int-snw-25902

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
tai-screen-luciferase	6.409	5.99e-138	2.87e-07	2.35e-03

tai-screen-luciferase-int-snw-25902 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	tai-screen-luciferase gene score	Best subnetwork score	Degree	List-Gonzales GI	Tai-Hits
COPZ1	22818	32	-8.301	9.063	13	Yes	Yes
COPA	1314	32	-9.395	9.063	170	Yes	Yes
SLC4A1AP	22950	1	-2.465	6.409	7	-	-
[ MTHFD1L ]	25902	1	-1.852	6.409	21	-	-
ILK	3611	2	2.764	6.968	91	-	-
ARCN1	372	32	-8.232	9.063	118	Yes	Yes
COPB1	1315	22	-6.221	9.063	118	Yes	Yes
COPG1	22820	9	-5.279	7.138	37	Yes	Yes
COPB2	9276	32	-13.168	9.063	41	Yes	Yes

Interactions (17)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ILK	3611	MTHFD1L	25902	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
COPA	1314	COPB1	1315	pp	--	int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh
ARCN1	372	COPG1	22820	pp	--	int.I2D: HPRD; int.HPRD: in vivo
ARCN1	372	COPA	1314	pp	--	int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core; int.HPRD: in vivo
ARCN1	372	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
COPA	1314	COPB2	9276	pp	--	int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vivo
ILK	3611	SLC4A1AP	22950	pp	--	int.Intact: MI:0915(physical association), MI:0403(colocalization); int.I2D: IntAct
ILK	3611	COPG1	22820	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid, IntAct
COPA	1314	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
COPB1	1315	COPG1	22820	pp	--	int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association)
ARCN1	372	COPB1	1315	pp	--	int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS; int.HPRD: in vivo
COPB2	9276	COPG1	22820	pp	--	int.I2D: BioGrid
COPZ1	22818	COPG1	22820	pp	--	int.I2D: BioGrid, HPRD, BIND; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association)
ARCN1	372	COPB2	9276	pp	--	int.I2D: HPRD, BCI; int.HPRD: in vivo
ILK	3611	COPB2	9276	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct, BioGrid
COPB1	1315	COPB2	9276	pp	--	int.I2D: BioGrid
COPB1	1315	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium; int.DIP: MI:0915(physical association)

Related GO terms (101)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0030126	COPI vesicle coat	6.21e-18	8.95e-14	9.646	6	7	12
GO:0048205	COPI coating of Golgi vesicle	1.15e-17	1.66e-13	9.531	6	8	13
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	1.19e-15	1.71e-11	8.587	6	8	25
GO:0061024	membrane organization	7.63e-11	1.10e-06	6.051	6	12	145
GO:0006886	intracellular protein transport	2.08e-10	2.99e-06	5.813	6	7	171
GO:0006891	intra-Golgi vesicle-mediated transport	1.14e-07	1.64e-03	8.144	3	4	17
GO:0005198	structural molecule activity	1.36e-06	1.96e-02	5.417	4	6	150
GO:0005829	cytosol	6.07e-06	8.76e-02	2.361	8	61	2496
GO:0021691	cerebellar Purkinje cell layer maturation	6.24e-04	1.00e+00	10.646	1	1	1
GO:0015942	formate metabolic process	1.25e-03	1.00e+00	9.646	1	1	2
GO:0016020	membrane	1.80e-03	1.00e+00	2.253	5	41	1681
GO:0051683	establishment of Golgi localization	1.87e-03	1.00e+00	9.061	1	2	3
GO:0006760	folic acid-containing compound metabolic process	1.87e-03	1.00e+00	9.061	1	1	3
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	1.87e-03	1.00e+00	9.061	1	1	3
GO:0009396	folic acid-containing compound biosynthetic process	1.87e-03	1.00e+00	9.061	1	1	3
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	1.87e-03	1.00e+00	9.061	1	1	3
GO:0004329	formate-tetrahydrofolate ligase activity	1.87e-03	1.00e+00	9.061	1	1	3
GO:0072384	organelle transport along microtubule	2.49e-03	1.00e+00	8.646	1	2	4
GO:0035999	tetrahydrofolate interconversion	3.74e-03	1.00e+00	8.061	1	1	6
GO:0032288	myelin assembly	3.74e-03	1.00e+00	8.061	1	1	6
GO:0010761	fibroblast migration	4.36e-03	1.00e+00	7.839	1	1	7
GO:0030157	pancreatic juice secretion	4.36e-03	1.00e+00	7.839	1	1	7
GO:0046653	tetrahydrofolate metabolic process	4.36e-03	1.00e+00	7.839	1	1	7
GO:2000178	negative regulation of neural precursor cell proliferation	4.98e-03	1.00e+00	7.646	1	1	8
GO:0010667	negative regulation of cardiac muscle cell apoptotic process	4.98e-03	1.00e+00	7.646	1	1	8
GO:0043206	extracellular fibril organization	5.60e-03	1.00e+00	7.476	1	1	9
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	6.22e-03	1.00e+00	7.324	1	1	10
GO:0005798	Golgi-associated vesicle	6.22e-03	1.00e+00	7.324	1	1	10
GO:0045663	positive regulation of myoblast differentiation	6.85e-03	1.00e+00	7.187	1	1	11
GO:0014912	negative regulation of smooth muscle cell migration	6.85e-03	1.00e+00	7.187	1	1	11
GO:0021675	nerve development	7.47e-03	1.00e+00	7.061	1	1	12
GO:0022011	myelination in peripheral nervous system	7.47e-03	1.00e+00	7.061	1	1	12
GO:0030131	clathrin adaptor complex	8.70e-03	1.00e+00	6.839	1	2	14
GO:0050775	positive regulation of dendrite morphogenesis	9.32e-03	1.00e+00	6.739	1	1	15
GO:0045773	positive regulation of axon extension	1.12e-02	1.00e+00	6.476	1	1	18
GO:0043034	costamere	1.24e-02	1.00e+00	6.324	1	2	20
GO:0043473	pigmentation	1.24e-02	1.00e+00	6.324	1	1	20
GO:0001954	positive regulation of cell-matrix adhesion	1.30e-02	1.00e+00	6.254	1	1	21
GO:0006730	one-carbon metabolic process	1.43e-02	1.00e+00	6.123	1	1	23
GO:0042327	positive regulation of phosphorylation	1.55e-02	1.00e+00	6.002	1	1	25
GO:0007569	cell aging	1.55e-02	1.00e+00	6.002	1	1	25
GO:0043231	intracellular membrane-bounded organelle	1.57e-02	1.00e+00	3.333	2	5	318
GO:0030513	positive regulation of BMP signaling pathway	1.61e-02	1.00e+00	5.946	1	1	26
GO:0048662	negative regulation of smooth muscle cell proliferation	1.73e-02	1.00e+00	5.839	1	1	28
GO:0043198	dendritic shaft	1.80e-02	1.00e+00	5.788	1	1	29
GO:0032956	regulation of actin cytoskeleton organization	1.86e-02	1.00e+00	5.739	1	2	30
GO:0048812	neuron projection morphogenesis	1.92e-02	1.00e+00	5.692	1	2	31
GO:0043491	protein kinase B signaling	1.98e-02	1.00e+00	5.646	1	1	32
GO:0000139	Golgi membrane	2.00e-02	1.00e+00	3.150	2	6	361
GO:0030017	sarcomere	2.10e-02	1.00e+00	5.559	1	2	34
GO:0034446	substrate adhesion-dependent cell spreading	2.22e-02	1.00e+00	5.476	1	1	36
GO:0070527	platelet aggregation	2.35e-02	1.00e+00	5.398	1	1	38
GO:0043195	terminal bouton	2.53e-02	1.00e+00	5.289	1	1	41
GO:0001658	branching involved in ureteric bud morphogenesis	2.65e-02	1.00e+00	5.220	1	1	43
GO:0008344	adult locomotory behavior	2.71e-02	1.00e+00	5.187	1	1	44
GO:0043406	positive regulation of MAP kinase activity	2.83e-02	1.00e+00	5.123	1	2	46
GO:0090263	positive regulation of canonical Wnt signaling pathway	2.96e-02	1.00e+00	5.061	1	2	48
GO:0045669	positive regulation of osteoblast differentiation	3.38e-02	1.00e+00	4.865	1	1	55
GO:0001725	stress fiber	3.38e-02	1.00e+00	4.865	1	1	55
GO:0051291	protein heterooligomerization	3.44e-02	1.00e+00	4.839	1	1	56
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	3.44e-02	1.00e+00	4.839	1	1	56
GO:0006469	negative regulation of protein kinase activity	3.98e-02	1.00e+00	4.624	1	1	65
GO:0034329	cell junction assembly	4.17e-02	1.00e+00	4.559	1	1	68
GO:0018105	peptidyl-serine phosphorylation	4.23e-02	1.00e+00	4.538	1	4	69
GO:0051897	positive regulation of protein kinase B signaling	4.29e-02	1.00e+00	4.517	1	2	70
GO:0007229	integrin-mediated signaling pathway	4.76e-02	1.00e+00	4.361	1	3	78
GO:0005179	hormone activity	4.82e-02	1.00e+00	4.342	1	1	79
GO:0007160	cell-matrix adhesion	5.00e-02	1.00e+00	4.289	1	1	82
GO:0005794	Golgi apparatus	5.28e-02	1.00e+00	2.393	2	9	610
GO:0005737	cytoplasm	5.81e-02	1.00e+00	1.089	5	43	3767
GO:0005178	integrin binding	5.83e-02	1.00e+00	4.061	1	2	96
GO:0017124	SH3 domain binding	6.84e-02	1.00e+00	3.826	1	1	113
GO:0043524	negative regulation of neuron apoptotic process	7.07e-02	1.00e+00	3.776	1	2	117
GO:0007050	cell cycle arrest	7.48e-02	1.00e+00	3.692	1	1	124
GO:0030027	lamellipodium	7.54e-02	1.00e+00	3.680	1	2	125
GO:0030335	positive regulation of cell migration	7.65e-02	1.00e+00	3.657	1	2	127
GO:0005911	cell-cell junction	8.18e-02	1.00e+00	3.559	1	2	136
GO:0004871	signal transducer activity	1.23e-01	1.00e+00	2.946	1	2	208
GO:0043025	neuronal cell body	1.43e-01	1.00e+00	2.710	1	4	245
GO:0043234	protein complex	1.70e-01	1.00e+00	2.442	1	6	295
GO:0004674	protein serine/threonine kinase activity	1.77e-01	1.00e+00	2.379	1	5	308
GO:0019901	protein kinase binding	1.81e-01	1.00e+00	2.338	1	6	317
GO:0008283	cell proliferation	1.87e-01	1.00e+00	2.289	1	4	328
GO:0005524	ATP binding	1.91e-01	1.00e+00	1.304	2	15	1298
GO:0030054	cell junction	1.91e-01	1.00e+00	2.254	1	4	336
GO:0005925	focal adhesion	2.07e-01	1.00e+00	2.130	1	19	366
GO:0008284	positive regulation of cell proliferation	2.15e-01	1.00e+00	2.069	1	7	382
GO:0055114	oxidation-reduction process	2.34e-01	1.00e+00	1.932	1	2	420
GO:0006468	protein phosphorylation	2.53e-01	1.00e+00	1.801	1	6	460
GO:0045893	positive regulation of transcription, DNA-templated	2.62e-01	1.00e+00	1.745	1	5	478
GO:0016032	viral process	2.88e-01	1.00e+00	1.585	1	33	534
GO:0005783	endoplasmic reticulum	2.98e-01	1.00e+00	1.527	1	3	556
GO:0042803	protein homodimerization activity	3.16e-01	1.00e+00	1.429	1	2	595
GO:0005615	extracellular space	4.61e-01	1.00e+00	0.744	1	2	957
GO:0005739	mitochondrion	4.76e-01	1.00e+00	0.683	1	8	998
GO:0044822	poly(A) RNA binding	4.96e-01	1.00e+00	0.602	1	32	1056
GO:0005886	plasma membrane	4.98e-01	1.00e+00	0.312	2	20	2582
GO:0005515	protein binding	5.61e-01	1.00e+00	0.090	4	62	6024
GO:0005730	nucleolus	6.63e-01	1.00e+00	-0.034	1	24	1641
GO:0070062	extracellular vesicular exosome	8.06e-01	1.00e+00	-0.583	1	40	2400
GO:0005634	nucleus	8.31e-01	1.00e+00	-0.508	2	43	4559

Tai-Luciferase

int-snw-25902

Statistics

Genes (9)

Interactions (17)

Related GO terms (101)