int-snw-23433

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
tai-screen-luciferase	6.337	2.49e-134	4.62e-07	2.89e-03

tai-screen-luciferase-int-snw-23433 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	tai-screen-luciferase gene score	Best subnetwork score	Degree	List-Gonzales GI	Tai-Hits
COPZ1	22818	32	-8.301	9.063	13	Yes	Yes
[ RHOQ ]	23433	1	1.414	6.337	19	-	-
COPA	1314	32	-9.395	9.063	170	Yes	Yes
CDC42EP2	10435	1	-2.649	6.337	5	-	-
CDC42	998	11	-6.960	8.389	265	Yes	Yes
GOPC	57120	1	1.749	6.337	31	-	-
ARCN1	372	32	-8.232	9.063	118	Yes	Yes
COPB2	9276	32	-13.168	9.063	41	Yes	Yes
COPG1	22820	9	-5.279	7.138	37	Yes	Yes
COPB1	1315	22	-6.221	9.063	118	Yes	Yes

Interactions (19)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
CDC42	998	CDC42EP2	10435	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid, HPRD, BIND, IntAct, SOURAV_MAPK_HIGH; int.HPRD: in vitro, in vivo
ARCN1	372	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
COPA	1314	COPB2	9276	pp	--	int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vivo
COPG1	22820	RHOQ	23433	pp	--	int.I2D: HPRD; int.HPRD: in vivo
ARCN1	372	COPB1	1315	pp	--	int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS; int.HPRD: in vivo
ARCN1	372	COPB2	9276	pp	--	int.I2D: HPRD, BCI; int.HPRD: in vivo
COPB1	1315	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium; int.DIP: MI:0915(physical association)
CDC42	998	GOPC	57120	pp	--	int.I2D: BioGrid
COPA	1314	COPB1	1315	pp	--	int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh
ARCN1	372	COPG1	22820	pp	--	int.I2D: HPRD; int.HPRD: in vivo
ARCN1	372	COPA	1314	pp	--	int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core; int.HPRD: in vivo
COPA	1314	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
COPB1	1315	RHOQ	23433	pp	--	int.I2D: HPRD, BCI; int.HPRD: in vivo
COPB1	1315	COPG1	22820	pp	--	int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association)
CDC42EP2	10435	RHOQ	23433	pp	--	int.I2D: BioGrid, HPRD, BIND; int.HPRD: in vitro, yeast 2-hybrid
COPB2	9276	COPG1	22820	pp	--	int.I2D: BioGrid
COPZ1	22818	COPG1	22820	pp	--	int.I2D: BioGrid, HPRD, BIND; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association)
COPB1	1315	COPB2	9276	pp	--	int.I2D: BioGrid
RHOQ	23433	GOPC	57120	pp	--	int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid

Related GO terms (149)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0030126	COPI vesicle coat	1.55e-17	2.24e-13	9.494	6	7	12
GO:0048205	COPI coating of Golgi vesicle	2.88e-17	4.15e-13	9.379	6	8	13
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	2.96e-15	4.28e-11	8.435	6	8	25
GO:0061024	membrane organization	1.89e-10	2.73e-06	5.899	6	12	145
GO:0006886	intracellular protein transport	5.14e-10	7.41e-06	5.661	6	7	171
GO:0006891	intra-Golgi vesicle-mediated transport	1.62e-07	2.34e-03	7.992	3	4	17
GO:0051683	establishment of Golgi localization	1.30e-06	1.87e-02	9.909	2	2	3
GO:0005198	structural molecule activity	2.25e-06	3.24e-02	5.265	4	6	150
GO:0072384	organelle transport along microtubule	2.59e-06	3.74e-02	9.494	2	2	4
GO:0031274	positive regulation of pseudopodium assembly	1.94e-05	2.80e-01	8.172	2	2	10
GO:0005829	cytosol	2.57e-05	3.71e-01	2.209	8	61	2496
GO:0000139	Golgi membrane	7.19e-05	1.00e+00	3.998	4	6	361
GO:0016020	membrane	3.44e-04	1.00e+00	2.364	6	41	1681
GO:0032427	GBD domain binding	6.93e-04	1.00e+00	10.494	1	1	1
GO:0021691	cerebellar Purkinje cell layer maturation	6.93e-04	1.00e+00	10.494	1	1	1
GO:0043004	cytoplasmic sequestering of CFTR protein	6.93e-04	1.00e+00	10.494	1	1	1
GO:0071338	positive regulation of hair follicle cell proliferation	1.39e-03	1.00e+00	9.494	1	1	2
GO:0090135	actin filament branching	1.39e-03	1.00e+00	9.494	1	1	2
GO:0060661	submandibular salivary gland formation	1.39e-03	1.00e+00	9.494	1	1	2
GO:0034191	apolipoprotein A-I receptor binding	2.08e-03	1.00e+00	8.909	1	1	3
GO:0003161	cardiac conduction system development	2.08e-03	1.00e+00	8.909	1	1	3
GO:0008360	regulation of cell shape	2.19e-03	1.00e+00	4.808	2	2	103
GO:0051056	regulation of small GTPase mediated signal transduction	2.72e-03	1.00e+00	4.649	2	4	115
GO:0060684	epithelial-mesenchymal cell signaling	2.77e-03	1.00e+00	8.494	1	1	4
GO:0051835	positive regulation of synapse structural plasticity	2.77e-03	1.00e+00	8.494	1	1	4
GO:0048664	neuron fate determination	2.77e-03	1.00e+00	8.494	1	1	4
GO:0001515	opioid peptide activity	2.77e-03	1.00e+00	8.494	1	1	4
GO:0030036	actin cytoskeleton organization	3.10e-03	1.00e+00	4.552	2	2	123
GO:0035088	establishment or maintenance of apical/basal cell polarity	3.46e-03	1.00e+00	8.172	1	1	5
GO:0036336	dendritic cell migration	3.46e-03	1.00e+00	8.172	1	1	5
GO:0031256	leading edge membrane	3.46e-03	1.00e+00	8.172	1	1	5
GO:0060789	hair follicle placode formation	4.15e-03	1.00e+00	7.909	1	1	6
GO:0007097	nuclear migration	4.15e-03	1.00e+00	7.909	1	1	6
GO:0003334	keratinocyte development	4.15e-03	1.00e+00	7.909	1	1	6
GO:0048554	positive regulation of metalloenzyme activity	4.15e-03	1.00e+00	7.909	1	1	6
GO:0043497	regulation of protein heterodimerization activity	4.15e-03	1.00e+00	7.909	1	1	6
GO:0030157	pancreatic juice secretion	4.84e-03	1.00e+00	7.687	1	1	7
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	4.84e-03	1.00e+00	7.687	1	1	7
GO:0090005	negative regulation of establishment of protein localization to plasma membrane	4.84e-03	1.00e+00	7.687	1	1	7
GO:0006893	Golgi to plasma membrane transport	4.84e-03	1.00e+00	7.687	1	1	7
GO:0051489	regulation of filopodium assembly	4.84e-03	1.00e+00	7.687	1	1	7
GO:0007289	spermatid nucleus differentiation	5.53e-03	1.00e+00	7.494	1	1	8
GO:0005522	profilin binding	5.53e-03	1.00e+00	7.494	1	1	8
GO:0090136	epithelial cell-cell adhesion	6.22e-03	1.00e+00	7.324	1	1	9
GO:0017049	GTP-Rho binding	6.22e-03	1.00e+00	7.324	1	1	9
GO:0005798	Golgi-associated vesicle	6.91e-03	1.00e+00	7.172	1	1	10
GO:0060047	heart contraction	6.91e-03	1.00e+00	7.172	1	1	10
GO:0005794	Golgi apparatus	7.23e-03	1.00e+00	2.826	3	9	610
GO:0045176	apical protein localization	7.60e-03	1.00e+00	7.035	1	1	11
GO:0003924	GTPase activity	7.77e-03	1.00e+00	3.872	2	7	197
GO:0030140	trans-Golgi network transport vesicle	8.29e-03	1.00e+00	6.909	1	1	12
GO:0031334	positive regulation of protein complex assembly	8.98e-03	1.00e+00	6.794	1	1	13
GO:0006184	GTP catabolic process	9.12e-03	1.00e+00	3.753	2	7	214
GO:0031333	negative regulation of protein complex assembly	9.67e-03	1.00e+00	6.687	1	1	14
GO:0031996	thioesterase binding	9.67e-03	1.00e+00	6.687	1	1	14
GO:0030131	clathrin adaptor complex	9.67e-03	1.00e+00	6.687	1	2	14
GO:0051233	spindle midzone	1.04e-02	1.00e+00	6.587	1	2	15
GO:0030225	macrophage differentiation	1.04e-02	1.00e+00	6.587	1	1	15
GO:0042176	regulation of protein catabolic process	1.10e-02	1.00e+00	6.494	1	3	16
GO:0030742	GTP-dependent protein binding	1.17e-02	1.00e+00	6.407	1	1	17
GO:0090316	positive regulation of intracellular protein transport	1.17e-02	1.00e+00	6.407	1	1	17
GO:0007088	regulation of mitosis	1.24e-02	1.00e+00	6.324	1	1	18
GO:0046847	filopodium assembly	1.31e-02	1.00e+00	6.246	1	1	19
GO:0030866	cortical actin cytoskeleton organization	1.31e-02	1.00e+00	6.246	1	1	19
GO:0043473	pigmentation	1.38e-02	1.00e+00	6.172	1	1	20
GO:0051491	positive regulation of filopodium assembly	1.45e-02	1.00e+00	6.102	1	1	21
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1.45e-02	1.00e+00	6.102	1	1	21
GO:0007264	small GTPase mediated signal transduction	1.51e-02	1.00e+00	3.370	2	7	279
GO:0031424	keratinization	1.52e-02	1.00e+00	6.035	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.52e-02	1.00e+00	6.035	1	3	22
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	1.58e-02	1.00e+00	5.971	1	1	23
GO:0005100	Rho GTPase activator activity	1.58e-02	1.00e+00	5.971	1	1	23
GO:0002040	sprouting angiogenesis	1.58e-02	1.00e+00	5.971	1	1	23
GO:0051017	actin filament bundle assembly	1.58e-02	1.00e+00	5.971	1	1	23
GO:0007163	establishment or maintenance of cell polarity	1.65e-02	1.00e+00	5.909	1	1	24
GO:0046326	positive regulation of glucose import	1.65e-02	1.00e+00	5.909	1	1	24
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	1.79e-02	1.00e+00	5.794	1	2	26
GO:0045859	regulation of protein kinase activity	1.79e-02	1.00e+00	5.794	1	1	26
GO:0005083	small GTPase regulator activity	1.79e-02	1.00e+00	5.794	1	1	26
GO:0005525	GTP binding	1.85e-02	1.00e+00	3.218	2	7	310
GO:0051149	positive regulation of muscle cell differentiation	1.86e-02	1.00e+00	5.739	1	1	27
GO:0032467	positive regulation of cytokinesis	1.86e-02	1.00e+00	5.739	1	1	27
GO:0031069	hair follicle morphogenesis	1.86e-02	1.00e+00	5.739	1	1	27
GO:0043231	intracellular membrane-bounded organelle	1.94e-02	1.00e+00	3.181	2	5	318
GO:0072686	mitotic spindle	1.99e-02	1.00e+00	5.636	1	1	29
GO:0032956	regulation of actin cytoskeleton organization	2.06e-02	1.00e+00	5.587	1	2	30
GO:0031647	regulation of protein stability	2.06e-02	1.00e+00	5.587	1	1	30
GO:0005886	plasma membrane	2.08e-02	1.00e+00	1.482	5	20	2582
GO:0030838	positive regulation of actin filament polymerization	2.33e-02	1.00e+00	5.407	1	1	34
GO:0042692	muscle cell differentiation	2.33e-02	1.00e+00	5.407	1	1	34
GO:0005737	cytoplasm	2.44e-02	1.00e+00	1.200	6	43	3767
GO:0034332	adherens junction organization	2.47e-02	1.00e+00	5.324	1	2	36
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	2.47e-02	1.00e+00	5.324	1	3	36
GO:0045740	positive regulation of DNA replication	2.47e-02	1.00e+00	5.324	1	1	36
GO:0007015	actin filament organization	2.54e-02	1.00e+00	5.285	1	1	37
GO:0021762	substantia nigra development	3.01e-02	1.00e+00	5.035	1	1	44
GO:0034613	cellular protein localization	3.01e-02	1.00e+00	5.035	1	2	44
GO:0008344	adult locomotory behavior	3.01e-02	1.00e+00	5.035	1	1	44
GO:0005884	actin filament	3.01e-02	1.00e+00	5.035	1	1	44
GO:0043525	positive regulation of neuron apoptotic process	3.14e-02	1.00e+00	4.971	1	2	46
GO:0007030	Golgi organization	3.35e-02	1.00e+00	4.879	1	2	49
GO:0030175	filopodium	3.41e-02	1.00e+00	4.850	1	2	50
GO:0006888	ER to Golgi vesicle-mediated transport	3.62e-02	1.00e+00	4.766	1	1	53
GO:0046330	positive regulation of JNK cascade	3.75e-02	1.00e+00	4.713	1	1	55
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	3.82e-02	1.00e+00	4.687	1	1	56
GO:0012505	endomembrane system	3.82e-02	1.00e+00	4.687	1	1	56
GO:0033138	positive regulation of peptidyl-serine phosphorylation	4.02e-02	1.00e+00	4.612	1	1	59
GO:0030141	secretory granule	4.22e-02	1.00e+00	4.540	1	1	62
GO:0032869	cellular response to insulin stimulus	4.28e-02	1.00e+00	4.517	1	2	63
GO:0031295	T cell costimulation	4.42e-02	1.00e+00	4.472	1	3	65
GO:0035264	multicellular organism growth	4.55e-02	1.00e+00	4.428	1	1	67
GO:0050790	regulation of catalytic activity	4.68e-02	1.00e+00	4.386	1	1	69
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.02e-02	1.00e+00	4.285	1	2	74
GO:0044325	ion channel binding	5.08e-02	1.00e+00	4.265	1	3	75
GO:0060070	canonical Wnt signaling pathway	5.08e-02	1.00e+00	4.265	1	1	75
GO:0010629	negative regulation of gene expression	5.21e-02	1.00e+00	4.227	1	2	77
GO:0005179	hormone activity	5.35e-02	1.00e+00	4.190	1	1	79
GO:0045177	apical part of cell	5.48e-02	1.00e+00	4.154	1	1	81
GO:0032321	positive regulation of Rho GTPase activity	5.54e-02	1.00e+00	4.137	1	1	82
GO:0014069	postsynaptic density	7.05e-02	1.00e+00	3.780	1	3	105
GO:0030496	midbody	7.24e-02	1.00e+00	3.739	1	2	108
GO:0005815	microtubule organizing center	7.31e-02	1.00e+00	3.726	1	3	109
GO:0015630	microtubule cytoskeleton	7.37e-02	1.00e+00	3.713	1	3	110
GO:0005911	cell-cell junction	9.04e-02	1.00e+00	3.407	1	2	136
GO:0008286	insulin receptor signaling pathway	9.42e-02	1.00e+00	3.344	1	3	142
GO:0051260	protein homooligomerization	9.61e-02	1.00e+00	3.314	1	2	145
GO:0010628	positive regulation of gene expression	9.68e-02	1.00e+00	3.304	1	4	146
GO:0045121	membrane raft	1.03e-01	1.00e+00	3.209	1	3	156
GO:0043005	neuron projection	1.04e-01	1.00e+00	3.200	1	6	157
GO:0045211	postsynaptic membrane	1.12e-01	1.00e+00	3.085	1	4	170
GO:0007173	epidermal growth factor receptor signaling pathway	1.24e-01	1.00e+00	2.932	1	4	189
GO:0030425	dendrite	1.49e-01	1.00e+00	2.649	1	2	230
GO:0043025	neuronal cell body	1.57e-01	1.00e+00	2.558	1	4	245
GO:0043234	protein complex	1.87e-01	1.00e+00	2.290	1	6	295
GO:0019901	protein kinase binding	1.99e-01	1.00e+00	2.186	1	6	317
GO:0007411	axon guidance	2.00e-01	1.00e+00	2.177	1	3	319
GO:0030054	cell junction	2.10e-01	1.00e+00	2.102	1	4	336
GO:0015031	protein transport	2.13e-01	1.00e+00	2.081	1	8	341
GO:0070062	extracellular vesicular exosome	2.24e-01	1.00e+00	0.850	3	40	2400
GO:0005925	focal adhesion	2.27e-01	1.00e+00	1.978	1	19	366
GO:0007596	blood coagulation	2.74e-01	1.00e+00	1.664	1	3	455
GO:0042802	identical protein binding	2.89e-01	1.00e+00	1.575	1	3	484
GO:0016032	viral process	3.14e-01	1.00e+00	1.433	1	33	534
GO:0005783	endoplasmic reticulum	3.25e-01	1.00e+00	1.375	1	3	556
GO:0045087	innate immune response	3.44e-01	1.00e+00	1.275	1	8	596
GO:0005515	protein binding	4.12e-01	1.00e+00	0.260	5	62	6024
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	4.30e-01	1.00e+00	0.870	1	6	789
GO:0005615	extracellular space	4.97e-01	1.00e+00	0.592	1	2	957
GO:0044822	poly(A) RNA binding	5.33e-01	1.00e+00	0.450	1	32	1056

Tai-Luciferase

int-snw-23433

Statistics

Genes (10)

Interactions (19)

Related GO terms (149)