int-snw-11316
Statistics
| Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
|---|---|---|---|---|
| tai-screen-luciferase | 6.597 | 1.07e-147 | 7.88e-08 | 1.33e-03 |
Genes (12)
| Gene Symbol | Entrez Gene ID | Frequency | tai-screen-luciferase gene score | Best subnetwork score | Degree | List-Gonzales GI | Tai-Hits |
|---|---|---|---|---|---|---|---|
| RPS4X | 6191 | 18 | -6.747 | 7.555 | 263 | Yes | - |
| COPZ1 | 22818 | 32 | -8.301 | 9.063 | 13 | Yes | Yes |
| COPA | 1314 | 32 | -9.395 | 9.063 | 170 | Yes | Yes |
| RPS29 | 6235 | 3 | -8.386 | 6.597 | 29 | - | - |
| UBA5 | 79876 | 1 | 1.951 | 6.597 | 524 | - | - |
| [ COPE ] | 11316 | 1 | -1.675 | 6.597 | 15 | - | - |
| RPS24 | 6229 | 21 | -7.034 | 8.389 | 217 | Yes | - |
| ARF1 | 375 | 2 | -2.777 | 7.138 | 93 | Yes | - |
| ARCN1 | 372 | 32 | -8.232 | 9.063 | 118 | Yes | Yes |
| COPG1 | 22820 | 9 | -5.279 | 7.138 | 37 | Yes | Yes |
| COPB2 | 9276 | 32 | -13.168 | 9.063 | 41 | Yes | Yes |
| COPB1 | 1315 | 22 | -6.221 | 9.063 | 118 | Yes | Yes |
Interactions (30)
| Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
|---|---|---|---|---|---|---|
| RPS4X | 6191 | RPS24 | 6229 | pp | -- | int.I2D: BioGrid_Yeast |
| ARF1 | 375 | COPE | 11316 | pp | -- | int.I2D: HPRD, BioGrid; int.HPRD: yeast 2-hybrid |
| COPB2 | 9276 | COPE | 11316 | pp | -- | int.I2D: BioGrid |
| ARCN1 | 372 | UBA5 | 79876 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
| COPA | 1314 | COPB1 | 1315 | pp | -- | int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh |
| RPS4X | 6191 | UBA5 | 79876 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
| ARF1 | 375 | UBA5 | 79876 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
| ARCN1 | 372 | COPG1 | 22820 | pp | -- | int.I2D: HPRD; int.HPRD: in vivo |
| RPS24 | 6229 | UBA5 | 79876 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
| ARCN1 | 372 | COPA | 1314 | pp | -- | int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core; int.HPRD: in vivo |
| ARCN1 | 372 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG |
| COPA | 1314 | COPB2 | 9276 | pp | -- | int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vivo |
| COPB1 | 1315 | UBA5 | 79876 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
| COPA | 1314 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium |
| COPE | 11316 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: yeast 2-hybrid |
| ARF1 | 375 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo |
| COPB1 | 1315 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association) |
| COPB1 | 1315 | COPE | 11316 | pp | -- | int.I2D: HPRD, BioGrid; int.HPRD: yeast 2-hybrid |
| ARF1 | 375 | COPB1 | 1315 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo |
| ARCN1 | 372 | COPB1 | 1315 | pp | -- | int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS; int.HPRD: in vivo |
| COPE | 11316 | UBA5 | 79876 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
| RPS29 | 6235 | UBA5 | 79876 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
| COPB2 | 9276 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid |
| COPB2 | 9276 | UBA5 | 79876 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: BEHRENDS_AUTOPHAGY_LOW, BioGrid, IntAct |
| COPZ1 | 22818 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid, HPRD, BIND; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association) |
| ARCN1 | 372 | COPB2 | 9276 | pp | -- | int.I2D: HPRD, BCI; int.HPRD: in vivo |
| COPA | 1314 | UBA5 | 79876 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
| COPB1 | 1315 | COPB2 | 9276 | pp | -- | int.I2D: BioGrid |
| COPA | 1314 | COPE | 11316 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: BioGrid, HPRD, IntAct, MINT, StelzlHigh, BCI, BIND; int.Mint: MI:0915(physical association); int.HPRD: in vivo, yeast 2-hybrid |
| COPB1 | 1315 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium; int.DIP: MI:0915(physical association) |
Related GO terms (90)
| Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
|---|---|---|---|---|---|---|---|
| GO:0048205 | COPI coating of Golgi vesicle | 1.37e-23 | 1.98e-19 | 9.531 | 8 | 8 | 13 |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | 1.15e-20 | 1.66e-16 | 8.587 | 8 | 8 | 25 |
| GO:0030126 | COPI vesicle coat | 2.43e-20 | 3.51e-16 | 9.454 | 7 | 7 | 12 |
| GO:0061024 | membrane organization | 4.11e-14 | 5.93e-10 | 6.051 | 8 | 12 | 145 |
| GO:0006891 | intra-Golgi vesicle-mediated transport | 6.50e-10 | 9.37e-06 | 8.144 | 4 | 4 | 17 |
| GO:0005829 | cytosol | 7.06e-10 | 1.02e-05 | 2.531 | 12 | 61 | 2496 |
| GO:0006886 | intracellular protein transport | 2.22e-09 | 3.20e-05 | 5.398 | 6 | 7 | 171 |
| GO:0005198 | structural molecule activity | 8.50e-08 | 1.23e-03 | 5.324 | 5 | 6 | 150 |
| GO:0015935 | small ribosomal subunit | 2.97e-07 | 4.29e-03 | 7.729 | 3 | 9 | 17 |
| GO:0022627 | cytosolic small ribosomal subunit | 3.95e-06 | 5.70e-02 | 6.531 | 3 | 20 | 39 |
| GO:0019083 | viral transcription | 3.62e-05 | 5.22e-01 | 5.476 | 3 | 20 | 81 |
| GO:0016032 | viral process | 4.36e-05 | 6.28e-01 | 3.492 | 5 | 33 | 534 |
| GO:0006415 | translational termination | 4.48e-05 | 6.47e-01 | 5.373 | 3 | 20 | 87 |
| GO:0006414 | translational elongation | 5.47e-05 | 7.90e-01 | 5.277 | 3 | 20 | 93 |
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 7.64e-05 | 1.00e+00 | 5.116 | 3 | 20 | 104 |
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 1.00e-04 | 1.00e+00 | 4.983 | 3 | 20 | 114 |
| GO:0019058 | viral life cycle | 1.03e-04 | 1.00e+00 | 4.971 | 3 | 23 | 115 |
| GO:0006413 | translational initiation | 1.52e-04 | 1.00e+00 | 4.783 | 3 | 21 | 131 |
| GO:0003735 | structural constituent of ribosome | 1.73e-04 | 1.00e+00 | 4.718 | 3 | 22 | 137 |
| GO:0016071 | mRNA metabolic process | 7.24e-04 | 1.00e+00 | 4.015 | 3 | 25 | 223 |
| GO:0006412 | translation | 7.92e-04 | 1.00e+00 | 3.971 | 3 | 23 | 230 |
| GO:0021691 | cerebellar Purkinje cell layer maturation | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
| GO:0071566 | UFM1 activating enzyme activity | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
| GO:0016070 | RNA metabolic process | 9.74e-04 | 1.00e+00 | 3.868 | 3 | 25 | 247 |
| GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
| GO:0097061 | dendritic spine organization | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
| GO:0043231 | intracellular membrane-bounded organelle | 2.01e-03 | 1.00e+00 | 3.503 | 3 | 5 | 318 |
| GO:0051683 | establishment of Golgi localization | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 2 | 3 |
| GO:0002090 | regulation of receptor internalization | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
| GO:0000139 | Golgi membrane | 2.89e-03 | 1.00e+00 | 3.320 | 3 | 6 | 361 |
| GO:0005925 | focal adhesion | 3.01e-03 | 1.00e+00 | 3.300 | 3 | 19 | 366 |
| GO:0072384 | organelle transport along microtubule | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 2 | 4 |
| GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 3 | 5 |
| GO:0071569 | protein ufmylation | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
| GO:0034101 | erythrocyte homeostasis | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
| GO:0030157 | pancreatic juice secretion | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
| GO:0044267 | cellular protein metabolic process | 6.22e-03 | 1.00e+00 | 2.927 | 3 | 23 | 474 |
| GO:0005798 | Golgi-associated vesicle | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 10 |
| GO:0016020 | membrane | 8.36e-03 | 1.00e+00 | 1.838 | 5 | 41 | 1681 |
| GO:0044822 | poly(A) RNA binding | 8.79e-03 | 1.00e+00 | 2.187 | 4 | 32 | 1056 |
| GO:0006878 | cellular copper ion homeostasis | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 12 |
| GO:0042274 | ribosomal small subunit biogenesis | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 6 | 12 |
| GO:0060292 | long term synaptic depression | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 2 | 13 |
| GO:0030131 | clathrin adaptor complex | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 2 | 14 |
| GO:0031369 | translation initiation factor binding | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 1 | 15 |
| GO:0005794 | Golgi apparatus | 1.24e-02 | 1.00e+00 | 2.563 | 3 | 9 | 610 |
| GO:0010467 | gene expression | 1.60e-02 | 1.00e+00 | 2.430 | 3 | 29 | 669 |
| GO:0043473 | pigmentation | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 20 |
| GO:0036464 | cytoplasmic ribonucleoprotein granule | 1.82e-02 | 1.00e+00 | 5.772 | 1 | 3 | 22 |
| GO:0005844 | polysome | 1.90e-02 | 1.00e+00 | 5.708 | 1 | 2 | 23 |
| GO:0050690 | regulation of defense response to virus by virus | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 1 | 27 |
| GO:0019843 | rRNA binding | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 4 | 27 |
| GO:0030017 | sarcomere | 2.79e-02 | 1.00e+00 | 5.144 | 1 | 2 | 34 |
| GO:0005057 | receptor signaling protein activity | 3.12e-02 | 1.00e+00 | 4.983 | 1 | 2 | 38 |
| GO:0015031 | protein transport | 3.15e-02 | 1.00e+00 | 2.817 | 2 | 8 | 341 |
| GO:0006892 | post-Golgi vesicle-mediated transport | 3.52e-02 | 1.00e+00 | 4.805 | 1 | 1 | 43 |
| GO:0045727 | positive regulation of translation | 3.60e-02 | 1.00e+00 | 4.772 | 1 | 1 | 44 |
| GO:0008344 | adult locomotory behavior | 3.60e-02 | 1.00e+00 | 4.772 | 1 | 1 | 44 |
| GO:0034976 | response to endoplasmic reticulum stress | 4.16e-02 | 1.00e+00 | 4.559 | 1 | 1 | 51 |
| GO:0006661 | phosphatidylinositol biosynthetic process | 4.24e-02 | 1.00e+00 | 4.531 | 1 | 1 | 52 |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | 4.56e-02 | 1.00e+00 | 4.424 | 1 | 1 | 56 |
| GO:0005840 | ribosome | 4.72e-02 | 1.00e+00 | 4.373 | 1 | 8 | 58 |
| GO:0005179 | hormone activity | 6.38e-02 | 1.00e+00 | 3.927 | 1 | 1 | 79 |
| GO:0005737 | cytoplasm | 6.58e-02 | 1.00e+00 | 0.937 | 6 | 43 | 3767 |
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | 7.24e-02 | 1.00e+00 | 3.739 | 1 | 1 | 90 |
| GO:0006364 | rRNA processing | 7.55e-02 | 1.00e+00 | 3.677 | 1 | 7 | 94 |
| GO:0014069 | postsynaptic density | 8.40e-02 | 1.00e+00 | 3.517 | 1 | 3 | 105 |
| GO:0030529 | ribonucleoprotein complex | 8.93e-02 | 1.00e+00 | 3.424 | 1 | 7 | 112 |
| GO:0006644 | phospholipid metabolic process | 1.02e-01 | 1.00e+00 | 3.220 | 1 | 3 | 129 |
| GO:0043005 | neuron projection | 1.23e-01 | 1.00e+00 | 2.937 | 1 | 6 | 157 |
| GO:0070062 | extracellular vesicular exosome | 1.25e-01 | 1.00e+00 | 1.002 | 4 | 40 | 2400 |
| GO:0045211 | postsynaptic membrane | 1.33e-01 | 1.00e+00 | 2.822 | 1 | 4 | 170 |
| GO:0003924 | GTPase activity | 1.52e-01 | 1.00e+00 | 2.609 | 1 | 7 | 197 |
| GO:0006184 | GTP catabolic process | 1.64e-01 | 1.00e+00 | 2.490 | 1 | 7 | 214 |
| GO:0000166 | nucleotide binding | 1.95e-01 | 1.00e+00 | 2.214 | 1 | 2 | 259 |
| GO:0007264 | small GTPase mediated signal transduction | 2.09e-01 | 1.00e+00 | 2.107 | 1 | 7 | 279 |
| GO:0005525 | GTP binding | 2.30e-01 | 1.00e+00 | 1.955 | 1 | 7 | 310 |
| GO:0007275 | multicellular organismal development | 2.34e-01 | 1.00e+00 | 1.927 | 1 | 1 | 316 |
| GO:0008284 | positive regulation of cell proliferation | 2.75e-01 | 1.00e+00 | 1.654 | 1 | 7 | 382 |
| GO:0048471 | perinuclear region of cytoplasm | 3.46e-01 | 1.00e+00 | 1.260 | 1 | 7 | 502 |
| GO:0005783 | endoplasmic reticulum | 3.76e-01 | 1.00e+00 | 1.112 | 1 | 3 | 556 |
| GO:0005730 | nucleolus | 4.04e-01 | 1.00e+00 | 0.551 | 2 | 24 | 1641 |
| GO:0005615 | extracellular space | 5.61e-01 | 1.00e+00 | 0.329 | 1 | 2 | 957 |
| GO:0008270 | zinc ion binding | 5.77e-01 | 1.00e+00 | 0.270 | 1 | 3 | 997 |
| GO:0044281 | small molecule metabolic process | 6.51e-01 | 1.00e+00 | -0.011 | 1 | 15 | 1211 |
| GO:0005886 | plasma membrane | 6.61e-01 | 1.00e+00 | -0.103 | 2 | 20 | 2582 |
| GO:0005524 | ATP binding | 6.78e-01 | 1.00e+00 | -0.111 | 1 | 15 | 1298 |
| GO:0046872 | metal ion binding | 6.80e-01 | 1.00e+00 | -0.121 | 1 | 10 | 1307 |
| GO:0005634 | nucleus | 7.84e-01 | 1.00e+00 | -0.338 | 3 | 43 | 4559 |
| GO:0005515 | protein binding | 8.10e-01 | 1.00e+00 | -0.325 | 4 | 62 | 6024 |