vesicle coat	9.60e-12	1.38e-07	9.424	4	7	12
GO:0048205	COPI coating of Golgi vesicle	1.39e-11	2.00e-07	9.308	4	8	13
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	2.45e-10	3.53e-06	8.365	4	8	25
GO:0061024	membrane organization	1.98e-09	2.86e-05	6.151	5	12	145
GO:0006886	intracellular protein transport	6.49e-07	9.37e-03	5.591	4	7	171
GO:0005829	cytosol	4.62e-06	6.66e-02	2.531	7	61	2496
GO:0015935	small ribosomal subunit	2.74e-05	3.95e-01	7.921	2	9	17
GO:0006891	intra-Golgi vesicle-mediated transport	2.74e-05	3.95e-01	7.921	2	4	17
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	1.26e-04	1.00e+00	6.839	2	3	36
GO:0022627	cytosolic small ribosomal subunit	1.48e-04	1.00e+00	6.723	2	20	39
GO:0016020	membrane	3.67e-04	1.00e+00	2.616	5	41	1681
GO:0021691	cerebellar Purkinje cell layer maturation	4.85e-04	1.00e+00	11.009	1	1	1
GO:0019083	viral transcription	6.42e-04	1.00e+00	5.669	2	20	81
GO:0006415	translational termination	7.41e-04	1.00e+00	5.566	2	20	87
GO:0006414	translational elongation	8.46e-04	1.00e+00	5.470	2	20	93
GO:0071338	positive regulation of hair follicle cell proliferation	9.70e-04	1.00e+00	10.009	1	1	2
GO:0090135	actin filament branching	9.70e-04	1.00e+00	10.009	1	1	2
GO:0060661	submandibular salivary gland formation	9.70e-04	1.00e+00	10.009	1	1	2
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	1.06e-03	1.00e+00	5.308	2	20	104
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1.27e-03	1.00e+00	5.176	2	20	114
GO:0019058	viral life cycle	1.29e-03	1.00e+00	5.163	2	23	115
GO:0051683	establishment of Golgi localization	1.46e-03	1.00e+00	9.424	1	2	3
GO:0034191	apolipoprotein A-I receptor binding	1.46e-03	1.00e+00	9.424	1	1	3
GO:0003161	cardiac conduction system development	1.46e-03	1.00e+00	9.424	1	1	3
GO:0006413	translational initiation	1.67e-03	1.00e+00	4.975	2	21	131
GO:0003735	structural constituent of ribosome	1.82e-03	1.00e+00	4.911	2	22	137
GO:0060684	epithelial-mesenchymal cell signaling	1.94e-03	1.00e+00	9.009	1	1	4
GO:0051835	positive regulation of synapse structural plasticity	1.94e-03	1.00e+00	9.009	1	1	4
GO:0048664	neuron fate determination	1.94e-03	1.00e+00	9.009	1	1	4
GO:0072384	organelle transport along microtubule	1.94e-03	1.00e+00	9.009	1	2	4
GO:0005198	structural molecule activity	2.18e-03	1.00e+00	4.780	2	6	150
GO:0035088	establishment or maintenance of apical/basal cell polarity	2.42e-03	1.00e+00	8.687	1	1	5
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.42e-03	1.00e+00	8.687	1	3	5
GO:0036336	dendritic cell migration	2.42e-03	1.00e+00	8.687	1	1	5
GO:0031256	leading edge membrane	2.42e-03	1.00e+00	8.687	1	1	5
GO:0060789	hair follicle placode formation	2.91e-03	1.00e+00	8.424	1	1	6
GO:0007097	nuclear migration	2.91e-03	1.00e+00	8.424	1	1	6
GO:0003334	keratinocyte development	2.91e-03	1.00e+00	8.424	1	1	6
GO:0048554	positive regulation of metalloenzyme activity	2.91e-03	1.00e+00	8.424	1	1	6
GO:0043497	regulation of protein heterodimerization activity	2.91e-03	1.00e+00	8.424	1	1	6
GO:0030157	pancreatic juice secretion	3.39e-03	1.00e+00	8.201	1	1	7
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	3.39e-03	1.00e+00	8.201	1	1	7
GO:0034101	erythrocyte homeostasis	3.39e-03	1.00e+00	8.201	1	1	7
GO:0051489	regulation of filopodium assembly	3.39e-03	1.00e+00	8.201	1	1	7
GO:0007173	epidermal growth factor receptor signaling pathway	3.44e-03	1.00e+00	4.446	2	4	189
GO:0090136	epithelial cell-cell adhesion	4.36e-03	1.00e+00	7.839	1	1	9
GO:0016071	mRNA metabolic process	4.75e-03	1.00e+00	4.208	2	25	223
GO:0031274	positive regulation of pseudopodium assembly	4.84e-03	1.00e+00	7.687	1	2	10
GO:0060047	heart contraction	4.84e-03	1.00e+00	7.687	1	1	10
GO:0006412	translation	5.04e-03	1.00e+00	4.163	2	23	230
GO:0016070	RNA metabolic process	5.80e-03	1.00e+00	4.060	2	25	247
GO:0019082	viral protein processing	5.81e-03	1.00e+00	7.424	1	2	12
GO:0042274	ribosomal small subunit biogenesis	5.81e-03	1.00e+00	7.424	1	6	12
GO:0032479	regulation of type I interferon production	6.29e-03	1.00e+00	7.308	1	2	13
GO:0031333	negative regulation of protein complex assembly	6.78e-03	1.00e+00	7.201	1	1	14
GO:0031996	thioesterase binding	6.78e-03	1.00e+00	7.201	1	1	14
GO:0030131	clathrin adaptor complex	6.78e-03	1.00e+00	7.201	1	2	14
GO:0031369	translation initiation factor binding	7.26e-03	1.00e+00	7.102	1	1	15
GO:0051233	spindle midzone	7.26e-03	1.00e+00	7.102	1	2	15
GO:0030225	macrophage differentiation	7.26e-03	1.00e+00	7.102	1	1	15
GO:0042176	regulation of protein catabolic process	7.74e-03	1.00e+00	7.009	1	3	16
GO:0075733	intracellular transport of virus	8.22e-03	1.00e+00	6.921	1	3	17
GO:0030742	GTP-dependent protein binding	8.22e-03	1.00e+00	6.921	1	1	17
GO:0090316	positive regulation of intracellular protein transport	8.22e-03	1.00e+00	6.921	1	1	17
GO:0019068	virion assembly	8.22e-03	1.00e+00	6.921	1	2	17
GO:0007088	regulation of mitosis	8.71e-03	1.00e+00	6.839	1	1	18
GO:0046847	filopodium assembly	9.19e-03	1.00e+00	6.761	1	1	19
GO:0043473	pigmentation	9.67e-03	1.00e+00	6.687	1	1	20
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1.01e-02	1.00e+00	6.616	1	1	21
GO:0031424	keratinization	1.06e-02	1.00e+00	6.549	1	1	22
GO:0007220	Notch receptor processing	1.06e-02	1.00e+00	6.549	1	2	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.06e-02	1.00e+00	6.549	1	3	22
GO:0044822	poly(A) RNA binding	1.10e-02	1.00e+00	2.549	3	32	1056
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	1.11e-02	1.00e+00	6.485	1	1	23
GO:0002040	sprouting angiogenesis	1.11e-02	1.00e+00	6.485	1	1	23
GO:0051017	actin filament bundle assembly	1.11e-02	1.00e+00	6.485	1	1	23
GO:0007163	establishment or maintenance of cell polarity	1.16e-02	1.00e+00	6.424	1	1	24
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	1.21e-02	1.00e+00	6.365	1	2	25
GO:0005978	glycogen biosynthetic process	1.26e-02	1.00e+00	6.308	1	2	26
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	1.26e-02	1.00e+00	6.308	1	2	26
GO:0045859	regulation of protein kinase activity	1.26e-02	1.00e+00	6.308	1	1	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.26e-02	1.00e+00	6.308	1	2	26
GO:0051149	positive regulation of muscle cell differentiation	1.30e-02	1.00e+00	6.254	1	1	27
GO:0032467	positive regulation of cytokinesis	1.30e-02	1.00e+00	6.254	1	1	27
GO:0031069	hair follicle morphogenesis	1.30e-02	1.00e+00	6.254	1	1	27
GO:0072686	mitotic spindle	1.40e-02	1.00e+00	6.151	1	1	29
GO:0031647	regulation of protein stability	1.45e-02	1.00e+00	6.102	1	1	30
GO:0032480	negative regulation of type I interferon production	1.54e-02	1.00e+00	6.009	1	2	32
GO:0042692	muscle cell differentiation	1.64e-02	1.00e+00	5.921	1	1	34
GO:0034332	adherens junction organization	1.73e-02	1.00e+00	5.839	1	2	36
GO:0045740	positive regulation of DNA replication	1.73e-02	1.00e+00	5.839	1	1	36
GO:0007249	I-kappaB kinase/NF-kappaB signaling	1.97e-02	1.00e+00	5.651	1	3	41
GO:0044267	cellular protein metabolic process	2.03e-02	1.00e+00	3.120	2	23	474
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	2.07e-02	1.00e+00	5.582	1	2	43
GO:0021762	substantia nigra development	2.12e-02	1.00e+00	5.549	1	1	44
GO:0034613	cellular protein localization	2.12e-02	1.00e+00	5.549	1	2	44
GO:0008344	adult locomotory behavior	2.12e-02	1.00e+00	5.549	1	1	44
GO:0043525	positive regulation of neuron apoptotic process	2.21e-02	1.00e+00	5.485	1	2	46
GO:0007030	Golgi organization	2.35e-02	1.00e+00	5.394	1	2	49
GO:0007254	JNK cascade	2.35e-02	1.00e+00	5.394	1	3	49
GO:0030175	filopodium	2.40e-02	1.00e+00	5.365	1	2	50
GO:0030666	endocytic vesicle membrane	2.54e-02	1.00e+00	5.281	1	2	53
GO:0016032	viral process	2.54e-02	1.00e+00	2.948	2	33	534
GO:0051403	stress-activated MAPK cascade	2.59e-02	1.00e+00	5.254	1	3	54
GO:0046330	positive regulation of JNK cascade	2.64e-02	1.00e+00	5.227	1	1	55
GO:0016197	endosomal transport	2.73e-02	1.00e+00	5.176	1	3	57
GO:0033138	positive regulation of peptidyl-serine phosphorylation	2.83e-02	1.00e+00	5.126	1	1	59
GO:0032481	positive regulation of type I interferon production	2.92e-02	1.00e+00	5.078	1	3	61
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	2.92e-02	1.00e+00	5.078	1	2	61
GO:0030141	secretory granule	2.97e-02	1.00e+00	5.055	1	1	62
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	3.07e-02	1.00e+00	5.009	1	6	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.11e-02	1.00e+00	4.986	1	6	65
GO:0034146	toll-like receptor 5 signaling pathway	3.11e-02	1.00e+00	4.986	1	4	65
GO:0031295	T cell costimulation	3.11e-02	1.00e+00	4.986	1	3	65
GO:0034166	toll-like receptor 10 signaling pathway	3.11e-02	1.00e+00	4.986	1	4	65
GO:0045087	innate immune response	3.12e-02	1.00e+00	2.790	2	8	596
GO:0035264	multicellular organism growth	3.21e-02	1.00e+00	4.943	1	1	67
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.35e-02	1.00e+00	4.879	1	8	70
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	3.40e-02	1.00e+00	4.859	1	4	71
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	3.40e-02	1.00e+00	4.859	1	4	71
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	3.44e-02	1.00e+00	4.839	1	6	72
GO:0034162	toll-like receptor 9 signaling pathway	3.44e-02	1.00e+00	4.839	1	4	72
GO:0034134	toll-like receptor 2 signaling pathway	3.49e-02	1.00e+00	4.819	1	4	73
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	3.54e-02	1.00e+00	4.799	1	2	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.54e-02	1.00e+00	4.799	1	8	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	3.58e-02	1.00e+00	4.780	1	6	75
GO:0060070	canonical Wnt signaling pathway	3.58e-02	1.00e+00	4.780	1	1	75
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	3.63e-02	1.00e+00	4.761	1	4	76
GO:0010629	negative regulation of gene expression	3.68e-02	1.00e+00	4.742	1	2	77
GO:0002756	MyD88-independent toll-like receptor signaling pathway	3.73e-02	1.00e+00	4.723	1	4	78
GO:0005179	hormone activity	3.77e-02	1.00e+00	4.705	1	1	79
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	3.77e-02	1.00e+00	4.705	1	8	79
GO:0034138	toll-like receptor 3 signaling pathway	3.77e-02	1.00e+00	4.705	1	4	79
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	3.82e-02	1.00e+00	4.687	1	4	80
GO:0010467	gene expression	3.86e-02	1.00e+00	2.623	2	29	669
GO:0045177	apical part of cell	3.87e-02	1.00e+00	4.669	1	1	81
GO:0050852	T cell receptor signaling pathway	4.05e-02	1.00e+00	4.599	1	2	85
GO:0000187	activation of MAPK activity	4.29e-02	1.00e+00	4.517	1	2	90
GO:0071456	cellular response to hypoxia	4.38e-02	1.00e+00	4.485	1	3	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	4.38e-02	1.00e+00	4.485	1	6	92
GO:0006364	rRNA processing	4.47e-02	1.00e+00	4.454	1	7	94
GO:0034142	toll-like receptor 4 signaling pathway	4.57e-02	1.00e+00	4.424	1	4	96
GO:0030496	midbody	5.13e-02	1.00e+00	4.254	1	2	108
GO:0002224	toll-like receptor signaling pathway	5.17e-02	1.00e+00	4.241	1	4	109
GO:0005815	microtubule organizing center	5.17e-02	1.00e+00	4.241	1	3	109
GO:0097190	apoptotic signaling pathway	5.36e-02	1.00e+00	4.189	1	3	113
GO:0051056	regulation of small GTPase mediated signal transduction	5.45e-02	1.00e+00	4.163	1	4	115
GO:0000209	protein polyubiquitination	5.50e-02	1.00e+00	4.151	1	7	116
GO:0006006	glucose metabolic process	5.59e-02	1.00e+00	4.126	1	3	118
GO:0007219	Notch signaling pathway	5.68e-02	1.00e+00	4.102	1	3	120
GO:0030036	actin cytoskeleton organization	5.82e-02	1.00e+00	4.066	1	2	123
GO:0051092	positive regulation of NF-kappaB transcription factor activity	5.87e-02	1.00e+00	4.055	1	3	124
GO:0007179	transforming growth factor beta receptor signaling pathway	6.05e-02	1.00e+00	4.009	1	3	128
GO:0000086	G2/M transition of mitotic cell cycle	6.42e-02	1.00e+00	3.921	1	5	136
GO:0005911	cell-cell junction	6.42e-02	1.00e+00	3.921	1	2	136
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	6.83e-02	1.00e+00	3.829	1	3	145
GO:0010628	positive regulation of gene expression	6.88e-02	1.00e+00	3.819	1	4	146
GO:0034220	ion transmembrane transport	7.01e-02	1.00e+00	3.790	1	2	149
GO:0000082	G1/S transition of mitotic cell cycle	7.01e-02	1.00e+00	3.790	1	9	149
GO:0042981	regulation of apoptotic process	7.06e-02	1.00e+00	3.780	1	7	150
GO:0010008	endosome membrane	7.10e-02	1.00e+00	3.770	1	5	151
GO:0008543	fibroblast growth factor receptor signaling pathway	7.33e-02	1.00e+00	3.723	1	3	156
GO:0043005	neuron projection	7.38e-02	1.00e+00	3.714	1	6	157
GO:0038095	Fc-epsilon receptor signaling pathway	7.88e-02	1.00e+00	3.616	1	3	168
GO:0005737	cytoplasm	8.13e-02	1.00e+00	1.130	4	43	3767
GO:0006367	transcription initiation from RNA polymerase II promoter	8.60e-02	1.00e+00	3.485	1	3	184
GO:0003924	GTPase activity	9.18e-02	1.00e+00	3.387	1	7	197
GO:0070062	extracellular vesicular exosome	9.54e-02	1.00e+00	1.365	3	40	2400
GO:0006184	GTP catabolic process	9.94e-02	1.00e+00	3.267	1	7	214
GO:0019221	cytokine-mediated signaling pathway	1.02e-01	1.00e+00	3.221	1	2	221
GO:0043025	neuronal cell body	1.13e-01	1.00e+00	3.072	1	4	245
GO:0005975	carbohydrate metabolic process	1.17e-01	1.00e+00	3.026	1	3	253
GO:0000166	nucleotide binding	1.19e-01	1.00e+00	2.992	1	2	259
GO:0006281	DNA repair	1.20e-01	1.00e+00	2.981	1	4	261
GO:0048011	neurotrophin TRK receptor signaling pathway	1.23e-01	1.00e+00	2.937	1	4	269
GO:0043065	positive regulation of apoptotic process	1.23e-01	1.00e+00	2.943	1	6	268
GO:0007264	small GTPase mediated signal transduction	1.28e-01	1.00e+00	2.885	1	7	279
GO:0005525	GTP binding	1.41e-01	1.00e+00	2.733	1	7	310
GO:0019901	protein kinase binding	1.44e-01	1.00e+00	2.700	1	6	317
GO:0043231	intracellular membrane-bounded organelle	1.45e-01	1.00e+00	2.696	1	5	318
GO:0007411	axon guidance	1.45e-01	1.00e+00	2.691	1	3	319
GO:0000139	Golgi membrane	1.63e-01	1.00e+00	2.513	1	6	361
GO:0005925	focal adhesion	1.65e-01	1.00e+00	2.493	1	19	366
GO:0000278	mitotic cell cycle	1.75e-01	1.00e+00	2.398	1	11	391
GO:0043066	negative regulation of apoptotic process	1.89e-01	1.00e+00	2.281	1	13	424
GO:0055085	transmembrane transport	1.93e-01	1.00e+00	2.244	1	3	435
GO:0007596	blood coagulation	2.01e-01	1.00e+00	2.179	1	3	455
GO:0042802	identical protein binding	2.13e-01	1.00e+00	2.090	1	3	484
GO:0006915	apoptotic process	2.40e-01	1.00e+00	1.892	1	9	555
GO:0005783	endoplasmic reticulum	2.41e-01	1.00e+00	1.890	1	3	556
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	2.46e-01	1.00e+00	1.854	1	7	570
GO:0005794	Golgi apparatus	2.61e-01	1.00e+00	1.756	1	9	610
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.26e-01	1.00e+00	1.385	1	6	789
GO:0005886	plasma membrane	3.65e-01	1.00e+00	0.674	2	20	2582
GO:0005615	extracellular space	3.82e-01	1.00e+00	1.106	1	2	957
GO:0005654	nucleoplasm	4.21e-01	1.00e+00	0.929	1	15	1082
GO:0044281	small molecule metabolic process	4.59e-01	1.00e+00	0.767	1	15	1211
GO:0046872	metal ion binding	4.86e-01	1.00e+00	0.657	1	10	1307
GO:0006351	transcription, DNA-templated	5.23e-01	1.00e+00	0.511	1	6	1446
GO:0005730	nucleolus	5.71e-01	1.00e+00	0.328	1	24	1641
GO:0005634	nucleus	9.30e-01	1.00e+00	-1.146	1	43	4559
GO:0005515	protein binding	9.77e-01	1.00e+00	-1.548	1	62	6024

Tai-Luciferase

int-snw-6233

Statistics

Genes (7)

Interactions (8)

Related GO terms (202)