int-snw-23193

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
tai-screen-luciferase	6.468	5.52e-141	1.92e-07	1.97e-03

tai-screen-luciferase-int-snw-23193 subnetwork

Genes (12)

Gene Symbol	Entrez Gene ID	Frequency	tai-screen-luciferase gene score	Best subnetwork score	Degree	List-Gonzales GI	Tai-Hits
MAPK8	5599	2	-4.403	6.468	153	-	-
COPZ1	22818	32	-8.301	9.063	13	Yes	Yes
ATP13A1	57130	1	3.062	6.468	110	-	-
COPA	1314	32	-9.395	9.063	170	Yes	Yes
RPS27A	6233	15	-5.631	8.389	342	Yes	-
RPS24	6229	21	-7.034	8.389	217	Yes	-
GGA3	23163	1	-2.668	6.468	62	Yes	-
[ GANAB ]	23193	1	-2.374	6.468	83	-	-
ARCN1	372	32	-8.232	9.063	118	Yes	Yes
RPS9	6203	18	-7.127	7.555	140	Yes	-
COPB2	9276	32	-13.168	9.063	41	Yes	Yes
COPB1	1315	22	-6.221	9.063	118	Yes	Yes

Interactions (18)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
RPS9	6203	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
RPS27A	6233	GGA3	23163	pp	--	int.I2D: BCI, BioGrid_Yeast, BIND, HPRD; int.HPRD: in vitro, yeast 2-hybrid
COPA	1314	COPB1	1315	pp	--	int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh
MAPK8	5599	GANAB	23193	pp	--	int.Intact: MI:0915(physical association)
GANAB	23193	ATP13A1	57130	pp	--	int.I2D: BioGrid_Yeast
ARCN1	372	COPB1	1315	pp	--	int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS; int.HPRD: in vivo
COPA	1314	RPS27A	6233	pp	--	int.I2D: YeastLow
ARCN1	372	COPA	1314	pp	--	int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core; int.HPRD: in vivo
COPA	1314	GANAB	23193	pp	--	int.I2D: IntAct_Yeast
ARCN1	372	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
COPA	1314	COPB2	9276	pp	--	int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vivo
GGA3	23163	GANAB	23193	pp	--	int.I2D: BioGrid_Yeast
ARCN1	372	COPB2	9276	pp	--	int.I2D: HPRD, BCI; int.HPRD: in vivo
COPA	1314	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
COPB1	1315	COPB2	9276	pp	--	int.I2D: BioGrid
RPS24	6229	GGA3	23163	pp	--	int.I2D: BioGrid_Yeast
RPS24	6229	RPS27A	6233	pp	--	int.I2D: YeastMedium
COPB1	1315	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium; int.DIP: MI:0915(physical association)

Related GO terms (176)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0030126	COPI vesicle coat	1.20e-13	1.74e-09	8.968	5	7	12
GO:0048205	COPI coating of Golgi vesicle	1.95e-13	2.82e-09	8.853	5	8	13
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	8.03e-12	1.16e-07	7.909	5	8	25
GO:0061024	membrane organization	8.18e-10	1.18e-05	5.636	6	12	145
GO:0006886	intracellular protein transport	2.22e-09	3.20e-05	5.398	6	7	171
GO:0006891	intra-Golgi vesicle-mediated transport	2.97e-07	4.29e-03	7.729	3	4	17
GO:0022627	cytosolic small ribosomal subunit	3.95e-06	5.70e-02	6.531	3	20	39
GO:0016020	membrane	1.08e-05	1.55e-01	2.516	8	41	1681
GO:0005829	cytosol	1.83e-05	2.63e-01	2.116	9	61	2496
GO:0019083	viral transcription	3.62e-05	5.22e-01	5.476	3	20	81
GO:0006415	translational termination	4.48e-05	6.47e-01	5.373	3	20	87
GO:0006414	translational elongation	5.47e-05	7.90e-01	5.277	3	20	93
GO:0030131	clathrin adaptor complex	5.74e-05	8.28e-01	7.424	2	2	14
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7.64e-05	1.00e+00	5.116	3	20	104
GO:0015935	small ribosomal subunit	8.57e-05	1.00e+00	7.144	2	9	17
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1.00e-04	1.00e+00	4.983	3	20	114
GO:0019058	viral life cycle	1.03e-04	1.00e+00	4.971	3	23	115
GO:0006413	translational initiation	1.52e-04	1.00e+00	4.783	3	21	131
GO:0003735	structural constituent of ribosome	1.73e-04	1.00e+00	4.718	3	22	137
GO:0005198	structural molecule activity	2.26e-04	1.00e+00	4.587	3	6	150
GO:0044267	cellular protein metabolic process	4.62e-04	1.00e+00	3.342	4	23	474
GO:0016071	mRNA metabolic process	7.24e-04	1.00e+00	4.015	3	25	223
GO:0016032	viral process	7.25e-04	1.00e+00	3.170	4	33	534
GO:0007254	JNK cascade	7.30e-04	1.00e+00	5.616	2	3	49
GO:0006412	translation	7.92e-04	1.00e+00	3.971	3	23	230
GO:0021691	cerebellar Purkinje cell layer maturation	8.32e-04	1.00e+00	10.231	1	1	1
GO:0033919	glucan 1,3-alpha-glucosidase activity	8.32e-04	1.00e+00	10.231	1	1	1
GO:0017177	glucosidase II complex	8.32e-04	1.00e+00	10.231	1	1	1
GO:0051403	stress-activated MAPK cascade	8.87e-04	1.00e+00	5.476	2	3	54
GO:0016070	RNA metabolic process	9.74e-04	1.00e+00	3.868	3	25	247
GO:0044822	poly(A) RNA binding	1.07e-03	1.00e+00	2.509	5	32	1056
GO:0034146	toll-like receptor 5 signaling pathway	1.28e-03	1.00e+00	5.209	2	4	65
GO:0034166	toll-like receptor 10 signaling pathway	1.28e-03	1.00e+00	5.209	2	4	65
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	1.53e-03	1.00e+00	5.081	2	4	71
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	1.53e-03	1.00e+00	5.081	2	4	71
GO:0034162	toll-like receptor 9 signaling pathway	1.57e-03	1.00e+00	5.061	2	4	72
GO:0034134	toll-like receptor 2 signaling pathway	1.61e-03	1.00e+00	5.041	2	4	73
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	1.75e-03	1.00e+00	4.983	2	4	76
GO:0002756	MyD88-independent toll-like receptor signaling pathway	1.84e-03	1.00e+00	4.946	2	4	78
GO:0034138	toll-like receptor 3 signaling pathway	1.89e-03	1.00e+00	4.927	2	4	79
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	1.93e-03	1.00e+00	4.909	2	4	80
GO:0090045	positive regulation of deacetylase activity	2.49e-03	1.00e+00	8.646	1	1	3
GO:0035033	histone deacetylase regulator activity	2.49e-03	1.00e+00	8.646	1	1	3
GO:2000017	positive regulation of determination of dorsal identity	2.49e-03	1.00e+00	8.646	1	1	3
GO:0004705	JUN kinase activity	2.49e-03	1.00e+00	8.646	1	1	3
GO:0034142	toll-like receptor 4 signaling pathway	2.77e-03	1.00e+00	4.646	2	4	96
GO:0007258	JUN phosphorylation	3.32e-03	1.00e+00	8.231	1	1	4
GO:0031063	regulation of histone deacetylation	3.32e-03	1.00e+00	8.231	1	1	4
GO:0002224	toll-like receptor signaling pathway	3.55e-03	1.00e+00	4.463	2	4	109
GO:0097190	apoptotic signaling pathway	3.81e-03	1.00e+00	4.411	2	3	113
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	4.15e-03	1.00e+00	7.909	1	3	5
GO:0097300	programmed necrotic cell death	4.15e-03	1.00e+00	7.909	1	1	5
GO:0030306	ADP-ribosylation factor binding	4.98e-03	1.00e+00	7.646	1	1	6
GO:0045182	translation regulator activity	4.98e-03	1.00e+00	7.646	1	2	6
GO:0030157	pancreatic juice secretion	5.81e-03	1.00e+00	7.424	1	1	7
GO:0034101	erythrocyte homeostasis	5.81e-03	1.00e+00	7.424	1	1	7
GO:0010008	endosome membrane	6.71e-03	1.00e+00	3.993	2	5	151
GO:0019829	cation-transporting ATPase activity	7.47e-03	1.00e+00	7.061	1	1	9
GO:0071732	cellular response to nitric oxide	7.47e-03	1.00e+00	7.061	1	1	9
GO:0038095	Fc-epsilon receptor signaling pathway	8.24e-03	1.00e+00	3.839	2	3	168
GO:0005798	Golgi-associated vesicle	8.29e-03	1.00e+00	6.909	1	1	10
GO:0019082	viral protein processing	9.94e-03	1.00e+00	6.646	1	2	12
GO:0042274	ribosomal small subunit biogenesis	9.94e-03	1.00e+00	6.646	1	6	12
GO:0032479	regulation of type I interferon production	1.08e-02	1.00e+00	6.531	1	2	13
GO:0031369	translation initiation factor binding	1.24e-02	1.00e+00	6.324	1	1	15
GO:0005794	Golgi apparatus	1.24e-02	1.00e+00	2.563	3	9	610
GO:0075733	intracellular transport of virus	1.41e-02	1.00e+00	6.144	1	3	17
GO:0019068	virion assembly	1.41e-02	1.00e+00	6.144	1	2	17
GO:0010467	gene expression	1.60e-02	1.00e+00	2.430	3	29	669
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	1.65e-02	1.00e+00	5.909	1	1	20
GO:0043473	pigmentation	1.65e-02	1.00e+00	5.909	1	1	20
GO:0007220	Notch receptor processing	1.82e-02	1.00e+00	5.772	1	2	22
GO:0046686	response to cadmium ion	1.82e-02	1.00e+00	5.772	1	1	22
GO:0043065	positive regulation of apoptotic process	2.01e-02	1.00e+00	3.165	2	6	268
GO:0048011	neurotrophin TRK receptor signaling pathway	2.02e-02	1.00e+00	3.160	2	4	269
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	2.06e-02	1.00e+00	5.587	1	2	25
GO:0005978	glycogen biosynthetic process	2.14e-02	1.00e+00	5.531	1	2	26
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	2.14e-02	1.00e+00	5.531	1	1	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	2.14e-02	1.00e+00	5.531	1	2	26
GO:0019843	rRNA binding	2.22e-02	1.00e+00	5.476	1	4	27
GO:0032091	negative regulation of protein binding	2.63e-02	1.00e+00	5.231	1	1	32
GO:0032480	negative regulation of type I interferon production	2.63e-02	1.00e+00	5.231	1	2	32
GO:0043231	intracellular membrane-bounded organelle	2.76e-02	1.00e+00	2.918	2	5	318
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	2.96e-02	1.00e+00	5.061	1	3	36
GO:0018107	peptidyl-threonine phosphorylation	3.04e-02	1.00e+00	5.022	1	1	37
GO:0032880	regulation of protein localization	3.04e-02	1.00e+00	5.022	1	1	37
GO:0007249	I-kappaB kinase/NF-kappaB signaling	3.36e-02	1.00e+00	4.874	1	3	41
GO:0070301	cellular response to hydrogen peroxide	3.36e-02	1.00e+00	4.874	1	2	41
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	3.52e-02	1.00e+00	4.805	1	2	43
GO:0008344	adult locomotory behavior	3.60e-02	1.00e+00	4.772	1	1	44
GO:0009411	response to UV	3.60e-02	1.00e+00	4.772	1	1	44
GO:0006950	response to stress	3.76e-02	1.00e+00	4.708	1	1	46
GO:0098655	cation transmembrane transport	3.92e-02	1.00e+00	4.646	1	1	48
GO:0030666	endocytic vesicle membrane	4.32e-02	1.00e+00	4.503	1	2	53
GO:0097193	intrinsic apoptotic signaling pathway	4.48e-02	1.00e+00	4.450	1	1	55
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	4.56e-02	1.00e+00	4.424	1	1	56
GO:0016197	endosomal transport	4.64e-02	1.00e+00	4.398	1	3	57
GO:0043066	negative regulation of apoptotic process	4.68e-02	1.00e+00	2.503	2	13	424
GO:0005840	ribosome	4.72e-02	1.00e+00	4.373	1	8	58
GO:0032481	positive regulation of type I interferon production	4.96e-02	1.00e+00	4.300	1	3	61
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	4.96e-02	1.00e+00	4.300	1	2	61
GO:0006417	regulation of translation	5.04e-02	1.00e+00	4.277	1	2	62
GO:0001503	ossification	5.20e-02	1.00e+00	4.231	1	1	64
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	5.20e-02	1.00e+00	4.231	1	6	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.28e-02	1.00e+00	4.209	1	6	65
GO:0071260	cellular response to mechanical stimulus	5.28e-02	1.00e+00	4.209	1	2	65
GO:0018105	peptidyl-serine phosphorylation	5.59e-02	1.00e+00	4.123	1	4	69
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.67e-02	1.00e+00	4.102	1	8	70
GO:0042826	histone deacetylase binding	5.83e-02	1.00e+00	4.061	1	1	72
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	5.83e-02	1.00e+00	4.061	1	6	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.99e-02	1.00e+00	4.022	1	8	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	6.07e-02	1.00e+00	4.002	1	6	75
GO:0005179	hormone activity	6.38e-02	1.00e+00	3.927	1	1	79
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	6.38e-02	1.00e+00	3.927	1	8	79
GO:0018279	protein N-linked glycosylation via asparagine	6.54e-02	1.00e+00	3.891	1	1	81
GO:0071222	cellular response to lipopolysaccharide	6.54e-02	1.00e+00	3.891	1	3	81
GO:0050852	T cell receptor signaling pathway	6.85e-02	1.00e+00	3.822	1	2	85
GO:0000187	activation of MAPK activity	7.24e-02	1.00e+00	3.739	1	2	90
GO:0042470	melanosome	7.32e-02	1.00e+00	3.723	1	2	91
GO:0071456	cellular response to hypoxia	7.39e-02	1.00e+00	3.708	1	3	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	7.39e-02	1.00e+00	3.708	1	6	92
GO:0006364	rRNA processing	7.55e-02	1.00e+00	3.677	1	7	94
GO:0006915	apoptotic process	7.56e-02	1.00e+00	2.115	2	9	555
GO:0045087	innate immune response	8.56e-02	1.00e+00	2.012	2	8	596
GO:0005802	trans-Golgi network	8.78e-02	1.00e+00	3.450	1	3	110
GO:0030529	ribonucleoprotein complex	8.93e-02	1.00e+00	3.424	1	7	112
GO:0000209	protein polyubiquitination	9.24e-02	1.00e+00	3.373	1	7	116
GO:0016192	vesicle-mediated transport	9.32e-02	1.00e+00	3.361	1	1	117
GO:0006006	glucose metabolic process	9.39e-02	1.00e+00	3.348	1	3	118
GO:0007219	Notch signaling pathway	9.54e-02	1.00e+00	3.324	1	3	120
GO:0051092	positive regulation of NF-kappaB transcription factor activity	9.85e-02	1.00e+00	3.277	1	3	124
GO:0007179	transforming growth factor beta receptor signaling pathway	1.01e-01	1.00e+00	3.231	1	3	128
GO:0030246	carbohydrate binding	1.06e-01	1.00e+00	3.165	1	1	134
GO:0000086	G2/M transition of mitotic cell cycle	1.08e-01	1.00e+00	3.144	1	5	136
GO:0006457	protein folding	1.13e-01	1.00e+00	3.071	1	2	143
GO:0005788	endoplasmic reticulum lumen	1.14e-01	1.00e+00	3.051	1	1	145
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	1.14e-01	1.00e+00	3.051	1	3	145
GO:0010628	positive regulation of gene expression	1.15e-01	1.00e+00	3.041	1	4	146
GO:0034220	ion transmembrane transport	1.17e-01	1.00e+00	3.012	1	2	149
GO:0000082	G1/S transition of mitotic cell cycle	1.17e-01	1.00e+00	3.012	1	9	149
GO:0042981	regulation of apoptotic process	1.18e-01	1.00e+00	3.002	1	7	150
GO:0008543	fibroblast growth factor receptor signaling pathway	1.22e-01	1.00e+00	2.946	1	3	156
GO:0070062	extracellular vesicular exosome	1.25e-01	1.00e+00	1.002	4	40	2400
GO:0043687	post-translational protein modification	1.27e-01	1.00e+00	2.891	1	1	162
GO:0006367	transcription initiation from RNA polymerase II promoter	1.43e-01	1.00e+00	2.708	1	3	184
GO:0007173	epidermal growth factor receptor signaling pathway	1.46e-01	1.00e+00	2.669	1	4	189
GO:0019221	cytokine-mediated signaling pathway	1.69e-01	1.00e+00	2.443	1	2	221
GO:0005737	cytoplasm	1.81e-01	1.00e+00	0.674	5	43	3767
GO:0005975	carbohydrate metabolic process	1.91e-01	1.00e+00	2.248	1	3	253
GO:0000166	nucleotide binding	1.95e-01	1.00e+00	2.214	1	2	259
GO:0006281	DNA repair	1.97e-01	1.00e+00	2.203	1	4	261
GO:0006200	ATP catabolic process	2.18e-01	1.00e+00	2.041	1	3	292
GO:0005654	nucleoplasm	2.26e-01	1.00e+00	1.152	2	15	1082
GO:0004674	protein serine/threonine kinase activity	2.28e-01	1.00e+00	1.964	1	5	308
GO:0000139	Golgi membrane	2.62e-01	1.00e+00	1.735	1	6	361
GO:0005925	focal adhesion	2.65e-01	1.00e+00	1.715	1	19	366
GO:0008284	positive regulation of cell proliferation	2.75e-01	1.00e+00	1.654	1	7	382
GO:0008150	biological_process	2.80e-01	1.00e+00	1.627	1	3	389
GO:0000278	mitotic cell cycle	2.81e-01	1.00e+00	1.620	1	11	391
GO:0005524	ATP binding	2.95e-01	1.00e+00	0.889	2	15	1298
GO:0046872	metal ion binding	2.98e-01	1.00e+00	0.879	2	10	1307
GO:0055085	transmembrane transport	3.08e-01	1.00e+00	1.466	1	3	435
GO:0003674	molecular_function	3.13e-01	1.00e+00	1.437	1	1	444
GO:0005783	endoplasmic reticulum	3.76e-01	1.00e+00	1.112	1	3	556
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.84e-01	1.00e+00	1.076	1	7	570
GO:0005789	endoplasmic reticulum membrane	3.84e-01	1.00e+00	1.076	1	3	570
GO:0005730	nucleolus	4.04e-01	1.00e+00	0.551	2	24	1641
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	4.91e-01	1.00e+00	0.607	1	6	789
GO:0005615	extracellular space	5.61e-01	1.00e+00	0.329	1	2	957
GO:0005739	mitochondrion	5.77e-01	1.00e+00	0.268	1	8	998
GO:0044281	small molecule metabolic process	6.51e-01	1.00e+00	-0.011	1	15	1211
GO:0005886	plasma membrane	6.61e-01	1.00e+00	-0.103	2	20	2582
GO:0006351	transcription, DNA-templated	7.19e-01	1.00e+00	-0.267	1	6	1446
GO:0005634	nucleus	7.84e-01	1.00e+00	-0.338	3	43	4559
GO:0005515	protein binding	8.10e-01	1.00e+00	-0.325	4	62	6024
GO:0016021	integral component of membrane	8.30e-01	1.00e+00	-0.722	1	5	1982

Tai-Luciferase

int-snw-23193

Statistics

Genes (12)

Interactions (18)

Related GO terms (176)