int-snw-27235

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
tai-screen-luciferase	6.540	1.10e-144	1.18e-07	1.59e-03

tai-screen-luciferase-int-snw-27235 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	tai-screen-luciferase gene score	Best subnetwork score	Degree	List-Gonzales GI	Tai-Hits
COPZ1	22818	32	-8.301	9.063	13	Yes	Yes
COPA	1314	32	-9.395	9.063	170	Yes	Yes
RPS27A	6233	15	-5.631	8.389	342	Yes	-
TBL3	10607	2	-3.692	7.486	102	Yes	Yes
[ COQ2 ]	27235	1	-2.044	6.540	44	-	-
ARCN1	372	32	-8.232	9.063	118	Yes	Yes
COPB1	1315	22	-6.221	9.063	118	Yes	Yes
COPB2	9276	32	-13.168	9.063	41	Yes	Yes
LYPLA2	11313	1	-2.172	6.540	10	-	-

Interactions (14)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
COPA	1314	COPB1	1315	pp	--	int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh
ARCN1	372	COPA	1314	pp	--	int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core; int.HPRD: in vivo
ARCN1	372	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
COPA	1314	COPB2	9276	pp	--	int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vivo
COPA	1314	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
ARCN1	372	COPB1	1315	pp	--	int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS; int.HPRD: in vivo
COPA	1314	RPS27A	6233	pp	--	int.I2D: YeastLow
COPA	1314	TBL3	10607	pp	--	int.I2D: YeastLow
TBL3	10607	COQ2	27235	pp	--	int.I2D: BioGrid_Yeast, BIND_Yeast, MINT_Yeast, MIPS, YeastMedium, IntAct_Yeast
ARCN1	372	COPB2	9276	pp	--	int.I2D: HPRD, BCI; int.HPRD: in vivo
COPA	1314	COQ2	27235	pp	--	int.I2D: BioGrid_Yeast
COPB1	1315	COPB2	9276	pp	--	int.I2D: BioGrid
LYPLA2	11313	COQ2	27235	pp	--	int.I2D: BioGrid_Yeast
COPB1	1315	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium; int.DIP: MI:0915(physical association)

Related GO terms (132)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0030126	COPI vesicle coat	1.92e-14	2.76e-10	9.383	5	7	12
GO:0048205	COPI coating of Golgi vesicle	3.11e-14	4.49e-10	9.268	5	8	13
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	1.28e-12	1.85e-08	8.324	5	8	25
GO:0061024	membrane organization	7.63e-11	1.10e-06	6.051	6	12	145
GO:0006886	intracellular protein transport	2.68e-08	3.86e-04	5.550	5	7	171
GO:0006891	intra-Golgi vesicle-mediated transport	1.14e-07	1.64e-03	8.144	3	4	17
GO:0005198	structural molecule activity	8.85e-05	1.00e+00	5.002	3	6	150
GO:0021691	cerebellar Purkinje cell layer maturation	6.24e-04	1.00e+00	10.646	1	1	1
GO:0002083	4-hydroxybenzoate decaprenyltransferase activity	6.24e-04	1.00e+00	10.646	1	1	1
GO:0047293	4-hydroxybenzoate nonaprenyltransferase activity	6.24e-04	1.00e+00	10.646	1	1	1
GO:0005829	cytosol	1.39e-03	1.00e+00	1.946	6	61	2496
GO:0030157	pancreatic juice secretion	4.36e-03	1.00e+00	7.839	1	1	7
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	4.98e-03	1.00e+00	7.646	1	1	8
GO:0006071	glycerol metabolic process	5.60e-03	1.00e+00	7.476	1	1	9
GO:0006744	ubiquinone biosynthetic process	6.22e-03	1.00e+00	7.324	1	1	10
GO:0005798	Golgi-associated vesicle	6.22e-03	1.00e+00	7.324	1	1	10
GO:0032040	small-subunit processome	6.22e-03	1.00e+00	7.324	1	2	10
GO:0008299	isoprenoid biosynthetic process	6.85e-03	1.00e+00	7.187	1	1	11
GO:0019082	viral protein processing	7.47e-03	1.00e+00	7.061	1	2	12
GO:0032479	regulation of type I interferon production	8.09e-03	1.00e+00	6.946	1	2	13
GO:0030131	clathrin adaptor complex	8.70e-03	1.00e+00	6.839	1	2	14
GO:0075733	intracellular transport of virus	1.06e-02	1.00e+00	6.559	1	3	17
GO:0015935	small ribosomal subunit	1.06e-02	1.00e+00	6.559	1	9	17
GO:0019068	virion assembly	1.06e-02	1.00e+00	6.559	1	2	17
GO:0043473	pigmentation	1.24e-02	1.00e+00	6.324	1	1	20
GO:0007220	Notch receptor processing	1.36e-02	1.00e+00	6.187	1	2	22
GO:0016020	membrane	1.43e-02	1.00e+00	1.931	4	41	1681
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	1.55e-02	1.00e+00	6.002	1	2	25
GO:0043231	intracellular membrane-bounded organelle	1.57e-02	1.00e+00	3.333	2	5	318
GO:0005978	glycogen biosynthetic process	1.61e-02	1.00e+00	5.946	1	2	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.61e-02	1.00e+00	5.946	1	2	26
GO:0032480	negative regulation of type I interferon production	1.98e-02	1.00e+00	5.646	1	2	32
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	2.22e-02	1.00e+00	5.476	1	3	36
GO:0044822	poly(A) RNA binding	2.35e-02	1.00e+00	2.187	3	32	1056
GO:0005057	receptor signaling protein activity	2.35e-02	1.00e+00	5.398	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.41e-02	1.00e+00	5.361	1	20	39
GO:0006631	fatty acid metabolic process	2.47e-02	1.00e+00	5.324	1	1	40
GO:0007249	I-kappaB kinase/NF-kappaB signaling	2.53e-02	1.00e+00	5.289	1	3	41
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	2.65e-02	1.00e+00	5.220	1	2	43
GO:0008344	adult locomotory behavior	2.71e-02	1.00e+00	5.187	1	1	44
GO:0007254	JNK cascade	3.02e-02	1.00e+00	5.031	1	3	49
GO:0030666	endocytic vesicle membrane	3.26e-02	1.00e+00	4.918	1	2	53
GO:0051403	stress-activated MAPK cascade	3.32e-02	1.00e+00	4.891	1	3	54
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	3.44e-02	1.00e+00	4.839	1	1	56
GO:0016197	endosomal transport	3.50e-02	1.00e+00	4.813	1	3	57
GO:0016787	hydrolase activity	3.56e-02	1.00e+00	4.788	1	1	58
GO:0032481	positive regulation of type I interferon production	3.74e-02	1.00e+00	4.715	1	3	61
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	3.74e-02	1.00e+00	4.715	1	2	61
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	3.92e-02	1.00e+00	4.646	1	6	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.98e-02	1.00e+00	4.624	1	6	65
GO:0034146	toll-like receptor 5 signaling pathway	3.98e-02	1.00e+00	4.624	1	4	65
GO:0034166	toll-like receptor 10 signaling pathway	3.98e-02	1.00e+00	4.624	1	4	65
GO:0016032	viral process	4.14e-02	1.00e+00	2.585	2	33	534
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.29e-02	1.00e+00	4.517	1	8	70
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	4.35e-02	1.00e+00	4.496	1	4	71
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	4.35e-02	1.00e+00	4.496	1	4	71
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	4.41e-02	1.00e+00	4.476	1	6	72
GO:0034162	toll-like receptor 9 signaling pathway	4.41e-02	1.00e+00	4.476	1	4	72
GO:0034134	toll-like receptor 2 signaling pathway	4.47e-02	1.00e+00	4.456	1	4	73
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.53e-02	1.00e+00	4.437	1	8	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	4.59e-02	1.00e+00	4.417	1	6	75
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	4.64e-02	1.00e+00	4.398	1	4	76
GO:0002756	MyD88-independent toll-like receptor signaling pathway	4.76e-02	1.00e+00	4.361	1	4	78
GO:0005179	hormone activity	4.82e-02	1.00e+00	4.342	1	1	79
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	4.82e-02	1.00e+00	4.342	1	8	79
GO:0034138	toll-like receptor 3 signaling pathway	4.82e-02	1.00e+00	4.342	1	4	79
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	4.88e-02	1.00e+00	4.324	1	4	80
GO:0019083	viral transcription	4.94e-02	1.00e+00	4.306	1	20	81
GO:0050852	T cell receptor signaling pathway	5.18e-02	1.00e+00	4.237	1	2	85
GO:0005794	Golgi apparatus	5.28e-02	1.00e+00	2.393	2	9	610
GO:0006415	translational termination	5.30e-02	1.00e+00	4.203	1	20	87
GO:0000187	activation of MAPK activity	5.48e-02	1.00e+00	4.154	1	2	90
GO:0071456	cellular response to hypoxia	5.60e-02	1.00e+00	4.123	1	3	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	5.60e-02	1.00e+00	4.123	1	6	92
GO:0006414	translational elongation	5.66e-02	1.00e+00	4.107	1	20	93
GO:0006364	rRNA processing	5.72e-02	1.00e+00	4.092	1	7	94
GO:0034142	toll-like receptor 4 signaling pathway	5.83e-02	1.00e+00	4.061	1	4	96
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	6.31e-02	1.00e+00	3.946	1	20	104
GO:0002224	toll-like receptor signaling pathway	6.60e-02	1.00e+00	3.878	1	4	109
GO:0097190	apoptotic signaling pathway	6.84e-02	1.00e+00	3.826	1	3	113
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.89e-02	1.00e+00	3.813	1	20	114
GO:0019058	viral life cycle	6.95e-02	1.00e+00	3.801	1	23	115
GO:0000209	protein polyubiquitination	7.01e-02	1.00e+00	3.788	1	7	116
GO:0006006	glucose metabolic process	7.13e-02	1.00e+00	3.764	1	3	118
GO:0007219	Notch signaling pathway	7.25e-02	1.00e+00	3.739	1	3	120
GO:0051092	positive regulation of NF-kappaB transcription factor activity	7.48e-02	1.00e+00	3.692	1	3	124
GO:0007179	transforming growth factor beta receptor signaling pathway	7.71e-02	1.00e+00	3.646	1	3	128
GO:0006413	translational initiation	7.89e-02	1.00e+00	3.613	1	21	131
GO:0000086	G2/M transition of mitotic cell cycle	8.18e-02	1.00e+00	3.559	1	5	136
GO:0003735	structural constituent of ribosome	8.23e-02	1.00e+00	3.548	1	22	137
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	8.69e-02	1.00e+00	3.466	1	3	145
GO:0034220	ion transmembrane transport	8.92e-02	1.00e+00	3.427	1	2	149
GO:0000082	G1/S transition of mitotic cell cycle	8.92e-02	1.00e+00	3.427	1	9	149
GO:0042981	regulation of apoptotic process	8.98e-02	1.00e+00	3.417	1	7	150
GO:0010008	endosome membrane	9.04e-02	1.00e+00	3.408	1	5	151
GO:0008543	fibroblast growth factor receptor signaling pathway	9.33e-02	1.00e+00	3.361	1	3	156
GO:0038095	Fc-epsilon receptor signaling pathway	1.00e-01	1.00e+00	3.254	1	3	168
GO:0006367	transcription initiation from RNA polymerase II promoter	1.09e-01	1.00e+00	3.123	1	3	184
GO:0007173	epidermal growth factor receptor signaling pathway	1.12e-01	1.00e+00	3.084	1	4	189
GO:0019221	cytokine-mediated signaling pathway	1.30e-01	1.00e+00	2.858	1	2	221
GO:0016071	mRNA metabolic process	1.31e-01	1.00e+00	2.845	1	25	223
GO:0006412	translation	1.35e-01	1.00e+00	2.801	1	23	230
GO:0016070	RNA metabolic process	1.44e-01	1.00e+00	2.698	1	25	247
GO:0005975	carbohydrate metabolic process	1.47e-01	1.00e+00	2.663	1	3	253
GO:0006281	DNA repair	1.52e-01	1.00e+00	2.618	1	4	261
GO:0043065	positive regulation of apoptotic process	1.55e-01	1.00e+00	2.580	1	6	268
GO:0048011	neurotrophin TRK receptor signaling pathway	1.56e-01	1.00e+00	2.575	1	4	269
GO:0005743	mitochondrial inner membrane	1.60e-01	1.00e+00	2.532	1	2	277
GO:0044281	small molecule metabolic process	1.71e-01	1.00e+00	1.404	2	15	1211
GO:0035556	intracellular signal transduction	1.74e-01	1.00e+00	2.403	1	4	303
GO:0070062	extracellular vesicular exosome	1.78e-01	1.00e+00	1.002	3	40	2400
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.767	4	43	3767
GO:0000139	Golgi membrane	2.04e-01	1.00e+00	2.150	1	6	361
GO:0000278	mitotic cell cycle	2.19e-01	1.00e+00	2.035	1	11	391
GO:0043066	negative regulation of apoptotic process	2.36e-01	1.00e+00	1.918	1	13	424
GO:0055085	transmembrane transport	2.41e-01	1.00e+00	1.881	1	3	435
GO:0044267	cellular protein metabolic process	2.60e-01	1.00e+00	1.757	1	23	474
GO:0006915	apoptotic process	2.98e-01	1.00e+00	1.530	1	9	555
GO:0005783	endoplasmic reticulum	2.98e-01	1.00e+00	1.527	1	3	556
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.04e-01	1.00e+00	1.491	1	7	570
GO:0045087	innate immune response	3.16e-01	1.00e+00	1.427	1	8	596
GO:0010467	gene expression	3.48e-01	1.00e+00	1.260	1	29	669
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.97e-01	1.00e+00	1.022	1	6	789
GO:0005615	extracellular space	4.61e-01	1.00e+00	0.744	1	2	957
GO:0005886	plasma membrane	4.98e-01	1.00e+00	0.312	2	20	2582
GO:0005654	nucleoplasm	5.04e-01	1.00e+00	0.567	1	15	1082
GO:0046872	metal ion binding	5.75e-01	1.00e+00	0.294	1	10	1307
GO:0006351	transcription, DNA-templated	6.14e-01	1.00e+00	0.148	1	6	1446
GO:0005730	nucleolus	6.63e-01	1.00e+00	-0.034	1	24	1641
GO:0016021	integral component of membrane	7.36e-01	1.00e+00	-0.307	1	5	1982
GO:0005515	protein binding	9.43e-01	1.00e+00	-0.910	2	62	6024
GO:0005634	nucleus	9.67e-01	1.00e+00	-1.508	1	43	4559

Tai-Luciferase

int-snw-27235

Statistics

Genes (9)

Interactions (14)

Related GO terms (132)