int-snw-375
Statistics
| Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
|---|---|---|---|---|
| tai-screen-luciferase | 7.138 | 1.50e-177 | 1.38e-09 | 2.17e-04 |
Genes (8)
| Gene Symbol | Entrez Gene ID | Frequency | tai-screen-luciferase gene score | Best subnetwork score | Degree | List-Gonzales GI | Tai-Hits |
|---|---|---|---|---|---|---|---|
| COPZ1 | 22818 | 32 | -8.301 | 9.063 | 13 | Yes | Yes |
| COPA | 1314 | 32 | -9.395 | 9.063 | 170 | Yes | Yes |
| [ ARF1 ] | 375 | 2 | -2.777 | 7.138 | 93 | Yes | - |
| ARCN1 | 372 | 32 | -8.232 | 9.063 | 118 | Yes | Yes |
| COPB2 | 9276 | 32 | -13.168 | 9.063 | 41 | Yes | Yes |
| SRPK1 | 6732 | 2 | -3.733 | 7.138 | 50 | - | - |
| COPB1 | 1315 | 22 | -6.221 | 9.063 | 118 | Yes | Yes |
| COPG1 | 22820 | 9 | -5.279 | 7.138 | 37 | Yes | Yes |
Interactions (16)
| Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
|---|---|---|---|---|---|---|
| ARCN1 | 372 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG |
| COPA | 1314 | COPB2 | 9276 | pp | -- | int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vivo |
| ARF1 | 375 | SRPK1 | 6732 | pp | -- | int.I2D: IntAct_Worm, BioGrid_Worm, BIND_Worm, MINT_Worm |
| ARF1 | 375 | COPB1 | 1315 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo |
| ARCN1 | 372 | COPB1 | 1315 | pp | -- | int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS; int.HPRD: in vivo |
| ARCN1 | 372 | COPB2 | 9276 | pp | -- | int.I2D: HPRD, BCI; int.HPRD: in vivo |
| COPB1 | 1315 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium; int.DIP: MI:0915(physical association) |
| COPA | 1314 | COPB1 | 1315 | pp | -- | int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh |
| ARCN1 | 372 | COPG1 | 22820 | pp | -- | int.I2D: HPRD; int.HPRD: in vivo |
| ARCN1 | 372 | COPA | 1314 | pp | -- | int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core; int.HPRD: in vivo |
| COPA | 1314 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium |
| ARF1 | 375 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo |
| COPB1 | 1315 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association) |
| COPB2 | 9276 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid |
| COPZ1 | 22818 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid, HPRD, BIND; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association) |
| COPB1 | 1315 | COPB2 | 9276 | pp | -- | int.I2D: BioGrid |
Related GO terms (70)
| Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
|---|---|---|---|---|---|---|---|
| GO:0048205 | COPI coating of Golgi vesicle | 5.33e-22 | 7.69e-18 | 9.923 | 7 | 8 | 13 |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | 1.49e-19 | 2.15e-15 | 8.980 | 7 | 8 | 25 |
| GO:0030126 | COPI vesicle coat | 2.07e-18 | 2.99e-14 | 9.816 | 6 | 7 | 12 |
| GO:0061024 | membrane organization | 7.12e-14 | 1.03e-09 | 6.444 | 7 | 12 | 145 |
| GO:0006886 | intracellular protein transport | 6.99e-11 | 1.01e-06 | 5.983 | 6 | 7 | 171 |
| GO:0006891 | intra-Golgi vesicle-mediated transport | 7.59e-08 | 1.09e-03 | 8.314 | 3 | 4 | 17 |
| GO:0005198 | structural molecule activity | 7.62e-07 | 1.10e-02 | 5.587 | 4 | 6 | 150 |
| GO:0005829 | cytosol | 3.14e-05 | 4.52e-01 | 2.338 | 7 | 61 | 2496 |
| GO:0021691 | cerebellar Purkinje cell layer maturation | 5.55e-04 | 1.00e+00 | 10.816 | 1 | 1 | 1 |
| GO:0000139 | Golgi membrane | 7.93e-04 | 1.00e+00 | 3.905 | 3 | 6 | 361 |
| GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation | 1.11e-03 | 1.00e+00 | 9.816 | 1 | 1 | 2 |
| GO:0097061 | dendritic spine organization | 1.11e-03 | 1.00e+00 | 9.816 | 1 | 1 | 2 |
| GO:0051683 | establishment of Golgi localization | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 2 | 3 |
| GO:0035092 | sperm chromatin condensation | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 3 |
| GO:0002090 | regulation of receptor internalization | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 3 |
| GO:0072384 | organelle transport along microtubule | 2.22e-03 | 1.00e+00 | 8.816 | 1 | 2 | 4 |
| GO:0016032 | viral process | 2.46e-03 | 1.00e+00 | 3.340 | 3 | 33 | 534 |
| GO:0050684 | regulation of mRNA processing | 2.77e-03 | 1.00e+00 | 8.494 | 1 | 1 | 5 |
| GO:0048024 | regulation of mRNA splicing, via spliceosome | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 2 | 6 |
| GO:0030157 | pancreatic juice secretion | 3.88e-03 | 1.00e+00 | 8.009 | 1 | 1 | 7 |
| GO:0005798 | Golgi-associated vesicle | 5.53e-03 | 1.00e+00 | 7.494 | 1 | 1 | 10 |
| GO:0006878 | cellular copper ion homeostasis | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 12 |
| GO:0060292 | long term synaptic depression | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 2 | 13 |
| GO:0030131 | clathrin adaptor complex | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 2 | 14 |
| GO:0045070 | positive regulation of viral genome replication | 9.39e-03 | 1.00e+00 | 6.729 | 1 | 2 | 17 |
| GO:0043473 | pigmentation | 1.10e-02 | 1.00e+00 | 6.494 | 1 | 1 | 20 |
| GO:0043231 | intracellular membrane-bounded organelle | 1.24e-02 | 1.00e+00 | 3.503 | 2 | 5 | 318 |
| GO:0050690 | regulation of defense response to virus by virus | 1.49e-02 | 1.00e+00 | 6.061 | 1 | 1 | 27 |
| GO:0044822 | poly(A) RNA binding | 1.66e-02 | 1.00e+00 | 2.357 | 3 | 32 | 1056 |
| GO:0045071 | negative regulation of viral genome replication | 1.87e-02 | 1.00e+00 | 5.729 | 1 | 2 | 34 |
| GO:0030017 | sarcomere | 1.87e-02 | 1.00e+00 | 5.729 | 1 | 2 | 34 |
| GO:0005057 | receptor signaling protein activity | 2.09e-02 | 1.00e+00 | 5.568 | 1 | 2 | 38 |
| GO:0006892 | post-Golgi vesicle-mediated transport | 2.36e-02 | 1.00e+00 | 5.390 | 1 | 1 | 43 |
| GO:0008344 | adult locomotory behavior | 2.42e-02 | 1.00e+00 | 5.357 | 1 | 1 | 44 |
| GO:0006661 | phosphatidylinositol biosynthetic process | 2.85e-02 | 1.00e+00 | 5.116 | 1 | 1 | 52 |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | 3.06e-02 | 1.00e+00 | 5.009 | 1 | 1 | 56 |
| GO:0007059 | chromosome segregation | 3.39e-02 | 1.00e+00 | 4.862 | 1 | 2 | 62 |
| GO:0005783 | endoplasmic reticulum | 3.56e-02 | 1.00e+00 | 2.697 | 2 | 3 | 556 |
| GO:0005794 | Golgi apparatus | 4.22e-02 | 1.00e+00 | 2.563 | 2 | 9 | 610 |
| GO:0005179 | hormone activity | 4.30e-02 | 1.00e+00 | 4.512 | 1 | 1 | 79 |
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | 4.89e-02 | 1.00e+00 | 4.324 | 1 | 1 | 90 |
| GO:0016363 | nuclear matrix | 4.94e-02 | 1.00e+00 | 4.308 | 1 | 2 | 91 |
| GO:0016020 | membrane | 5.64e-02 | 1.00e+00 | 1.686 | 3 | 41 | 1681 |
| GO:0014069 | postsynaptic density | 5.68e-02 | 1.00e+00 | 4.102 | 1 | 3 | 105 |
| GO:0006644 | phospholipid metabolic process | 6.94e-02 | 1.00e+00 | 3.805 | 1 | 3 | 129 |
| GO:0043005 | neuron projection | 8.39e-02 | 1.00e+00 | 3.521 | 1 | 6 | 157 |
| GO:0006397 | mRNA processing | 8.54e-02 | 1.00e+00 | 3.494 | 1 | 1 | 160 |
| GO:0000287 | magnesium ion binding | 8.74e-02 | 1.00e+00 | 3.459 | 1 | 2 | 164 |
| GO:0045211 | postsynaptic membrane | 9.05e-02 | 1.00e+00 | 3.407 | 1 | 4 | 170 |
| GO:0004672 | protein kinase activity | 9.41e-02 | 1.00e+00 | 3.348 | 1 | 4 | 177 |
| GO:0003924 | GTPase activity | 1.04e-01 | 1.00e+00 | 3.194 | 1 | 7 | 197 |
| GO:0006184 | GTP catabolic process | 1.13e-01 | 1.00e+00 | 3.075 | 1 | 7 | 214 |
| GO:0008380 | RNA splicing | 1.20e-01 | 1.00e+00 | 2.983 | 1 | 3 | 228 |
| GO:0005737 | cytoplasm | 1.30e-01 | 1.00e+00 | 0.937 | 4 | 43 | 3767 |
| GO:0007264 | small GTPase mediated signal transduction | 1.45e-01 | 1.00e+00 | 2.692 | 1 | 7 | 279 |
| GO:0035556 | intracellular signal transduction | 1.56e-01 | 1.00e+00 | 2.573 | 1 | 4 | 303 |
| GO:0005886 | plasma membrane | 1.59e-01 | 1.00e+00 | 1.067 | 3 | 20 | 2582 |
| GO:0004674 | protein serine/threonine kinase activity | 1.59e-01 | 1.00e+00 | 2.549 | 1 | 5 | 308 |
| GO:0005525 | GTP binding | 1.60e-01 | 1.00e+00 | 2.540 | 1 | 7 | 310 |
| GO:0015031 | protein transport | 1.74e-01 | 1.00e+00 | 2.402 | 1 | 8 | 341 |
| GO:0005925 | focal adhesion | 1.86e-01 | 1.00e+00 | 2.300 | 1 | 19 | 366 |
| GO:0006468 | protein phosphorylation | 2.28e-01 | 1.00e+00 | 1.971 | 1 | 6 | 460 |
| GO:0048471 | perinuclear region of cytoplasm | 2.47e-01 | 1.00e+00 | 1.845 | 1 | 7 | 502 |
| GO:0045087 | innate immune response | 2.87e-01 | 1.00e+00 | 1.597 | 1 | 8 | 596 |
| GO:0070062 | extracellular vesicular exosome | 3.95e-01 | 1.00e+00 | 0.587 | 2 | 40 | 2400 |
| GO:0005615 | extracellular space | 4.23e-01 | 1.00e+00 | 0.914 | 1 | 2 | 957 |
| GO:0005515 | protein binding | 4.47e-01 | 1.00e+00 | 0.260 | 4 | 62 | 6024 |
| GO:0044281 | small molecule metabolic process | 5.04e-01 | 1.00e+00 | 0.574 | 1 | 15 | 1211 |
| GO:0005524 | ATP binding | 5.30e-01 | 1.00e+00 | 0.474 | 1 | 15 | 1298 |
| GO:0005634 | nucleus | 9.52e-01 | 1.00e+00 | -1.338 | 1 | 43 | 4559 |