int-snw-112950
Statistics
| Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
|---|---|---|---|---|
| tai-screen-luciferase | 6.537 | 1.50e-144 | 1.20e-07 | 1.60e-03 |
Genes (9)
| Gene Symbol | Entrez Gene ID | Frequency | tai-screen-luciferase gene score | Best subnetwork score | Degree | List-Gonzales GI | Tai-Hits |
|---|---|---|---|---|---|---|---|
| SNTA1 | 6640 | 1 | 2.065 | 6.537 | 73 | - | - |
| COPZ1 | 22818 | 32 | -8.301 | 9.063 | 13 | Yes | Yes |
| DMD | 1756 | 1 | -4.338 | 6.537 | 47 | - | - |
| [ MED8 ] | 112950 | 1 | 1.834 | 6.537 | 42 | - | - |
| COPA | 1314 | 32 | -9.395 | 9.063 | 170 | Yes | Yes |
| ARCN1 | 372 | 32 | -8.232 | 9.063 | 118 | Yes | Yes |
| COPB1 | 1315 | 22 | -6.221 | 9.063 | 118 | Yes | Yes |
| COPG1 | 22820 | 9 | -5.279 | 7.138 | 37 | Yes | Yes |
| COPB2 | 9276 | 32 | -13.168 | 9.063 | 41 | Yes | Yes |
Interactions (17)
| Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
|---|---|---|---|---|---|---|
| COPA | 1314 | COPB1 | 1315 | pp | -- | int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh |
| ARCN1 | 372 | COPG1 | 22820 | pp | -- | int.I2D: HPRD; int.HPRD: in vivo |
| ARCN1 | 372 | COPA | 1314 | pp | -- | int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core; int.HPRD: in vivo |
| ARCN1 | 372 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG |
| COPA | 1314 | COPB2 | 9276 | pp | -- | int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vivo |
| COPA | 1314 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium |
| COPB1 | 1315 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association) |
| SNTA1 | 6640 | MED8 | 112950 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: HPRD, MINT, StelzlLow, IntAct; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid |
| ARCN1 | 372 | COPB1 | 1315 | pp | -- | int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS; int.HPRD: in vivo |
| DMD | 1756 | SNTA1 | 6640 | pp | -- | int.I2D: BCI, BioGrid, BIND_Mouse, HPRD, IntAct_Mouse, MINT_Mouse; int.HPRD: in vitro, in vivo |
| DMD | 1756 | MED8 | 112950 | pp | -- | int.I2D: BioGrid_Fly, FlyLow, IntAct_Fly |
| COPB2 | 9276 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid |
| COPZ1 | 22818 | COPG1 | 22820 | pp | -- | int.I2D: BioGrid, HPRD, BIND; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association) |
| ARCN1 | 372 | COPB2 | 9276 | pp | -- | int.I2D: HPRD, BCI; int.HPRD: in vivo |
| COPB1 | 1315 | COPB2 | 9276 | pp | -- | int.I2D: BioGrid |
| COPB1 | 1315 | SNTA1 | 6640 | pp | -- | int.I2D: INNATEDB |
| COPB1 | 1315 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium; int.DIP: MI:0915(physical association) |
Related GO terms (96)
| Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
|---|---|---|---|---|---|---|---|
| GO:0030126 | COPI vesicle coat | 6.21e-18 | 8.95e-14 | 9.646 | 6 | 7 | 12 |
| GO:0048205 | COPI coating of Golgi vesicle | 1.15e-17 | 1.66e-13 | 9.531 | 6 | 8 | 13 |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | 1.19e-15 | 1.71e-11 | 8.587 | 6 | 8 | 25 |
| GO:0061024 | membrane organization | 7.63e-11 | 1.10e-06 | 6.051 | 6 | 12 | 145 |
| GO:0006886 | intracellular protein transport | 2.08e-10 | 2.99e-06 | 5.813 | 6 | 7 | 171 |
| GO:0006891 | intra-Golgi vesicle-mediated transport | 1.14e-07 | 1.64e-03 | 8.144 | 3 | 4 | 17 |
| GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation | 1.04e-06 | 1.50e-02 | 10.061 | 2 | 2 | 3 |
| GO:0005198 | structural molecule activity | 1.36e-06 | 1.96e-02 | 5.417 | 4 | 6 | 150 |
| GO:0016013 | syntrophin complex | 2.08e-06 | 2.99e-02 | 9.646 | 2 | 2 | 4 |
| GO:0050998 | nitric-oxide synthase binding | 4.13e-05 | 5.96e-01 | 7.646 | 2 | 2 | 16 |
| GO:0005829 | cytosol | 1.20e-04 | 1.00e+00 | 2.168 | 7 | 61 | 2496 |
| GO:0002027 | regulation of heart rate | 1.39e-04 | 1.00e+00 | 6.788 | 2 | 2 | 29 |
| GO:0016328 | lateral plasma membrane | 3.53e-04 | 1.00e+00 | 6.123 | 2 | 2 | 46 |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 6.24e-04 | 1.00e+00 | 10.646 | 1 | 1 | 1 |
| GO:0021691 | cerebellar Purkinje cell layer maturation | 6.24e-04 | 1.00e+00 | 10.646 | 1 | 1 | 1 |
| GO:0003117 | regulation of vasoconstriction by circulating norepinephrine | 6.24e-04 | 1.00e+00 | 10.646 | 1 | 1 | 1 |
| GO:0042383 | sarcolemma | 8.41e-04 | 1.00e+00 | 5.496 | 2 | 2 | 71 |
| GO:0014819 | regulation of skeletal muscle contraction | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 2 |
| GO:0086001 | cardiac muscle cell action potential | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 2 |
| GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion | 1.87e-03 | 1.00e+00 | 9.061 | 1 | 1 | 3 |
| GO:1901385 | regulation of voltage-gated calcium channel activity | 1.87e-03 | 1.00e+00 | 9.061 | 1 | 1 | 3 |
| GO:0051683 | establishment of Golgi localization | 1.87e-03 | 1.00e+00 | 9.061 | 1 | 2 | 3 |
| GO:0072384 | organelle transport along microtubule | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 2 | 4 |
| GO:0043043 | peptide biosynthetic process | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 1 | 5 |
| GO:2000651 | positive regulation of sodium ion transmembrane transporter activity | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 1 | 5 |
| GO:0044458 | motile cilium assembly | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 1 | 5 |
| GO:0030157 | pancreatic juice secretion | 4.36e-03 | 1.00e+00 | 7.839 | 1 | 1 | 7 |
| GO:0002162 | dystroglycan binding | 4.36e-03 | 1.00e+00 | 7.839 | 1 | 1 | 7 |
| GO:1902305 | regulation of sodium ion transmembrane transport | 4.36e-03 | 1.00e+00 | 7.839 | 1 | 1 | 7 |
| GO:0045211 | postsynaptic membrane | 4.71e-03 | 1.00e+00 | 4.237 | 2 | 4 | 170 |
| GO:0005798 | Golgi-associated vesicle | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 1 | 10 |
| GO:0017166 | vinculin binding | 6.85e-03 | 1.00e+00 | 7.187 | 1 | 1 | 11 |
| GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization | 6.85e-03 | 1.00e+00 | 7.187 | 1 | 1 | 11 |
| GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 12 |
| GO:0033137 | negative regulation of peptidyl-serine phosphorylation | 8.70e-03 | 1.00e+00 | 6.839 | 1 | 1 | 14 |
| GO:0030131 | clathrin adaptor complex | 8.70e-03 | 1.00e+00 | 6.839 | 1 | 2 | 14 |
| GO:0043623 | cellular protein complex assembly | 9.32e-03 | 1.00e+00 | 6.739 | 1 | 1 | 15 |
| GO:0016010 | dystrophin-associated glycoprotein complex | 9.32e-03 | 1.00e+00 | 6.739 | 1 | 1 | 15 |
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 16 |
| GO:0086005 | ventricular cardiac muscle cell action potential | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 16 |
| GO:0031527 | filopodium membrane | 1.06e-02 | 1.00e+00 | 6.559 | 1 | 1 | 17 |
| GO:0017022 | myosin binding | 1.06e-02 | 1.00e+00 | 6.559 | 1 | 1 | 17 |
| GO:0003779 | actin binding | 1.12e-02 | 1.00e+00 | 3.591 | 2 | 3 | 266 |
| GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 1.18e-02 | 1.00e+00 | 6.398 | 1 | 1 | 19 |
| GO:0043034 | costamere | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 2 | 20 |
| GO:0043473 | pigmentation | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 1 | 20 |
| GO:0017080 | sodium channel regulator activity | 1.30e-02 | 1.00e+00 | 6.254 | 1 | 1 | 21 |
| GO:0005856 | cytoskeleton | 1.33e-02 | 1.00e+00 | 3.461 | 2 | 4 | 291 |
| GO:0043234 | protein complex | 1.37e-02 | 1.00e+00 | 3.442 | 2 | 6 | 295 |
| GO:0043231 | intracellular membrane-bounded organelle | 1.57e-02 | 1.00e+00 | 3.333 | 2 | 5 | 318 |
| GO:0030054 | cell junction | 1.75e-02 | 1.00e+00 | 3.254 | 2 | 4 | 336 |
| GO:0007528 | neuromuscular junction development | 1.98e-02 | 1.00e+00 | 5.646 | 1 | 1 | 32 |
| GO:0000139 | Golgi membrane | 2.00e-02 | 1.00e+00 | 3.150 | 2 | 6 | 361 |
| GO:0001104 | RNA polymerase II transcription cofactor activity | 2.04e-02 | 1.00e+00 | 5.602 | 1 | 1 | 33 |
| GO:0016592 | mediator complex | 2.16e-02 | 1.00e+00 | 5.517 | 1 | 1 | 35 |
| GO:0030049 | muscle filament sliding | 2.35e-02 | 1.00e+00 | 5.398 | 1 | 2 | 38 |
| GO:0060048 | cardiac muscle contraction | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 1 | 39 |
| GO:0051117 | ATPase binding | 2.47e-02 | 1.00e+00 | 5.324 | 1 | 1 | 40 |
| GO:0008307 | structural constituent of muscle | 2.53e-02 | 1.00e+00 | 5.289 | 1 | 1 | 41 |
| GO:0008344 | adult locomotory behavior | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 1 | 44 |
| GO:0034613 | cellular protein localization | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 2 | 44 |
| GO:0031594 | neuromuscular junction | 2.77e-02 | 1.00e+00 | 5.154 | 1 | 1 | 45 |
| GO:0030175 | filopodium | 3.08e-02 | 1.00e+00 | 5.002 | 1 | 2 | 50 |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | 3.44e-02 | 1.00e+00 | 4.839 | 1 | 1 | 56 |
| GO:0010976 | positive regulation of neuron projection development | 3.56e-02 | 1.00e+00 | 4.788 | 1 | 2 | 58 |
| GO:0045666 | positive regulation of neuron differentiation | 3.86e-02 | 1.00e+00 | 4.669 | 1 | 1 | 63 |
| GO:0044325 | ion channel binding | 4.59e-02 | 1.00e+00 | 4.417 | 1 | 3 | 75 |
| GO:0005179 | hormone activity | 4.82e-02 | 1.00e+00 | 4.342 | 1 | 1 | 79 |
| GO:0007517 | muscle organ development | 5.06e-02 | 1.00e+00 | 4.271 | 1 | 1 | 83 |
| GO:0005794 | Golgi apparatus | 5.28e-02 | 1.00e+00 | 2.393 | 2 | 9 | 610 |
| GO:0006936 | muscle contraction | 5.30e-02 | 1.00e+00 | 4.203 | 1 | 1 | 87 |
| GO:0005200 | structural constituent of cytoskeleton | 5.54e-02 | 1.00e+00 | 4.138 | 1 | 3 | 91 |
| GO:0030165 | PDZ domain binding | 5.72e-02 | 1.00e+00 | 4.092 | 1 | 1 | 94 |
| GO:0016020 | membrane | 7.75e-02 | 1.00e+00 | 1.516 | 3 | 41 | 1681 |
| GO:0045121 | membrane raft | 9.33e-02 | 1.00e+00 | 3.361 | 1 | 3 | 156 |
| GO:0005516 | calmodulin binding | 9.55e-02 | 1.00e+00 | 3.324 | 1 | 1 | 160 |
| GO:0015629 | actin cytoskeleton | 1.05e-01 | 1.00e+00 | 3.179 | 1 | 1 | 177 |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | 1.09e-01 | 1.00e+00 | 3.123 | 1 | 3 | 184 |
| GO:0005622 | intracellular | 1.22e-01 | 1.00e+00 | 2.953 | 1 | 1 | 207 |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | 1.53e-01 | 1.00e+00 | 2.602 | 1 | 1 | 264 |
| GO:0030198 | extracellular matrix organization | 1.63e-01 | 1.00e+00 | 2.502 | 1 | 1 | 283 |
| GO:0016567 | protein ubiquitination | 1.70e-01 | 1.00e+00 | 2.442 | 1 | 3 | 295 |
| GO:0005737 | cytoplasm | 1.87e-01 | 1.00e+00 | 0.767 | 4 | 43 | 3767 |
| GO:0009986 | cell surface | 2.25e-01 | 1.00e+00 | 1.995 | 1 | 1 | 402 |
| GO:0005509 | calcium ion binding | 2.87e-01 | 1.00e+00 | 1.594 | 1 | 2 | 531 |
| GO:0016032 | viral process | 2.88e-01 | 1.00e+00 | 1.585 | 1 | 33 | 534 |
| GO:0005783 | endoplasmic reticulum | 2.98e-01 | 1.00e+00 | 1.527 | 1 | 3 | 556 |
| GO:0005515 | protein binding | 3.04e-01 | 1.00e+00 | 0.412 | 5 | 62 | 6024 |
| GO:0010467 | gene expression | 3.48e-01 | 1.00e+00 | 1.260 | 1 | 29 | 669 |
| GO:0005615 | extracellular space | 4.61e-01 | 1.00e+00 | 0.744 | 1 | 2 | 957 |
| GO:0008270 | zinc ion binding | 4.75e-01 | 1.00e+00 | 0.685 | 1 | 3 | 997 |
| GO:0044822 | poly(A) RNA binding | 4.96e-01 | 1.00e+00 | 0.602 | 1 | 32 | 1056 |
| GO:0005886 | plasma membrane | 4.98e-01 | 1.00e+00 | 0.312 | 2 | 20 | 2582 |
| GO:0005654 | nucleoplasm | 5.04e-01 | 1.00e+00 | 0.567 | 1 | 15 | 1082 |
| GO:0070062 | extracellular vesicular exosome | 8.06e-01 | 1.00e+00 | -0.583 | 1 | 40 | 2400 |
| GO:0005634 | nucleus | 9.67e-01 | 1.00e+00 | -1.508 | 1 | 43 | 4559 |