int-snw-1812
Statistics
| Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
|---|---|---|---|---|
| tai-screen-luciferase | 6.767 | 9.13e-157 | 2.34e-08 | 7.76e-04 |
Genes (8)
| Gene Symbol | Entrez Gene ID | Frequency | tai-screen-luciferase gene score | Best subnetwork score | Degree | List-Gonzales GI | Tai-Hits |
|---|---|---|---|---|---|---|---|
| COPZ1 | 22818 | 32 | -8.301 | 9.063 | 13 | Yes | Yes |
| DNAJC14 | 85406 | 1 | -1.851 | 6.767 | 9 | - | - |
| COPA | 1314 | 32 | -9.395 | 9.063 | 170 | Yes | Yes |
| ARCN1 | 372 | 32 | -8.232 | 9.063 | 118 | Yes | Yes |
| COPB1 | 1315 | 22 | -6.221 | 9.063 | 118 | Yes | Yes |
| COPG1 | 22820 | 9 | -5.279 | 7.138 | 37 | Yes | Yes |
| COPB2 | 9276 | 32 | -13.168 | 9.063 | 41 | Yes | Yes |
| [ DRD1 ] | 1812 | 1 | -1.689 | 6.767 | 12 | - | - |
Interactions (15)
| Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
|---|---|---|---|---|---|---|
| COPA | 1314 | COPB1 | 1315 | pp | -- | int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh |
| ARCN1 | 372 | COPG1 | 22820 | pp | -- | int.I2D: HPRD; int.HPRD: in vivo |
| DRD1 | 1812 | DNAJC14 | 85406 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: in vitro, yeast 2-hybrid |
| ARCN1 | 372 | COPA | 1314 | pp | -- | int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core; int.HPRD: in vivo |
| ARCN1 | 372 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG |
| COPA | 1314 | COPB2 | 9276 | pp | -- | int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vivo |
| COPA | 1314 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium |
| COPB1 | 1315 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association) |
| ARCN1 | 372 | COPB1 | 1315 | pp | -- | int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS; int.HPRD: in vivo |
| DRD1 | 1812 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo |
| COPB2 | 9276 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid |
| COPZ1 | 22818 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid, HPRD, BIND; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association) |
| ARCN1 | 372 | COPB2 | 9276 | pp | -- | int.I2D: HPRD, BCI; int.HPRD: in vivo |
| COPB1 | 1315 | COPB2 | 9276 | pp | -- | int.I2D: BioGrid |
| COPB1 | 1315 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium; int.DIP: MI:0915(physical association) |
Related GO terms (85)
| Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
|---|---|---|---|---|---|---|---|
| GO:0030126 | COPI vesicle coat | 2.07e-18 | 2.99e-14 | 9.816 | 6 | 7 | 12 |
| GO:0048205 | COPI coating of Golgi vesicle | 3.84e-18 | 5.54e-14 | 9.701 | 6 | 8 | 13 |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | 3.96e-16 | 5.71e-12 | 8.757 | 6 | 8 | 25 |
| GO:0061024 | membrane organization | 2.56e-11 | 3.70e-07 | 6.221 | 6 | 12 | 145 |
| GO:0006886 | intracellular protein transport | 6.99e-11 | 1.01e-06 | 5.983 | 6 | 7 | 171 |
| GO:0006891 | intra-Golgi vesicle-mediated transport | 7.59e-08 | 1.09e-03 | 8.314 | 3 | 4 | 17 |
| GO:0005198 | structural molecule activity | 7.62e-07 | 1.10e-02 | 5.587 | 4 | 6 | 150 |
| GO:0005829 | cytosol | 5.44e-04 | 1.00e+00 | 2.116 | 6 | 61 | 2496 |
| GO:0021691 | cerebellar Purkinje cell layer maturation | 5.55e-04 | 1.00e+00 | 10.816 | 1 | 1 | 1 |
| GO:0046960 | sensitization | 1.11e-03 | 1.00e+00 | 9.816 | 1 | 1 | 2 |
| GO:0001588 | dopamine neurotransmitter receptor activity, coupled via Gs | 1.11e-03 | 1.00e+00 | 9.816 | 1 | 1 | 2 |
| GO:0046959 | habituation | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 3 |
| GO:0021853 | cerebral cortex GABAergic interneuron migration | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 3 |
| GO:0051683 | establishment of Golgi localization | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 2 | 3 |
| GO:0004952 | dopamine neurotransmitter receptor activity | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 3 |
| GO:0035106 | operant conditioning | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 3 |
| GO:0072384 | organelle transport along microtubule | 2.22e-03 | 1.00e+00 | 8.816 | 1 | 2 | 4 |
| GO:0051584 | regulation of dopamine uptake involved in synaptic transmission | 2.77e-03 | 1.00e+00 | 8.494 | 1 | 1 | 5 |
| GO:0001661 | conditioned taste aversion | 2.77e-03 | 1.00e+00 | 8.494 | 1 | 1 | 5 |
| GO:0015872 | dopamine transport | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 6 |
| GO:0010579 | positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 6 |
| GO:0046323 | glucose import | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 6 |
| GO:0071870 | cellular response to catecholamine stimulus | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 6 |
| GO:0030157 | pancreatic juice secretion | 3.88e-03 | 1.00e+00 | 8.009 | 1 | 1 | 7 |
| GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway | 4.43e-03 | 1.00e+00 | 7.816 | 1 | 1 | 8 |
| GO:0030432 | peristalsis | 4.43e-03 | 1.00e+00 | 7.816 | 1 | 1 | 8 |
| GO:0007617 | mating behavior | 4.43e-03 | 1.00e+00 | 7.816 | 1 | 1 | 8 |
| GO:0042053 | regulation of dopamine metabolic process | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 1 | 9 |
| GO:0035240 | dopamine binding | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 1 | 9 |
| GO:0043268 | positive regulation of potassium ion transport | 5.53e-03 | 1.00e+00 | 7.494 | 1 | 1 | 10 |
| GO:0005798 | Golgi-associated vesicle | 5.53e-03 | 1.00e+00 | 7.494 | 1 | 1 | 10 |
| GO:0001963 | synaptic transmission, dopaminergic | 5.53e-03 | 1.00e+00 | 7.494 | 1 | 1 | 10 |
| GO:0042711 | maternal behavior | 5.53e-03 | 1.00e+00 | 7.494 | 1 | 1 | 10 |
| GO:0007191 | adenylate cyclase-activating dopamine receptor signaling pathway | 5.53e-03 | 1.00e+00 | 7.494 | 1 | 1 | 10 |
| GO:0021756 | striatum development | 5.53e-03 | 1.00e+00 | 7.494 | 1 | 1 | 10 |
| GO:0014002 | astrocyte development | 6.09e-03 | 1.00e+00 | 7.357 | 1 | 2 | 11 |
| GO:0060134 | prepulse inhibition | 6.09e-03 | 1.00e+00 | 7.357 | 1 | 1 | 11 |
| GO:0007625 | grooming behavior | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 12 |
| GO:0048148 | behavioral response to cocaine | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 12 |
| GO:0060292 | long term synaptic depression | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 2 | 13 |
| GO:0021542 | dentate gyrus development | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 1 | 13 |
| GO:0042417 | dopamine metabolic process | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 1 | 13 |
| GO:0030131 | clathrin adaptor complex | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 2 | 14 |
| GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 1 | 14 |
| GO:0019226 | transmission of nerve impulse | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 1 | 14 |
| GO:0001659 | temperature homeostasis | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 15 |
| GO:0016020 | membrane | 8.74e-03 | 1.00e+00 | 2.101 | 4 | 41 | 1681 |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 8.84e-03 | 1.00e+00 | 6.816 | 1 | 1 | 16 |
| GO:0042311 | vasodilation | 8.84e-03 | 1.00e+00 | 6.816 | 1 | 1 | 16 |
| GO:0019228 | neuronal action potential | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 18 |
| GO:0043473 | pigmentation | 1.10e-02 | 1.00e+00 | 6.494 | 1 | 1 | 20 |
| GO:0001662 | behavioral fear response | 1.21e-02 | 1.00e+00 | 6.357 | 1 | 1 | 22 |
| GO:0043231 | intracellular membrane-bounded organelle | 1.24e-02 | 1.00e+00 | 3.503 | 2 | 5 | 318 |
| GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 1 | 24 |
| GO:0007628 | adult walking behavior | 1.54e-02 | 1.00e+00 | 6.009 | 1 | 1 | 28 |
| GO:0000139 | Golgi membrane | 1.58e-02 | 1.00e+00 | 3.320 | 2 | 6 | 361 |
| GO:0001975 | response to amphetamine | 1.60e-02 | 1.00e+00 | 5.958 | 1 | 1 | 29 |
| GO:0060291 | long-term synaptic potentiation | 1.60e-02 | 1.00e+00 | 5.958 | 1 | 1 | 29 |
| GO:0006606 | protein import into nucleus | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 30 |
| GO:0030819 | positive regulation of cAMP biosynthetic process | 1.76e-02 | 1.00e+00 | 5.816 | 1 | 1 | 32 |
| GO:0007416 | synapse assembly | 1.82e-02 | 1.00e+00 | 5.772 | 1 | 1 | 33 |
| GO:0007190 | activation of adenylate cyclase activity | 1.82e-02 | 1.00e+00 | 5.772 | 1 | 1 | 33 |
| GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway | 1.87e-02 | 1.00e+00 | 5.729 | 1 | 1 | 34 |
| GO:0008542 | visual learning | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 1 | 39 |
| GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 1 | 39 |
| GO:0008344 | adult locomotory behavior | 2.42e-02 | 1.00e+00 | 5.357 | 1 | 1 | 44 |
| GO:0007613 | memory | 2.90e-02 | 1.00e+00 | 5.088 | 1 | 1 | 53 |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | 3.06e-02 | 1.00e+00 | 5.009 | 1 | 1 | 56 |
| GO:0005789 | endoplasmic reticulum membrane | 3.73e-02 | 1.00e+00 | 2.661 | 2 | 3 | 570 |
| GO:0005794 | Golgi apparatus | 4.22e-02 | 1.00e+00 | 2.563 | 2 | 9 | 610 |
| GO:0005179 | hormone activity | 4.30e-02 | 1.00e+00 | 4.512 | 1 | 1 | 79 |
| GO:0030335 | positive regulation of cell migration | 6.83e-02 | 1.00e+00 | 3.827 | 1 | 2 | 127 |
| GO:0042493 | response to drug | 1.47e-01 | 1.00e+00 | 2.666 | 1 | 2 | 284 |
| GO:0015031 | protein transport | 1.74e-01 | 1.00e+00 | 2.402 | 1 | 8 | 341 |
| GO:0016032 | viral process | 2.61e-01 | 1.00e+00 | 1.755 | 1 | 33 | 534 |
| GO:0005783 | endoplasmic reticulum | 2.70e-01 | 1.00e+00 | 1.697 | 1 | 3 | 556 |
| GO:0005737 | cytoplasm | 3.49e-01 | 1.00e+00 | 0.522 | 3 | 43 | 3767 |
| GO:0070062 | extracellular vesicular exosome | 3.95e-01 | 1.00e+00 | 0.587 | 2 | 40 | 2400 |
| GO:0005887 | integral component of plasma membrane | 3.99e-01 | 1.00e+00 | 1.022 | 1 | 2 | 888 |
| GO:0005615 | extracellular space | 4.23e-01 | 1.00e+00 | 0.914 | 1 | 2 | 957 |
| GO:0005886 | plasma membrane | 4.34e-01 | 1.00e+00 | 0.482 | 2 | 20 | 2582 |
| GO:0044822 | poly(A) RNA binding | 4.56e-01 | 1.00e+00 | 0.772 | 1 | 32 | 1056 |
| GO:0016021 | integral component of membrane | 6.94e-01 | 1.00e+00 | -0.137 | 1 | 5 | 1982 |
| GO:0005515 | protein binding | 7.20e-01 | 1.00e+00 | -0.155 | 3 | 62 | 6024 |
| GO:0005634 | nucleus | 9.52e-01 | 1.00e+00 | -1.338 | 1 | 43 | 4559 |