int-snw-10607
Statistics
| Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
|---|---|---|---|---|
| tai-screen-luciferase | 7.486 | 3.28e-198 | 7.90e-11 | 5.86e-05 |
Genes (8)
| Gene Symbol | Entrez Gene ID | Frequency | tai-screen-luciferase gene score | Best subnetwork score | Degree | List-Gonzales GI | Tai-Hits |
|---|---|---|---|---|---|---|---|
| COPZ1 | 22818 | 32 | -8.301 | 9.063 | 13 | Yes | Yes |
| COPA | 1314 | 32 | -9.395 | 9.063 | 170 | Yes | Yes |
| WDR46 | 9277 | 3 | -4.290 | 7.486 | 87 | Yes | Yes |
| ARCN1 | 372 | 32 | -8.232 | 9.063 | 118 | Yes | Yes |
| [ TBL3 ] | 10607 | 2 | -3.692 | 7.486 | 102 | Yes | Yes |
| COPB1 | 1315 | 22 | -6.221 | 9.063 | 118 | Yes | Yes |
| COPB2 | 9276 | 32 | -13.168 | 9.063 | 41 | Yes | Yes |
| RPS13 | 6207 | 17 | -6.589 | 7.555 | 174 | Yes | - |
Interactions (12)
| Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
|---|---|---|---|---|---|---|
| WDR46 | 9277 | TBL3 | 10607 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastLow |
| ARCN1 | 372 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG |
| COPA | 1314 | COPB2 | 9276 | pp | -- | int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vivo |
| ARCN1 | 372 | COPB1 | 1315 | pp | -- | int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS; int.HPRD: in vivo |
| COPA | 1314 | TBL3 | 10607 | pp | -- | int.I2D: YeastLow |
| ARCN1 | 372 | COPB2 | 9276 | pp | -- | int.I2D: HPRD, BCI; int.HPRD: in vivo |
| COPB1 | 1315 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium; int.DIP: MI:0915(physical association) |
| COPA | 1314 | COPB1 | 1315 | pp | -- | int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh |
| ARCN1 | 372 | COPA | 1314 | pp | -- | int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core; int.HPRD: in vivo |
| RPS13 | 6207 | WDR46 | 9277 | pp | -- | int.I2D: BioGrid_Yeast |
| COPA | 1314 | COPZ1 | 22818 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium |
| COPB1 | 1315 | COPB2 | 9276 | pp | -- | int.I2D: BioGrid |
Related GO terms (55)
| Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
|---|---|---|---|---|---|---|---|
| GO:0030126 | COPI vesicle coat | 8.52e-15 | 1.23e-10 | 9.553 | 5 | 7 | 12 |
| GO:0048205 | COPI coating of Golgi vesicle | 1.38e-14 | 2.00e-10 | 9.438 | 5 | 8 | 13 |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | 5.70e-13 | 8.23e-09 | 8.494 | 5 | 8 | 25 |
| GO:0061024 | membrane organization | 5.24e-09 | 7.56e-05 | 5.958 | 5 | 12 | 145 |
| GO:0006886 | intracellular protein transport | 1.20e-08 | 1.73e-04 | 5.720 | 5 | 7 | 171 |
| GO:0006891 | intra-Golgi vesicle-mediated transport | 7.59e-08 | 1.09e-03 | 8.314 | 3 | 4 | 17 |
| GO:0005198 | structural molecule activity | 5.94e-05 | 8.57e-01 | 5.172 | 3 | 6 | 150 |
| GO:0005829 | cytosol | 5.44e-04 | 1.00e+00 | 2.116 | 6 | 61 | 2496 |
| GO:0021691 | cerebellar Purkinje cell layer maturation | 5.55e-04 | 1.00e+00 | 10.816 | 1 | 1 | 1 |
| GO:0044822 | poly(A) RNA binding | 1.57e-03 | 1.00e+00 | 2.772 | 4 | 32 | 1056 |
| GO:0033119 | negative regulation of RNA splicing | 2.77e-03 | 1.00e+00 | 8.494 | 1 | 2 | 5 |
| GO:0030157 | pancreatic juice secretion | 3.88e-03 | 1.00e+00 | 8.009 | 1 | 1 | 7 |
| GO:0007199 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger | 4.43e-03 | 1.00e+00 | 7.816 | 1 | 1 | 8 |
| GO:0032040 | small-subunit processome | 5.53e-03 | 1.00e+00 | 7.494 | 1 | 2 | 10 |
| GO:0005798 | Golgi-associated vesicle | 5.53e-03 | 1.00e+00 | 7.494 | 1 | 1 | 10 |
| GO:0030131 | clathrin adaptor complex | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 2 | 14 |
| GO:0016020 | membrane | 8.74e-03 | 1.00e+00 | 2.101 | 4 | 41 | 1681 |
| GO:0043473 | pigmentation | 1.10e-02 | 1.00e+00 | 6.494 | 1 | 1 | 20 |
| GO:0043231 | intracellular membrane-bounded organelle | 1.24e-02 | 1.00e+00 | 3.503 | 2 | 5 | 318 |
| GO:0005057 | receptor signaling protein activity | 2.09e-02 | 1.00e+00 | 5.568 | 1 | 2 | 38 |
| GO:0022627 | cytosolic small ribosomal subunit | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 20 | 39 |
| GO:0008344 | adult locomotory behavior | 2.42e-02 | 1.00e+00 | 5.357 | 1 | 1 | 44 |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | 3.06e-02 | 1.00e+00 | 5.009 | 1 | 1 | 56 |
| GO:0005840 | ribosome | 3.17e-02 | 1.00e+00 | 4.958 | 1 | 8 | 58 |
| GO:0016032 | viral process | 3.30e-02 | 1.00e+00 | 2.755 | 2 | 33 | 534 |
| GO:0003729 | mRNA binding | 3.93e-02 | 1.00e+00 | 4.646 | 1 | 2 | 72 |
| GO:0005794 | Golgi apparatus | 4.22e-02 | 1.00e+00 | 2.563 | 2 | 9 | 610 |
| GO:0005179 | hormone activity | 4.30e-02 | 1.00e+00 | 4.512 | 1 | 1 | 79 |
| GO:0019083 | viral transcription | 4.41e-02 | 1.00e+00 | 4.476 | 1 | 20 | 81 |
| GO:0006415 | translational termination | 4.73e-02 | 1.00e+00 | 4.373 | 1 | 20 | 87 |
| GO:0006414 | translational elongation | 5.04e-02 | 1.00e+00 | 4.277 | 1 | 20 | 93 |
| GO:0006364 | rRNA processing | 5.10e-02 | 1.00e+00 | 4.261 | 1 | 7 | 94 |
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 5.63e-02 | 1.00e+00 | 4.116 | 1 | 20 | 104 |
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 6.15e-02 | 1.00e+00 | 3.983 | 1 | 20 | 114 |
| GO:0019058 | viral life cycle | 6.20e-02 | 1.00e+00 | 3.971 | 1 | 23 | 115 |
| GO:0006413 | translational initiation | 7.04e-02 | 1.00e+00 | 3.783 | 1 | 21 | 131 |
| GO:0003735 | structural constituent of ribosome | 7.35e-02 | 1.00e+00 | 3.718 | 1 | 22 | 137 |
| GO:0016071 | mRNA metabolic process | 1.17e-01 | 1.00e+00 | 3.015 | 1 | 25 | 223 |
| GO:0006412 | translation | 1.21e-01 | 1.00e+00 | 2.971 | 1 | 23 | 230 |
| GO:0016070 | RNA metabolic process | 1.29e-01 | 1.00e+00 | 2.868 | 1 | 25 | 247 |
| GO:0005575 | cellular_component | 1.45e-01 | 1.00e+00 | 2.692 | 1 | 1 | 279 |
| GO:0035556 | intracellular signal transduction | 1.56e-01 | 1.00e+00 | 2.573 | 1 | 4 | 303 |
| GO:0000139 | Golgi membrane | 1.84e-01 | 1.00e+00 | 2.320 | 1 | 6 | 361 |
| GO:0005925 | focal adhesion | 1.86e-01 | 1.00e+00 | 2.300 | 1 | 19 | 366 |
| GO:0008150 | biological_process | 1.97e-01 | 1.00e+00 | 2.212 | 1 | 3 | 389 |
| GO:0005730 | nucleolus | 2.29e-01 | 1.00e+00 | 1.136 | 2 | 24 | 1641 |
| GO:0044267 | cellular protein metabolic process | 2.35e-01 | 1.00e+00 | 1.927 | 1 | 23 | 474 |
| GO:0005783 | endoplasmic reticulum | 2.70e-01 | 1.00e+00 | 1.697 | 1 | 3 | 556 |
| GO:0010467 | gene expression | 3.16e-01 | 1.00e+00 | 1.430 | 1 | 29 | 669 |
| GO:0005737 | cytoplasm | 3.49e-01 | 1.00e+00 | 0.522 | 3 | 43 | 3767 |
| GO:0070062 | extracellular vesicular exosome | 3.95e-01 | 1.00e+00 | 0.587 | 2 | 40 | 2400 |
| GO:0005615 | extracellular space | 4.23e-01 | 1.00e+00 | 0.914 | 1 | 2 | 957 |
| GO:0005515 | protein binding | 7.20e-01 | 1.00e+00 | -0.155 | 3 | 62 | 6024 |
| GO:0005634 | nucleus | 7.75e-01 | 1.00e+00 | -0.338 | 2 | 43 | 4559 |
| GO:0005886 | plasma membrane | 7.94e-01 | 1.00e+00 | -0.518 | 1 | 20 | 2582 |